Honokiol ameliorates cerebral infarction from ischemia-reperfusion injury in rats

Planta Medica

Volumn 69, Issue 2, 2003, Pages 130-134

  Liou, Kuo Tong ^a   Lin, Su Man ^a   Huang, Shiang Suo ^b   Chih, Chun Lien ^a   Tsai, Shen Kou ^b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Antioxidant; Cerebral infarction; Free radical; Honokiol; Ischemia; Magnolia officinalis; Magnoliaceae; Reperfusion

Indexed keywords

HONOKIOL; RESVERATROL;

ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; COMMON CAROTID ARTERY; DRUG POTENCY; HEMODYNAMICS; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; RAT; REPERFUSION INJURY; THROMBOCYTE AGGREGATION INHIBITION;

ANIMALS; ANTIOXIDANTS; BIPHENYL COMPOUNDS; BRAIN ISCHEMIA; DOSE-RESPONSE RELATIONSHIP, DRUG; INFARCTION, MIDDLE CEREBRAL ARTERY; INFUSIONS, INTRAVENOUS; LIGNANS; MAGNOLIA; MALE; PHYTOTHERAPY; PLATELET AGGREGATION INHIBITORS; RANDOM ALLOCATION; RATS; RATS, LONG-EVANS;

MAGNOLIA; MAGNOLIA OFFICINALIS; MAGNOLIACEAE;

EID: 0037302151     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-37707     Document Type: Article

References (16)

1. Taira J, Ikemoto T, Miruma K, Hagi A, Murakami A, Makino K. Effective inhibition of hydroxyl radicals by hydroxylated biphenyl compounds. Free Radic Res Commun 1993; 19: S71-7
2. Teng CM, Chen CC, Ko FN, Lee LG, Huang TF, Chen YP et al. Two antiplatelet agents from Magnolia officinalis. Thromb Res 1988; 50: 757-65
3. Lo YC, Teng CM, Chen CF, Chen CC, Hong CY. Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation. Biochem Pharmacol 1994; 47: 549-53
4. Chiu JH, Ho CT, Wei YH, Liu WY, Hong CY. In vitro and in vivo protective effect of honokiol on rat liver from lipid peroxidative injury. Life Sci 1997; 61: 1967-71
5. Tsai SK, Huang SS, Hong CY. Myocardial protective effect of honokiol: an active component in Magnolia officinalis. Planta Med 1996; 62: 503-6
6. Tsai SK, Hong CY, Huang SS, Hung LM, Hong CY. Antiarrhythmic effect of magnolol and honokiol during acute phase of coronary occlusion in anesthetized rats: influence of L-NAME and aspirin. Pharmacology 1999; 59: 227-33
7. Son HJ, Lee HJ, Yun-Choi HS, Ryu JH. Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages. Planta Med 2000; 66: 469-71
8. Hall ED, Braughler JM. Central nervous system trauma and stroke, II. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation. Free Radio Biol Med 1989; 6: 303-13
9. Flamm ES, Demopoulos HB, Seligman MI, Poser GR, Ransohoff J. Free radicals in cerebral ischemia. Stroke 1978; 9: 445-7
10. Kitagawa K, Matsumoto M, Oda T, Niinobe M, Hata R, Handa N et al. Free radical generation during brief period of cerebral ischemia may trigger delayed neuronal death. Neuroscience 1990; 35: 551-8
11. Huang SS, Tsai MC, Chih CL, Hung LM, Tsai SK. Resveratrol reduction of infarct size in Long-Evans rats subjected to focal cerebral ischemia. Life Sci 2001; 69: 1057-65
12. Isayama K, Pitts LH, Nishimura MC. Evaluation of 2,3,5-triphenyltetra-zolium chloride staining to delineate rat brain infarcts. Stroke 1991; 22: 1394-8
13. Chen ST, Hsu CY, Hogan EL, Marico H, Balentine JD. A model of focal ischemic stroke in the rat: reproducible extensive cortical infarction. Stroke 1986; 17: 738-43
14. Coyle P, Middle cerebral artery occlusion in the young rat. Stroke 1982; 13: 855-9
15. Garcia JH. Experimental ischemic stroke: a review. Stroke 1984; 15: 5-14
16. Mendelow AD, Graham DI, Mc Culloch J, Mohaned A. The distribution of ischemic damage and cerebral blood flow after unilateral carotid occlusion and hypotension in the rat. Stroke 1984; 15: 704-10