Determination of diosbulbin B in rat plasma and urine by LC-MS/MS and its application in pharmacokinetic and urinary excretion studies

Journal of Pharmaceutical and Biomedical Analysis

Volumn 77, Issue , 2013, Pages 133-138

  Li, Yujuan ^a   Tian, Yuan ^a   Gan, Lin ^a   Li, Yongzhi ^b   Chen, Bo ^a   Qiao, Jinyuan ^a  

^a BEIJING INSTITUTE OF TECHNOLOGY   (China)

^b CHINA ASTRONAUT RESEARCH AND TRAINING CENTER   (China)

Author keywords

Diosbulbin B; HPLC MS MS; Pharmacokinetics; Rat; Urinary excretion

Indexed keywords

BUSPIRONE; DIOSBULBIN B; DITERPENOID; LACTONE; METHANOL; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EXCRETION; DRUG HALF LIFE; DRUG URINE LEVEL; ELECTROSPRAY MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; BUSPIRONE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; MALE; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84874001857     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2013.01.030     Document Type: Article

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