Contrasting roles of IL-22 and IL-17 in murine genital tract infection by Neisseria gonorrhoeae

Frontiers in Immunology

Volumn 3, Issue FEB, 2012, Pages

  Feinen, Brandon ^a,b   Russell, Michael W ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

Genital infection; Immune response; Interleukin 22; Mouse; Neisseria gonorrhoeae

Indexed keywords

EID: 84874072165     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2012.00011     Document Type: Article

References (32)

1. Allen, V. G., Farrell, D. J., Rebbapragada, A., Tan, J., Tijet, N., Perusini, S. J., Towns, L., Lo, S., Low, D. E., and Melano, R. G. (2011). Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. Antimicrob. Agents Chemother. (Bethesda) 55, 703-712.
2. Andoh, A., Zhang, Z., Inatomi, O., Fujino, S., Deguchi, Y., Araki, Y., Tsujikawa, T., Kitoh, K., KimMitsuyama, S., Takayanagi, A., Shimizu, N., and Fujiyama, Y. (2005). Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts. Gastroenterology 129, 969-984.
3. Aujla, S. J., Chan, Y. R., Zheng, M., Fei, M., Askew, D. J., Pociask, D. A., Reinhart, T. A., McAllister, F., Edeal, J., Gaus, K., Husain, S., Kreindler, J. L., Dubin, P. J., Pilewski, J. M., Myerburg, M. M., Mason, C. A., Iwakura, Y., and Kolls, J. K. (2008). IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat. Med. 14, 275-281.
4. Boniface, K., Bernard, F. X., Garcia, M., Gurney, A. L., Lecron, J. C., and Morel, F. (2005). IL22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes. J. Immunol. 174, 3695-3702.
5. Conti, H. R., Shen, F., Nayyar, N., Stocum, E., Sun, J. N., Lindemann, M. J., Ho, A. W., Hai, J. H., Yu, J. J., Jung, J. W., Filler, S. G., Masso Welch, P., Edgerton, M., and Gaffen, S. L. (2009). Th17 cells and IL17 receptor signaling are essential for mucosal host defense against oral candidiasis. J. Exp. Med. 206, 299-311.
6. Cupedo, T., Crellin, N. K., Papazian, N., Rombouts, E. J., Weijer, K., Grogan, J. L., Fibbe, W. E., Cornelissen, J. J., and Spits, H. (2009). Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells. Nat. Immunol. 10, 66-74.
7. Duhen, T., Geiger, R., Jarrossay, D., Lanzavecchia, A., and Sallusto, F. (2009). Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nat. Immunol. 10, 857-863.
8. Eyerich, S., Eyerich, K., Pennino, D., Carbone, T., Nasorri, F., Pallotta, S., Cianfarani, F., Odorisio, T., Traidl-Hoffmann, C., Behrendt, H., Durham, S. R., Schmidt-Weber, C. B., and Cavani, A. (2009). Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J. Clin. Invest. 119, 3573-3585.
9. Feinen, B., Jerse, A. E., Gaffen, S. L., and Russell, M. W. (2010). Critical role of Th17 responses in a murine model of Neisseria gonorrhoeae genital infection. Mucosal Immunol. 3, 312-321.
10. Fujita, H., Nograles, K. E., Kikuchi, T., Gonzalez, J., Carucci, J. A., and Krueger, J. G. (2009). Human Langerhans cells induce distinct IL22-producing CD4+ T cells lacking IL-17 production. Proc. Natl. Acad. Sci. U.S.A. 106, 21795-21800.
11. Hook, E. W., and Handsfield, H. H. (1999). "Gonococcal infections in the adult," in Sexually Transmitted Diseases, 3rd Edn, eds K. K. Holmes, P. F. Sparling, P.-A. Mårdh, S. M. Lemon, W. E. Stamm, P. Piot, and J. N. Wasserheit (New York: McGrawHill), 451-466.
12. Jerse, A. E. (1999). Experimental gonococcal genital tract infection and opacity protein expression in estradiol-treated mice. Infect. Immun. 67, 5699-5708.
13. Jerse, A. E., Wu, H., Packiam, M.,Vonck, R. A., Begum, A. A., and Garvin, L. E. (2011). Estradiol-treated female mice as surrogate hosts for Neisseria gonorrhoeae genital tract infections. Front. Microbiol. 2:107. doi:10.3389/fmicb.2011.00107
14. Liang, S. C., Tan, X. Y., Luxenberg, D. P., Karim, R., Dunussi-Joannopoulos, K., Collins, M., and Fouser, L. A. (2006). Interleukin (IL)-22 and IL17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J. Exp. Med. 203, 2271-2279.
15. Liu, Y., Feinen, B., and Russell, M. W. (2011). New concepts in immunity to Neisseria gonorrhoeae: innate responses and suppression of adaptive immunity favor the pathogen, not the host. Front. Microbiol. 2:52. doi:10.3389/fmicb.2011.00052
16. Liu, Y., Islam, E., Jarvis, G. A., Gray Owen, S., and Russell, M. W. (2012). Neisseria gonorrhoeae selectively suppresses the development of Th1 and Th2 cells, and enhances Th17 cell responses, through TGF(β-dependent mechanisms. Mucosal Immunol. 5. (in press).
17. Liu,Y.,and Russell,M.W. (2011). Diversion of the immune response to Neisseria gonorrhoeae from Th17 to Th1/Th2 by treatment with antiTGF-β antibody generates immunological memory and protective immunity. mBio 2, e00095-11.
18. Ouyang, W., Kolls, J. K., and Zheng, Y. (2008). The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 28, 454-467.
19. Ouyang, W., and Valdez, P. (2008). IL22 in mucosal immunity. Mucosal Immunol. 1, 335-338.
20. Packiam, M., Veit, S. J., Anderson, D. J., Ingalls, R. R., and Jerse, A. E. (2010). Mouse strain-dependent differences in susceptibility to Neisseria gonorrhoeae infection and induction of innate immune responses. Infect. Immun. 78, 433-440.
21. Packiam, M., Wu, H., Veit, S. J., Mavrogiorgos, N., Jerse, A. E., and Ingalls, R. R. (2011). Protective role of Toll-like receptor 4 in experimental gonococcal infection of female mice. Mucosal Immunol. 4, 2011.2038.
22. Raffatellu, M., George, M. D., Akiyama, Y., Hornsby, M. J., Nuccio, S.-P., Paixao, T. A., Butler, B. P., Chu, H., Santos, R. L., Berger, T., Mak, T. W., Tsolis, R. M., Bevins, C. L., Solnick, J. V., Dandekar, S., and Bäumler, A. J. (2009). Lipocalin2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine. Cell Host Microbe 5, 476-486.
23. Siegemund, S., Schutze, N., Schulz, S., Wolk, K., Nasilowska, K., Straubinger, R. K., Sabat, R., and Alber, G. (2009). Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis. Int. Immunol. 21, 555-565.
24. Simms, A. N., and Jerse, A. E. (2006). In vivo selection for Neisseria gonorrhoeae opacity protein expression in the absence of human carcinoembryonic antigen cell adhesion molecules. Infect. Immun. 74, 2965-2974.
25. Sonnenberg, G. F., Fouser, L. A., and Artis, D. (2011). Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22. Nat. Immunol. 12, 383-390.
26. Sonnenberg, G. F., Nair, M. G., Kirn, T. J., Zaph, C., Fouser, L. A., and Artis, D. (2010). Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A. J. Exp. Med. 207,1293-1305.
27. Weber, G. F., Schlautkotter, S., Kaiser Moore, S., Altmayr, F., Holzmann, B., and Weighardt, H. (2007). Inhibition of interleukin-22 attenuates bacterial load and organ failure during acute polymicrobial sepsis. Infect. Immun. 75, 1690-1697.
28. Wolk, K., Haugen, H. S., Xu, W., Witte, E., Waggie, K., Anderson, M., Vom Baur, E., Witte, K., Warszawska, K., Philipp, S., Johnson-Leger, C., Volk, H. D., Sterry, W., and Sabat, R. (2009). IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not. J. Mol. Med. (Berl.) 87, 523-536.
29. Wolk, K., Kunz, S., Witte, E., Friedrich, M., Asadullah, K., and Sabat, R. (2004). IL-22 increases the innate immunity of tissues. Immunity 21, 241-254.
30. Wolk, K., Witte, E., Witte, K., Warszawska, K., and Sabat, R. (2010). Biology of interleukin-22. Semin. Immunopathol. 32, 17-31.
31. Zenewicz, L. A., Yancopoulos, G. D., Valenzuela, D. M., Murphy, A. J., Karow, M., and Flavell, R. A. (2007). Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity 27, 647-659.
32. Zheng, Y., Valdez, P. A., Danilenko, D. M., Hu, Y., Sa, S. M., Gong, Q., Abbas, A. R., Modrusan, Z., Ghilardi, N., de Sauvage, F. J., and Ouyang, W. (2008). Interleukin22 mediates early host defense against attaching and effacing bacterial pathogens. Nat. Med. 14, 282-289.