Allele-specific transcriptional activity of the variable number of tandem repeats in 5′ region of the DRD4 gene is stimulus specific in human neuronal cells

Genes, Brain and Behavior

Volumn 12, Issue 2, 2013, Pages 282-287

  Paredes, U M ^a   Quinn, J P ^b   D'Souza, U M ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Dopamine receptor; Gene expression; Neuronal cultures; VNTR

Indexed keywords

DOPAMINE 4 RECEPTOR; LUCIFERASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CTCF; UPSTREAM STIMULATORY FACTOR 2;

ALLELE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL SPECIFICITY; CELL STRAIN; CELL TYPE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE CONSTRUCT; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE LOCUS; GENETIC TRANSFECTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; MALE; MOLECULAR CLONING; NERVE CELL CULTURE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RAT; REPORTER GENE; SIGNAL TRANSDUCTION; TANDEM REPEAT; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

5' FLANKING REGION; ALLELES; ANIMALS; BRAIN; CELL LINE; GENES, REPORTER; HUMANS; LUCIFERASES; MALE; MINISATELLITE REPEATS; NEURONS; POLYMORPHISM, GENETIC; RATS; RATS, WISTAR; RECEPTORS, DOPAMINE D4; REPRESSOR PROTEINS; TRANSCRIPTION, GENETIC; UPSTREAM STIMULATORY FACTORS;

RATTUS;

EID: 84874191082     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2012.00857.x     Document Type: Article

References (25)

1. Ali, F.R., Vasiliou, S.A., Haddley, K., Paredes, U.M., Roberts, J.C., Miyajima, F., Klenova, E., Bubb, V.J. & Quinn, J.P. (2010) Combinatorial interaction between two human serotonin transporter gene variable number tandem repeats and their regulation by CTCF. J Neurochem 112, 296-306.
2. Czermak, C., Lehofer, M., Wagner, E.M., Prietl, B., Lemonis, L., Rohrhofer, A., Schauenstein, K. & Liebmann, P.M. (2004) Reduced dopamine D4 receptor mRNA expression in lymphocytes of long-term abstinent alcohol and heroin addicts. Addiction 99, 251-257.
3. D'Souza, U.M., Russ, C., Tahir, E., Mill, J., McGuffin, P., Asherson, P.J. & Craig, I.W. (2004) Functional effects of a tandem duplication polymorphism in the 5'flanking region of the DRD4 gene. Biol Psychiatry 56, 691-697.
4. Grabe, N. (2002) AliBaba2: context specific identification of transcription factor binding sites. In Silico Biol 2, 1-15.
5. Haddley, K., Spencer, E.M., Vasiliou, S.A., Howard, M., Thippeswamy, T., Bubb, V.J. & Quinn, J.P. (2011) Lithium chloride regulation of the substance P encoding preprotachykinin a, Tac1 gene in rat hippocampal primary cells. J Mol Neurosci 45, 94-100.
6. Kamakura, S., Iwaki, A., Matsumoto, M. & Fukumaki, Y. (1997) Cloning and characterization of the 5′-flanking region of the human dopamine D4 receptor gene. Biochem Biophys Res Commun 235, 321-326.
7. Kereszturi, E., Kiraly, O., Barta, C., Molnar, N., Sasvari-Szekely, M. & Csapo, Z. (2006) No direct effect of the -521 C/T polymorphism in the human dopamine D4 receptor gene promoter on transcriptional activity. BMC Mol Biol 7, 18.
8. Kereszturi, E., Kiraly, O., Csapo, Z., Tarnok, Z., Gadoros, J., Sasvari-Szekely, M. & Nemoda, Z. (2007) Association between the 120-bp duplication of the dopamine D4 receptor gene and attention deficit hyperactivity disorder: genetic and molecular analyses. Am J Med Genet B Neuropsychiatr Genet 144B, 231-236.
9. Klenova, E., Scott, A.C., Roberts, J., Shamsuddin, S., Lovejoy, E.A., Bergmann, S., Bubb, V.J., Royer, H.D. & Quinn, J.P. (2004) YB-1 and CTCF differentially regulate the 5-HTT polymorphic intron 2 enhancer which predisposes to a variety of neurological disorders. J Neurosci 24, 5966-5973.
10. Li, T., Chen, C., Hu, X., Ball, D., Lin, S.K., Chen, W., Sham, P.C., Loh, E.W., Murray, R.M. & Collier, D.A. (2004) Association analysis of the DRD4 and COMT genes in methamphetamine abuse. Am J Med Genet B Neuropsychiatr Genet 129B, 120-124.
11. Matsumoto, M., Hidaka, K., Tada, S., Tasaki, Y. & Yamaguchi, T. (1996) Low levels of mRNA for dopamine D4 receptor in human cerebral cortex and striatum. J Neurochem 66, 915-919.
12. Nakajima, M., Hattori, E., Yamada, K., Iwayama, Y., Toyota, T., Iwata, Y., Tsuchiya, K.J., Sugihara, G., Hashimoto, K. & Watanabe, H. (2007) Association and synergistic interaction between promoter variants of the DRD4 gene in Japanese schizophrenics. J Hum Genet 52, 86-91.
13. Oak, J.N., Oldenhof, J. & Van Tol, H.H.M. (2000) The dopamine D4 receptor: one decade of research. Eur J Pharmacol 404, 303-327.
14. Okuyama, Y., Ishiguro, H., Nankai, M., Shibuya, H., Watanabe, A. & Arinami, T. (2000) Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait. Mol Psychiatry 5, 64-69.
15. Paredes, U.M., Macho, G.A., Bubb, V.J., Haddley, K. & Quinn, J.P. (2011) Evolutionary conserved region in the H. sapiens DRD4 gene supports differential levels of reporter gene expression in cortical cultures. BMC Neurosci 12, 46.
16. Paterson, J.M., Morrison, C.F., Mendelson, S.C., McAllister, J. & Quinn, J.P. (1995) An upstream stimulatory factor (USF) binding motif is critical for rat preprotachykinin-A promoter activity in PC12 cells. Biochem J 310, 401-406.
17. Roberts, J., Scott, A.C., Howard, M.R., Breen, G., Bubb, V.J., Klenova, E. & Quinn, J.P. (2007) Differential regulation of the serotonin transporter gene by lithium is mediated by transcription factors, CCCTC binding protein and Y-box binding protein 1, through the polymorphic intron 2 variable number tandem repeat. J Neurosci 27, 2793-2801.
18. Ronai, Z., Guttman, A., Keszler, G. & Sasvari-Szekely, M. (2004) Capillary electrophoresis study on DNA-protein complex formation in the polymorphic 5′ upstream region of the dopamine D4 receptor (DRD4) gene. Curr Med Chem 11, 1023-1029.
19. Rosenbloom, K.R., Dreszer, T.R., Pheasant, M., Barber, G.P., Meyer, L.R., Pohl, A., Raney, B.J., Wang, T., Hinrichs, A.S., Zweig, A.S., Fujita, P.A., Learned, K., Rhead, B., Smith, K.E., Kuhn, R.M., Karolchik, D., Haussler, D. & Kent, W.J. (2010) ENCODE whole-genome data in the UCSC Genome Browser. Nucleic Acids Res 38, D620-D625.
20. Seaman, M.I., Fisher, J.B., Chang, F. & Kidd, K.K. (1999) Tandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4). Am J Med Genet 88, 705-709.
21. Simpson, J., Vetuz, G., Wilson, M., Brookes, K. & Kent, L. (2010) The DRD4 receptor exon 3 VNTR and 5′ SNP variants and mRNA expression in human post-mortem brain tissue. Am J Med Genet B Neuropsychiatr Genet 153B, 1228-1233.
22. Smith, T.F. (2010) Meta-analysis of the heterogeneity in association of DRD4 7-repeat allele and AD/HD: stronger association with AD/HD combined. Am J Med Genet B Neuropsychiatr Genet 153B, 1189-1199.
23. Todd, R.D., Neuman, R.J., Lobos, E.A., Jong, Y.J., Reich, W. & Heath, A.C. (2001) Lack of association of dopamine D4 receptor gene polymorphisms with ADHD subtypes in a population sample of twins. Am J Med Genet 8, 432-438.
24. Tompa, M., Li, N., Bailey, T.L. et al. (2005) Assessing computational tools for the discovery of transcription factor binding sites. Nat Biotechnol 23, 137-144.
25. Xiang, L., Szebeni, K., Szebeni, A., Klimek, V., Stockmeier, C.A., Karolewicz, B., Kalbfleisch, J. & Ordwaym, G.A. (2008) Dopamine receptor gene expression in human amygdaloid nuclei: elevated D4 receptor mRNA in major depression. Brain Res 1207, 214-224.