Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans

Science Translational Medicine

Volumn 5, Issue 172, 2013, Pages

  Titus, Shiny ^a,b   Li, Fang ^a,b   Stobezki, Robert ^a,b   Akula, Komala ^a,b   Unsal, Evrim ^a,b,c   Jeong, Kyungah ^a,b   Dickler, Maura ^d   Robson, Mark ^d   Moy, Fred ^a,b   Goswami, Sumanta ^a,b,e   Oktay, Kutluk ^a,b  

^a Institute for Reproductive Medicine and Fertility Preservation   (United States)

^b NEW YORK MEDICAL COLLEGE   (United States)

^c ISTANBUL BILIM UNIVERSITY   (Turkey)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e YESHIVA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; BRCA1 PROTEIN; BRCA2 PROTEIN; MRE11 PROTEIN; MUELLERIAN INHIBITING FACTOR; RAD51 PROTEIN;

ADULT; AGING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATM GENE; CHILD; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; FEMALE; FEMALE INFERTILITY; GENE EXPRESSION; GENE MUTATION; HORMONE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; MRE11 GENE; NONHUMAN; OVARIAN RESERVE; OVARY FOLLICLE; PRESCHOOL CHILD; PRIORITY JOURNAL; RAD51 GENE; REPRODUCTIVE HEALTH; TUMOR SUPPRESSOR GENE;

ADOLESCENT; ADULT; AGE FACTORS; AGING; ANIMALS; ANTI-MULLERIAN HORMONE; BRCA1 PROTEIN; BRCA2 PROTEIN; CELL AGING; CHILD; CHILD, PRESCHOOL; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; FEMALE; FERTILITY; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, TRANSGENIC; MUTATION; OOCYTES; OVARY; RNA INTERFERENCE; YOUNG ADULT;

EID: 84874063839     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3004925     Document Type: Article

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