TLR3-mediated apoptosis and activation of phosphorylated Akt in the salivary gland epithelial cells of primary Sjögren's syndrome patients

Rheumatology International

Volumn 33, Issue 2, 2013, Pages 441-450

  Nakamura, Hideki ^a   Horai, Yoshiro ^a   Suzuki, Takahisa ^a   Okada, Akitomo ^a   Ichinose, Kunihiro ^a   Yamasaki, Satoshi ^a   Koji, Takehiko ^a   Kawakami, Atsushi ^a  

^a NAGASAKI UNIVERSITY   (Japan)

Author keywords

Akt; Caspase3; MAP kinase; Sj gren's syndrome; TLR3

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; PEPTIDOGLYCAN; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3;

ADULT; APOPTOSIS; ARTICLE; CASE REPORT; CELL DEATH; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVATION; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; INHIBITION KINETICS; INNATE IMMUNITY; NICK END LABELING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SALIVARY GLAND; SIGNAL TRANSDUCTION; SJOEGREN SYNDROME; WESTERN BLOTTING;

AGED; APOPTOSIS; CASPASE 3; ENZYME ACTIVATION; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; MIDDLE AGED; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; POLY I-C; PROTO-ONCOGENE PROTEINS C-AKT; SALIVARY GLANDS; SIGNAL TRANSDUCTION; SJOGREN'S SYNDROME; TOLL-LIKE RECEPTOR 3;

EID: 84873992995     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-012-2381-9     Document Type: Article

References (28)

1. Kawai T, Akira S (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11:373-384
2. Akira S (2006) TLR signaling. Curr Top Microbiol Immunol 311:1-16
3. Takeuchi O, Akira S (2010) Pattern recognition receptors and inflammation. Cell 140:805-820
4. Kawakami A, Nakashima K, Tamai M, Nakamura H, Iwanaga N, Fujikawa K et al (2007) Toll-like receptor in salivary glands from patients with Sjögren's syndrome: functional analysis by human salivary gland cell line. J Rheumatol 34:1019-1026
5. Fox RI (2005) Sjögren's syndrome. Lancet 366(9482):321-331
6. Nakamura H, Kawakami A, Eguchi K (2006) Mechanisms of autoantibody production and the relationship between autoantibodies and the clinical manifestations in Sjögren's syndrome. Transl Res 148:281-288
7. Nakamura H, Kawakami A, Ida H, Koji T, Eguchi K (2007) Epidermal growth factor inhibits Fas-mediated apoptosis in salivary epithelial cells of patients with primary Sjögren's syndrome. Clin Exp Rheumatol 25:831-837
8. Nakamura H, Kawakami A, Iwamoto N, Ida H, Koji T, Eguchi K (2008) Rapid and significant induction of TRAIL-mediated type II cells in apoptosis of primary salivary epithelial cells in primary Sjögren's syndrome. Apoptosis 13:1322-1330
9. Salaun B, Coste I, Rissoan MC, Lebecque SJ, Renno T (2006) TLR3 can directly trigger apoptosis in human cancer cells. J Immunol 176:4894-4901
10. Khvalevsky E, Rivkin L, Rachmilewitz J, Galun E, Giladi H (2007) TLR3 signaling in a hepatoma cell line is skewed towards apoptosis. J Cell Biochem 100:1301-1312
11. Vitali C, Bombardieri S, Jonsson R et al (2002) Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 61:554-558
12. Nakamura H, Kawakami A, Iwamoto N, Okada A, Yamasaki S, Tamai M et al (2010) A single centre retrospective analysis of AECG classification criteria for primary Sjogren's syndrome based on 112 minor salivary gland biopsies in a Japanese population. Rheumatology (Oxford) 49:1290-1293
13. Nakamura H, Koji T, Tominaga M et al (1998) Apoptosis in labial salivary glands from Sjögren's syndrome (SS) patients: comparison with human T lymphotropic virus-I (HTLV-I)-seronegative and -seropositive SS patients. Clin Exp Immunol 114:106-112
14. Nakamura H, Kawakami A, Hayashi T, Iwamoto N, Okada A, Tamai M et al (2010) Anti-centromere antibody-seropositive Sjögren's syndrome differs from conventional subgroup in clinical and pathological study. BMC Musculoskelet Disord 11:140
15. Hsu LC, Park JM, Zhang K, Luo JL, Maeda S, Kaufman RJ et al (2004) The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature 428(6980):341-345
16. Liew FY, Xu D, Brint EK, O'Neill LA (2005) Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol 5:446-458
17. Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H et al (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301(5633):640-643
18. Meylan E, Burns K, Hofmann K, Blancheteau V, Martinon F, Kelliher M et al (2004) RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol 5:503-507
19. Sarkar SN, Peters KL, Elco CP, Sakamoto S, Pal S, Sen GC (2004) Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. Nat Struct Mol Biol 11:1060-1067
20. Kong L, Ogawa N, Nakabayashi T et al (1997) Fas and Fas ligand expression in the salivary glands of patients with primary Sjögren's syndrome. Arthritis Rheum 40:87-97
21. Matsumura R, Umemiya K, Kagami M et al (1998) Glandular and extraglandular expression of the Fas-Fas ligand and apoptosis in patients with Sjögren's syndrome. Clin Exp Rheumatol 16:561-568
22. Ohlsson M, Skarstein K, Bolstad AI, Johannessen AC, Jonsson R (2001) Fas-induced apoptosis is a rare event in Sjögren's syndrome. Lab Invest 81:95-105
23. Tsubota K, Saito I, Miyasaka N (1994) Expression of granzyme A and perforin in lacrimal gland of Sjögren's syndrome. Adv Exp Med Biol 1350:637-640
24. Kolkowski EC, Reth P, Pelusa F, Bosch J, Pujol-Borrell R, Coll J et al (1999) Th1 predominance and perforin expression in minor salivary glands from patients with primary Sjögren's syndrome. J Autoimmun 13:155-162
25. Manoussakis MN, Spachidou MP, Maratheftis CI (2010) Salivary epithelial cells from Sjogren's syndrome patients are highly sensitive to anoikis induced by TLR-3 ligation. J Autoimmun 35:212-218
26. Numata T, Araya J, Fujii S, Hara H, Takasaka N, Kojima J et al (2011) Insulin-dependent phosphatidylinositol 3-kinase/Akt and ERK signaling pathways inhibit TLR3-mediated human bronchial epithelial cell apoptosis. J Immunol 187:510-519
27. Gitlin L, Barchet W, Gilfillan S, Cella M, Beutler B, Flavell RA et al (2006) Essential role of mda-5 in type I IFN responses to polyriboinosinic: polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci USA 103:8459-8464
28. Liu Y, Kimura K, Yanai R, Chikama T, Nishida T (2008) Cytokine, chemokine, and adhesion molecule expression mediated by MAPKs in human corneal fibroblasts exposed to poly(I:C). Invest Ophthalmol Vis Sci 49:3336-3344