Novel three-dimensional analysis tool for vascular trees indicates complete micro-networks, not single capillaries, as the angiogenic endpoint in mice overexpressing human VEGF165 in the brain

NeuroImage

Volumn 39, Issue 4, 2008, Pages 1549-1558

  Heinzer, Stefan ^a   Kuhn, Gisela ^b   Krucker, Thomas ^c   Meyer, Eric ^b   Ulmann Schuler, Alexandra ^b   Stampanoni, Marco ^d   Gassmann, Max ^b   Marti, Hugo H ^e   Müller, Ralph ^a   Vogel, Johannes ^b  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^d PAUL SCHERRER INSTITUTE   (Switzerland)

^e UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Micro computed tomography; Morphometry; Network analysis; Vascular endothelial growth factor; Vascular remodeling

Indexed keywords

VASCULOTROPIN 165;

ANGIOGENESIS; ANIMAL EXPERIMENT; ARTICLE; BRAIN BLOOD FLOW; BRAIN CAPILLARY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORPUS CALLOSUM; GENE OVEREXPRESSION; GRAY MATTER; HIPPOCAMPUS; MICROVASCULARIZATION; MORPHOMETRICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; THREE DIMENSIONAL IMAGING; VASCULARIZATION;

ALGORITHMS; ANIMALS; BLOOD VESSELS; BRAIN; CAPILLARIES; CEREBROVASCULAR CIRCULATION; HIPPOCAMPUS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MICE; MICE, TRANSGENIC; NEOVASCULARIZATION, PATHOLOGIC; QUALITY CONTROL; REPRODUCIBILITY OF RESULTS; TOMOGRAPHY, X-RAY COMPUTED; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 38749114645     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2007.10.054     Document Type: Article

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