Conference Scene: A symphony on C: Orchestrating DNA repair for gene expression via cytosine modification

Epigenomics

Volumn 5, Issue 1, 2013, Pages 25-28

  Rots, Marianne G ^a   Petersen Mahrt, Svend K ^b  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; DNA;

CHROMATIN; CONFERENCE PAPER; DEMETHYLATION; DNA DAMAGE; DNA END JOINING REPAIR; DNA METHYLATION; DNA MODIFICATION; DNA REPAIR; EPIGENETICS; FEEDBACK SYSTEM; GENE EXPRESSION; HISTONE MODIFICATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; RNA TRANSCRIPTION; UBIQUITINATION; CPG ISLAND; GENETIC EPIGENESIS; GENETICS; GERMANY; HUMAN;

CHROMATIN; CPG ISLANDS; DNA; DNA METHYLATION; DNA REPAIR; EPIGENESIS, GENETIC; GERMANY; HUMANS;

EID: 84874060521     PISSN: 17501911     EISSN: 1750192X     Source Type: Journal    
DOI: 10.2217/epi.12.73     Document Type: Conference Paper

References (19)

1. Franchini DM, Schmitz KM, Petersen-Mahrt SK. 5-methylcytosine DNA demethylation: more than losing a methyl group. Annu. Rev. Genet. 46, 419-441 (2012).
2. Tahiliani M, Koh KP, Shen Y et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324(5929), 930-935 (2009).
3. Iyer LM, Tahiliani M, Rao A, Aravind L. Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids. Cell Cycle 8(11), 1698-1710 (2009).
4. Hajkova P, Jeffries SJ, Lee C, Miller N, Jackson SP, Surani MA. Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway. Science 329(5987), 78-82 (2010).
5. Barreto G, Schäfer A, Marhold J et al. Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature 445(7128), 671-675 (2007).
6. Shibata A, Conrad S, Birraux J et al. Factors determining DNA double-strand break repair pathway choice in G2 phase. EMBO J. 30(6), 1079-1092 (2011).
7. Ulrich HD. Ubiquitin, SUMO, and phosphate: how a trio of posttranslational modifiers governs protein fate. Mol. Cell. 47(3), 335-337 (2012).
8. Le May N, Fradin D, Iltis I, Bougneres P, Egly JM. XPG and XPF endonucleases trigger chromatin looping and DNA demethylation for accurate expression of activated genes. Mol. Cell. 47(4), 622-632 (2012).
9. Kangaspeska S, Stride B, Metivier R et al. Transient cyclical methylation of promoter DNA. Nature 452(7183), 112-115 (2008).
10. Le May N, Mota-Fernandes D, Vélez-Cruz R, Iltis I, Biard D, Egly JM. NER factors are recruited to active promoters and facilitate chromatin modification for transcription in the absence of exogenous genotoxic attack. Mol. Cell. 38(1), 54-66 (2010).
11. Pastor WA, Pape UJ, Huang Y et al. Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature 473(7347), 394-397 (2011).
12. Yamaguchi S, Hong K, Liu R et al. Tet1 controls meiosis by regulating meiotic gene expression. Nature doi:10.1038/nature11709 (2012) (Epub ahead of print).
13. Arand J, Spieler D, Karius T et al. In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases. PLoS Genet. 8(6), e1002750 (2012).
14. Gu TP, Guo F, Yang H et al. The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature 477(7366), 606-610 (2011).
15. Cortazar D, Kunz C, Selfridge J et al. Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability. Nature 470(7334), 419-423 (2011).
16. Morgan HD, Dean W, Coker HA, Reik W, Petersen-Mahrt SK. Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming. J. Biol. Chem. 279(50), 52353-52360 (2004).
17. Popp C, Dean W, Feng S et al. Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature 463(7284), 1101-1105 (2010).
18. Schiesser S, Hackner B, Pfaffeneder T et al. Mechanism and stem-cell activity of 5-carboxycytosine decarboxylation determined by isotope tracing. Angew. Chem. Int. Ed. Engl. 51(26), 6516-6520 (2012).
19. De Groote ML, Verschure PJ, Rots MG. Epigenetic editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes. Nucleic Acids Res. 40(21), 10596-10613 (2012).