Synthesis and docking study of diaryl-isothiazole and 1,2,3-thiadiazole derivatives as potential neuroprotective agents

Medicinal Chemistry Research

Volumn 22, Issue 3, 2013, Pages 1212-1223

  Amirhamzeh, Amirali ^a   Vosoughi, Mohsen ^a   Shafiee, Abass ^a   Amini, Mohsen ^a,b  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Cyclo oxygenase; Docking; LogBB; Neuroinflammation; p38 MAP kinase; QSAR

Indexed keywords

4 (4 CHLOROPHENYL) 5 (3 METHYLTHIOPHEN 2 YL) ISOTHIAZOLE; 4 (4 CHLOROPHENYL) 5 (5 METHYLTHIOPHEN 2 YL) ISOTHIAZOLE; 4 (4 FLUOROPHENYL) 5 (3 METHYLTHIOPHEN 2 YL) ISOTHIAZOLE; 4 (4 FLUOROPHENYL) 5 (4 METHYLTHIOPHEN 2 YL) ISOTHIAZOLE; 4 (4 METHOXYHENYL) 5 (5 METHYLTHIOPHEN 2 YL) ISOTHIAZOLE; 4 (5 METHYLTHIOPHEN 2 YL) 5 PHENYL 1,2,3 THIADIAZOLE; 5 (4 CHLOROPHENYL) 4 (3 METHYLTHIOPHEN 2 YL) 1,2,3 THIADIAZOLE; 5 (4 CHLOROPHENYL) 4 (5 METHYLTHIOPHEN 2 YL) 1,2,3 THIADIAZOLE; 5 (4 FLUOROPHENYL) 4 (5 METHYLTHIOPHEN 2 YL) 1,2,3 THIADIAZOLE; 5 (4 METHOXYPHENYL) 4 (5 METHYLTHIOPHEN 2 YL) 1,2,3 THIADIAZOLE; 5 (5 METHYLTHIOPHEN 2 YL) 4 (4 NITROPHENYL) ISOTHIAZOLE; 5 (5 METHYLTHIOPHEN 2 YL) 4 PHENYL ISOTHIAZOLE; ISOTHIAZOLE DERIVATIVE; NEUROPROTECTIVE AGENT; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD BRAIN BARRIER; DRUG DESIGN; DRUG SYNTHESIS; MOLECULAR DOCKING; NEUROPROTECTION; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

EID: 84874108028     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-012-0124-9     Document Type: Article

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