β-Catenin is required in odontoblasts for tooth root formation

Journal of Dental Research

Volumn 92, Issue 3, 2013, Pages 215-221

  Kim, T H ^a   Bae, C H ^a   Lee, J C ^a   Ko, S O ^a   Yang, X ^b   Jiang, R ^c   Cho, E S ^a  

^a Chonbuk National University   (South Korea)

^b BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

differentiation; mice; rootless teeth; tooth development; tooth eruption; Wnt signaling pathway

Indexed keywords

BETA CATENIN;

ANIMAL; ANIMAL MODEL; ARTICLE; BONE REMODELING; GENETICS; GROWTH, DEVELOPMENT AND AGING; MOUSE; MOUSE MUTANT; ODONTOBLAST; PHYSIOLOGY; TOOTH DEVELOPMENT; TOOTH ERUPTION; TOOTH FLORA; TOOTH ROOT; WNT SIGNALING PATHWAY;

ANIMALS; BETA CATENIN; BONE REMODELING; ENAMEL ORGAN; MICE; MICE, KNOCKOUT; MODELS, ANIMAL; ODONTOBLASTS; ODONTOGENESIS; TOOTH ERUPTION; TOOTH ROOT; WNT SIGNALING PATHWAY;

EID: 84874048317     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034512470137     Document Type: Article

References (25)

1. Baek JA, Lan Y, Liu H, Maltby KM, Mishina Y, Jiang R. Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation. Dev Biol. 2011 ; 350: 520-531
2. Brault V, Moore R, Kutsch S, Ishibashi M, Rowitch DH, McMahon AP, et al. Inactivation of the β-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development. 2001 ; 128: 1253-1264
3. Chen J, Lan Y, Baek JA, Gao Y, Jiang R. Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development. Dev Biol. 2009 ; 334: 174-185
4. Fjeld K, Kettunen P, Furmanek T, Kvinnsland IH, Luukko K. Dynamic expression of Wnt signaling-related Dickkof1, -2, and -3 mRNAs in the developing mouse tooth. Dev Dyn. 2005 ; 233: 161-166
5. Gao Y, Yang G, Weng T, Du J, Wang X, Zhou J, et al. Disruption of Smad4 in odontoblasts causes multiple keratinocystic odontogenic tumors and tooth malformation in mice. Mol Cell Biol. 2009 ; 29: 5941-5951
6. Glass II, Bialek P, Ahn JD, Starbuck M, Patel MS, Clevers H, et al. Canonical Wnt signaling in differentiated osteoblasts control osteoclast differentiation. Dev Cell. 2005 ; 8: 751-764
7. Huang X, Xu X, Bringas P, Hung YP, Chai Y. Smad4-Shh-Nfic signaling cascade-mediated epithelial-mesenchymal interaction is crucial in regulating tooth root development. J Bone Miner Res. 2009 ; 25: 1167-1178
8. Kim TH, Lee JY, Baek JA, Lee JC, Yang X, Taketo MM, et al. Constitutive stabilization of β-catenin in the dental mesenchyme leads to excessive dentin and cementum formation. Biochem Biophys Res Commun. 2011 ; 412: 549-555
9. Liu F, Millar SE. Wnt/β-catenin signaling in oral tissue development and disease. J Dent Res. 2010 ; 89: 318-330
10. Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol. 2004 ; 20: 781-810
11. Lohi M, Tucker AS, Sharpe PT. Expression of Axin2 indicates a role for canonical Wnt signaling in development of the crown and root during pre- and postnatal tooth development. Dev Dyn. 2010 ; 239: 160-167
12. Lu X, Rios HF, Jiang B, Xing L, Kadlcek R, Greenfield EM, et al. A new osteopetrosis mutant mouse strain (ntl) with odontoma-like proliferations and lack of tooth roots. Eur J Oral Sci. 2009 ; 117: 625-635
13. Nakatomi M, Morita I, Eto K, Ota MS. Sonic hedgehog signaling is important in tooth root development. J Dent Res. 2006 ; 85: 427-431
14. Qin C, Brunn JC, Cadena E, Ridall A, Butler WT. Dentin sialoprotein in bone and dentin sialophosphoprotein gene expressed by osteoblasts. Connect Tissue Res. 2003 ; 44: 179-183
15. Reya T, Clevers H. Wnt signaling in stem cells and cancer. Nature. 2005 ; 434: 843-850
16. Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nature Genet. 1999 ; 21: 70-71
17. Steele-Perkins G, Butz KG, Lyons GE, Zeichner-David M, Kim HJ, Cho MI, et al. Essential role for NFI-C/CTF transcription- replication factor in tooth root development. Mol Cell Biol. 2003 ; 23: 1075-1084
18. Tan X, Weng T, Zhang J, Wang J, Li W, Wan H, et al. Smad4 is required for maintaining normal murine postnatal bone homeostasis. J Cell Sci. 2007 ; 120 (Pt 13). 2162-2170
19. Ten Cate AR. The role of epithelium in development, structure and function of the tissues of tooth support. Oral Dis. 1996 ; 2: 55-62
20. Thomas HF. Root formation. Int J Dev Biol. 1995 ; 39: 231-237
21. Tiffee JC, Xing L, Nilsson S, Boyce BF. Dental abnormalities associated with failure of tooth eruption in src knockout and op/op mice. Calcif Tissue Int. 1999 ; 65: 53-58
22. Wise GE, King GJ. Mechanisms of tooth eruption and orthodontic tooth movement. J Dent Res. 2008 ; 87: 414-435
23. Yamashiro T, Tummers M, Thesleff I. Expression of bone morphogenetic proteins and Msx genes during root formation. J Dent Res. 2003 ; 82: 172-176
24. Yamashiro T, Zheng L, Shitaku Y, Saito M, Tsubakimoto T, Takada K, et al. Wnt10a regulates dentin sialophosphoprotein mRNA expression and possibly links odontoblast differentiation and tooth morphogenesis. Differentiation. 2007 ; 75: 452-462
25. Yokose S, Naka T. Lymphocyte enhancer-binding factor 1: an essential factor in odontoblastic differentiation of dental pulp cells enzymatically isolated from rat incisors. J Bone Miner Metab. 2010 ; 28: 650-658