Mechanisms of Linezolid resistance among staphylococci in a tertiary hospital

Journal of Clinical Microbiology

Volumn 51, Issue 3, 2013, Pages 998-1001

  Quiles Melero, Inmaculada ^a   Gómez Gil, Rosa ^a   Romero Gómez, María Pilar ^a   Sánchez Díaz, Ana María ^b   De Pablos, Manuela ^a   García Rodriguez, Julio ^a   Gutiérrez, Avelino ^a   Mingorance, Jesús ^a  

^a HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^b HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CLINDAMYCIN; ERYTHROMYCIN; LINEZOLID; METICILLIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RNA 23S;

ANTIBIOTIC RESISTANCE; ARTICLE; CFR GENE; GENE; GENE MUTATION; HUMAN; MAJOR CLINICAL STUDY; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS HAEMOLYTICUS; TERTIARY HEALTH CARE;

ACETAMIDES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DRUG RESISTANCE, BACTERIAL; HUMANS; INTENSIVE CARE UNITS; OXAZOLIDINONES; POINT MUTATION; RNA, RIBOSOMAL, 23S; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS HAEMOLYTICUS; TERTIARY CARE CENTERS;

EID: 84874103671     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.01598-12     Document Type: Article

References (27)

1. Livermore DM. 2003. Linezolid in vitro: mechanism and antibacterial spectrum. J. Antimicrob. Chemother. 51(Suppl 2):ii9-ii16.
2. Long KS, Vester B. 2012. Resistance to linezolid caused by modifications at its binding site on the ribosome. Antimicrob. Agents Chemother. 56: 603-612.
3. Meka VG, Pillai SK, Sakoulas G, Wennersten C, Venkataraman L, DeGirolami PC, Eliopoulos GM, Moellering RC, Gold HS. 2004. Linezolid resistance in sequential Staphylococcus aureus isolates associated with a T2500A mutation in the 23S rRNA gene and loss of a single copy of rRNA. J. Infect. Dis. 190:311-317.
4. Miller K, O'Neill AJ, Wilcox MH, Ingham E, Chopra I. 2008. Delayed development of linezolid resistance in Staphylococcus aureus following exposure to low levels of antimicrobial agents. Antimicrob. Agents Chemother. 52:1940-1944.
5. Bonilla H, Huband MD, Seidel J, Schmidt H, Lescoe M, McCurdy SP, Lemmon MM, Brennan LA, Tait-Kamradt A, Puzniak L, Quinn JP. 2010. Multicity outbreak of linezolid-resistant Staphylococcus epidermidis associated with clonal spread of a cfr-containing strain. Clin. Infect. Dis. 51:796-800.
6. Farrell D, Morrissey I. 2004. In vitro activities of telithromycin, linezolid, and quinupristin-dalfopristin against Streptococcus pneumoniae with macrolide resistance due to ribosomal mutations. Antimicrob. Agents Chemother. 48:3169-3171.
7. Locke JB, Hilgers M, Shaw KJ. 2009. Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin. Antimicrob. Agents Chemother. 53:5275-5278.
8. Arias CA, Vallejo M, Reyes J, Panesso D, Moreno J, Castañeda E, Villegas MV, Murray BE, Quinn JP. 2008. Clinical and microbiological aspects of linezolid resistance mediated by the cfr gene encoding a 23S rRNA methyltransferase. J. Clin. Microbiol. 46:892-896.
9. Gómez-Gil R, Romero-Gómez MP, García-Arias A, Ubeda MG, Busselo MS, Cisterna R, Gutiérrez-Altés A, Mingorance J. 2009. Nosocomial outbreak of linezolid-resistant Enterococcus faecalis infection in a tertiary care hospital. Diagn. Microbiol. Infect. Dis. 65:175-179.
10. National Committee for Clinical Laboratory Standards 2006. Performance standards for antimicrobial susceptibility testing. Document M100-S16. NCCLS, Wayne, PA.
11. Kehrenberg C, Schwarz S. 2006. Distribution of florfenicol resistance genes fexA and cfr among chloramphenicol-resistant Staphylococcus isolates. Antimicrob. Agents Chemother. 50:1156-1163.
12. Wolter N, Smith AM, Farrell DJ, Schaffner W, Moore M, Whitney CG, Jorgensen JH, Klugman KP. 2005. Novel mechanism of resistance to oxazolidinones, macrolides, and chloramphenicol in ribosomal protein L4 of the pneumococcus. Antimicrob. Agents Chemother. 49:3554-3557.
13. Shopsin B, Gómez M, Montgomery SO, Smith DH, Waddington M, Dodge DE, Bost DA, Riehman M, Naidich S, Kreiswirth BN, Arbeit R, Archer G, Biddle J, Byrne S, Goering R, Hancock G, He GA, Hill B, Hollis R, Jarvis WR, Eisner W, Maslow J, Mcdougal LK, Miller JM, Mulligan M. 1999. Evaluation of protein A gene polymorphic region DNA sequencing for typing of Staphylococcus aureus strains. J. Clin. Microbiol. 37:3556-3563.
14. Enright MC, Day NP, Davies CE, Peacock SJ, Spratt BG. 2000. Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus. J. Clin. Microbiol. 38:1008-1015.
15. Ohlin A, Bäckman A, Söderquist B, Wingren S, Björkqvist M. 2010. Rapid typing of neonatal Staphylococcus epidermidis isolates using polymerase chain reaction for repeat regions in surface protein genes. Eur. J. Clin. Microbiol. Infect. Dis. 29:699-704.
16. Thomas JC, Vargas MR, Miragaia M, Peacock SJ, Archer GL, Enright MC. 2007. Improved multilocus sequence typing scheme for Staphylococcus epidermidis. J. Clin. Microbiol. 45:616-619.
17. Boye K, Bartels MD, Andersen IS, Møller JA, Westh H. 2007. A new multiplex PCR for easy screening of methicillin-resistant Staphylococcus aureus SCCmec types I-V. Clin. Microbiol. Infect. 13:725-727.
18. Quiles-Melero I, García-Perea A, de Pablos M, Gómez-Gil R, Mingorance J. 2012. Resistance to linezolid in a methicillin-susceptible Staphylococcus aureus clinical isolate without previous exposure to oxazolidinones. Int. J. Med. Microbiol. 302:145-147.
19. Bongiorno D, Campanile F, Mongelli G, Baldi MT, Provenzani R, Reali S, Lo Russo C, Santagati M, Stefani S. 2010. DNA methylase modifica-tions and other linezolid resistance mutations in coagulase-negative staphylococci in Italy. J. Antimicrob. Chemother. 65:2336-2340.
20. Lozano C, Ruiz-García M, Gómez-Sanz E, López- García P, Royo-García G, Zarazaga M, Torres C. 2012. Characterization of a cfrpositive methicillin-resistant Staphylococcus epidermidis strain of the lineage ST22 implicated in a life-threatening human infection. Diagn. Microbiol. Infect. Dis. 73:380-382.
21. Mendes RE, Deshpande LM, Farrell DJ, Spanu T, Fadda G, Jones RN. 2010. Assessment of linezolid resistance mechanisms among Staphylococcus epidermidis causing bacteraemia in Rome, Italy. J. Antimicrob. Chemother. 65:2329-2335.
22. Besier S, Ludwig A, Zander J, Brade V, Wichelhaus TA. 2008. Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances. Antimicrob. Agents Chemother. 52:1570-1572.
23. Marshall S. 2002. Gene dosage and linezolid resistance in Enterococcus faecium and Enterococcus faecalis. Antimicrob. Agents Chemother. 46: 3334-3336.
24. Ikeda-Dantsuji Y, Hanaki H, Sakai F, Tomono K, Takesue Y, Honda J, Nonomiya Y, Suwabe A, Nagura O, Yanagihara K, Mikamo H, Fukuchi K, Kaku M, Kohno S, Yanagisawa C, Nakae T, Yoshida K, Niki Y. 2011. Linezolid-resistant Staphylococcus aureus isolated from 2006 through 2008 at six hospitals in Japan. J. Infect. Chemother. 17:45-51.
25. Forbes BA, Schaberg DR. 1983. Transfer of resistance plasmids from Staphylococcus epidermidis to Staphylococcus aureus: evidence for conjugative exchange of resistance. J. Bacteriol. 153:627-634.
26. Pérez-Jorge C, Isea-Peña M-C, Heili S, Esteban J. 2012. Spread of cfr gene among staphylococci conferring resistance to linezolid in a patient under treatment. J. Antibiot. 65:151-152.
27. Ramírez E, Gómez-Gil R, Borobia AM, Moreno F, Zegarra C, Muñoz R, Reutero Z, de Montreuil C, González D, Hernández S, Herrero A, Gutiérrez A, Frías J. 2013. Improving linezolid use decreases the incidence of resistance among Gram-positive microorganisms. Int. J. Antimicrob. Agents. 41:174-178.