Androgen sulfation in healthy UDP-glucuronosyl transferase 2B17 enzyme-deficient men

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 11, 2011, Pages 3440-3447

  Schulze, Jenny J ^a   Thor̈ngren, John Olof ^a   Garle, Mats ^a   Ekstrom̈, Lena ^a   Rane, Anders ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROSTERONE DERIVATIVE; ANDROSTERONE GLUCURONIDE; ETIOCHOLANOLONE; ETIOCHOLANOLONE SULFATE; GLUCURONOSYLTRANSFERASE; TESTOSTERONE DERIVATIVE; TESTOSTERONE ENANTATE; TESTOSTERONE SULFATE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 2B17;

ADULT; ARTICLE; DRUG ABUSE; ENZYME DEFICIENCY; GENE; GENE DELETION; GENE INSERTION; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; STEROID EXCRETION; SULFATION; TANDEM MASS SPECTROMETRY; TESTOSTERONE METABOLISM; UGT2B17 GENE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ADOLESCENT; ADULT; ALLELES; ANDROGENS; DOPING IN SPORTS; GENE FREQUENCY; GLUCURONOSYLTRANSFERASE; HUMANS; MALE; MIDDLE AGED; TESTOSTERONE;

EID: 80655137176     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-0521     Document Type: Article

References (32)

1. Sjöqvist F, Garle M, Rane A 2008 Use of doping agents, particularly anabolic steroids, in sports and society. Lancet 371:1872-1882 (Pubitemid 351734542)
2. Handelsman DJ, Heather A 2008 Androgen abuse in sports. Asian J Androl 10:403-415 (Pubitemid 351584116)
3. Donike M, Bärwald K-R, Klostermann K, Schänzer W, Zimmermann J 1983 Nachweis von exogenem testosteron. In: Heck H, Hollmann W, Liesen H, Rost R, eds. Sport: Leistung und Gesundheit, Köln, Deutscher Ärzte Verlag; 293-298
4. Jakobsson J, Ekström L, Inotsume N, Garle M, Lorentzon M, Ohlsson C, Roh HK, Carlström K, Rane A 2006 Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism. J Clin Endocrinol Metab 91:687-693 (Pubitemid 43236944)
5. Donike M, Mareck-Engelke U, Rauth S 1995 Statistical evaluation of longitudinal studies. Part 2. The usefulness of subject-based reference ranges. In: Donike MHG, Gotzmann A, Mareck-Engelke U, Rauth S, eds. Proceedings of the 12th Cologne Workshop on Dope Analysis. Koln, Germany: Sport und Buch Strauß; 157-165
6. Schulze JJ, Lundmark J, Garle M, Skilving I, Ekstrom L, Rane A 2008 Doping test results dependent on genotype of uridine diphospho-glucuronosyl transferase 2B17, the major enzyme for testosterone glucuronidation. J Clin Endocrinol Metab 93:2500-2506 (Pubitemid 352008513)
7. Sottas PE, Baume N, Saudan C, Schweizer C, Kamber M, Saugy M 2007 Bayesian detection of abnormal values in longitudinal biomarkers with an application to T/E ratio. Biostatistics (Oxford, England) 8:285-296 (Pubitemid 46569590)
8. Sottas PE, Saudan C, Schweizer C, Baume N, Mangin P, Saugy M 2008 From population- to subject-based limits of T/E ratio to detect testosterone abuse in elite sports. Forensic Sci Int 174:166-172
9. Schulze JJ, Rane A, Ekstrom L 2009 Genetic variation in androgen disposition: implications in clinical medicine including testosterone abuse. Expert Opin Drug Metab Toxicol 5:731-744
10. Bowers LD 2008 Testosterone doping: dealing with genetic differences in metabolism and excretion. J Clin Endocrinol Metab 93:2469-2471 (Pubitemid 352008506)
11. Wilson 3rd W, Pardo-Manuel de Villena F, Lyn-Cook BD, Chatterjee PK, Bell TA, Detwiler DA, Gilmore RC, Valladeras IC, Wright CC, Threadgill DW, Grant DJ 2004 Characterization of a common deletion polymorphism of the UGT2B17 gene linked to UGT2B15. Genomics 84:707-714 (Pubitemid 39310948)
12. Schulze JJ, Lorentzon M, Ohlsson C, Lundmark J, Roh HK, Rane A, Ekström L 2008 Genetic aspects of epitestosterone formation and androgen disposition: influence of polymorphisms in CYP17 and UGT2B enzymes. Pharmacogenet Genomics 18:477-485 (Pubitemid 351769915)
13. Sottas PE, Saugy M, Saudan C 2010 Endogenous steroid profiling in the athlete biological passport. Endocrinol Metab Clin North Am 39:59-73, viii-ix
14. Schulze JJ, Lundmark J, Garle M, Ekström L, Sottas PE, Rane A 2009 Substantial advantage of a combined Bayesian and genotyping approach in testosterone doping tests. Steroids 74:365-368
15. Labrie F, Dupont A, Simard J, Luu-The V, Belanger A 1993 Intracrinology: the basis for the rational design of endocrine therapy at all stages of prostate cancer. Eur Urol 24(Suppl 2):94-105 (Pubitemid 23320413)
16. Reed MJ, Purohit A, Woo LW, Newman SP, Potter BV 2005 Steroid sulfatase: molecular biology, regulation, and inhibition. Endocr Rev 26:171-202
17. Falany CN 1997 Enzymology of human cytosolic sulfotransferases. FASEB J 11:206-216 (Pubitemid 27118321)
18. Gamage N, Barnett A, Hempel N, Duggleby RG, Windmill KF, Martin JL, McManus ME 2006 Human sulfotransferases and their role in chemical metabolism. Toxicol Sci 90:5-22 (Pubitemid 43264722)
19. Bovenberg SA, van Uum SH, Hermus AR 2005 Dehydroepiandrosterone administration in humans: evidence based? Neth J Med 63:300-304 (Pubitemid 41404264)
20. Bowers LD, Sanaullah 1996 Direct measurement of steroid sulfate and glucuronide conjugates with high-performance liquid chromatography-mass spectrometry. J Chromatogr B Biomed Appl 687:61-68
21. Bean KA, Henion JD 1997 Direct determination of anabolic steroid conjugates in human urine by combined high-performance liquid chromatography and tandem mass spectrometry. J Chromatogr 690:65-75 (Pubitemid 27136456)
22. Borts DJ, Bowers LD 2000 Direct measurement of urinary testosterone and epitestosterone conjugates using high-performance liquid chromatography/tandem mass spectrometry. J Mass Spectrom 35:50-61 (Pubitemid 30060152)
23. Hintikka L, Kuuranne T, Leinonen A, Thevis M, Schänzer W, Halket J, Cowan D, Grosse J, Hemmersbach P, Nielen MW, Kostiainen R 2008 Liquid chromatographic-mass spectrometric analysis of glucuronide-conjugated anabolic steroid metabolites: method validation and interlaboratory comparison. J Mass Spectrom 43:965-973 (Pubitemid 352029665)
24. Strahm E, Kohler I, Rudaz S, Martel S, Carrupt PA, Veuthey JL, Saugy M, Saudan C 2008 Isolation and quantification by high-performance liquid chromatography-ion-trap mass spectrometry of androgen sulfoconjugates in human urine. J Chromatogr A 1196:153-160
25. Pozo OJ, Van Eenoo P, Van Thuyne W, Deventer K, Delbeke FT 2008 Direct quantification of steroid glucuronides in human urine by liquid chromatography-electrospray tandem mass spectrometry. J Chromatogr A 1183:108-118
26. Annesley TM 2003 Ion suppression in mass spectrometry. Clin Chem 49:1041-1044 (Pubitemid 36751088)
27. Dehennin L 1993 Secretion by the human testis of epitestosterone, with its sulfoconjugate and precursor androgen 5-androstene-3β,17α-diol. J Steroid Biochem Mol Biol 44:171-177 (Pubitemid 23072269)
28. Dehennin L, Matsumoto AM 1993 Long-term administration of testosterone enanthate to normal men: alterations of the urinary profile of androgen metabolites potentially useful for detection of testosterone misuse in sport. J Steroid Biochem Mol Biol 44:179-189 (Pubitemid 23072270)
29. Palonek E, Gottlieb C, Garle M, Björkhem I, Carlström K 1995 Serum and urinary markers of exogenous testosterone administration. J Steroid Biochem Mol Biol 55:121-127
30. Pacifici GM, Gucci A, Giuliani L 1997 Testosterone sulphation and glucuronidation in the human liver: interindividual variability. Eur J Drug Metab Pharmacokinet 22:253-258 (Pubitemid 27475116)
31. Strahm E 2010 Étude du métabolisme des androgènes et implications dans la lutte contre le dopage. PhD thesis, Facultédes Sciences, Section des Sciences Pharmaceutiques, University of Geneva, Geneva, Switzerland
32. Sten T, Bichlmaier I, Kuuranne T, Leinonen A, Yli-Kauhaluoma J, Finel M 2009 UDP-glucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly. Drug Metab Dispos 37:417-423