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2842549051
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Eur.Pat. 104375, to Hoffmann-La Roche (1983)
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a) H.-J. Hansen and R. Schmid, Eur.Pat. 104375, to Hoffmann-La Roche (1983); cf. R. Schmid, M. Cereghetti, B. Heiser, P. Schönholzer and H.-J. Hansen, Hetl.Chim.Acta 71, 897 (1988)
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Hansen, H.-J.1
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a) H.-J. Hansen and R. Schmid, Eur.Pat. 104375, to Hoffmann-La Roche (1983); cf. R. Schmid, M. Cereghetti, B. Heiser, P. Schönholzer and H.-J. Hansen, Hetl.Chim.Acta 71, 897 (1988)
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Hetl.Chim.Acta
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b) G. Svensson, J. Albertsson, T. Frejd and T. Klingstedt, Acta Crystallogr., Sect.C 42, 1324 (1986)
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A. Miyashita, K. Nagano, T. Abe, M. Abe, T. Ojima, H. Nohira, H. Takaya and R. Noyori, 51th Ann.Meeting Chem.Soc.Jpn., Kyoto, April 1986, Abstr. 1TO6, p. 1267
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Miyashita, A.1
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R. Schmid, J. Foricher, M. Cereghetti and P. Schönholzer, Helv.Chim.Acta 74, 370, (1991).
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Schmid, R.1
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-
15
-
-
0009127891
-
-
For precedents of achiral diphosphine synthesis via bis(phosphonous dichlorides) or bis(prirnary phosphines) see: a) D.L. Allen, V.C. Gibson, M.L.H. Green, J.F. Skinner, J. Bashkin and P.D. Grebenik, J.Chem.Soc.,Chem.Commun., 895 (1983) b) E. Kyba, S. Liu and R.L. Harris, Organometallics 2, 1877 (1983) E.P. Kyba, M.C. Kerby and S.P. Rines, Organometallics 5, 1189 (1986).
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Allen, D.L.1
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Grebenik, P.D.6
-
16
-
-
0000976107
-
-
For precedents of achiral diphosphine synthesis via bis(phosphonous dichlorides) or bis(prirnary phosphines) see: a) D.L. Allen, V.C. Gibson, M.L.H. Green, J.F. Skinner, J. Bashkin and P.D. Grebenik, J.Chem.Soc.,Chem.Commun., 895 (1983) b) E. Kyba, S. Liu and R.L. Harris, Organometallics 2, 1877 (1983) E.P. Kyba, M.C. Kerby and S.P. Rines, Organometallics 5, 1189 (1986).
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Organometallics
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Kyba, E.1
Liu, S.2
Harris, R.L.3
-
17
-
-
0040222457
-
-
For precedents of achiral diphosphine synthesis via bis(phosphonous dichlorides) or bis(prirnary phosphines) see: a) D.L. Allen, V.C. Gibson, M.L.H. Green, J.F. Skinner, J. Bashkin and P.D. Grebenik, J.Chem.Soc.,Chem.Commun., 895 (1983) b) E. Kyba, S. Liu and R.L. Harris, Organometallics 2, 1877 (1983) E.P. Kyba, M.C. Kerby and S.P. Rines, Organometallics 5, 1189 (1986).
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Organometallics
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Kyba, E.P.1
Kerby, M.C.2
Rines, S.P.3
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20
-
-
2842594562
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F.Hoffmann-La Roche Ltd., unpublished results
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M. Cereghetti, F.Hoffmann-La Roche Ltd., unpublished results; cf. M. Cereghetti, A. Rageot, Eur.Pat. 511558, to Hoffmann-La Roche (1992).
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Cereghetti, M.1
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21
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2842565791
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Eur.Pat. 511558, to Hoffmann-La Roche (1992)
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M. Cereghetti, F.Hoffmann-La Roche Ltd., unpublished results; cf. M. Cereghetti, A. Rageot, Eur.Pat. 511558, to Hoffmann-La Roche (1992).
-
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Cereghetti, M.1
Rageot, A.2
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22
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0021338980
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For the first time realized in the binaphthalene series: D.L. Coffen and B. Rossiter, Hoffmann-La Roche Inc., unpublished results; cf. D.L. Coffen, B. Schaer, F.T. Bizzarro and J.B. Cheung, J.Org.Chem. 49, 296 (1984).
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2842543522
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US Pat. 5302738, to Hoffmann-La Roche (1992)
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a) J. Foricher, B. Heiser and R. Schmid, US Pat. 5302738, to Hoffmann-La Roche (1992)
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Foricher, J.1
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2842554553
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Eur.Pat. 583433, to Hoffmann-La Roche (1994)
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J. Foricher and R. Schmid, Eur.Pat. 583433, to Hoffmann-La Roche (1994)
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Foricher, J.1
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2842533486
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Eur.Pat. 579797, to Hoffmann-La Roche (1994)
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J. Foricher and R. Schmid, Eur.Pat. 579797, to Hoffmann-La Roche (1994)
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2842605651
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e) E. Broger and M. Cereghetti, Eur.Pat. 582692, to Hoffmann-La Roche (1993).
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For yeast reductions of α-pyridyl ketones see: a) M. Takeshita, K. Terada, N. Akutsu, S. Yoshida and T. Sato, Heterocycles 26, 3051 (1987) b) M. Takeshita, S. Yoshida, S. Sato and N. Akutsu, Heterocycles 35, 879 (1993) D. Bailey, U. Dyer, D. O'Hagan and R.B. Lamont, Tetrahedron: Asymmetry 4, 1255 (1993).
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Heterocycles
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Takeshita, M.1
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30
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0011168014
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For yeast reductions of α-pyridyl ketones see: a) M. Takeshita, K. Terada, N. Akutsu, S. Yoshida and T. Sato, Heterocycles 26, 3051 (1987) b) M. Takeshita, S. Yoshida, S. Sato and N. Akutsu, Heterocycles 35, 879 (1993) D. Bailey, U. Dyer, D. O'Hagan and R.B. Lamont, Tetrahedron: Asymmetry 4, 1255 (1993).
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Heterocycles
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Takeshita, M.1
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0027324510
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For yeast reductions of α-pyridyl ketones see: a) M. Takeshita, K. Terada, N. Akutsu, S. Yoshida and T. Sato, Heterocycles 26, 3051 (1987) b) M. Takeshita, S. Yoshida, S. Sato and N. Akutsu, Heterocycles 35, 879 (1993) D. Bailey, U. Dyer, D. O'Hagan and R.B. Lamont, Tetrahedron: Asymmetry 4, 1255 (1993).
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Tetrahedron: Asymmetry
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Bailey, D.1
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a) U. Hengartner, D. Valentine, Jr., K.K. Johnson, M.E. Larscheid, F. Pigott, F. Scheidl, J.W. Scott, R.C. Sun, J.M. Townsend and T. H. Williams, J.Org.Chem. 44, 3741 (1979)
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Townsend, J.M.9
Williams, T.H.10
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34
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-
0028246815
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and references cited therein
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Rate increases of Rh-catalyzed non-asymmetric C=O reductions by use of trialkylphosphine or bis(dialkylphosphine) ligands is well documented; see e.g. M.J. Burk, T.G.P. Harper, J.R. Lee and C. Kalberg, Tetrahedron Lett. 35, 4963 (1994) and references cited therein.
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35
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2842559070
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note
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The average turnover frequency (TOF) is defined as molar substrate/catalyst ratio (S/C) divided by reaction time in h.
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36
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2842587857
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Eur.Pat. 553778, to Hoffmann-La Roche (1993)
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E. Broger, W. Hofheinz and A. Meili, Eur.Pat. 553778, to Hoffmann-La Roche (1993).
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2842601174
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Eur.Pat. 565975, to Hoffmann-La Roche (1993)
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E. Broger and R.K. Müller, Eur.Pat. 565975, to Hoffmann-La Roche (1993).
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a) P. Barbier and F. Schneider, J.Org.Chem. 53, 1218 (1988) and references cited therein
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E. Broger, M. Karpf and U. Zutter, Eur.Pat. 643052, to Hoffmann-La Roche (1994).
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a) M. Lalonde and R. Schmid, Eur.Pat. 667350, to Hoffmann-La Roche (1995)
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|