In vivo evidence for GABAA receptor changes in the sensorimotor system in primary dystonia

Movement Disorders

Volumn 26, Issue 5, 2011, Pages 852-857

  Garibotto, Valentina ^a,b   Romito, Luigi M ^c,d   Elia, Antonio E ^c,d   Soliveri, Paola ^c   Panzacchi, Andrea ^b   Carpinelli, Assunta ^e   Tinazzi, Michele ^f,g   Albanese, Alberto ^c,d   Perani, Daniela ^a,b  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c DEPARTMENT OF NEUROSURGERY   (Italy)

^d UNIVERSITÀ CATTOLICA DEL SACRO CUORE   (Italy)

^e INSTITUTE OF MOLECULAR BIOIMAGING AND PHYSIOLOGY   (Italy)

^f UNIVERSITY OF VERONA   (Italy)

^g BORGO TRENTO HOSPITAL   (Italy)

Author keywords

Dystonia; GABA; GABAA receptors; PET; Sensorimotor cortex

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; FLUMAZENIL C 11;

ADULT; ARTICLE; BINDING AFFINITY; CINGULATE GYRUS; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DYSTONIA; FEMALE; GABAERGIC SYSTEM; GENE EXPRESSION; GENE MUTATION; HUMAN; IN VIVO STUDY; MALE; NEUROIMAGING; POSITRON EMISSION TOMOGRAPHY; PREMOTOR CORTEX; PRIMARY MOTOR CORTEX; PRIORITY JOURNAL; SECONDARY SOMATOSENSORY CORTEX; SENSORIMOTOR FUNCTION; VOXEL BASED MORPHOMETRY;

ADULT; ANALYSIS OF VARIANCE; BRAIN MAPPING; CEREBRAL CORTEX; DYSTONIC DISORDERS; FEMALE; FLUMAZENIL; GABA MODULATORS; HUMANS; MALE; MIDDLE AGED; MOLECULAR CHAPERONES; RECEPTORS, GABA-A; SEQUENCE DELETION; TRINUCLEOTIDE REPEATS;

EID: 79955093492     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.23553     Document Type: Article

References (38)

1. Breakefield XO, Blood AJ, Li Y, Hallett M, Hanson PI, Standaert DG. The pathophysiological basis of dystonias. Nat Rev Neurosci 2008; 9: 222-234.
2. Albanese A, Lalli S. Is this dystonia. Mov Disord 2009; 24: 1725-1731.
3. Alterman RL, Snyder BJ. Deep brain stimulation for torsion dystonia. Acta Neurochir Suppl 2007; 97: 191-199.
4. Beales M, Lorden JF, Walz E, Oltmans GA. Quantitative autoradiography reveals selective changes in cerebellar GABA receptors of the rat mutant dystonic. J Neurosci 1990; 10: 1874-1885.
5. Berardelli A, Rothwell JC, Hallett M, Thompson PD, Manfredi M, Marsden CD. The pathophysiology of primary dystonia. Brain 1998; 121: 1195-1212.
6. Ceballos-Baumann AO, Passingham RE, Warner T, Playford ED, Marsden CD, Brooks DJ. Overactive prefrontal and underactive motor cortical areas in idiopathic dystonia. Ann Neurol 1995; 37: 363-372.
7. Edwards MJ, Talelli P, Rothwell JC. Clinical applications of transcranial magnetic stimulation in patients with movement disorders. Lancet Neurol 2008; 7: 827-840.
8. Eidelberg D, Moeller JR, Antonini A, et al. Functional brain networks in DYT1 dystonia. Ann Neurol 1998; 44: 303-312.
9. Galardi G, Perani D, Grassi F, et al. Basal ganglia and thalamo-cortical hypermetabolism in patients with spasmodic torticollis. Acta Neurol Scand 1996; 94: 172-176.
10. Gernert M, Richter A, Löscher W. Alterations in spontaneous single unit activity of striatal subdivisions during ontogenesis in mutant dystonic hamsters. Brain Res 1999; 821: 277-285.
11. Löscher W, Hörstermann D. Abnormalities in amino acid neurotransmitters in discrete brain regions of genetically dystonic hamsters. J Neurochem 1992; 59: 689-694.
12. Messer A, Gordon D. Changes in whole tissue biosynthesis of gamma-amino butyric acid (GABA) in basal ganglia of the dystonia (dtAlb) mouse. Life Sci 1979; 25: 2217-2221.
13. Nobrega JN, Richter A, Burnham WM, Lôscher W. Alterations in the brain GABAA/benzodiazepine receptor-chloride ionophore complex in a genetic model of paroxysmal dystonia: a quantitative autoradiographic analysis. Neuroscience 1995; 64: 229-239.
14. Pratt GD, Richter A, Möhler H, Löscher W. Regionally selective and age-dependent alterations in benzodiazepine receptor binding in the genetically dystonic hamster. J Neurochem 1995; 64: 2153-2158.
15. Romito LM, Franzini A, Perani D, et al. Fixed dystonia unresponsive to pallidal stimulation improved by motor cortex stimulation. Neurology 2007; 68: 875-876.
16. Tinazzi M, Fiorio M, Fiaschi A, Rothwell JC, Bhatia KP. Sensory functions in dystonia: insights from behavioral studies. Mov Disord 2009; 24: 1427-1436.
17. Levy LM, Hallett M. Impaired brain GABA in focal dystonia. Ann Neurol 2002; 51: 93-101.
18. Draganski B, Schneider SA, Fiorio M, et al. Genotype-phenotype interactions in primary dystonias revealed by differential changes in brain structure. Neuroimage 2009; 47: 1141-1147.
19. Edwards MJ, Huang Y, Wood NW, Rothwell JC, Bhatia KP. Different patterns of electrophysiological deficits in manifesting and non-manifesting carriers of the DYT1 gene mutation. Brain 2003; 126: 2074-2080.
20. Burke RE, Fahn S, Marsden CD, Bressman SB, Moskowitz C, Friedman J. Validity and reliability of a rating scale for the primary torsion dystonias. Neurology 1985; 35: 73-77.
21. Perani D, Garibotto V, Hadjigeorgiou GM, Papadimitriou D, Fazio F, Papadimitriou A. Positron emission tomography changes in PARK1 mutation. Mov Disord 2006; 21: 127-130.
22. Gunn RN, Lammertsma AA, Hume SP, Cunningham VJ. Parametric imaging of ligand-receptor binding in PET using a simplified reference region model. Neuroimage 1997; 6: 279-287.
23. Klumpers UMH, Veltman DJ, Boellaard R, et al. Comparison of plasma input and reference tissue models for analysing [(11)C]flumazenil studies. J Cereb Blood Flow Metab 2008; 28: 579-587.
24. Fink GR, Frackowiak RS, Pietrzyk U, Passingham RE. Multiple nonprimary motor areas in the human cortex. J Neurophysiol 1997; 77: 2164-2174.
25. Gilbert SL, Zhang L, Forster ML, et al. Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice. Nat Genet 2006; 38: 245-250.
26. Frankle WG, Cho RY, Narendran R, et al. Tiagabine increases [11C]flumazenil binding in cortical brain regions in healthy control subjects. Neuropsychopharmacology 2009; 34: 624-633.
27. Braestrup C, Schmiechen R, Neef G, Nielsen M, Petersen EN. Interaction of convulsive ligands with benzodiazepine receptors. Science 1982; 216: 1241-1243.
28. Bottlaender M, Schmid L, Fuseau C, Fournier D, Brouillet E, Mazière M. In vivo modulation of benzodiazepine receptor function after inhibition of endogenous gamma-aminobutyric acid synthesis. Eur J Pharmacol 1997; 321: 13-17.
29. Schmid L, Bottlaender M, Brouillet E, Fuseau C, Mazière M. Vigabatrin modulates benzodiazepine receptor activity in vivo: a positron emission tomography study in baboon. J Pharmacol Exp Ther 1996; 276: 977-983.
30. Tanabe LM, Kim CE, Alagem N, Dauer WT. Primary dystonia: molecules and mechanisms. Nat Rev Neurol 2009; 5: 598-609.
31. Tepper JM, Bolam JP. Functional diversity and specificity of neostriatal interneurons. Curr Opin Neurobiol 2004; 14: 685-692.
32. Ziemann U, Muellbacher W, Hallett M, Cohen LG. Modulation of practice-dependent plasticity in human motor cortex. Brain 2001; 124: 1171-1181.
33. Matsumura M, Sawaguchi T, Oishi T, Ueki K, Kubota K. Behavioral deficits induced by local injection of bicuculline and muscimol into the primate motor and premotor cortex. J Neurophysiol 1991; 65: 1542-1553.
34. Quartarone A, Morgante F, Sant'angelo A, et al. Abnormal plasticity of sensorimotor circuits extends beyond the affected body part in focal dystonia. J Neurol Neurosurg Psychiatry 2008; 79: 985-990.
35. Tamura Y, Ueki Y, Lin P, et al. Disordered plasticity in the primary somatosensory cortex in focal hand dystonia. Brain 2009; 132: 749-755.
36. Dykes RW, Landry P, Metherate R, Hicks TP. Functional role of GABA in cat primary somatosensory cortex: shaping receptive fields of cortical neurons. J Neurophysiol 1984; 52: 1066-1093.
37. Weise D, Schramm A, Stefan K, Wolters A, Reiners K, Naumann M, Classen J. The two sides of associative plasticity in writer's cramp. Brain 2006; 129: 2709-2721.
38. Tamburin S, Manganotti P, Marzi CA, Fiaschi A, Zanette G. Abnormal somatotopic arrangement of sensorimotor interactions in dystonic patients. Brain 2002; 125: 2719-2730.