-
1
-
-
0017402583
-
The natural history of chronic airflow obstruction
-
6077
-
Fletcher C, Peto R. The natural history of chronic airflow obstruction. Br Med J 1977;1(6077):1645-8
-
(1977)
Br Med J
, vol.1
, pp. 1645-1648
-
-
Fletcher, C.1
Peto, R.2
-
3
-
-
34247500507
-
New molecular targets for the treatment of neutrophilic diseases
-
Barnes PJ. New molecular targets for the treatment of neutrophilic diseases. J Allergy Clin Immunol 2007;119(5):1055-62
-
(2007)
J Allergy Clin Immunol
, vol.119
, Issue.5
, pp. 1055-1062
-
-
Barnes, P.J.1
-
4
-
-
67649224269
-
Progression of chronic obstructive pulmonary disease: Impact of inflammation, comorbidities and therapeutic intervention
-
Stockley RA. Progression of chronic obstructive pulmonary disease: impact of inflammation, comorbidities and therapeutic intervention. Curr Med Res Opin 2009;25(5):1235-45
-
(2009)
Curr Med Res Opin
, vol.25
, Issue.5
, pp. 1235-1245
-
-
Stockley, R.A.1
-
5
-
-
0042387838
-
The role of interleukin-8 and its receptors in inflammatory lung disease: Implications for therapy
-
Pease JE, Sabroe I. The role of interleukin-8 and its receptors in inflammatory lung disease: implications for therapy. Am J Respir Med 2002;1(1):19-25
-
(2002)
Am J Respir Med
, vol.1
, Issue.1
, pp. 19-25
-
-
Pease, J.E.1
Sabroe, I.2
-
6
-
-
67649425653
-
Chemokine receptor antagonists: Part 2
-
Pease JE, Horuk R. Chemokine receptor antagonists: Part 2. Expert Opin Ther Pat 2009;19(2):199-221
-
(2009)
Expert Opin Ther Pat
, vol.19
, Issue.2
, pp. 199-221
-
-
Pease, J.E.1
Horuk, R.2
-
7
-
-
46849120181
-
Phenol-containing antagonists of the CXCR2 receptor
-
Busch-Petersen J, Wang Y. Phenol-containing antagonists of the CXCR2 receptor. Expert Opin Ther Pat 2008;18(6):629-37
-
(2008)
Expert Opin Ther Pat
, vol.18
, Issue.6
, pp. 629-637
-
-
Busch-Petersen, J.1
Wang, Y.2
-
8
-
-
0032562614
-
Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration
-
White JR, Lee JM, Young PR, et al. Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem 1998;273(17):10095-8
-
(1998)
J Biol Chem
, vol.273
, Issue.17
, pp. 10095-10098
-
-
White, J.R.1
Lee, J.M.2
Young, P.R.3
-
9
-
-
84874035482
-
IL-8 receptor antagonists
-
SmithKline Beecham Corp
-
SmithKline Beecham Corp. IL-8 Receptor Antagonists. WO1996025157; 1996
-
(1996)
WO1996025157
-
-
-
10
-
-
33845963398
-
Discovery of 2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl) propyl] amino]-3,4-dioxocyclobut-1-enylamino} benzamide (SCH 527123): A potent, orally bioavailable CXCR2/ CXCR1 receptor antagonist
-
Dwyer MP, Yu Y, Chao J, et al. Discovery of 2-hydroxy-N,N-dimethyl-3-{2- [[(R)-1-(5- methylfuran-2-yl)propyl] amino]-3,4-dioxocyclobut-1-enylamino} benzamide (SCH 527123): A potent, orally bioavailable CXCR2/ CXCR1 receptor antagonist. J Med Chem 2006;49(26):7603-6
-
(2006)
J Med Chem
, vol.49
, Issue.26
, pp. 7603-7606
-
-
Dwyer, M.P.1
Yu, Y.2
Chao, J.3
-
11
-
-
84874058191
-
Bicyclic ring system substituted amide functionalised phenols as medicaments
-
Boehringer Ingelheim International GmbH
-
Boehringer Ingelheim International GmbH. Bicyclic ring system substituted amide functionalised phenols as medicaments. WO2012080456 ; 2012
-
(2012)
WO2012080456
-
-
-
12
-
-
84874058191
-
Bicyclic ring system substituted sulfonamide functionalised phenols as medicaments
-
Boehringer Ingelheim International GmbH
-
Boehringer Ingelheim International GmbH. Bicyclic ring system substituted sulfonamide functionalised phenols as medicaments. WO2012080457 ; 2012
-
(2012)
WO2012080457
-
-
-
13
-
-
84874078737
-
3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
-
Pharmacopeia Inc
-
Pharmacopeia, Inc. 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands. US20040097547 ; 2004
-
(2004)
US20040097547
-
-
-
14
-
-
84874078984
-
3,4-Di-substituted cyclobutene-1,2-diones as CXCR2 receptor antagonists
-
Novartis AG. 3,4-Di-substituted cyclobutene-1,2-diones as CXCR2 receptor antagonists. WO2010063802 ; 2010
-
(2010)
WO2010063802
-
-
Novartis, A.G.1
-
16
-
-
34547114011
-
Pharmacological characterization of Sch527123, a potent allosteric CXCR1/ CXCR2 antagonist
-
Gonsiorek W, Fan X, Hesk D, et al. Pharmacological characterization of Sch527123, a potent allosteric CXCR1/ CXCR2 antagonist. J Pharm Exp Ther 2007;322:477-85
-
(2007)
J Pharm Exp Ther
, vol.322
, pp. 477-485
-
-
Gonsiorek, W.1
Fan, X.2
Hesk, D.3
-
17
-
-
34547122884
-
A novel, orally active CXCR1/ 2 receptor antagonist, Sch527123, inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammation
-
Chapman RW, Minnicozzi M, Celly CS, et al. A novel, orally active CXCR1/ 2 receptor antagonist, Sch527123, inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammation. J Pharmacol Exp Ther 2007;322(2):486-93
-
(2007)
J Pharmacol Exp Ther
, vol.322
, Issue.2
, pp. 486-493
-
-
Chapman, R.W.1
Minnicozzi, M.2
Celly, C.S.3
-
18
-
-
77951165310
-
SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects
-
Holz O, Khalilieh S, Ludwig-Sengpiel A, et al. SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects. Eur Respir J 2010;35(3):564-70
-
(2010)
Eur Respir J
, vol.35
, Issue.3
, pp. 564-570
-
-
Holz, O.1
Khalilieh, S.2
Ludwig-Sengpiel, A.3
-
19
-
-
84862519263
-
Safety And Efficacy Of A CXCR2 Antagonist In Patients With Severe Asthma And Sputum Neutrophils: A Randomized Placebo-controlled Clinical Trial
-
for navirixin
-
Nair P, Gaga M, Zervas E, et al. Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: A randomized, placebo-controlled clinical trial. Clin Exp Allergy 2012 ;42(7):1097-103 for navirixin
-
(2012)
Clin Exp Allergy
, vol.42
, Issue.7
, pp. 1097-103
-
-
Nair, P.1
Gaga, M.2
Zervas, E.3
-
22
-
-
77949852055
-
High content screening of CXCR2-dependent signalling pathways
-
Wolff M, Kredel S, Haasen D, et al. High content screening of CXCR2-dependent signalling pathways. Comb Chem High Throughput Screen 2010;13(1):3-15
-
(2010)
Comb Chem High Throughput Screen
, vol.13
, Issue.1
, pp. 3-15
-
-
Wolff, M.1
Kredel, S.2
Haasen, D.3
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