Expression of the renin-angiotensin system in a human placental cell line

Clinical Medicine and Research

Volumn 11, Issue 1, 2013, Pages 1-6

  Pan, Nan ^a   Frome, Wayne L ^a   Dart, Richard A ^a   Tewksbury, Duane ^a   Luo, Jiangming ^a  

^a MARSHFIELD CLINIC   (United States)

Author keywords

Expression; Placenta; Pre eclampsia; Pregnancy; Renin angiotensin system

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN I; ANGIOTENSIN II; DIPEPTIDYL CARBOXYPEPTIDASE; MESSENGER RNA; RNA;

ARTICLE; BLOOD FLOW; CELL CULTURE; CELL LYSATE; CONTROLLED STUDY; CULTURE MEDIUM; FEMALE; FETOMATERNAL TRANSFUSION; HUMAN; HUMAN CELL; IN VITRO STUDY; NUCLEOTIDE SEQUENCE; PLACENTA; PLASMA RENIN ACTIVITY; PREGNANCY; RADIOIMMUNOASSAY; REAL TIME POLYMERASE CHAIN REACTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RNA EXTRACTION; WESTERN BLOTTING;

ANGIOTENSIN II; CELL LINE; FEMALE; HUMANS; PEPTIDYL-DIPEPTIDASE A; PLACENTA; PREGNANCY; RECEPTOR, ANGIOTENSIN, TYPE 1; RENIN; RENIN-ANGIOTENSIN SYSTEM; RNA, MESSENGER;

EID: 84874149013     PISSN: 15394182     EISSN: 15546179     Source Type: Journal    
DOI: 10.3121/cmr.2012.1094     Document Type: Article

References (33)

1. Hagemann A, Nielsen AH, Poulsen K. The uteroplacental renin-angiotensin system: a review. Exp Clin Endocrinol 1994;102:252-261.
2. Poisner AM. The human placental renin-angiotensin system. Front Neuroendocrinol 1998;19:232-252.
3. Bader M, Peters J, Baltatu O, Muller DN, Luft FC, Ganten D. Tissue renin-angiotensin systems: new insights from experimental animal models in hypertension research. J Mol Med (Berl) 2001;79:76-102.
4. MacKenzie SM, Fraser R, Connell JM, Davies E. Local renin-angiotensin systems and their interactions with extra-adrenal corticosteroid production. J Renin Angiotensin Aldosterone Syst 2002;3:214-221.
5. Williams PJ, Mistry HD, Innes BA, Bulmer JN, Pipkin FB. Expression of AT1R, AT2R and AT4R and their roles in extravillous trophoblast invasion in the human. Placenta 2010;31:448-455.
6. Pringle KG, Tadros MA, Callister RJ, Lumbers ER. The expression and localization of the human placental prorenin/ renin-angiotensin system throughout pregnancy: roles in trophoblast invasion and angiogenesis? Placenta 2011;32:956-962.
7. Anton L, Brosnihan KB. Systemic and uteroplacental reninangiotensin system in normal and pre-eclamptic pregnancies. Ther Adv Cardiovasc Dis 2008;2:349-362.
8. Irani RA, Xia Y. The functional role of the renin-angiotensin system in pregnancy and preeclampsia. Placenta 2008;29:763-771.
9. Poston L. The control of blood flow to the placenta. Exp Physiol 1997;82:377-387.
10. Speroff L, Haning RV Jr, Levin RM. The effect of angiotensin II and indomethacin on uterine artery blood flow in pregnant monkeys. Obstet Gynecol 1977;50:611-614.
11. Naden RP, Rosenfeld CR. Effect of angiotensin II on uterine and systemic vasculature in pregnant sheep. J Clin Invest 1981;68:468-474.
12. Xia Y, Wen HY, Kellems RE. Angiotensin II inhibits human trophoblast invasion through AT1 receptor activation. J Biol Chem 2002;277:24601-24608.
13. Lenz R, Sealey JE, August P, James GD, Laragh JH. Tissue levels of active and total renin, angiotensinogen, human chorionic gonadotropin, estradiol, and progesterone in human placentas from different methods of delivery. J Clin Endocrinol Metab 1989;69:31-37.
14. Lenz T, Sealey JE, Tewksbury DA. Regional distribution of the angiotensinogens in human placentae. Placenta 1993;14:695-699.
15. Paul M, Wagner J, Dzau VJ. Gene expression of the reninangiotensin system in human tissues. Quantitative analysis by the polymerase chain reaction. J Clin Invest 1993;91:2058-2064.
16. Cooper AC, Robinson G, Vinson GP, Cheung WT, Broughton Pipkin F. The localization and expression of the reninangiotensin system in the human placenta throughout pregnancy. Placenta 1999;20:467-474.
17. Downing GJ, Poisner R, Poisner AM. Beta-adrenoceptor activation stimulates, and phosphodiesterase inhibition potentiates, placental prorenin synthesis and release. J Clin Endocrinol Metab 1994;78:41-47.
18. Poisner AM, Downing GJ, Poisner R. Prorenin secretion from villous placenta: regulation by cyclic AMP and angiotensin. Placenta 1994;15:487-499.
19. Downing GJ, Yan B, Poisner AM. Beta-adrenoceptor activation-induced placental prorenin secretion is mediated by increased renin messenger RNA and protein synthesis. Mol Pharmacol 1997;51:201-208.
20. Yagami H, Kurauchi O, Murata Y, Okamoto T, Mizutani S, Tomoda Y. Expression of angiotensin-converting enzyme in human placenta and its physiologic role in the fetal circulation. Obstet Gynecol 1994;84:453-457.
21. Knock GA, Sullivan MH, McCarthy A, Elder MG, Polak JM, Wharton J. Angiotensin II (AT1) vascular binding sites in human placentae from normal-term, preeclamptic and growth retarded pregnancies. J Pharmacol Exp Ther 1994;271:1007-1015.
22. Li X, Shams M, Zhu J, Khalig A, Wilkes M, Whittle M, Barnes N, Ahmed A. Cellular localization of AT1 receptor mRNA and protein in normal placenta and its reduced expression in intrauterine growth restriction. Angiotensin II stimulates the release of vasorelaxants. J Clin Invest 1998;101:442:54.
23. Kingdom JC, McQueen J, Connell JM, Whittle MJ. Fetal angiotensin II levels and vascular (type I) angiotensin receptors in pregnancies complicated by intrauterine growth retardation. Br J Obstet Gynaecol 1993;100:476-482.
24. Kalenga MK, De Gasparo M, Thomas K, De Hertogh R. Down-regulation of angiotensin AT1 receptor by progesterone in human placenta. J Clin Endocrinol Metab 1996;81:998-1002.
25. Kalenga MK, de Gasparo M, Thomas K, de Hertogh R. Angiotensin II and its different receptor subtypes in placenta and fetal membranes. Placenta 1996;17:103-110.
26. Kalenga MK, Thomas K, de Gasparo M, de Hertogh R. Determination of renin, angiotensin converting enzyme and angiotensin II levels in human placenta, chorion and amnion from women with pregnancy induced hypertension. Clin Endocrinol (Oxf) 1996;44:429-433.
27. Petit A, Geoffroy P, Bélisle S. Expression of angiotensin II type-I receptor and phospholipase C-linked G alpha q/11 protein in the human placenta. J Soc Gynecol Investig 1996;3:316-321.
28. Shah DM. Role of the renin-angiotensin system in the pathogenesis of preeclampsia. Am J Physiol Renal Physiol 2005;288:F614-F625.
29. Shah DM. Preeclampsia: new insights. Curr Opin Nephrol Hypertens 2007;16:213-220.
30. Wang Y, Pringle KG, Chen YX, Zakar T, Lumbers ER. Regulation of the renin-angiotensin system (RAS) in BeWo and HTR-8/SVneo trophoblast cell lines. Placenta 2012;33:634-639.
31. Anton L, Merrill DC, Neves LA, Diz DI, Corthorn J, Valdes G, Stovall K, Gallagher PE, Moorefield C, Gruver C, Brosnihan KB. The uterine placental bed Renin-Angiotensin system in normal and preeclamptic pregnancy. Endocrinology 2009;150:4316-4325.
32. Tewksbury DA. Angiotensinogen - Biochemistry and Molecular Biology. In: Laragh JH, Brenner BM, Eds. Hypertension: pathophysiology, diagnosis and management. New York, NY: Raven Press; 1990. pp. 1197-1216.
33. Tewksbury DA, Pan N, Kaiser SJ. Detection of a receptor for angiotensinogen on placental cells. Am J Hypertension 2003;16:59-62.