Role of Androgen Receptor in Progression of LNCaP Prostate Cancer Cells from G1 to S Phase

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Murthy, Shalini ^a   Wu, Min ^a   Bai, V Uma ^a   Hou, Zizheng ^a   Menon, Mani ^a   Barrack, Evelyn R ^a   Kim, Sahn Ho ^a   Reddy, G Prem Veer ^a  

^a HENRY FORD HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; BICALUTAMIDE; CELL CYCLE PROTEIN 6; CYCLIN A; CYCLIN E; CYCLINE; DNA DIRECTED DNA POLYMERASE ALPHA; RIBONUCLEOTIDE REDUCTASE;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL DIVISION; CELL PROLIFERATION; CELL STRAIN LNCAP; COMPLEX FORMATION; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS; DRUG PULSE THERAPY; IMMUNOPRECIPITATION; PROSTATE CANCER; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SEDIMENTATION; TREATMENT DURATION;

ANDROGEN RECEPTOR ANTAGONISTS; ANILIDES; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN A; CYCLIN E; DNA REPLICATION; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; MALE; NITRILES; NUCLEAR PROTEINS; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; TOSYL COMPOUNDS;

EID: 84874239421     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0056692     Document Type: Article

References (51)

1. Siegel R, Naishadham D, Jemal A, (2012) Cancer statistics, 2012. CA Cancer J Clin 62: 10-29.
2. Huggins C, Hodges CV (2002) Studies on prostatic cancer. I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. 1941. J Urol 167: 948-951; discussion 952.
3. Feldman BJ, Feldman D, (2001) The development of androgen-independent prostate cancer. Nat Rev Cancer 1: 34-45.
4. Pienta KJ, Bradley D, (2006) Mechanisms underlying the development of androgen-independent prostate cancer. Clin Cancer Res 12: 1665-1671.
5. Chen CD, Welsbie DS, Tran C, Baek SH, Chen R, et al. (2004) Molecular determinants of resistance to antiandrogen therapy. Nat Med 10: 33-39.
6. Shah RB, Mehra R, Chinnaiyan AM, Shen R, Ghosh D, et al. (2004) Androgen-independent prostate cancer is a heterogeneous group of diseases: lessons from a rapid autopsy program. Cancer Res 64: 9209-9216.
7. Ricciardelli C, Choong CS, Buchanan G, Vivekanandan S, Neufing P, et al. (2005) Androgen receptor levels in prostate cancer epithelial and peritumoral stromal cells identify non-organ confined disease. Prostate 63: 19-28.
8. Compagno D, Merle C, Morin A, Gilbert C, Mathieu JR, et al. (2007) siRNA-directed in vivo silencing of androgen receptor inhibits the growth of castration-resistant prostate carcinomas. PLoS One 2: e1006.
9. Haag P, Bektic J, Bartsch G, Klocker H, Eder IE, (2005) Androgen receptor down regulation by small interference RNA induces cell growth inhibition in androgen sensitive as well as in androgen independent prostate cancer cells. J Steroid Biochem Mol Biol 96: 251-258.
10. Snoek R, Cheng H, Margiotti K, Wafa LA, Wong CA, et al. (2009) In vivo knockdown of the androgen receptor results in growth inhibition and regression of well-established, castration-resistant prostate tumors. Clin Cancer Res 15: 39-47.
11. Yuan X, Li T, Wang H, Zhang T, Barua M, et al. (2006) Androgen receptor remains critical for cell-cycle progression in androgen-independent CWR22 prostate cancer cells. Am J Pathol 169: 682-696.
12. Eder IE, Culig Z, Ramoner R, Thurnher M, Putz T, et al. (2000) Inhibition of LncaP prostate cancer cells by means of androgen receptor antisense oligonucleotides. Cancer Gene Ther 7: 997-1007.
13. Zegarra-Moro OL, Schmidt LJ, Huang H, Tindall DJ, (2002) Disruption of androgen receptor function inhibits proliferation of androgen-refractory prostate cancer cells. Cancer Res 62: 1008-1013.
14. Bai VU, Cifuentes E, Menon M, Barrack ER, Reddy GP, (2005) Androgen receptor regulates Cdc6 in synchronized LNCaP cells progressing from G1 to S phase. J Cell Physiol 204: 381-387.
15. Cifuentes E, Croxen R, Menon M, Barrack ER, Reddy GP, (2003) Synchronized prostate cancer cells for studying androgen regulated events in cell cycle progression from G1 into S phase. J Cell Physiol 195: 337-345.
16. Reddy GP, Cifuentes E, Bai U, Menon M, Barrack ER (2004) Onset of DNA synthesis and S phase. In: Stein GS, Pardee AB, editors. Cell Cycle and Growth Control: Biological Regulation and Cancer. Second Edition ed: John Wiley & Sons, Inc. 149-200.
17. Bai VU, Hwang O, Divine GW, Barrack ER, Menon M, et al. (2012) Averaged differential expression for the discovery of biomarkers in the blood of patients with prostate cancer. PLoS One 7: e34875.
18. Subramanyam C, Honn SC, Reed WC, Reddy GP, (1990) Nuclear localization of 68 kDa calmodulin-binding protein is associated with the onset of DNA replication. J Cell Physiol 144: 423-428.
19. Reddy GPV, Pardee AB, (1980) Multienzyme complex for metabolic channeling in mammalian DNA replication. Proc Natl Acad Sci U S A 77: 3312-3316.
20. Murthy S, Reddy GP, (2006) Replitase: complete machinery for DNA synthesis. J Cell Physiol 209: 711-717.
21. Koochekpour S, Lee TJ, Wang R, Culig Z, Delorme N, et al. (2007) Prosaposin upregulates AR and PSA expression and activity in prostate cancer cells (LNCaP). Prostate 67: 178-189.
22. Arnold JT, Liu X, Allen JD, Le H, McFann KK, et al. (2007) Androgen receptor or estrogen receptor-beta blockade alters DHEA-, DHT-, and E(2)-induced proliferation and PSA production in human prostate cancer cells. Prostate 67: 1152-1162.
23. Riegman PH, Vlietstra RJ, van der Korput JA, Brinkmann AO, Trapman J, (1991) The promoter of the prostate-specific antigen gene contains a functional androgen responsive element. Mol Endocrinol 5: 1921-1930.
24. Lee EC, Zhan P, Schallhom R, Packman K, Tenniswood M, (2003) Antiandrogen-induced cell death in LNCaP human prostate cancer cells. Cell Death Differ 10: 761-771.
25. Quero L, Giocanti N, Hennequin C, Favaudon V, (2010) Antagonistic interaction between bicalutamide (Casodex) and radiation in androgen-positive prostate cancer LNCaP cells. Prostate 70: 401-411.
26. Zhan P, Lee EC, Packman K, Tenniswood M, (2002) Induction of invasive phenotype by Casodex in hormone-sensitive prostate cancer cells. J Steroid Biochem Mol Biol 83: 101-111.
27. Cifuentes E, Mataraza JM, Yoshida BA, Menon M, Sacks DB, et al. (2004) Physical and functional interaction of androgen receptor with calmodulin in prostate cancer cells. Proc Natl Acad Sci U S A 101: 464-469.
28. Jaumot M, Grana X, Giordano A, Reddy PV, Agell N, et al. (1994) Cyclin/cdk2 complexes in the nucleus of HeLa cells. Biochem Biophys Res Commun 203: 1527-1534.
29. Noguchi H, Prem veer Reddy G, Pardee AB, (1983) Rapid incorporation of label from ribonucleoside disphosphates into DNA by a cell-free high molecular weight fraction from animal cell nuclei. Cell 32: 443-451.
30. Reddy GP, Pardee AB, (1980) Multienzyme complex for metabolic channeling in mammalian DNA replication. Proc Natl Acad Sci U S A 77: 3312-3316.
31. Jin F, Fondell JD, (2009) A novel androgen receptor-binding element modulates Cdc6 transcription in prostate cancer cells during cell-cycle progression. Nucleic Acids Res 37: 4826-4838.
32. Liao X, Tang S, Thrasher JB, Griebling TL, Li B, (2005) Small-interfering RNA-induced androgen receptor silencing leads to apoptotic cell death in prostate cancer. Mol Cancer Ther 4: 505-515.
33. Carter MF, Chung LWK, Coffey DS (1972) The temporal requirements for androgens during the cell cycle of the prostate gland. In: King LR, Murphy GP, editors. Fetschrift Urological Research. New York: Plennum Publishers. 27-33.
34. D'Antonio JM, Vander Griend DJ, Isaacs JT, (2009) DNA licensing as a novel androgen receptor mediated therapeutic target for prostate cancer. Endocr Relat Cancer 16: 325-332.
35. Shi YK, Yu YP, Zhu ZH, Han YC, Ren B, et al. (2008) MCM7 interacts with androgen receptor. Am J Pathol 173: 1758-1767.
36. Frouin I, Montecucco A, Spadari S, Maga G, (2003) DNA replication: a complex matter. EMBO Rep 4: 666-670.
37. Dai H, Liu J, Malkas LH, Hickey RJ, (2009) Characterization of RNA primers synthesized by the human breast cancer cell DNA synthesome. J Cell Biochem 106: 798-811.
38. Reddy GP, Fager RS, (1993) Replitase: a complex integrating dNTP synthesis and DNA replication. Crit Rev Eukaryot Gene Expr 3: 255-277.
39. Sivanandam A, Murthy S, Kim SH, Barrack ER, Veer Reddy GP, (2010) Role of androgen receptor in prostate cancer cell cycle regulation: interaction with cell cycle regulatory proteins and enzymes of DNA synthesis. Curr Protein Pept Sci 11: 451-458.
40. Sathya G, Chang CY, Kazmin D, Cook CE, McDonnell DP, (2003) Pharmacological uncoupling of androgen receptor-mediated prostate cancer cell proliferation and prostate-specific antigen secretion. Cancer Res 63: 8029-8036.
41. DeGregori J, Kowalik T, Nevins JR, (1995) Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes. Mol Cell Biol 15: 4215-4224.
42. Hateboer G, Wobst A, Petersen BO, Le Cam L, Vigo E, et al. (1998) Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F. Mol Cell Biol 18: 6679-6697.
43. Bosco G, Du W, Orr-Weaver TL, (2001) DNA replication control through interaction of E2F-RB and the origin recognition complex. Nat Cell Biol 3: 289-295.
44. Mendoza-Maldonado R, Paolinelli R, Galbiati L, Giadrossi S, Giacca M, (2010) Interaction of the retinoblastoma protein with Orc1 and its recruitment to human origins of DNA replication. PLoS One 5: e13720.
45. Snyder M, Huang XY, Zhang JJ, (2009) The minichromosome maintenance proteins 2-7 (MCM2-7) are necessary for RNA polymerase II (Pol II)-mediated transcription. J Biol Chem 284: 13466-13472.
46. Gilbert DM, (2002) Replication timing and transcriptional control: beyond cause and effect. Curr Opin Cell Biol 14: 377-383.
47. Schwaiger M, Schubeler D, (2006) A question of timing: emerging links between transcription and replication. Curr Opin Genet Dev 16: 177-183.
48. Holmquist G, Gray M, Porter T, Jordan J, (1982) Characterization of Giemsa dark- and light-band DNA. Cell 31: 121-129.
49. Yunis JJ, Kuo MT, Saunders GF, (1977) Localization of sequences specifying messenger RNA to light-staining G-bands of human chromosomes. Chromosoma 61: 335-344.
50. Karnani N, Taylor CM, Malhotra A, Dutta A, (2010) Genomic study of replication initiation in human chromosomes reveals the influence of transcription regulation and chromatin structure on origin selection. Mol Biol Cell 21: 393-404.
51. Sequeira-Mendes J, Diaz-Uriarte R, Apedaile A, Huntley D, Brockdorff N, et al. (2009) Transcription initiation activity sets replication origin efficiency in mammalian cells. PLoS Genet 5: e1000446.