Human organic anion transporter OAT1 is not responsible for glutathione transport but mediates transport of glutamate derivatives

American Journal of Physiology - Renal Physiology

Volumn 304, Issue 4, 2013, Pages

  Hagos, Yohannes ^a   Burckhardt, Gerhard ^a   Burckhardt, Birgitta C ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

N acetyl glutamate; Nephrotoxicity; Organic anion transport; Proximal tubule

Indexed keywords

4 AMINOHIPPURIC ACID; CYSTEINE; ESTRONE SULFATE; GLUTAMIC ACID DERIVATIVE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLYCINE; N ACETYLASPARTIC ACID; N ACETYLGLUTAMIC ACID; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3;

ANION TRANSPORT; ARTICLE; CONTROLLED STUDY; IC 50; PRECURSOR; PRIORITY JOURNAL; PROTEIN INTERACTION;

EID: 84874086899     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00412.2012     Document Type: Article

References (30)

1. Anzai N, Kanai Y, Endou H. Organic anion transporter family: current knowledge. J Pharm Sci 100: 411-426, 2006.
2. Ballatori N, Krance SM, Marchan R, Hammond CL. Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology. Mol Aspects Med 30: 13-28, 2009.
3. Ballatori N, Krance SM, Notenboom S, Shi S, Tieu K, Hammond CL. Glutathione dysregulation and the etiology and progression of human diseases. Biol Chem 390: 191-214, 2009.
4. Bradford MM. A rapid and sensitive method for quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
5. Burckhardt G, Burckhardt BC. In vitro and in vivo evidence for the importance of organic anion transporters (OATs) in drug therapy. In: Handbook of Exp Pharmacol 201, Drug Transporters, edited by Fromm MF, Kim RB. Heidelberg, Germany: Springer-Verlag 2011, p. 29-104.
6. Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H. Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol 59: 1277-1286, 2001.
7. Dalton TP, Chen Y, Schneider SN, Nebert DW, Shertzer HG. Genetically altered mice to evaluate glutathione homeostasis in health and disease. Free Radic Biol Med 10: 1511-1526, 2004.
8. Eraly SA, Vallon V, Vaughn DA, Gangoiti JA, Richter K, Nagle M, Monte JC, Rieg T, Truong DV, Long JM, Barshop BA, Kaler G, Nigam SK. Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knockout mice. J Biol Chem 281: 5073-5083, 2006.
9. Franco R, Schoneveld OJ, Pappa A, Panayiotidis MI. The central role of glutathione in the pathophysiology of human diseases. Arch Physiol Biochem 113: 234-258, 2007.
10. Hammond CL, Lee TK, Ballatori N. Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes. J Hepatol 34: 946-954, 2001.
11. Kaufhold M, Schulz K, Breljak D, Gupta S, Henjakovic M, Krick W, Hagos Y, Sabolic I, Burckhardt BC, Burckhardt G. Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3. Am J Physiol Renal Physiol 301: F1026-F1034, 2011.
12. Krick W, Dölle A, Hagos Y, Burckhardt G. Characterization of a chloride conductance in porcine renal brush-border membrane vesicles. Pflügers Arch 435: 415-421, 1998.
13. Lash LH, Jones DP. Transport of glutathione by renal basal-lateral membrane vesicles. Biochem Biophys Res Commun 112: 55-60, 1983.
14. Lash LH, Jones DP. Renal glutathione transport. Characteristics of the sodium-dependent system in the basal-lateral membrane. J Biol Chem 259: 14508-14514, 1984.
15. Lash LH, Putt DA. Renal cellular transport of exogenous glutathione: heterogeneity at physiological and pharmacological concentrations. Biochem Pharmacol 58: 897-907, 1999.
16. Lash LH. Role of glutathione transport in kidney function. Toxicol Appl Pharmacol 204: 329-342, 2005.
17. Lash LH, Putt DA, Feng X, Matherly LH. Role of rat organic anion transporter 3 (Oat3) in the renal basolateral transport of glutathione. Chem Biol Interact 170: 124-134, 2007.
18. Lash LH. Renal membrane transport of glutathione in toxicology and disease. Vet Pathol 48: 408-419, 2011.
19. Lohr JW, Wilsky GR, Acara MA. Renal drug metabolism. Pharmacol Rev 50: 107141, 1998.
20. Meister A, Anderson ME. Glutathione. Annu Rev Biochem 52: 711-760, 1983.
21. Ohtsuki S, Kikkawa T, Mori S, Hori S, Takanaga H, Otagiri M, Terasaki T. Mouse reduced in osteoscleosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. J Pharmacol Exp Ther 309: 1273-1281, 2004.
22. Orlowski M, Meister A. γ-Glutamyl-p-nitroanilide: a new convenient substrate for determination and study of L-and D-γ-glutamyl transpeptidase activities. Biochim Biophys Acta 73: 676-679, 1963.
23. Parks LD, Zalups RK, Barfuss DW. Luminal and basolateral membrane transport of glutathione in isolated perfused S1, S2, and S3 segments of the rabbit proximal tubule. J Am Soc Nephrol 11: 1008-1015, 2000.
24. Rankin BB, Curthoys NP. Evidence for the renal peritubular transport of glutathione. FEBS Lett 147: 193-196, 1982.
25. Rankin BB, Wells W, Curthoys NP. Rat renal peritubular transport and metabolism of plasma [35S]glutathione. Am J Physiol Renal Fluid Electrolyte Physiol 249: F198-F205, 1985.
26. Ristoff E, Larsson A. Inborn errors in the metabolism of glutathione. Orphanet J Rare Dis 2: 16-24, 2007.
27. Ullrich KJ, Rumrich G, Wieland T, Dekant W. Contraluminal paraaminohippurate (PAH) transport in the proximal tubule of the rat kidney. VI. Specificity: amino acids, their N-methyl-, N-acetyl-and N-benzoylderivatives; gluthathione-and cysteine conjugates, di-and oligopeptides. Pflügers Arch 415: 342-350, 1989.
28. VanWert Al Gionfriddo MR, Sweet DH. Organic anion transporters: Discovery, pharmacology, regulation and roles in pathophysiology. Biopharm Drug Dispos 31: 1-71, 2010.
29. Wang W, Ballatori N. Endogenous glutathione conjugates: Occurrence and biological functions. Pharmacol Rev 50: 335-355, 1998.
30. Zalups RK, Ahmad S. Transport of N-acetylcysteine S-conjugates of methylmercury in Madin-Darby canine kidney cells stably transfected with human isoform of organic anion transporter 1. J Pharmacol Exp Ther 314: 1158-1168, 2005.