Nosocomial outbreak of linezolid-resistant Enterococcus faecalis infection in a tertiary care hospital

Diagnostic Microbiology and Infectious Disease

Volumn 65, Issue 2, 2009, Pages 175-179

  Gómez Gil, Rosa ^a   Romero Gómez, Maria Pilar ^a   García Arias, Africa ^a   Ubeda, M Gallego ^a   Busselo, M Sota ^b   Cisterna, Ramón ^b   Gutiérrez Altés, Avelino ^a   Mingorance, Jesus ^a  

^a HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^b HOSPITAL DE BASURTO   (Spain)

Author keywords

Enterococcus faecalis; Linezolid

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; AMPHOTERICIN; AMPICILLIN; CEFTRIAXONE; CHLORAMPHENICOL; CLINDAMYCIN; COTRIMOXAZOLE; DALFOPRISTIN PLUS QUINUPRISTIN; ERYTHROMYCIN; FLUCONAZOLE; FOSFOMYCIN; GENTAMICIN; GUANINE; LEVOFLOXACIN; LINEZOLID; MEROPENEM; METRONIDAZOLE; NEOMYCIN; PENICILLIN G; PIPERACILLIN PLUS TAZOBACTAM; RIFAMPICIN; TEICOPLANIN; TOBRAMYCIN; TYROSINE; VANCOMYCIN; VORICONAZOLE;

ADULT; AGED; ALLELE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CONTROLLED STUDY; DRUG INDICATION; DRUG TREATMENT FAILURE; DRUG UTILIZATION; ENTEROCOCCAL INFECTION; ENTEROCOCCUS FAECALIS; FEMALE; GENE MUTATION; GRAM POSITIVE BACTERIUM; HOSPITAL INFECTION; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; PYROSEQUENCING; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RESUSCITATION; RISK FACTOR; SPAIN; TERTIARY HEALTH CARE; TREATMENT DURATION; UNIVERSITY HOSPITAL; WILD TYPE;

ACETAMIDES; ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BACTERIAL TYPING TECHNIQUES; CLUSTER ANALYSIS; CROSS INFECTION; DISEASE OUTBREAKS; DNA FINGERPRINTING; DNA, BACTERIAL; DNA, RIBOSOMAL; DRUG RESISTANCE, BACTERIAL; ELECTROPHORESIS, GEL, PULSED-FIELD; ENTEROCOCCUS FAECALIS; FEMALE; GENOTYPE; GRAM-POSITIVE BACTERIAL INFECTIONS; HOSPITALS; HUMANS; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; OXAZOLIDINONES; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; SEQUENCE ANALYSIS, DNA; SPAIN; YOUNG ADULT;

EID: 69949098097     PISSN: 07328893     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diagmicrobio.2009.06.010     Document Type: Article

References (24)

1. Auckland C., Teare L., Cooke F., et al. Linezolid-resistant enterococci: report of the first isolates in the United Kingdom. J. Antimicrob. Chemother. 50 (2002) 743-746
2. Bonora M.G., Solbiati M., Stepan E., Zorzi A., Luzzani A., Catania M.R., and Fontana R. Emergence of linezolid resistance in the vancomycin-resistant Enterococcus faecium multilocus sequence typing C1 epidemic lineage. J. Clin. Microbiol. 44 (2006) 1153-1155
3. Dibo I., Pillai S.K., Gold H.S., et al. Linezolid-resistant Enterococcus faecalis isolated from a cord blood transplant recipient. J. Clin. Microbiol. 42 (2004) 1843-1845
4. Halle E., Padberg J., Rosseau S., et al. Linezolid-resistant Enterococcus faecium and Enterococcus faecalis isolated from a septic patient: report of first isolates in Germany. Infection 32 (2004) 182-183
5. Healy M., Huong J., Bittner T., Lising M., Frye S., Raza S., Schrock R., Manry J., Renwick A., Nieto R., Woods C., Versalovic J., and Lupski J.R. Microbial DNA typing by automated repetitive-sequence-based PCR. J. Clin. Microbiol. 43 (2005) 199-207
6. Herrero I.A., Issa N.C., and Patel R. Nosocomial spread of linezolid-resistant, vancomycin-resistant Enterococcus faecium. N. Engl. J. Med. 346 (2002) 867-869
7. Johnson A.P., Tysall L., Stockdale M.V., et al. Emerging linezolid resistant Enterococcus faecalis and Enterococcus faecium isolated from two Austrian patients in the same intensive care unit. Eur. J. Clin. Microbiol. Infect. Dis. 21 (2002) 751-754
8. Kainer M.A., Devasia R.A., Jones T.F., Simmons B.P., Melton K., Chow S., Broyles J., Moore K.L., Craig A.S., and Schaffner W. Response to emerging infection leading to outbreak of linezolid-resistant enterococci. Emerg. Infect. Dis. 13 (2007) 1024-1030
9. Kloss P., Xiong L., Shinabarger D., and Mankin A.S. Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center. J. Mol. Biol. 294 (1999) 93-101
10. Lobritz M., Hutton-Thomas R., Marshall S., et al. Recombination proficiency influences frequency and locus of mutational resistance to linezolid in Enterococcus faecalis. Antimicrob. Agents Chemother. 47 (2003) 3318-3320
11. Marshall S.H., Donskey C.J., Hutton-Thomas R., et al. Gene dosage and linezolid resistance in Enterococcus faecium and Enterococcus faecalis. Antimicrob. Agents Chemother. 46 (2002) 3334-3336
12. Meka V.G., Pillai S.K., Sakoulas G., et al. Linezolid resistance in sequential Staphylococcus aureus isolates associated with a T2500A mutation in the 23S rRNA gene and loss of a single copy of rRNA. J. Infect. Dis. 190 (2004) 311-317
13. Multnick A.H., Enne V., and Jones R.N. Linezolid resistance since 2001: SENTRY Antimicrobial Surveillance Program. Ann Pharmacother. 37 (2003) 769-774
14. National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial susceptibility testing. Document M100-S16 (2006), NCCLS, Wayne, PA
15. Plosker G.L., and Figgitt D.P. Linezolid: a pharmacoeconomic review of its use in serious Gram-positive infections. Pharmacoeconomics 23 (2005) 945-964
16. Prystowsky J., Siddiqui F., Chosay J., et al. Resistance to linezolid: characterization of mutations in rRNA and comparison of their occurrences in vancomycin-resistant enterococci. Antimicrob. Agents Chemother. 45 (2001) 2154-2156
17. Rahim S., Pillai S.K., Gold H.S., Venkataraman L., Inglima K., and Press R.A. Linezolid-resistant, vancomycin-resistant Enterococcus faecium infection in patients without prior exposure to linezolid. Clin. Infect. Dis. 36 (2003) 146-148
18. Ruggero K.A., Schroeder L.K., Schreckenberger P.C., et al. Nosocomial superinfections due to linezolid-resistant Enterococcus faecalis: evidence for a gene dosage effect on linezolid MICs. Diag. Microb. Infect. Dis. 47 (2003) 511-513
19. Saeedi B., Hällgren A., Jonasson J., Nilsson L.E., Hanberger H., and Isaksson B. Modified pulse-field gel electrophoresis protocol for typing enterococci. APMIS 110 (2002) 869-874
20. Sinclair A., Arnold C., and Woodford N. Rapid detection and estimation by pyrosequencing of 23S rRNA genes with a single nucleotide polymorphism conferring linezolid resistance in Enterococci. Antimicrob. Agents Chemother. 47 (2003) 3620-3622
21. Tsiodras S., Gold H.S., Sakoulas G., et al. Linezolid resistance in a clinical isolate of Staphylococcus aureus. Lancet 358 (2001) 207-208
22. Werner G., Strommenger B., Klare I., and Witte W. Molecular detection of linezolid resistance in Enterococcus faecium and Enterococcus faecalis by use of 5′ nuclease real-time PCR compared to a modified classical approach. J. Clin. Microbiol. 42 (2004) 5327-5331
23. Wilson P., Andrews J.A., Charlesworth R., et al. Linezolid resistance in clinical isolates of Staphylococcus aureus. J. Antimicrob. Chemother. 51 (2003) 186-188
24. Zhanel G., Schroeder C., Vercaigne L., et al. A critical review of oxazolidinones: an alternative or replacement for glycopeptides and streptogramins?. Can. J. Infect. Dis. 12 (2001) 6