-
1
-
-
33644847440
-
Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer
-
Faivre S, Delbaldo C, Vera K, et al. Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J Clin Oncol 2006; 24: 25-35.
-
(2006)
J Clin Oncol
, vol.24
, pp. 25-35
-
-
Faivre, S.1
Delbaldo, C.2
Vera, K.3
-
2
-
-
77953944562
-
Hematologic toxicity in patients treated with sunitinib for advanced thyroid cancer
-
Gkountouvas A, Kostoglou-Athanassiou I, Veniou E, Repousis P, Ziras N, Kaldrimidis P. Hematologic toxicity in patients treated with sunitinib for advanced thyroid cancer. Thyroid 2010; 20: 597-600.
-
(2010)
Thyroid
, vol.20
, pp. 597-600
-
-
Gkountouvas, A.1
Kostoglou-Athanassiou, I.2
Veniou, E.3
Repousis, P.4
Ziras, N.5
Kaldrimidis, P.6
-
3
-
-
42949148257
-
Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
-
Burstein HJ, Elias AD, Rugo HS, et al. Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. J Clin Oncol 2008; 26: 1810-6.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1810-1816
-
-
Burstein, H.J.1
Elias, A.D.2
Rugo, H.S.3
-
4
-
-
39149120621
-
Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer
-
Socinski MA, Novello S, Brahmer JR, et al. Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer. J Clin Oncol 2008; 26: 650-6.
-
(2008)
J Clin Oncol
, vol.26
, pp. 650-656
-
-
Socinski, M.A.1
Novello, S.2
Brahmer, J.R.3
-
5
-
-
79851482955
-
Sunitinib malate for the treatment of pancreatic neuroendocrine tumors
-
Raymond E, Dahan L, Raoul JL, et al. Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N Engl J Med 2011; 364: 501-13.
-
(2011)
N Engl J Med
, vol.364
, pp. 501-513
-
-
Raymond, E.1
Dahan, L.2
Raoul, J.L.3
-
6
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007; 356: 115-24.
-
(2007)
N Engl J Med
, vol.356
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
7
-
-
68949145218
-
Overall survival and updated results for sunitinib compared with interferonalfa in patients with metastatic renal cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P, et al. Overall survival and updated results for sunitinib compared with interferonalfa in patients with metastatic renal cell carcinoma. J Clin Oncol 2009; 27: 3584-90.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3584-3590
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
8
-
-
65249087328
-
A population pharmacokinetic meta-analysis of sunitinib malate (SU11248) and its primary metabolite (SU12662) in healthy volunteers and oncology patients
-
Houk BE, Bello CL, Kang D, Amantea MA. A population pharmacokinetic meta-analysis of sunitinib malate (SU11248) and its primary metabolite (SU12662) in healthy volunteers and oncology patients. Clin Cancer Res 2009; 15: 2497-506.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2497-2506
-
-
Houk, B.E.1
Bello, C.L.2
Kang, D.3
Amantea, M.A.4
-
9
-
-
57149116216
-
Short-and long-term safety with sunitinib in an expanded access trial in metastatic renal cell carcinoma (mRCC)
-
May 20, abstr 5114
-
Porta C, Szczylik C, Bracarda S, et al. Short-and long-term safety with sunitinib in an expanded access trial in metastatic renal cell carcinoma (mRCC). J Clin Oncol 2008; 26: May 20 suppl; abstr 5114.
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.
-
-
Porta, C.1
Szczylik, C.2
Bracarda, S.3
-
10
-
-
48649094719
-
Overall survival with sunitinib versus interferon (IFN)-alfa as first-line treatment of metastatic renal cell carcinoma (mRCC)
-
May 20, abstr 5024
-
Figlin RA, Hutson TE, Tomczak P, et al. Overall survival with sunitinib versus interferon (IFN)-alfa as first-line treatment of metastatic renal cell carcinoma (mRCC). J Clin Oncol 2008; 26: May 20 suppl; abstr 5024.
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.
-
-
Figlin, R.A.1
Hutson, T.E.2
Tomczak, P.3
-
11
-
-
77953033291
-
Relationsheep between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: Results of a pharmacokinetic/pharmacodinamic meta-analysis
-
Houk BE, Bello CL, Poland B, Rosen LS, Demetri GD, Motzer RJ. Relationsheep between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: results of a pharmacokinetic/pharmacodinamic meta-analysis. Cancer Chemother Pharmacol 2010; 66: 357-71.
-
(2010)
Cancer Chemother Pharmacol
, vol.66
, pp. 357-371
-
-
Houk, B.E.1
Bello, C.L.2
Poland, B.3
Rosen, L.S.4
Demetri, G.D.5
Motzer, R.J.6
-
12
-
-
12244301581
-
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
-
Mendel DB, Laird AD, Xin X, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 2000; 9: 327-37.
-
(2000)
Clin Cancer Res
, vol.9
, pp. 327-337
-
-
Mendel, D.B.1
Laird, A.D.2
Xin, X.3
-
13
-
-
77950348305
-
A phase II study of sunitinib in Japanese patients with metastatic renal cell carcinoma: Insights into the treatment, efficacy and safety
-
Uemura H, Shinohara N, Yuasa T, et al. A phase II study of sunitinib in Japanese patients with metastatic renal cell carcinoma: insights into the treatment, efficacy and safety. Jpn J Clin Oncol 2010; 40: 194-202.
-
(2010)
Jpn J Clin Oncol
, vol.40
, pp. 194-202
-
-
Uemura, H.1
Shinohara, N.2
Yuasa, T.3
-
14
-
-
34548316976
-
Molecular basis for sunitinib efficacy and future clinical development
-
Faivre S, Demetri G, Sargent W, Raymond E. Molecular basis for sunitinib efficacy and future clinical development. Nat Rev Drug Discov 2007; 6: 734-45.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 734-745
-
-
Faivre, S.1
Demetri, G.2
Sargent, W.3
Raymond, E.4
-
15
-
-
2442669093
-
Preclinical evaluation of the tyrosine kinase inhibitor SU11248 as a single agent and in combination with "standard of care" therapeutic agents for the treatment of breast cancer
-
Abrams TJ, Murray LJ, Pesenti E, et al. Preclinical evaluation of the tyrosine kinase inhibitor SU11248 as a single agent and in combination with "standard of care" therapeutic agents for the treatment of breast cancer. Mol Cancer Ther 2003; 2: 1011-21.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 1011-1021
-
-
Abrams, T.J.1
Murray, L.J.2
Pesenti, E.3
-
16
-
-
79955728914
-
Randomized phase II multicenter study of the efficacy and safety of sunitinib on the 4/2 versus continuous dosing schedule as first-line therapy of metastatic renal cell carcinoma: Renal EFFECT Trial
-
abstr LBA308
-
Motzer RJ, Hutson T, Olsen MR, et al. Randomized phase II multicenter study of the efficacy and safety of sunitinib on the 4/2 versus continuous dosing schedule as first-line therapy of metastatic renal cell carcinoma: Renal EFFECT Trial. J Clin Oncol 2011; 29:suppl 7; abstr LBA308.
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL. 7
-
-
Motzer, R.J.1
Hutson, T.2
Olsen, M.R.3
-
17
-
-
0034594628
-
New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
-
Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 2000; 92: 205-16.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 205-216
-
-
Therasse, P.1
Arbuck, S.G.2
Eisenhauer, E.A.3
-
18
-
-
0036138580
-
Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
-
Motzer RJ, Bacik J, Murphy BA, Russo P, Mazumdar M. Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol 2002; 20: 289-96.
-
(2002)
J Clin Oncol
, vol.20
, pp. 289-296
-
-
Motzer, R.J.1
Bacik, J.2
Murphy, B.A.3
Russo, P.4
Mazumdar, M.5
-
19
-
-
77955176213
-
Dose-finding trial of a combined regimen with bevacizumab, immunotherapy, and chemotherapy in patients with metastatic renal cell cancer: An Italian Oncology Group for Clinical Research (GOIRC) study
-
Buti S, Lazzarelli S, Chiesa MD, et al. Dose-finding trial of a combined regimen with bevacizumab, immunotherapy, and chemotherapy in patients with metastatic renal cell cancer: An Italian Oncology Group for Clinical Research (GOIRC) study. J Immunother 2010; 33: 735-41.
-
(2010)
J Immunother
, vol.33
, pp. 735-741
-
-
Buti, S.1
Lazzarelli, S.2
Chiesa, M.D.3
-
20
-
-
84858701414
-
Sunitinib: The first to arrive at first-line metastatic renal cell carcinoma
-
doi: 10.1007/s12325-011-0099-9. Epub 2012 Feb 7
-
Vázquez S, León L, Fernández O, Lázaro M, Grande E, Aparicio L. Sunitinib: the first to arrive at first-line metastatic renal cell carcinoma. Adv Ther 2012; 29:202-217. doi: 10.1007/s12325-011-0099-9. Epub 2012 Feb 7.
-
(2012)
Adv Ther
, vol.29
, pp. 202-217
-
-
Vázquez, S.1
León, L.2
Fernández, O.3
Lázaro, M.4
Grande, E.5
Aparicio, L.6
-
21
-
-
0041672482
-
SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models
-
Schueneman AJ, Himmelfarb E, Geng L, et al. SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models. Cancer Res 2003; 63: 4009-16.
-
(2003)
Cancer Res
, vol.63
, pp. 4009-4016
-
-
Schueneman, A.J.1
Himmelfarb, E.2
Geng, L.3
-
22
-
-
84857366750
-
Determining the optimal dose and schedule of sunitinib. Some answers, more questions
-
Suarez C, Rini BI. Determining the optimal dose and schedule of sunitinib. Some answers, more questions. Cancer 2012; 118: 1178-80.
-
(2012)
Cancer
, vol.118
, pp. 1178-1180
-
-
Suarez, C.1
Rini, B.I.2
-
23
-
-
79955072210
-
Exposure-response relationships in patients with metastatic renal cell carcinoma receiving sunitinib: Maintaining optimum efficacy in clinical practice
-
Ravaud A, Bello CL. Exposure-response relationships in patients with metastatic renal cell carcinoma receiving sunitinib: maintaining optimum efficacy in clinical practice. Anticancer Drugs 2011; 22: 377-83.
-
(2011)
Anticancer Drugs
, vol.22
, pp. 377-383
-
-
Ravaud, A.1
Bello, C.L.2
|