Psychotropic drug initiation or increased dosage and the acute risk of falls: A prospective cohort study of nursing home residents

BMC Geriatrics

Volumn 13, Issue 1, 2013, Pages

  Echt, Murray A ^a,b   Samelson, Elizabeth J ^a,c   Hannan, Marian T ^a,c   Dufour, Alyssa B ^a   Berry, Sarah D ^a,c  

^a Hebrew Senior Life   (United States)

^b Downstate Health Sciences University   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Falls; Nursing home; Psychotropic drug change

Indexed keywords

PSYCHOTROPIC AGENT;

AGED; ARTICLE; COHORT ANALYSIS; DOSE RESPONSE; FALLING; FEMALE; FOLLOW UP; HUMAN; MALE; MULTICENTER STUDY; NURSING HOME; PROSPECTIVE STUDY; RISK FACTOR; STANDARD; TIME; VERY ELDERLY;

ACCIDENTAL FALLS; AGED; AGED, 80 AND OVER; COHORT STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; NURSING HOMES; PROSPECTIVE STUDIES; PSYCHOTROPIC DRUGS; RISK FACTORS; TIME FACTORS;

EID: 84874046867     PISSN: None     EISSN: 14712318     Source Type: Journal    
DOI: 10.1186/1471-2318-13-19     Document Type: Review

References (27)

1. Falls in the nursing home. Rubenstein LZ, Josephson KR, Robbins AS, Ann Intern Med 1994 121 442 451 8053619
2. Injurious falls in nonambulatory nursing home residents: a comparative study of circumstances, incidence, and risk factors. Thapa PB, Brockman KG, Gideon P, Fought RL, Ray WA, J Am Geriatr Soc 1996 44 273 278 8600195 (Pubitemid 26081093)
3. Measuring the direct healthcare costs of a fall injury event. Findorff MJ, Wyman JF, Nyman JA, Croghan CF, Nurs Res 2007 56 283 287 10.1097/01.NNR.0000280613.90694.b2 17625468
4. The costs of fatal and non-fatal falls among older adults. Stevens JA, Corso PS, Finkelstein EA, Miller TR, Inj Prev 2006 12 290 295 10.1136/ip.2005.011015 17018668 (Pubitemid 44621760)
5. Drugs and falls in older people: a systematic review and meta-analysis: I. Psychotropic drugs. Leipzig RM, Cumming RG, Tinetti ME, J Am Geriatr Soc 1999 47 30 39 9920227 (Pubitemid 29044264)
6. Meta-analysis of the impact of 9 medication classes on falls in elderly persons. Woolcott JC, Richardson KJ, Wiens MO, Patel B, Marin J, Khan KM, Marra CA, Arch Intern Med 2009 169 1952 1960 10.1001/archinternmed.2009.357 19933955
7. Medication use and risk of falls. Neutel CI, Perry S, Maxwell C, Pharmacoepidemiol Drug Saf 2002 11 97 104 10.1002/pds.686 11998544 (Pubitemid 34464329)
8. Central nervous system medication changes and falls in nursing home residents. Sorock GS, Quigley PA, Rutledge MK, Taylor J, Luo X, Foulis P, Wang MC, Varadhan R, Bellantoni M, Baker SP, Geriatr Nurs 2009 30 334 340 10.1016/j.gerinurse.2009.07.001 19818269
9. Pharmacists ASoH-S, American Hospital Formulary Services http://www.ahfsdruginformation.com. Accessed August 21, 2011
10. The resident assessment instrument-minimum data set 2.0 quality indicators: a systematic review. Hutchinson AM, Milke DL, Maisey S, Johnson C, Squires JE, Teare G, Estabrooks CA, BMC Health Serv Res 2010 10 166 10.1186/1472-6963-10-166 20550719
11. Validation of the minimum data set cognitive performance scale: agreement with the mini-mental state examination. Hartmaier SL, Sloane PD, Guess HA, Koch GG, Mitchell CM, Phillips CD, J Gerontol A Biol Sci Med Sci 1995 50 128 M133 7874589
12. Pain in U.S. nursing homes: validating a pain scale for the minimum data set. Fries BE, Simon SE, Morris JN, Flodstrom C, Bookstein FL, Gerontologist 2001 41 173 179 10.1093/geront/41.2.173 11327482 (Pubitemid 32295091)
13. Validity and responsiveness to change of clinically derived MDS scales in Alzheimer disease outcomes research. Smart KA, Herrmann N, Lanctot KL, J Geriatr Psychiatry Neurol 2011 24 67 72 10.1177/0891988711402347 21460341
14. Statistical analysis of efficacy in falls prevention trials. Robertson MC, Campbell AJ, Herbison P, J Gerontol A Biol Sci Med Sci 2005 60 530 534 10.1093/gerona/60.4.530 15933397 (Pubitemid 40712875)
15. Antidepressants and the risk of falls among nursing home residents. Thapa PB, Gideon P, Cost TW, Milam AB, Ray WA, N Engl J Med 1998 339 875 882 10.1056/NEJM199809243391303 9744971 (Pubitemid 28446845)
16. Atypical antipsychotic medications and risk of falls in residents of aged care facilities. le Hien TT, Cumming RG, Cameron ID, Chen JS, Lord SR, March LM, Schwarz J, Le Couteur DG, Sambrook PN, J Am Geriatr Soc 2005 53 1290 1295 10.1111/j.1532-5415.2005.53403.x 16078953 (Pubitemid 41602473)
17. Psychotropic medications and risk for falls among community-dwelling frail older people: an observational study. Landi F, Onder G, Cesari M, Barillaro C, Russo A, Bernabei R, J Gerontol A Biol Sci Med Sci 2005 60 622 626 10.1093/gerona/60.5.622 15972615 (Pubitemid 40847931)
18. Central nervous system-active medications and risk for falls in older women. Ensrud KE, Blackwell TL, Mangione CM, Bowman PJ, Whooley MA, Bauer DC, Schwartz AV, Hanlon JT, Nevitt MC, J Am Geriatr Soc 2002 50 1629 1637 10.1046/j.1532-5415.2002.50453.x 12366615 (Pubitemid 35192533)
19. Antidepressant prescriptions: an acute window for falls in the nursing home. Berry SD, Zhang Y, Lipsitz LA, Mittleman MA, Solomon DH, Kiel DP, J Gerontol A Biol Sci Med Sci 2011 66 10 1124 30 21764842
20. Impact of drug interactions, dosage, and duration of therapy on the risk of hip fracture associated with benzodiazepine use in older adults. Zint K, Haefeli WE, Glynn RJ, Mogun H, Avorn J, Sturmer T, Pharmacoepidemiol Drug Saf 2010 19 1248 1255 10.1002/pds.2031 20931664
21. Approaches to combat with confounding by indication in observational studies of intended drug effects. McMahon AD, Pharmacoepidemiol Drug Saf 2003 12 551 558 10.1002/pds.883 14558178 (Pubitemid 37220641)
22. The implications of propensity score variable selection strategies in pharmacoepidemiology: an empirical illustration. Patrick AR, Schneeweiss S, Brookhart MA, Glynn RJ, Rothman KJ, Avorn J, Sturmer T, Pharmacoepidemiol Drug Saf 2011 20 551 559 10.1002/pds.2098 21394812
23. Number and dosage of central nervous system medications on recurrent falls in community elders: the health, aging and body composition study. Hanlon JT, Boudreau RM, Roumani YF, Newman AB, Ruby CM, Wright RM, Hilmer SN, Shorr RI, Bauer DC, Simonsick EM, Studenski SA, J Gerontol A Biol Sci Med Sci 2009 64 492 498 19196642
24. A randomized trial of a consultation service to reduce falls in nursing homes. Ray WA, Taylor JA, Meador KG, Thapa PB, Brown AK, Kajihara HK, Davis C, Gideon P, Griffin MR, JAMA 1997 278 557 562 10.1001/jama.1997.03550070049037 9268276 (Pubitemid 27353604)
25. Clinical medication review by a pharmacist of elderly people living in care homes-randomised controlled trial. Zermansky AG, Alldred DP, Petty DR, Raynor DK, Freemantle N, Eastaugh J, Bowie P, Age Ageing 2006 35 586 591 10.1093/ageing/afl075 16905764 (Pubitemid 44614153)
26. Antidepressant prescribing in US nursing homes between 1996 and 2006 and its relationship to staffing patterns and use of other psychotropic medications. Hanlon JT, Handler SM, Castle NG, J Am Med Dir Assoc 2010 11 320 324 10.1016/j.jamda.2010.01.007 20511098
27. Antipsychotic and benzodiazepine use among nursing home residents: findings from the 2004 national nursing home survey. Stevenson DG, Decker SL, Dwyer LL, Huskamp HA, Grabowski DC, Metzger ED, Mitchell SL, Am J Geriatr Psychiatry 2010 18 1078 1092 10.1097/JGP.0b013e3181d6c0c6 20808119