The use of donor-derived veto cells in hematopoietic stem cell transplantation

Frontiers in Immunology

Volumn 3, Issue MAY, 2012, Pages

  Ophir, Eran ^a   Reisner, Yair ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Anti third party CD8+Tcm; CD34+ cells; Hematopoietic stem cell transplantation; Megadose; Veto

Indexed keywords

EID: 84874094828     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2012.00093     Document Type: Review

References (51)

1. Adams, A. B., Williams, M. A., Jones, T. R., Shirasugi, N., Durham, M. M., Kaech, S. M., Wherry, E. J., Onami, T., Lanier, J. G., Kokko, K. E., Pearson, T. C., Ahmed, R., and Larsen, C. P. (2003). Heterologous immunity provides a potent barrier to transplantation tolerance. J. Clin. Invest. 111, 1887-1895.
2. Anderson, K. M., and Zimring, J. C. (2006). Rapamycin prolongs susceptibility of responding T c+ells to tolerance induction by CD8 veto cells. Transplantation 81, 88-94.
3. Arditti, F. D., Aviner, S., Dekel, B., Krauthgamer, R., Gan, J., Nagler, A., Tabilio, A., Martelli, M., Berrebi, A., and Reisner, Y. (2005). Eradication of B-CLL by autologous and allogeneic host nonreactive anti-thirdparty CTLs. Blood 105, 3365-3371.
4. Asiedu, C., Meng, Y., Wang, W., Huang, Z., Contreras, J. L., George, J. F., and Thomas, J. (1999). Immunoregulatory role of CD8alpha in the veto effect. Transplantation 67, 372-380.
5. Aversa, F., Tabilio, A., Terenzi, A., Velardi, A., Falzetti, F., Giannoni, C., Iacucci, R., Zei, T., Martelli, M. P., and Gambelunghe, C. (1994). Successful engraftment of Tcell-depleted haploidentical "threeloci" incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum. Blood 84, 3948-3955.
6. Aversa, F., Terenzi, A., Tabilio, A., Falzetti, F., Carotti, A., Ballanti, S., Felicini, R., Falcinelli, F., Velardi, A., Ruggeri, L., Aloisi, T., Saab, J. P., Santucci, A., Perruccio, K., Martelli, M. P., Mecucci, C., Reisner, Y., and Martelli, M. F. (2005). Full haplotype-mismatched hematopoieticstem-celltransplantation:aphase II study in patients with acute leukemia at high risk of relapse. J. Clin. Oncol. 23, 3447-3454.
7. Bachar-Lustig, E., Reich-Zeliger, S., and Reisner, Y. (2003). Anti-thirdparty veto CTLs overcome rejection of hematopoietic allografts: synergism with rapamycin and BM cell dose. Blood 102, 1943-1950.
8. Ballen, K. K., and Spitzer, T. R. (2010). The great debate: haploidentical or cord blood transplant. Bone Marrow Transplant. 46, 323-329.
9. Chrobak, P., and Gress, R. E. (2001). Veto activity of activated bone marrow does not require perforin and Fas ligand. Cell. Immunol. 208, 80-87.
10. Claesson, M. H., and Miller, R. G. (1989). Functional heterogeneity in allospecific cytotoxic T lymphocyte clones. III. Direct correlation between development of syngeneic cytotoxicity and loss of veto activity; implications for the mechanism of veto action. Scand. J. Immunol. 29, 493-497.
11. Claesson, M. H., and Miller, R. G. (1984). Functional heterogeneity in allospecific cytotoxic T lymphocyte clones. I. CTL clones express strong anti-self suppressive activity. J. Exp. Med. 160, 1702-1716.
12. Claesson, M. H., and Ropke, C. (1986). Antiself suppressive (veto) activity of responder cells in mixed lymphocyte cultures. Curr. Top. Microbiol. Immunol. 126, 213-223.
13. Clement, A., Pereboev, A., Curiel, D. T., Dong, S. S., Hutchings, A., and Thomas, J. M. (2002). Converting nonhuman primate dendritic cells into potent antigen-specific cellular immunosuppressants by genetic modification. Immunol. Res. 26, 297-302.
14. Erdmann, A. A., Jung, U., Foley, J. E., Toda, Y., and Fowler, D. H. (2004). Co-stimulated/Tc2 cells abrogate murine marrow graft rejection. Biol. Blood Marrow Transplant. 10, 604-613.
15. Fink, P. J., Rammensee, H. G., Benedetto, J. D., Staerz, U. D., Lefrancois, L., and Bevan, M. J. (1984). Studies on the mechanism of suppression of primary cytotoxic responses by cloned cytotoxic T lymphocytes. J. Immunol. 133, 1769-1774.
16. Fowler, D. H., and Gress, R. E. (2000). Th2 and Tc2 cells in the regulation of GVHD, GVL, and graft rejection: considerations for the allogeneic transplantation therapy of leukemiaandlymphoma. Leuk. Lymphoma 38, 221-234.
17. Gale, R. P., and Reisner, Y. (1986). Graft rejection and graft-versus-host Ophir and Reisner Veto cells in HSCT disease: mirror images. Lancet, 1, 1468-1470.
18. + progenitor cells: evidence for a deletion-based mechanism mediated by TNF-alpha. Blood 105, 2585-2593.
19. Gur, H., Krauthgamer, R., Berrebi, A., Klein, T., Nagler, A., Tabilio, A., Martelli, M. F., and Reisner, Y. (2002). Tolerance induction by megadose hematopoietic progenitor cells: expansion of veto cells by short-termcultureofpurifiedhuman CD34(+) cells. Blood 99, 4174-4181.
20. Gyurkocza, B., Rezvani, A., andStorb, R. F. (2010). Allogeneic hematopoietic cell transplantation: the state of the art. Expert Rev. Hematol. 3, 285-299.
21. Kawai, T., Cosimi, A. B., Spitzer, T. R., Tolkoff-Rubin, N., Suthanthiran, M., Saidman, S. L., Shaffer, J., Preffer, F. I., Ding, R., Sharma, V., Fishman, J. A., Dey, B., Ko, D. S., Hertl, M., Goes, N. B., Wong, W., Williams, W. W. Jr., Colvin, R. B., Sykes, M., and Sachs, D. H. (2008). HLA-mismatched renal transplantation without maintenance immunosuppression. N. Engl. J. Med. 358, 353-361.
22. Kernan, N. A., Flomenberg, N., Dupont, B., and O'Reilly, R. J. (1987). Graft rejection in recipients of T-cell-depleted HLA-nonidentical marrow transplants for leukemia. Identification of host-derived antidonor allocytotoxic T lymphocytes. Transplantation 43, 842-847.
23. Lask, A., Goichberg, P., Cohen, A., Goren-Arbel, R., Milstein, O., Aviner, S., Feine, I., Ophir, E., Reich Zeliger, S., Hagin, D., Klein, T., Nagler, A., Berrebi, A., and Reisner, Y. (2011). TCR-independent killing of B cell malignancies by anti-thirdpartyCTLs:thecriticalroleof MHCCD8 engagement. J Immunol. 187, 2006-2014.
24. Lask, A., Ophir, E., Or-Geva, N., Cohen, A., Afik, R., Eidelstein, Y., Negrin, R. S., Nagler, A., Berrebi, A., Hagin, D., and Reisner, Y. (2010). Ex vivo generated donor central memory CD8 T cells, previously shown to enhance engraftment of allogeneic bone marrow, also exhibit significant GVL activity without causing Gvhd in an in vivo b cell lymphoma model. Blood 116, a424(ASH Annual Meeting Abstracts).
25. Mariotti, J., Foley, J., Jung, U., Borenstein, T., Kantardzic, N., Han, S., Hanson, J. T., Wong, E., Buxhoeveden, N., Trepel, J. B., Fojo, A. T., Telford, W., and Fowler, D. H. (2008). Ex vivo rapamycin generates apoptosis-resistant donor Th2 cells that persist in vivo and prevent hemopoietic stem cell graft rejection. J. Immunol. 180, 89-105.
26. Martelli, M.F., Aversa, F., Bachar-Lustig, E., Velardi, A., Reich-Zelicher, S., Tabilio, A., Gur, H., and Reisner, Y. (2002). Transplants across human leukocyte antigen barriers. Semin. Hematol. 39, 48-56.
27. Miller, R. G. (1980). An immunological suppressor cell inactivating cytotoxic T-lymphocyte precursor cells recognizing it. Nature 287, 544-546.
28. Milstein, O., Hagin, D., Lask, A., ReichZeliger, S., Shezan, E., Ophir, E., Eidelstein, Y., Afik, R., Antebi, Y. E., Dustin, M. L., and Reisner, Y. (2010). CTLs respond with activation and granulesecretionwhenservingastargetsforT-cellrecognition. Blood 117, 1042-1052.
29. Muraoka, S., and Miller, R. G. (1980). Cells in bone marrow and in T cell colonies grown from bone marrow can suppress generation of cytotoxic T lymphocytes directed against their self antigens. J. Exp. Med. 152, 54-71.
30. Muraoka, S., and Miller, R. G. (1983). Cellsinmurinefetalliverandinlymphoid colonies grown from fetal liver can suppress generation of cytotoxic T lymphocytes directed against their self antigens. J. Immunol. 131, 45-49.
31. Nguyen, P., and Geiger, T. L. (2010). Induction of B-cell immune tolerance by antigen-modified cytotoxic T lymphocytes. Transplantation 89, 667-676.
32. Ophir, E., Eidelstein, Y., Afik, R., BacharLustig, E., and Reisner, Y. (2010). Induction of tolerance to bone marrow allografts by donor-derived host nonreactive ex vivo-induced central memory CD8 T cells. Blood 115, 2095-2104.
33. Pantenburg, B., Heinzel, F., Das, L., Heeger, P. S., and Valujskikh, A. (2002). T cells primed by Leishmania major infection cross-react with alloantigens and alter the course of allograft rejection. J. Immunol. 169, 3686-3693.
34. Rachamim, N., Gan, J., Segall, H., Krauthgamer, R., Marcus, H., Berrebi, A., Martelli, M., and Reisner, Y. (1998). Tolerance induction by "megadose" hematopoietic transplants: donor-type human CD34 stem cells induce potent specific reduction of host anti-donor cytotoxic T lymphocyte precursors in mixed lymphocyte culture. Transplantation 65, 1386-1393.
35. Reich-Zeliger, S., Bachar-Lustig, E., BarIlan, A., and Reisner, Y. (2007). Tolerance induction in presensitized bone marrow recipients by veto CTLs: effective deletion of host anti-donor memory effector cells. J. Immunol. 179, 6389-6394.
36. Reich-Zeliger, S., Bachar-Lustig, E., Gan, J., and Reisner, Y. (2004a). Tolerance induction by veto CTLs in the TCR transgenic 2C mouse model. I. Relative reactivity of different veto cells. J. Immunol. 173, 6654-6659.
37. Reich-Zeliger, S., Gan, J., Bachar-Lustig, E., and Reisner, Y. (2004b). Tolerance induction by veto CTLs in the TCR transgenic 2C mouse model. II. Deletion of effector cells by Fas-Fas ligand apoptosis. J. Immunol. 173, 6660-6666.
38. Reich-Zeliger, S., Eidelstein, Y., Hagin, D., Antebi, Y. E., Seger, R., and Reisner, Y. (2010). Deletion of alloreactive T cells by veto cytotoxic T lymphocytes is mediated through extracellular signal-regulated kinase phosphorylation. Transplantation 90, 380-386.
39. Reich-Zeliger, S., Zhao, Y., Krauthgamer, R., Bachar-Lustig, E., and Reisner, Y. (2000). Anti-third party CD8 CTLs as potent veto cells: coexpression of CD8 and FasL is a prerequisite. Immunity 13, 507-515.
40. Reisner, Y., and Martelli, M. F. (1995). Bone marrow transplantation across HLA barriers by increasing the number of transplanted cells. Immunol. Today 16, 437-440.
41. Reisner, Y., Reich-Zeliger, S., and Bachar-Lustig, E. (2006). The role of veto cells in bone marrow transplantation. Curr. Opin. Organ Transplant. 11, 366-372.
42. Ringden, O., Remberger, M., Svahn, B. M., Barkholt, L., Mattsson, J., Aschan, J., Le Blanc, K., Gustafsson, B., Hassan, Z., Omazic, B., Svenberg, P., Solders, G., vonDöbeln, U., Winiarski, J., Ljungman, P., and Malm, G. (2006). Allogeneic hematopoietic stem cell transplantation for inherited disorders: experience in a single center. Transplantation 81, 718-725.
43. Sallusto, F., Lenig, D., Forster, R., Lipp, M., and Lanzavecchia, A. (1999). Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 708-712.
44. Scandling, J. D., Busque, S., Dejbakhsh Jones, S., Benike, C., Millan, M. T., Shizuru, J. A., Hoppe, R. T., Lowsky, R., Engleman, E. G., and Strober, S. (2008). Tolerance and chimerism after renal and hematopoietic-cell transplantation. N. Engl. J. Med. 358, 362-368.
45. Seggewiss, R., and Einsele, H. (2010). Immune reconstitution after allogeneic transplantation and expanding options for immunomodulation: an update. Blood 115, 3861-3868.
46. Steward, C. G., and Jarisch, A. (2005). Haemopoietic stem cell transplantation for genetic disorders. Arch. Dis. Child. 90, 1259-1263.
47. Thomas, J. M., Carver, F. M., Cunningham, P. R., Olson, L. C., and Thomas, F. T. (1991). Kidney allograft tolerance in primates without chronic immunosuppression - the role of veto cells. Transplantation 51, 198-207.
48. Weninger, W., Crowley, M. A., Manjunath, N., and von Andrian, U. H. (2001). Migratory properties of naive, effector, and memory CD8(+) T cells. J. Exp. Med. 194, 953-966.
49. Wood, M. L., Orosz, C. G., Gottschalk, R., and Monaco, A. P. (1992). The effect of injection of donor bone marrow on the frequency of donor-reactive CTL in antilymphocyte serum-treated, grafted mice. Transplantation 54, 665-671.
50. Wu, Z., Bensinger, S. J., Zhang, J., Chen, C., Yuan, X., Huang, X., Markmann, J. F., Kassaee, A., Rosengard, B. R., Hancock, W. W., Sayegh, M. H., and Turka, L. A. (2004). Homeostatic proliferation is a barrier to transplantation tolerance. Nat. Med. 10, 87-92.
51. Zangi, L., Edelshtein, Y., Klionsky, Y., Bachar-Lustig, E., Shezen, E., Reich Zeliger, S., Lask, A., Milstein, O., Shinder, V., and Reisner, Y.;1; (2009). Tolerance induction by immature dendritic cells is mediated by distinct MHC dependent and independent mechanisms: a novel role for perforin, granzymeAandTolllikereceptor 7. Blood (ASH Annual Meeting Abstracts), 114, a65.