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Volumn 17, Issue 2, 2013, Pages 247-256

Synthesis of a spiroindolinone pyrrolidinecarboxamide MDM2 antagonist

Author keywords

[No Author keywords available]

Indexed keywords

ASYMMETRIC SYNTHESIS; CHIRAL AMINES; CHIRAL PHOSPHINE LIGANDS; COMPLEX MIXTURE; DIASTEREOMERS; ENANTIOPURE; SCALED-UP;

EID: 84874085048     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op3003213     Document Type: Article
Times cited : (31)

References (30)
  • 2
    • 0030941458 scopus 로고    scopus 로고
    • Levin, A. J. Cell 1997, 88, 323
    • (1997) Cell , vol.88 , pp. 323
    • Levin, A.J.1
  • 12
    • 84874029851 scopus 로고    scopus 로고
    • Chem. Abstr. 2011, 155, 11779.
    • (2011) Chem. Abstr. , vol.155 , pp. 11779
  • 13
    • 84874049778 scopus 로고    scopus 로고
    • Spiroindolinone Pyrrolidines. PCT Int. Appl. WO/2011/134925, November 3
    • Chu, X. J.; Ding, Q.; Zhang, J.; Zhang, Z. Spiroindolinone Pyrrolidines. PCT Int. Appl. WO/2011/134925, November 3, 2011
    • (2011)
    • Chu, X.J.1    Ding, Q.2    Zhang, J.3    Zhang, Z.4
  • 14
    • 84874075040 scopus 로고    scopus 로고
    • Chem. Abstr. 2011, 155, 615124.
    • (2011) Chem. Abstr. , vol.155 , pp. 615124
  • 15
    • 84874042904 scopus 로고    scopus 로고
    • N-Substituted Pyrrolidines. U.S. Pat. Appl. 0,010,235, January 12
    • Chu, X. J.; Ding, Q.; Jiang, N.; Liu, J. J.; Ross, T. M.; Zhang, Z. N-Substituted Pyrrolidines. U.S. Pat. Appl. 0,010,235, January 12, 2012
    • (2012)
    • Chu, X.J.1    Ding, Q.2    Jiang, N.3    Liu, J.J.4    Ross, T.M.5    Zhang, Z.6
  • 16
    • 84874036380 scopus 로고    scopus 로고
    • Chem. Abstr. 2012, 156, 148264.
    • (2012) Chem. Abstr. , vol.156 , pp. 148264
  • 23
    • 70349742473 scopus 로고    scopus 로고
    • A three-component 1,3-dipolar cycloaddition catalyzed by a chiral phosphoric acid was found to give the product with regiochemistry the same as that of 35. The authors attributed this unusual behavior to a favorable π-π stacking interaction between the oxoindole moiety and the imine. For details, see
    • A three-component 1,3-dipolar cycloaddition catalyzed by a chiral phosphoric acid was found to give the product with regiochemistry the same as that of 35. The authors attributed this unusual behavior to a favorable π-π stacking interaction between the oxoindole moiety and the imine. For details, see Chen, X. H.; Wei, Q.; Luo, S. W.; Xiao, H.; Gong, L. Z. J. Am. Chem. Soc. 2009, 131, 13819
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 13819
    • Chen, X.H.1    Wei, Q.2    Luo, S.W.3    Xiao, H.4    Gong, L.Z.5
  • 24
    • 27144481089 scopus 로고    scopus 로고
    • For examples of alkaloid-catalyzed enantioselective cycloadditions of N -metalated azomethine ylides, see
    • For examples of alkaloid-catalyzed enantioselective cycloadditions of N -metalated azomethine ylides, see Alemparte, C.; Blay, G.; Jørgensen, K. A. Org. Lett. 2005, 7, 4569
    • (2005) Org. Lett. , vol.7 , pp. 4569
    • Alemparte, C.1    Blay, G.2    Jørgensen, K.A.3
  • 25
    • 66149095568 scopus 로고    scopus 로고
    • For a review of chiral guanidine-catalyzed enantioselective reactions, see
    • For a review of chiral guanidine-catalyzed enantioselective reactions, see Leow, D.; Tan, C. H. Chem.-Asian J. 2009, 4, 488
    • (2009) Chem. - Asian J. , vol.4 , pp. 488
    • Leow, D.1    Tan, C.H.2
  • 27
    • 33646874558 scopus 로고    scopus 로고
    • For examples of chiral phase transfer catalyst-catalyzed cycloadditions of azomethine ylides, see
    • For examples of chiral phase transfer catalyst-catalyzed cycloadditions of azomethine ylides, see Arai, S.; Takahashi, F.; Tsuji, R.; Nishida, A. Heterocycles 2006, 67, 495
    • (2006) Heterocycles , vol.67 , pp. 495
    • Arai, S.1    Takahashi, F.2    Tsuji, R.3    Nishida, A.4
  • 29
    • 84874074683 scopus 로고
    • Chiral Phosphines. U.S. Patent 5,302,738, April 12
    • Foricher, J.; Heiser, B.; Schmid, R. Chiral Phosphines. U.S. Patent 5,302,738, April 12, 1994
    • (1994)
    • Foricher, J.1    Heiser, B.2    Schmid, R.3
  • 30
    • 0013489025 scopus 로고
    • Chem. Abstr. 1993, 118, 147774.
    • (1993) Chem. Abstr. , vol.118 , pp. 147774


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.