Integrins 4 and m, collagen1A1, and matrix metalloproteinase 7 are upregulated in acute Kawasaki disease vasculopathy

Pediatric Research

Volumn 73, Issue 3, 2013, Pages 332-336

  Reindel, Rebecca ^a   Baker, Susan C ^b   Kim, Kwang Youn ^a   Rowley, Carol A ^b   Shulman, Stanford T ^a   Orenstein, Jan M ^c   Perlman, Elizabeth J ^a   Lingen, Mark W ^d   Rowley, Anne H ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

^c GEORGE WASHINGTON UNIVERSITY   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTEGRIN; ALPHA4 INTEGRIN; CELL ADHESION MOLECULE; COLLAGEN TYPE 1; COLLAGEN TYPE 1 ALPHA 1; INTEGRIN ALPHA M; MATRILYSIN; UNCLASSIFIED DRUG; CD11B ANTIGEN;

ARTERY WALL; ARTICLE; CHILD; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY DISEASE; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; MALE; MOLECULAR PATHOLOGY; MUCOCUTANEOUS LYMPH NODE SYNDROME; MYOFIBROBLAST; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SCHOOL CHILD; UPREGULATION; CORONARY BLOOD VESSEL; GENE EXPRESSION REGULATION; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANTIGENS, CD11B; CELL ADHESION MOLECULES; COLLAGEN TYPE I; CORONARY VESSELS; EXTRACELLULAR MATRIX; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; INTEGRIN ALPHA4; MATRIX METALLOPROTEINASE 7; MUCOCUTANEOUS LYMPH NODE SYNDROME; REAL-TIME POLYMERASE CHAIN REACTION;

MLCS; MLOWN;

EID: 84874065713     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2012.185     Document Type: Article

References (36)

1. Pham MX, Teuteberg JJ, Kfoury AG, et al. Gene-expression profiling for rejection surveillance after cardiac transplantation. N Engl J Med 2010;362:1890-900.
2. Deng MC, Eisen HJ, Mehra MR, et al. Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling. Am J Transplant 2006;6:150-60.
3. Kittleson MM, Minhas KM, Irizarry RA, et al. Gene expression analysis of ischemic and nonischemic cardiomyopathy: shared and distinct genes in the development of heart failure. Physiol Genomics 2005;21:299-307.
4. Tan FL, Moravec CS, Li J, et al. The gene expression fingerprint of human heart failure. Proc Natl Acad Sci USA 2002;99:11387-92.
5. Orenstein JM, Shulman ST, Fox LM, et al. Three linked vasculopathic processes characterize Kawasaki disease: a light and transmission electron microscopic study. PLoS ONE 2012;7:e38998.
6. Fukazawa R, Ikegam E, Watanabe M, et al. Coronary artery aneurysm induced by Kawasaki disease in children show features typical senescence. Circ J 2007;71:709-15.
7. Takada Y, Ye X, Simon S. The integrins. Genome Biol 2007;8:215.
8. Avraamides CJ, Garmy-Susini B, Varner JA. Integrins in angiogenesis and lymphangiogenesis. Nat Rev Cancer 2008;8:604-17.
9. Cantor JM, Ginsberg MH, Rose DM. Integrin-associated proteins as potential therapeutic targets. Immunol Rev 2008;223:236-51.
10. Hom G, Graham RR, Modrek B, et al. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med 2008;358:900-9.
11. Simon DI, Dhen Z, Seifert P, Edelman ER, Ballantyne CM, Rogers C. Decreased neointimal formation in Mac-1(-/-) mice reveals a role for inflammation in vascular repair after angioplasty. J Clin Invest 2000;105:293-300.
12. Wang Y, Sakuma M, Chen Z, et al. Leukocyte engagement of platelet glycoprotein Ibalpha via the integrin Mac-1 is critical for the biological response to vascular injury. Circulation 2005;112:2993-3000.
13. Abe J, Ebata R, Jibiki T, Yasukawa K, Saito H, Terai M. Elevated granulocyte colony-stimulating factor levels predict treatment failure in patients with Kawasaki disease. J Allergy Clin Immunol 2008;122:1008-1013.e8.
14. Kitayama J, Fuhlbrigge RC, Puri KD, Springer TA. P-selectin, L-selectin, and alpha 4 integrin have distinct roles in eosinophil tethering and arrest on vascular endothelial cells under physiological flow conditions. J Immunol 1997;159:3929-39.
15. Johnston B, Issekutz TB, Kubes P. The alpha 4-integrin supports leukocyte rolling and adhesion in chronically inflamed postcapillary venules in vivo. J Exp Med 1996;183:1995-2006.
16. Garmy-Susini B, Avraamides CJ, Schmid MC, et al. Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis. Cancer Res 2010;70:3042-51.
17. Lenk GM, Tromp G, Weinsheimer S, Gatalica Z, Berguer R, Kuivaniemi H. Whole genome expression profiling reveals a significant role for immune function in human abdominal aortic aneurysms. BMC Genomics 2007;8:237.
18. Bernstein D, Williams GE, Eisen H, et al. Gene expression profiling distinguishes a molecular signature for grade 1B mild acute cellular rejection in cardiac allograft recipients. J Heart Lung Transplant 2007;26:1270-80.
19. Coussens LM, Werb Z. Inflammation and cancer. Nature 2002;420:860-7.
20. Popper SJ, Shimizu C, Shike H, et al. Gene-expression patterns reveal underlying biological processes in Kawasaki disease. Genome Biol 2007;8:R261.
21. Lee Y, Schulte DJ, Shimada K, et al. Interleukin-1ß is crucial for the induction of coronary artery inflammation in a mouse model of Kawasaki disease. Circulation 2012;125:1542-50.
22. Newby AC, Zaltsman AB. Molecular mechanisms in intimal hyperplasia. J Pathol 2000;190:300-9.
23. Busiek DF, Baragi V, Nehring LC, Parks WC, Welgus HG. Matrilysin expression by human mononuclear phagocytes and its regulation by cytokines and hormones. J Immunol 1995;154:6484-91.
24. Swee M, Wilson CL, Wang Y, McGuire JK, Parks WC. Matrix metalloproteinase- 7 (matrilysin) controls neutrophil egress by generating chemokine gradients. J Leukoc Biol 2008;83:1404-12.
25. Parks WC, Wilson CL, López-Boado YS. Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat Rev Immunol 2004;4:617-29.
26. Wielockx B, Libert C, Wilson C. Matrilysin (matrix metalloproteinase-7): a new promising drug target in cancer and inflammation? Cytokine Growth Factor Rev 2004;15:111-5.
27. Nilsson L, Jonasson L, Nijm J, Hamsten A, Eriksson P. Increased plasma concentration of matrix metalloproteinase-7 in patients with coronary artery disease. Clin Chem 2006;52:1522-7.
28. Bäck M, Ketelhuth DF, Agewall S. Matrix metalloproteinases in atherothrombosis. Prog Cardiovasc Dis 2010;52:410-28.
29. Kurokawa S, Arimura Y, Yamamoto H, et al. Tumour matrilysin expression predicts metastatic potential of stage I (pT1) colon and rectal cancers. Gut 2005;54:1751-8.
30. Kuhlmann KF, van Till JW, Boermeester MA, et al. Evaluation of matrix metalloproteinase 7 in plasma and pancreatic juice as a biomarker for pancreatic cancer. Cancer Epidemiol Biomarkers Prev 2007;16:886-91.
31. Roy R, Yang J, Moses MA. Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer. J Clin Oncol 2009;27: 5287-97.
32. Brown TJ, Crawford SE, Cornwall ML, Garcia F, Shulman ST, Rowley AH. CD8 T lymphocytes and macrophages infiltrate coronary artery aneurysms in acute Kawasaki disease. J Infect Dis 2001;184:940-3.
33. Gavin PJ, Crawford SE, Shulman ST, Garcia FL, Rowley AH. Systemic arterial expression of matrix metalloproteinases 2 and 9 in acute Kawasaki disease. Arterioscler Thromb Vasc Biol 2003;23:576-81.
34. Storey JD. A direct approach to false discovery rates. J R Stat Soc Series B Stat Methodol 2002;64:479-98.
35. Storey JD, Taylor JE, Siegmund D. Strong control, conservative point estimation and simultaneous conservative consistency of false discovery rates: a unified approach. J R Stat Soc Series B Stat Methodol 2004;66:187-205.
36. Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci USA 2003;100:9440-5.