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Volumn 23, Issue 3, 2013, Pages 383-388

Evaluation of WO2012080456 and WO2012080457; boheringer Ingleheim's first CXCR2 antagonists

Author keywords

Chemokine; COPD; CXCR2; IL 8; Inflammation

Indexed keywords

1 (2 BROMOPHENYL) 3 (2 HYDROXY 4 NITROPHENYL)UREA; 2 AMINOPHENOL; ARYLCARBONYL; ARYLSULFONYL; CARBONYL DERIVATIVE; CHEMOKINE RECEPTOR CXCR2 ANTAGONIST; DANIRIXIN; ELUBRIXIN; NAVARIXIN; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

EID: 84874063627     PISSN: 13543776     EISSN: 17447674     Source Type: Journal    
DOI: 10.1517/13543776.2013.754424     Document Type: Article
Times cited : (2)

References (22)
  • 1
    • 0017402583 scopus 로고
    • The natural history of chronic airflow obstruction
    • 6077
    • Fletcher C, Peto R. The natural history of chronic airflow obstruction. Br Med J 1977;1(6077):1645-8
    • (1977) Br Med J , vol.1 , pp. 1645-1648
    • Fletcher, C.1    Peto, R.2
  • 3
    • 34247500507 scopus 로고    scopus 로고
    • New molecular targets for the treatment of neutrophilic diseases
    • Barnes PJ. New molecular targets for the treatment of neutrophilic diseases. J Allergy Clin Immunol 2007;119(5):1055-62
    • (2007) J Allergy Clin Immunol , vol.119 , Issue.5 , pp. 1055-1062
    • Barnes, P.J.1
  • 4
    • 67649224269 scopus 로고    scopus 로고
    • Progression of chronic obstructive pulmonary disease: Impact of inflammation, comorbidities and therapeutic intervention
    • Stockley RA. Progression of chronic obstructive pulmonary disease: impact of inflammation, comorbidities and therapeutic intervention. Curr Med Res Opin 2009;25(5):1235-45
    • (2009) Curr Med Res Opin , vol.25 , Issue.5 , pp. 1235-1245
    • Stockley, R.A.1
  • 5
    • 0042387838 scopus 로고    scopus 로고
    • The role of interleukin-8 and its receptors in inflammatory lung disease: Implications for therapy
    • Pease JE, Sabroe I. The role of interleukin-8 and its receptors in inflammatory lung disease: implications for therapy. Am J Respir Med 2002;1(1):19-25
    • (2002) Am J Respir Med , vol.1 , Issue.1 , pp. 19-25
    • Pease, J.E.1    Sabroe, I.2
  • 6
    • 67649425653 scopus 로고    scopus 로고
    • Chemokine receptor antagonists: Part 2
    • Pease JE, Horuk R. Chemokine receptor antagonists: Part 2. Expert Opin Ther Pat 2009;19(2):199-221
    • (2009) Expert Opin Ther Pat , vol.19 , Issue.2 , pp. 199-221
    • Pease, J.E.1    Horuk, R.2
  • 7
    • 46849120181 scopus 로고    scopus 로고
    • Phenol-containing antagonists of the CXCR2 receptor
    • Busch-Petersen J, Wang Y. Phenol-containing antagonists of the CXCR2 receptor. Expert Opin Ther Pat 2008;18(6):629-37
    • (2008) Expert Opin Ther Pat , vol.18 , Issue.6 , pp. 629-637
    • Busch-Petersen, J.1    Wang, Y.2
  • 8
    • 0032562614 scopus 로고    scopus 로고
    • Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration
    • White JR, Lee JM, Young PR, et al. Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem 1998;273(17):10095-8
    • (1998) J Biol Chem , vol.273 , Issue.17 , pp. 10095-10098
    • White, J.R.1    Lee, J.M.2    Young, P.R.3
  • 9
    • 84874035482 scopus 로고    scopus 로고
    • IL-8 receptor antagonists
    • SmithKline Beecham Corp
    • SmithKline Beecham Corp. IL-8 Receptor Antagonists. WO1996025157; 1996
    • (1996) WO1996025157
  • 10
    • 33845963398 scopus 로고    scopus 로고
    • Discovery of 2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl) propyl] amino]-3,4-dioxocyclobut-1-enylamino} benzamide (SCH 527123): A potent, orally bioavailable CXCR2/ CXCR1 receptor antagonist
    • Dwyer MP, Yu Y, Chao J, et al. Discovery of 2-hydroxy-N,N-dimethyl-3-{2- [[(R)-1-(5- methylfuran-2-yl)propyl] amino]-3,4-dioxocyclobut-1-enylamino} benzamide (SCH 527123): A potent, orally bioavailable CXCR2/ CXCR1 receptor antagonist. J Med Chem 2006;49(26):7603-6
    • (2006) J Med Chem , vol.49 , Issue.26 , pp. 7603-7606
    • Dwyer, M.P.1    Yu, Y.2    Chao, J.3
  • 11
    • 84874058191 scopus 로고    scopus 로고
    • Bicyclic ring system substituted amide functionalised phenols as medicaments
    • Boehringer Ingelheim International GmbH
    • Boehringer Ingelheim International GmbH. Bicyclic ring system substituted amide functionalised phenols as medicaments. WO2012080456 ; 2012
    • (2012) WO2012080456
  • 12
    • 84874058191 scopus 로고    scopus 로고
    • Bicyclic ring system substituted sulfonamide functionalised phenols as medicaments
    • Boehringer Ingelheim International GmbH
    • Boehringer Ingelheim International GmbH. Bicyclic ring system substituted sulfonamide functionalised phenols as medicaments. WO2012080457 ; 2012
    • (2012) WO2012080457
  • 13
    • 84874078737 scopus 로고    scopus 로고
    • 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
    • Pharmacopeia Inc
    • Pharmacopeia, Inc. 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands. US20040097547 ; 2004
    • (2004) US20040097547
  • 14
    • 84874078984 scopus 로고    scopus 로고
    • 3,4-Di-substituted cyclobutene-1,2-diones as CXCR2 receptor antagonists
    • Novartis AG. 3,4-Di-substituted cyclobutene-1,2-diones as CXCR2 receptor antagonists. WO2010063802 ; 2010
    • (2010) WO2010063802
    • Novartis, A.G.1
  • 16
    • 34547114011 scopus 로고    scopus 로고
    • Pharmacological characterization of Sch527123, a potent allosteric CXCR1/ CXCR2 antagonist
    • Gonsiorek W, Fan X, Hesk D, et al. Pharmacological characterization of Sch527123, a potent allosteric CXCR1/ CXCR2 antagonist. J Pharm Exp Ther 2007;322:477-85
    • (2007) J Pharm Exp Ther , vol.322 , pp. 477-485
    • Gonsiorek, W.1    Fan, X.2    Hesk, D.3
  • 17
    • 34547122884 scopus 로고    scopus 로고
    • A novel, orally active CXCR1/ 2 receptor antagonist, Sch527123, inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammation
    • Chapman RW, Minnicozzi M, Celly CS, et al. A novel, orally active CXCR1/ 2 receptor antagonist, Sch527123, inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammation. J Pharmacol Exp Ther 2007;322(2):486-93
    • (2007) J Pharmacol Exp Ther , vol.322 , Issue.2 , pp. 486-493
    • Chapman, R.W.1    Minnicozzi, M.2    Celly, C.S.3
  • 18
    • 77951165310 scopus 로고    scopus 로고
    • SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects
    • Holz O, Khalilieh S, Ludwig-Sengpiel A, et al. SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects. Eur Respir J 2010;35(3):564-70
    • (2010) Eur Respir J , vol.35 , Issue.3 , pp. 564-570
    • Holz, O.1    Khalilieh, S.2    Ludwig-Sengpiel, A.3
  • 19
    • 84862519263 scopus 로고    scopus 로고
    • Safety And Efficacy Of A CXCR2 Antagonist In Patients With Severe Asthma And Sputum Neutrophils: A Randomized Placebo-controlled Clinical Trial
    • for navirixin
    • Nair P, Gaga M, Zervas E, et al. Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: A randomized, placebo-controlled clinical trial. Clin Exp Allergy 2012 ;42(7):1097-103 for navirixin
    • (2012) Clin Exp Allergy , vol.42 , Issue.7 , pp. 1097-103
    • Nair, P.1    Gaga, M.2    Zervas, E.3
  • 22
    • 77949852055 scopus 로고    scopus 로고
    • High content screening of CXCR2-dependent signalling pathways
    • Wolff M, Kredel S, Haasen D, et al. High content screening of CXCR2-dependent signalling pathways. Comb Chem High Throughput Screen 2010;13(1):3-15
    • (2010) Comb Chem High Throughput Screen , vol.13 , Issue.1 , pp. 3-15
    • Wolff, M.1    Kredel, S.2    Haasen, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.