Transfusion of prion-filtered red cells does not increase the rate of alloimmunization or transfusion reactions in patients: Results Of The UK trial of prion-filtered versus standard red cells in surgical patients (PRISM A)

British Journal of Haematology

Volumn 160, Issue 5, 2013, Pages 701-708

  Elebute, Modupe O ^a,b   Choo, Louise ^c   Mora, Ana ^b   Macrury, Coral ^d   Llewelyn, Charlotte ^b   Purohit, Shilpi ^b   Hicks, Vicky ^b   Casey, Caroline ^d   Malfroy, Moira ^b   Deary, Alison ^b   Reed, Tania ^b   Meredith, Sarah ^c   Manson, Lynn ^d   Williamson, Lorna M ^b  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

^b NHS BLOOD AND TRANSPLANT   (United Kingdom)

^c MRC CLINICAL TRIALS UNIT   (United Kingdom)

^d SCOTTISH NATIONAL BLOOD TRANSFUSION SERVICE   (United Kingdom)

Author keywords

Blood transfusion; Prion filtration; Red cell alloimmunization; Variant Creutzfeldt Jacob disease

Indexed keywords

ALLOANTIBODY; ERYTHROCYTE ANTIBODY;

ADULT; AGED; ALLOIMMUNIZATION; ANTIBODY DETECTION; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ARTICLE; BLOOD TRANSFUSION REACTION; COMPARATIVE STUDY; CONTROLLED STUDY; ELECTIVE SURGERY; ERYTHROCYTE CONCENTRATE; ERYTHROCYTE TRANSFUSION; FEMALE; HUMAN; IMMUNOREACTIVITY; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OPEN STUDY; PATIENT SAFETY; PRION FILTERED ERYTHROCYTE CONCENTRATE; PRIORITY JOURNAL; SURGICAL PATIENT; TREATMENT INDICATION;

ADSORPTION; AGED; AGED, 80 AND OVER; BLOOD GROUP ANTIGENS; BLOOD GROUP INCOMPATIBILITY; BLOOD LOSS, SURGICAL; BLOOD SAFETY; ERYTHROCYTE TRANSFUSION; FEMALE; FILTRATION; HUMANS; IMMUNIZATION; ISOANTIBODIES; MALE; MIDDLE AGED; PRION DISEASES; PRIONS; RESINS, SYNTHETIC; SORPTION DETOXIFICATION; SURGICAL PROCEDURES, ELECTIVE;

EID: 84873991791     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12188     Document Type: Article

References (21)

1. Cahill, M.R., Murphy, T., Khan, M., Fagan, J. & Murphy, W.G. (2010) Phase I/II safety study of transfusion of prion-filtered red cell concentrates in transfusion-dependent patients. Vox Sanguinis, 99, 174-176.
2. Cancelas, J.A., Rugg, N., Pratt, P.G., Worsham, D.N., Pehta, J.C., Banks, K., Davenport, R.D. & Judd, W.J. (2011) Infusion of P-Capt prion-filtered red blood cell products demonstrate acceptable in vivo viability and no evidence of neoantigen formation. Transfusion, 51, 2228-2236.
3. Fried, M.R., Eastlund, T., Christie, B., Mullin, G.T. & Key, N.S. (1996) Hypotensive reactions to white cell-reduced plasma in a patient undergoing angiotensin-converting enzyme inhibitor therapy. Transfusion, 36, 900-903.
4. Garske, T. & Ghani, A.C. (2010) Uncertainty in the tail of the variant Creutzfeldt-Jakob disease epidemic in the UK. PLoS ONE, 5, e15626.
5. Ghani, A.C., Ferguson, N.M., Donnelly, C.A. & Anderson, R.M. (2003) Factors determining the pattern of the variant Creutzfeldt-Jakob disease (vCJD) epidemic in the UK. Proceedings Biological Sciences, 270, 689-698.
6. Gregori, L., McCombie, N., Palmer, D., Birch, P., Sowemimo-Coker, S.O., Giulivi, A. & Rohwer, R.G. (2004) Effectiveness of leucoreduction for removal of infectivity of transmissible spongiform encephalopathies from blood. Lancet, 364, 529-531.
7. Gregori, L., Lambert, B.C., Gurgel, P.V., Gheorghiu, L., Edwardson, P., Lathrop, J.T., Macauley, C., Carbonell, R.G., Burton, S.J., Hammond, D. & Rohwer, R.G. (2006) Reduction of transmissible spongiform encephalopathy infectivity from human red blood cells with prion protein affinity ligands. Transfusion, 46, 1152-1161.
8. Haley, N.R., Sledge, L. & Feller, I.T. (1998) Post transfusion "red eye" syndrome: discovery, investigation, and control [abstract]. Transfusion, 1998, 77A.
9. Hewitt, P.E., Llewelyn, C.A., Mackenzie, J. & Will, R.G. (2006) Creutzfeldt-Jakob disease and blood transfusion: results of the UK Transfusion Medicine Epidemiological Review study. Vox Sanguinis, 91, 221-230.
10. Ibojie, J., Greiss, M. & Urbaniak, S.J. (2002) Limited efficacy of universal leucodepletion in reducing the incidence of febrile non-haemolytic reactions in red cell transfusion. Transfusion Medicine (Oxford, England), 12, 387-389.
11. ICH (1996) Guideline For Good Clinical Practice; ICH Harmonised Tripartite Guideline. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH), Geneva, Switzerland. http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Efficacy/E6_R1/Step4/E6_R1__Guideline.pdf
12. Llewelyn, C.A., Hewitt, P.E., Knight, R.S., Amar, K., Cousens, S., Mackenzie, J. & Will, R.G. (2004) Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion. Lancet, 363, 417-421.
13. Murphy, C.V., Eakins, E., Fagan, J., Croxon, H. & Murphy, W.G. (2009) In vitro assessment of red-cell concentrates in SAG-M filtered through the MacoPharma P-CAPT prion-reduction filter. Transfusion Medicine (Oxford, England), 19, 109-116.
14. National Blood Service (2005) Guidelines for the Blood Transfusion Services in the United Kingdom, 7th Edition. TSO (The Stationery Office), Norwich, UK. ISBN 9780117033719.
15. Peden, A.H., Head, M.W., Ritchie, D.L., Bell, J.E. & Ironside, J.W. (2004) Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient. Lancet, 364, 527-529.
16. Redman, M., Regan, F. & Contreras, M. (1996) A prospective study of the incidence of red cell allo-immunisation following transfusion. Vox Sanguinis, 71, 216-220.
17. Sweeney, J.D., Dupuis, M. & Mega, A.P. (1998) Hypotensive reactions to red cells filtered at the bedside, but not to those filtered before storage, in patients taking ACE inhibitors. Transfusion, 38, 410-411.
18. Uhlmann, E.J., Isgriggs, E., Wallhermfechtel, M. & Goodnough, L.T. (2001) Prestorage universal WBC reduction of RBC units does not affect the incidence of transfusion reactions. Transfusion, 41, 997-1000.
19. van de Watering, L., Hermans, J., Witvliet, M., Versteegh, M. & Brand, A. (2003) HLA and RBC immunization after filtered and buffy coat-depleted blood transfusion in cardiac surgery: a randomized controlled trial. Transfusion, 43, 765-771.
20. Wilson, K. & Ricketts, M.N. (2004) The success of precaution? Managing the risk of transfusion transmission of variant Creutzfeldt-Jakob disease. Transfusion, 44, 1475-1478.
21. Wiltshire, M., Thomas, S., Scott, J., Hicks, V., Haines, M., Cookson, P., Garwood, M. & Cardigan, R. (2010) Prion reduction of red blood cells: impact on component quality. Transfusion, 50, 970-979.