Brain dynamic neurochemical changes in dystonic patients: A magnetic resonance spectroscopy study

Movement Disorders

Volumn 28, Issue 2, 2013, Pages 201-209

  Marjańska, Malgorzata ^a   Lehéricy, Stéphane ^b,c,d,e,f,g   Valabrègue, Romain ^b   Popa, Traian ^b,c,d,e,f   Worbe, Yulia ^c,d,e,f   Russo, Margherita ^c,d,e   Auerbach, Edward J ^a   Grabli, David ^g   Bonnet, Cecilia ^g,h   Gallea, Cécile ^b   Coudert, Mathieu ^g   Yahia Cherif, Lydia ^b,d   Vidailhet, Marie ^c,d,e,f,g   Meunier, Sabine ^c,d,e,f  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b Centre de NeuroImagerie de Recherche (CENIR)   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d CNRS   (France)

^e INSERM   (France)

^f INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE   (France)

^g PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^h CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Dystonia; Gamma aminobutyric acid (GABA); NAA; Spectroscopy; Transcranial magnetic stimulation

Indexed keywords

4 AMINOBUTYRIC ACID; GLUTAMIC ACID; GLUTAMINE; N ACETYLASPARTIC ACID;

4 AMINOBUTYRIC ACID METABOLISM; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DISEASE DURATION; DYSTONIA; FEMALE; HUMAN; MALE; MOTOR CORTEX; NEUROCHEMISTRY; NEUROTRANSMISSION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OCCIPITAL CORTEX; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SENSORIMOTOR CORTEX; TRANSCRANIAL MAGNETIC STIMULATION; TREMOR;

ADULT; AGED; ASPARTIC ACID; BRAIN CHEMISTRY; DATA INTERPRETATION, STATISTICAL; DYSTONIA; ENERGY METABOLISM; FEMALE; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; GLUTAMINE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; MOTOR CORTEX; NEOSTRIATUM; NEURAL PATHWAYS; SOMATOSENSORY CORTEX; TRANSCRANIAL MAGNETIC STIMULATION; UPPER EXTREMITY; YOUNG ADULT;

EID: 84874221524     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.25279     Document Type: Article

References (47)

1. Ridding MC, Sheean G, Rothwell JC, Inzelberg R, Kujirai T. Changes in the balance between motor cortical excitation and inhibition in focal, task specific dystonia. J Neurol Neurosurg Psychiatry 1995;59:493-498.
2. Edwards MJ, Huang YZ, Wood NW, Rothwell JC, Bhatia KP. Different patterns of electrophysiological deficits in manifesting and non-manifesting carriers of the DYT1 gene mutation. Brain 2003;126:2074-2080.
3. Hornykiewicz O, Kish SJ, Becker LE, Farley I, Shannak K. Brain neurotransmitters in dystonia musculorum deformans. New Engl J Med 1986;315:347-353.
4. de Yebenes JG, Vazquez A, Martinez A, et al. Biochemical findings in symptomatic dystonias. Adv Neurol 1988;50:167-175.
5. Mescher M, Merkle H, Kirsch J, Garwood M, Gruetter R. Simultaneous in vivo spectral editing and water suppression. NMR Biomed 1998;11:266-272.
6. Levy LM, Hallett M. Impaired brain GABA in focal dystonia. Ann Neurol 2002;51:93-101.
7. Herath P, Gallea C, van der Veen JW, Horovitz SG, Hallett M. In vivo neurochemistry of primary focal hand dystonia: a magnetic resonance spectroscopic neurometabolite profiling study at 3T. Mov Disord 2010;25:2800-2808.
8. Michael N, Gösling M, Reutemann M, et al. Metabolic changes after repetitive transcranial magnetic stimulation (rTMS) of the left prefrontal cortex: a sham-controlled proton magnetic resonance spectroscopy (1H MRS) study of healthy brain. Eur J Neurosci 2003;17:2462-2468.
9. Luborzewski A, Schubert F, Seifert F, et al. Metabolic alterations in the dorsolateral prefrontal cortex after treatment with high-frequency repetitive transcranial magnetic stimulation in patients with unipolar major depression. J Psychiatr Res 2007;41:606-615.
10. 1H magnetic resonance spectroscopy study. Neurosci Lett 2011;500:67-71.
11. Fregni F, Potvin K, Dasilva D, et al. Clinical effects and brain metabolic correlates in non-invasive cortical neuromodulation for visceral pain. Eur J Pain 2011;15:53-60.
12. Stagg CJ, Wylezinska M, Matthews PM, et al. Neurochemical effects of theta burst stimulation as assessed by magnetic resonance spectroscopy. J Neurophysiol 2009;101:2872-2877.
13. Stagg CJ, Best JG, Stephenson MC, et al. Polarity-sensitive modulation of cortical neurotransmitters by transcranial stimulation. J Neurosci 2009;29:5202-5206.
14. Petroff OA. GABA and glutamate in the human brain. Neuroscientist 2002;8:562-573.
15. Moffett JR, Ross B, Arun P, Madhavarao CN, Namboodiri AM. N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology. Prog Neurobiol 2007;81:89-131.
16. Gilio F, Suppa A, Bologna M, Lorenzano C, Fabbrini G, Berardelli A. Short-term cortical plasticity in patients with dystonia: a study with repetitive transcranial magnetic stimulation. Mov Disord 2007;22:1436-1443.
17. Mescher M, Tannus A, Johnson MO, Garwood M. Solvent suppression using selective echo dephasing. J Magn Reson 1996;123:226-229.
18. 1H NMR spectroscopy of rat brain at 1 ms echo time. Magn Reson Med 1999;41:649-656.
19. Gruetter R, Tkac I. Field mapping without reference scan using asymmetric echo-planar techniques. Magn Reson Med 2000;43:319-323.
20. Yousry TA, Schmid UD, Alkadhi H, et al. Localization of the motor hand area to a knob on the precentral gyrus. A new landmark. Brain 1997;120:141-157.
21. Quartarone A, Bagnato S, Rizzo V, et al. Distinct changes in cortical and spinal excitability following high-frequency repetitive TMS to the human motor cortex. Exp Brain Res 2005;61:114-124.
22. Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 1993;30:672-679.
23. 1H spectra with LCModel. NMR Biomed 2001;14:260-264.
24. Gasparovic C, Song T, Devier D, et al. Use of tissue water as a concentration reference for proton spectroscopic imaging. Magn Reson Med 2006;55:1219-1226.
25. 1H metabolite relaxation times at 3.0 tesla: Measurements of T1 and T2 values in normal brain and determination of regional differences in transverse relaxation. J Magn Reson Imaging 2004;19:537-545.
26. Littell RC, Milliken GA, Stroup WW, Wolfinger RD, Schabenberge O. SAS for Mixed Models. 2nd ed.Cary, NC:SAS Institute Inc.;2006
27. Garibotto V, Romito LM, Elia AE, et al. In vivo evidence for GABA(A) receptor changes in the sensorimotor system in primary dystonia. Mov Disord 2011;26:852-827.
28. Patel AB, de Graaf RA, Mason GF, Rothman DL, Shulman RG, Behar KL. The contribution of GABA to glutamate/glutamine cycling and energy metabolism in the rat cortex in vivo. Proc Natl Acad Sci U S A 2005;102:5588-5593.
29. Tegenthoff M, Ragert P, Pleger B, Schwenkreis P, Förster AF, Nicolas V, Dinse HR. Improvement of tactile discrimination performance and enlargement of cortical somatosensory maps after 5 Hz rTMS. PLoS Biol 2005;3:e362.
30. Rounis E, Lee L, Siebner HR, et al. Frequency specific changes in regional cerebral blood flow and motor system connectivity following rTMS to the primary motor cortex. Neuroimage 2005;26:164-176.
31. Semyanov A, Walker MC, Kullmann DM, Silver RA. Tonically active GABA A receptors: modulating gain and maintaining the tone. Trends Neurosci 2004;27:262-269.
32. Fitzgerald PB, Fountain S, Daskalakis ZJ. A comprehensive review of the effects of rTMS on motor cortical excitability and inhibition. Clin Neurophysiol 2006;117:2584-2596.
33. Stagg CJ, Bestmann S, Constantinescu AO, et al. Relationship between physiological measures of excitability and levels of glutamate and GABA in the human motor cortex. J Physiol 2011;589:5845-5855.
34. Kullmann DM, Ruiz A, Rusakov DM, Scott R, Semyanov A, Walker MC. Presynaptic, extrasynaptic and axonal GABAA receptors in the CNS: where and why? Progr Biophys Mol Biol 2005;87:33-46.
35. Quartarone A, Bagnato S, Rizzo V, et al. Abnormal associative plasticity of the human motor cortex in writer's cramp. Brain 2003;126:2586-2596.
36. Martin LJ, Zurek AA, MacDonald JF, Roder JC, Jackson MF, Orser BA. α5GABAA receptor activity sets the threshold for long-term potentiation and constrains hippocampus-dependent memory. J Neurosci 2010;30:5269-5282.
37. Arima-Yoshida F, Watabe AM, Manabe T. The mechanisms of the strong inhibitory modulation of long-term potentiation in the rat dentate gyrus. Eur J Neurosci 2011;33:1637-1646.
38. Castro-Alamancos MA, Donoghue JP, Connors BW. Different forms of synaptic plasticity in somatosensory and motor areas of the neocortex. J Neurosci 1995;15:5324-5333.
39. Ziemann U, Hallett M, Cohen LG. Mechanisms of deafferentation-induced plasticity in human motor cortex. J Neurosci 1998;18:7000-7007.
40. Peinemann A, Reimer B, Löer C, et al. Long-lasting increase in corticospinal excitability after 1800 pulses of subthreshold 5 Hz repetitive TMS to the primary motor cortex. Clin Neurophysiol 2004;115:1519-1526.
41. 1H NMR spectroscopy in the human visual cortex. J Cereb Blood Flow Metab 2007;27:1055-1063.
42. Strafella AP, Paus T. Cerebral blood-flow changes induced by paired-pulse transcranial magnetic stimulation of the primary motor cortex. J Neurophysiol 2001;85:2624-2629.
43. Baslow MH, Hrabe J, Guilfoyle DN. Dynamic relationship between neurostimulation and N-acetylaspartate metabolism in the human visual cortex: evidence that NAA functions as a molecular water pump during visual stimulation. J Mol Neurosci 2007;32:235-245.
44. Pouwels PJ, Frahm J. Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS. Magn Reson Med 1998;39:53-60.
45. Kloppel S, Mangin JF, Vongerichten A, Frackowiak RS, Siebner HR. Nurture versus nature: long-term impact of forced right-handedness on structure of pericentral cortex and basal ganglia. J Neurosci 2010;30:3271-3275.
46. Iturria-Medina Y, Pérez Fernández A, Morris DM, et al. Brain hemispheric structural efficiency and interconnectivity rightward asymmetry in human and nonhuman primates. Cereb Cortex 2011;21:56-67.
47. Woolley DG, Wenderoth N, Heuninckx S, Zhang X, Callaert D, Swinnen SP. Visual guidance modulates hemispheric asymmetries during an interlimb coordination task. Neuroimage 2010;50:1566-1577.