메뉴 건너뛰기




Volumn 39, Issue 3, 2013, Pages 241-251

Managing inadequate responses to frontline treatment of chronic myeloid leukemia: A case-based review

Author keywords

Adherence; Adverse events; Case study; Chronic myeloid leukemia; Drug resistance; Suboptimal response; Tyrosine kinase inhibitor

Indexed keywords

DASATINIB; DICYCLOVERINE; IMATINIB; NILOTINIB;

EID: 84873991298     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2012.04.010     Document Type: Review
Times cited : (6)

References (98)
  • 1
    • 84873996344 scopus 로고    scopus 로고
    • National Cancer Institute
    • [accessed 20.12.2011]
    • National Cancer Institute. SEER Stat Fact Sheets: Chronic Myeloid Leukemia. <>; 2011 [accessed 20.12.2011]. http://www.seer.cancer.gov/statfacts/html/cmyl.html.
    • (2011) SEER Stat Fact Sheets: Chronic Myeloid Leukemia
  • 2
    • 0033520092 scopus 로고    scopus 로고
    • Chronic myelogenous leukemia: biology and therapy
    • Faderl S., Talpaz M., Estrov Z., Kantarjian H.M. Chronic myelogenous leukemia: biology and therapy. Ann Int Med 1999, 131(3):207-219.
    • (1999) Ann Int Med , vol.131 , Issue.3 , pp. 207-219
    • Faderl, S.1    Talpaz, M.2    Estrov, Z.3    Kantarjian, H.M.4
  • 3
    • 84873985767 scopus 로고    scopus 로고
    • National Cancer Institute
    • [accessed 07.03.2011]
    • National Cancer Institute. Chronic Myelogenous Leukemia Treatment (PDQ). >; 2011 [accessed 07.03.2011]. http://www.cancer.gov/cancertopics/pdq/treatment/CML/healthprofessional/allpages.
    • (2011) Chronic Myelogenous Leukemia Treatment (PDQ)
  • 4
    • 72849159485 scopus 로고
    • Chromosome studies on normal and leukemic human leukocytes
    • Nowell P.C., Hungerford D.A. Chromosome studies on normal and leukemic human leukocytes. J Natl Cancer Inst 1960, 25:85-109.
    • (1960) J Natl Cancer Inst , vol.25 , pp. 85-109
    • Nowell, P.C.1    Hungerford, D.A.2
  • 5
    • 0015694748 scopus 로고
    • Letter: a new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
    • Rowley J.D. Letter: a new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 1973, 243(5405):290-293.
    • (1973) Nature , vol.243 , Issue.5405 , pp. 290-293
    • Rowley, J.D.1
  • 6
    • 0032533257 scopus 로고    scopus 로고
    • Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 BCR/ABL-transduced bone marrow
    • Pear W.S., Miller J.P., Xu L., Pui J.C., Soffer B., Quackenbush R.C., et al. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 BCR/ABL-transduced bone marrow. Blood 1998, 92(10):3780-3792.
    • (1998) Blood , vol.92 , Issue.10 , pp. 3780-3792
    • Pear, W.S.1    Miller, J.P.2    Xu, L.3    Pui, J.C.4    Soffer, B.5    Quackenbush, R.C.6
  • 7
    • 65249148501 scopus 로고    scopus 로고
    • Signaling networks associated with BCR-ABL-dependent transformation
    • Hazlehurst L.A., Bewry N.N., Nair R.R., Pinilla-Ibarz J. Signaling networks associated with BCR-ABL-dependent transformation. Cancer Control 2009, 16(2):100-107.
    • (2009) Cancer Control , vol.16 , Issue.2 , pp. 100-107
    • Hazlehurst, L.A.1    Bewry, N.N.2    Nair, R.R.3    Pinilla-Ibarz, J.4
  • 8
    • 0021811764 scopus 로고
    • Structural organization of the BCR gene and its role in the Ph[prime] translocation
    • Heisterkamp N., Stam K., Groffen J., de Klein A., Grosveld G. Structural organization of the BCR gene and its role in the Ph[prime] translocation. Nature 1985, 315(6022):758-761.
    • (1985) Nature , vol.315 , Issue.6022 , pp. 758-761
    • Heisterkamp, N.1    Stam, K.2    Groffen, J.3    de Klein, A.4    Grosveld, G.5
  • 9
    • 84873990750 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology
    • National Comprehensive Cancer Network Inc.. <>; 2011 [accessed 1.12.2011] Version 2.2012
    • National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology. Chronic Myelogenous Leukemia. Version 2.2012. © 2011 National Comprehensive Cancer Network, Inc.. <>; 2011 [accessed 1.12.2011]. http://www.NCCN.org.
    • (2011) Chronic Myelogenous Leukemia
  • 10
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • O'Brien S.G., Guilhot F., Larson R.A., Gathmann I., Baccarani M., Cervantes F., et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003, 348(11):994-1004.
    • (2003) N Engl J Med , vol.348 , Issue.11 , pp. 994-1004
    • O'Brien, S.G.1    Guilhot, F.2    Larson, R.A.3    Gathmann, I.4    Baccarani, M.5    Cervantes, F.6
  • 12
  • 13
    • 68549097002 scopus 로고    scopus 로고
    • International Randomized Study of Interferon Versus STI571 (IRIS) 7-year follow-up: sustained survival, low rate of transformation and increased rate of major molecular response (MMR) in patients (pts) with newly diagnosed chronic myeloid leukemia in chronic phase (CMLCP) treated with imatinib (IM)
    • O'Brien S.G., Guilhot F., Goldman J.M., Hochhaus A., Hughes T.P., Radich J.P., et al. International Randomized Study of Interferon Versus STI571 (IRIS) 7-year follow-up: sustained survival, low rate of transformation and increased rate of major molecular response (MMR) in patients (pts) with newly diagnosed chronic myeloid leukemia in chronic phase (CMLCP) treated with imatinib (IM). ASH Annual Meeting Abstr 2008, 112(11):186.
    • (2008) ASH Annual Meeting Abstr , vol.112 , Issue.11 , pp. 186
    • O'Brien, S.G.1    Guilhot, F.2    Goldman, J.M.3    Hochhaus, A.4    Hughes, T.P.5    Radich, J.P.6
  • 14
    • 77949767505 scopus 로고    scopus 로고
    • International Randomized Study of Interferon Vs STI571 (IRIS) 8-year follow up: sustained survival and low risk for progression or events in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib
    • Deininger M., O'Brien S.G., Guilhot F., Goldman J.M., Hochhaus A., Hughes T.P., et al. International Randomized Study of Interferon Vs STI571 (IRIS) 8-year follow up: sustained survival and low risk for progression or events in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib. ASH Annual Meeting Abstr 2009, 114(22):1126.
    • (2009) ASH Annual Meeting Abstr , vol.114 , Issue.22 , pp. 1126
    • Deininger, M.1    O'Brien, S.G.2    Guilhot, F.3    Goldman, J.M.4    Hochhaus, A.5    Hughes, T.P.6
  • 15
    • 49149111543 scopus 로고    scopus 로고
    • Imatinib for newly diagnosed patients with chronic myeloid leukemia: incidence of sustained responses in an intention-to-treat analysis
    • de Lavallade H., Apperley J.F., Khorashad J.S., Milojkovic D., Reid A.G., Bua M., et al. Imatinib for newly diagnosed patients with chronic myeloid leukemia: incidence of sustained responses in an intention-to-treat analysis. J Clin Oncol 2008, 26(20):3358-3363.
    • (2008) J Clin Oncol , vol.26 , Issue.20 , pp. 3358-3363
    • de Lavallade, H.1    Apperley, J.F.2    Khorashad, J.S.3    Milojkovic, D.4    Reid, A.G.5    Bua, M.6
  • 16
    • 79952081141 scopus 로고    scopus 로고
    • Front-line and salvage therapies with tyrosine kinase inhibitors and other treatments in chronic myeloid leukemia
    • Cortes J., Hochhaus A., Hughes T., Kantarjian H. Front-line and salvage therapies with tyrosine kinase inhibitors and other treatments in chronic myeloid leukemia. J Clin Oncol 2011, 29(5):524-531.
    • (2011) J Clin Oncol , vol.29 , Issue.5 , pp. 524-531
    • Cortes, J.1    Hochhaus, A.2    Hughes, T.3    Kantarjian, H.4
  • 17
    • 79953295145 scopus 로고    scopus 로고
    • Second-generation tyrosine kinase inhibitors: the future of frontline CML therapy
    • Kantarjian H.M., Baccarani M., Jabbour E., Saglio G., Cortes J.E. Second-generation tyrosine kinase inhibitors: the future of frontline CML therapy. Clin Cancer Res 2011, 17(7):1674-1683.
    • (2011) Clin Cancer Res , vol.17 , Issue.7 , pp. 1674-1683
    • Kantarjian, H.M.1    Baccarani, M.2    Jabbour, E.3    Saglio, G.4    Cortes, J.E.5
  • 18
    • 77953725855 scopus 로고    scopus 로고
    • Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia
    • Kantarjian H., Shah N.P., Hochhaus A., Cortes J., Shah S., Ayala M., et al. Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2010, 362(24):2260-2270.
    • (2010) N Engl J Med , vol.362 , Issue.24 , pp. 2260-2270
    • Kantarjian, H.1    Shah, N.P.2    Hochhaus, A.3    Cortes, J.4    Shah, S.5    Ayala, M.6
  • 19
    • 77953691179 scopus 로고    scopus 로고
    • Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia
    • Saglio G., Kim D.W., Issaragrisil S., le Coutre P., Etienne G., Lobo C., et al. Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia. N Engl J Med 2010, 362(24):2251-2259.
    • (2010) N Engl J Med , vol.362 , Issue.24 , pp. 2251-2259
    • Saglio, G.1    Kim, D.W.2    Issaragrisil, S.3    le Coutre, P.4    Etienne, G.5    Lobo, C.6
  • 20
    • 84873993080 scopus 로고    scopus 로고
    • Tasigna (nilotinib) [prescribing information]
    • NJ: Novartis Pharmaceuticals Corporation; October
    • Tasigna (nilotinib) [prescribing information]. East Hanover, NJ: Novartis Pharmaceuticals Corporation; October 2011.
    • (2011) East Hanover
  • 21
    • 84873988762 scopus 로고    scopus 로고
    • Sprycel (dasatinib) [prescribing information]
    • NJ: Bristol-Myers Squibb; October
    • Sprycel (dasatinib) [prescribing information]. Princeton, NJ: Bristol-Myers Squibb; October 2011.
    • (2011) Princeton
  • 22
    • 84873996719 scopus 로고    scopus 로고
    • Dasatinib or imatinib in newly diagnosed chronic phase chronic myeloid leukemia: 2-year follow-up from a randomized phase 3 trial (DASISION). Blood Dec 9 [Epub ahead of print]
    • Kantarjian HM, Shah NP, Cortes JE, Baccarani M, Agarwal MB, Undurraga MS, et al. Dasatinib or imatinib in newly diagnosed chronic phase chronic myeloid leukemia: 2-year follow-up from a randomized phase 3 trial (DASISION). Blood 2011;Dec 9 [Epub ahead of print].
    • (2011)
    • Kantarjian, H.M.1    Shah, N.P.2    Cortes, J.E.3    Baccarani, M.4    Agarwal, M.B.5    Undurraga, M.S.6
  • 23
    • 80052383499 scopus 로고    scopus 로고
    • Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial
    • Kantarjian H.M., Hochhaus A., Saglio G., Souza C.D., Flinn I.W., Stenke L., et al. Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial. Lancet Oncol 2011, 12(9):841-851.
    • (2011) Lancet Oncol , vol.12 , Issue.9 , pp. 841-851
    • Kantarjian, H.M.1    Hochhaus, A.2    Saglio, G.3    Souza, C.D.4    Flinn, I.W.5    Stenke, L.6
  • 25
    • 75749105885 scopus 로고    scopus 로고
    • Phase III, randomized, open-label study of daily imatinib mesylate 400mg versus 800mg in patients with newly diagnosed, previously untreated chronic myeloid leukemia in chronic phase using molecular end points: tyrosine kinase inhibitor optimization and selectivity study
    • Cortes J.E., Baccarani M., Guilhot F., Druker B.J., Branford S., Kim D.-W., et al. Phase III, randomized, open-label study of daily imatinib mesylate 400mg versus 800mg in patients with newly diagnosed, previously untreated chronic myeloid leukemia in chronic phase using molecular end points: tyrosine kinase inhibitor optimization and selectivity study. J Clin Oncol 2010, 28(3):424-430.
    • (2010) J Clin Oncol , vol.28 , Issue.3 , pp. 424-430
    • Cortes, J.E.1    Baccarani, M.2    Guilhot, F.3    Druker, B.J.4    Branford, S.5    Kim, D.-W.6
  • 26
    • 70350442594 scopus 로고    scopus 로고
    • High-dose imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: high rates of rapid cytogenetic and molecular responses
    • Cortes J.E., Kantarjian H.M., Goldberg S.L., Powell B.L., Giles F.J., Wetzler M., et al. High-dose imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: high rates of rapid cytogenetic and molecular responses. J Clin Oncol 2009, 27(28):4754-4759.
    • (2009) J Clin Oncol , vol.27 , Issue.28 , pp. 4754-4759
    • Cortes, J.E.1    Kantarjian, H.M.2    Goldberg, S.L.3    Powell, B.L.4    Giles, F.J.5    Wetzler, M.6
  • 27
    • 81155133285 scopus 로고    scopus 로고
    • Front-line therapy with second-generation tyrosine kinase inhibitors in patients with early chronic phase chronic myeloid leukemia: what is the optimal response?
    • Jabbour E., Kantarjian H.M., O'Brien S., Shan J., Quintás-Cardama A., Garcia-Manero G., et al. Front-line therapy with second-generation tyrosine kinase inhibitors in patients with early chronic phase chronic myeloid leukemia: what is the optimal response?. J Clin Oncol 2011, 29(32):4260-4265.
    • (2011) J Clin Oncol , vol.29 , Issue.32 , pp. 4260-4265
    • Jabbour, E.1    Kantarjian, H.M.2    O'Brien, S.3    Shan, J.4    Quintás-Cardama, A.5    Garcia-Manero, G.6
  • 28
    • 84873993188 scopus 로고    scopus 로고
    • ClinicalTrials.gov. NCT00802841. Suboptimal study comparing nilotinib and imatinib (LASOR).[accessed 1.12.2011]
    • ClinicalTrials.gov. NCT00802841. Suboptimal study comparing nilotinib and imatinib (LASOR). ; 2011 [accessed 1.12.2011]. http://www.clinicaltrials.gov/ct2/show/NCT00802841?term=nct00802841&rank=1.
    • (2011)
  • 29
    • 84873999959 scopus 로고    scopus 로고
    • ClinicalTrials.gov. NCT01043874. Study to evaluate nilotinib in chronic myelogenous leukemia (CML) patients with suboptimal response (SENSOR) <>; 2011 [accessed 1.12.2011]
    • ClinicalTrials.gov. NCT01043874. Study to evaluate nilotinib in chronic myelogenous leukemia (CML) patients with suboptimal response (SENSOR) <>; 2011 [accessed 1.12.2011]. http://www.clinicaltrials.gov/ct2/show/NCT01043874?term=nct01043874&rank=1.
  • 30
    • 84873985553 scopus 로고    scopus 로고
    • ClinicalTrials.gov. NCT01400074. Efficacy of nilotinib versus imatinib in Ph+ CML in early CP who have a suboptimal molecular response to imatinib (RE-NICE). [accessed 1.12.2011]
    • ClinicalTrials.gov. NCT01400074. Efficacy of nilotinib versus imatinib in Ph+ CML in early CP who have a suboptimal molecular response to imatinib (RE-NICE). <>; 2011 [accessed 1.12.2011]. http://www.clinicaltrials.gov/ct2/show/NCT01400074?term=nct01400074&rank=1.
    • (2011)
  • 31
    • 84874000891 scopus 로고    scopus 로고
    • ClinicalTrials.gov. NCT00644878. Study of molecular response in adult patients on nilotinib with Philadelphia chromosome positive chronic myelogenous leukemia (Ph+ CML) in chronic phase and a suboptimal molecular response to imatinib.[accessed 1.12.2011]
    • ClinicalTrials.gov. NCT00644878. Study of molecular response in adult patients on nilotinib with Philadelphia chromosome positive chronic myelogenous leukemia (Ph+ CML) in chronic phase and a suboptimal molecular response to imatinib. <>; 2011 [accessed 1.12.2011]. http://www.clinicaltrials.gov/ct2/show/NCT00644878?term=nct00644878&rank=1.
    • (2011)
  • 34
    • 84874000012 scopus 로고    scopus 로고
    • ClinicalTrials.gov. NCT01218477. Dasatinib combo with SMO inhibitor (BMS-833923).[accessed 1.12.2011]
    • ClinicalTrials.gov. NCT01218477. Dasatinib combo with SMO inhibitor (BMS-833923). <>; 2010 [accessed 1.12.2011]. http://www.clinicaltrials.gov/ct2/show/NCT01218477?term=nct01218477&rank=1
    • (2010)
  • 35
    • 84865285654 scopus 로고    scopus 로고
    • Effect of nilotinib (NIL) on molecular response in chronic myelogenous leukemia - chronic phase (CML-CP) patients (pts) with a suboptimal molecular response to imatinib (IM)-ENABL study update
    • Ailawadhi S., Miller C.B., Jillella A.P., Koshy N., Tudor B., Akard L.P., et al. Effect of nilotinib (NIL) on molecular response in chronic myelogenous leukemia - chronic phase (CML-CP) patients (pts) with a suboptimal molecular response to imatinib (IM)-ENABL study update. ASH Annual Meeting Abstr 2011, 118(21):2771.
    • (2011) ASH Annual Meeting Abstr , vol.118 , Issue.21 , pp. 2771
    • Ailawadhi, S.1    Miller, C.B.2    Jillella, A.P.3    Koshy, N.4    Tudor, B.5    Akard, L.P.6
  • 36
    • 58149396984 scopus 로고    scopus 로고
    • European LeukemiaNet criteria for failure or suboptimal response reliably identify patients with CML in early chronic phase treated with imatinib whose eventual outcome is poor
    • Marin D., Milojkovic D., Olavarria E., Khorashad J.S., de Lavallade H., Reid A.G., et al. European LeukemiaNet criteria for failure or suboptimal response reliably identify patients with CML in early chronic phase treated with imatinib whose eventual outcome is poor. Blood 2008, 112(12):4437-4444.
    • (2008) Blood , vol.112 , Issue.12 , pp. 4437-4444
    • Marin, D.1    Milojkovic, D.2    Olavarria, E.3    Khorashad, J.S.4    de Lavallade, H.5    Reid, A.G.6
  • 37
    • 68549098145 scopus 로고    scopus 로고
    • Significance of suboptimal response to imatinib, as defined by the European LeukemiaNet, in the long-term outcome of patients with early chronic myeloid leukemia in chronic phase
    • Alvarado Y., Kantarjian H., O'Brien S., Faderl S., Borthakur G., Burger J., et al. Significance of suboptimal response to imatinib, as defined by the European LeukemiaNet, in the long-term outcome of patients with early chronic myeloid leukemia in chronic phase. Cancer 2009, 115(16):3709-3718.
    • (2009) Cancer , vol.115 , Issue.16 , pp. 3709-3718
    • Alvarado, Y.1    Kantarjian, H.2    O'Brien, S.3    Faderl, S.4    Borthakur, G.5    Burger, J.6
  • 38
    • 67650587143 scopus 로고    scopus 로고
    • Delayed achievement of cytogenetic and molecular response is associated with increased risk of progression among patients with chronic myeloid leukemia in early chronic phase receiving high-dose or standard-dose imatinib therapy
    • Quintás-Cardama A., Kantarjian H., Jones D., Shan J., Borthakur G., Thomas D., et al. Delayed achievement of cytogenetic and molecular response is associated with increased risk of progression among patients with chronic myeloid leukemia in early chronic phase receiving high-dose or standard-dose imatinib therapy. Blood 2009, 113(25):6315-6321.
    • (2009) Blood , vol.113 , Issue.25 , pp. 6315-6321
    • Quintás-Cardama, A.1    Kantarjian, H.2    Jones, D.3    Shan, J.4    Borthakur, G.5    Thomas, D.6
  • 39
    • 77958595179 scopus 로고    scopus 로고
    • Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the International Randomized Study of Interferon and STI571 (IRIS)
    • Hughes T.P., Hochhaus A., Branford S., Muller M.C., Kaeda J.S., Foroni L., et al. Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the International Randomized Study of Interferon and STI571 (IRIS). Blood 2010, 116(19):3758-3765.
    • (2010) Blood , vol.116 , Issue.19 , pp. 3758-3765
    • Hughes, T.P.1    Hochhaus, A.2    Branford, S.3    Muller, M.C.4    Kaeda, J.S.5    Foroni, L.6
  • 40
    • 79955018499 scopus 로고    scopus 로고
    • Tolerability-adapted imatinib 800mg/d versus 400mg/d versus 400mg/d plus interferon-α in newly diagnosed chronic myeloid leukemia
    • Hehlmann R., Lauseker M., Jung-Munkwitz S., Leitner A., Müller M.C., Pletsch N., et al. Tolerability-adapted imatinib 800mg/d versus 400mg/d versus 400mg/d plus interferon-α in newly diagnosed chronic myeloid leukemia. J Clin Oncol 2011, 29(12):1634-1642.
    • (2011) J Clin Oncol , vol.29 , Issue.12 , pp. 1634-1642
    • Hehlmann, R.1    Lauseker, M.2    Jung-Munkwitz, S.3    Leitner, A.4    Müller, M.C.5    Pletsch, N.6
  • 41
    • 84862907694 scopus 로고    scopus 로고
    • Assessment of BCR-ABL1 transcript levels at 3months is the only requirement for predicting outcome for patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors
    • Marin D., Ibrahim A.R., Lucas C., Gerrard G., Wang L., Szydlo R.M., et al. Assessment of BCR-ABL1 transcript levels at 3months is the only requirement for predicting outcome for patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors. J Clin Oncol 2012, 30(3):232-238.
    • (2012) J Clin Oncol , vol.30 , Issue.3 , pp. 232-238
    • Marin, D.1    Ibrahim, A.R.2    Lucas, C.3    Gerrard, G.4    Wang, L.5    Szydlo, R.M.6
  • 42
    • 83655200863 scopus 로고    scopus 로고
    • Nilotinib is associated with fewer treatment failures and suboptimal responses vs imatinib in patients with newly diagnosed chronic myeloid leukemia chronic phase (CML-CP): results from ENESTnd
    • Saglio G., Hochhaus A., Guilhot F., Gattermann N., Wang M.-C., De Souza C., et al. Nilotinib is associated with fewer treatment failures and suboptimal responses vs imatinib in patients with newly diagnosed chronic myeloid leukemia chronic phase (CML-CP): results from ENESTnd. Haematologica 2011, 96(Suppl. 2):58-59.
    • (2011) Haematologica , vol.96 , Issue.2 SUPPL. , pp. 58-59
    • Saglio, G.1    Hochhaus, A.2    Guilhot, F.3    Gattermann, N.4    Wang, M.-C.5    De Souza, C.6
  • 43
    • 67049087117 scopus 로고    scopus 로고
    • Prevalence, determinants, and outcomes of nonadherence to imatinib therapy in patients with chronic myeloid leukemia: the ADAGIO study
    • Noens L., van Lierde M.A., De Bock R., Verhoef G., Zachee P., Berneman Z., et al. Prevalence, determinants, and outcomes of nonadherence to imatinib therapy in patients with chronic myeloid leukemia: the ADAGIO study. Blood 2009, 113(22):5401-5411.
    • (2009) Blood , vol.113 , Issue.22 , pp. 5401-5411
    • Noens, L.1    van Lierde, M.A.2    De Bock, R.3    Verhoef, G.4    Zachee, P.5    Berneman, Z.6
  • 44
    • 23044442340 scopus 로고    scopus 로고
    • Adherence to medication
    • Osterberg L., Blaschke T. Adherence to medication. N Engl J Med 2005, 353(5):487-497.
    • (2005) N Engl J Med , vol.353 , Issue.5 , pp. 487-497
    • Osterberg, L.1    Blaschke, T.2
  • 45
    • 0036040466 scopus 로고    scopus 로고
    • The odds of the three nons when an aptly prescribed medicine isn't working: non-compliance, non-absorption, non-response
    • Urquhart J. The odds of the three nons when an aptly prescribed medicine isn't working: non-compliance, non-absorption, non-response. Br J Clin Pharmacol 2002, 54(2):212-220.
    • (2002) Br J Clin Pharmacol , vol.54 , Issue.2 , pp. 212-220
    • Urquhart, J.1
  • 46
    • 77952467377 scopus 로고    scopus 로고
    • Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib
    • Marin D., Bazeos A., Mahon F.X., Eliasson L., Milojkovic D., Bua M., et al. Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib. J Clin Oncol 2010, 28(14):2381-2388.
    • (2010) J Clin Oncol , vol.28 , Issue.14 , pp. 2381-2388
    • Marin, D.1    Bazeos, A.2    Mahon, F.X.3    Eliasson, L.4    Milojkovic, D.5    Bua, M.6
  • 47
    • 79953823237 scopus 로고    scopus 로고
    • Poor adherence is the main reason for loss of CCyR and imatinib failure for CML patients on long term therapy
    • Ibrahim A.R., Eliasson L., Apperley J.F., Milojkovic D., Bua M., Szydlo R., et al. Poor adherence is the main reason for loss of CCyR and imatinib failure for CML patients on long term therapy. Blood 2011, 117(14):3733-3736.
    • (2011) Blood , vol.117 , Issue.14 , pp. 3733-3736
    • Ibrahim, A.R.1    Eliasson, L.2    Apperley, J.F.3    Milojkovic, D.4    Bua, M.5    Szydlo, R.6
  • 48
    • 34249782019 scopus 로고    scopus 로고
    • Treatment interruptions and non-adherence with imatinib and associated healthcare costs: a retrospective analysis among managed care patients with chronic myelogenous leukaemia
    • Darkow T., Henk H.J., Thomas S.K., Feng W., Baladi J.F., Goldberg G.A., et al. Treatment interruptions and non-adherence with imatinib and associated healthcare costs: a retrospective analysis among managed care patients with chronic myelogenous leukaemia. Pharmacoeconomics 2007, 25(6):481-496.
    • (2007) Pharmacoeconomics , vol.25 , Issue.6 , pp. 481-496
    • Darkow, T.1    Henk, H.J.2    Thomas, S.K.3    Feng, W.4    Baladi, J.F.5    Goldberg, G.A.6
  • 49
    • 77649221871 scopus 로고    scopus 로고
    • Healthcare resource utilization and costs associated with non-adherence to imatinib treatment in chronic myeloid leukemia patients
    • Wu E.Q., Johnson S., Beaulieu N., Arana M., Bollu V., Guo A., et al. Healthcare resource utilization and costs associated with non-adherence to imatinib treatment in chronic myeloid leukemia patients. Curr Med Res Opin 2010, 26(1):61-69.
    • (2010) Curr Med Res Opin , vol.26 , Issue.1 , pp. 61-69
    • Wu, E.Q.1    Johnson, S.2    Beaulieu, N.3    Arana, M.4    Bollu, V.5    Guo, A.6
  • 50
    • 63249106651 scopus 로고    scopus 로고
    • Practical considerations for the management of patients in the tyrosine kinase inhibitor era
    • O'Dwyer M., Atallah E. Practical considerations for the management of patients in the tyrosine kinase inhibitor era. Semin Hematol 2009, 46(2 (Suppl. 3)):S16-21.
    • (2009) Semin Hematol , vol.46 , Issue.2-3 SUPPL.
    • O'Dwyer, M.1    Atallah, E.2
  • 51
    • 79751533746 scopus 로고    scopus 로고
    • Management of adverse events associated with tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia
    • Jabbour E., Deininger M., Hochhaus A. Management of adverse events associated with tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia. Leukemia 2011, 25(2):201-210.
    • (2011) Leukemia , vol.25 , Issue.2 , pp. 201-210
    • Jabbour, E.1    Deininger, M.2    Hochhaus, A.3
  • 52
    • 84855779920 scopus 로고    scopus 로고
    • A global retrospective and physician-based analysis of adherence to tyrosine kinase inhibitor (TKI) therapies for chronic myeloid leukemia (CML)
    • Guilhot F., Coombs J., Zernovak O., Szczudlo T., Rosti G. A global retrospective and physician-based analysis of adherence to tyrosine kinase inhibitor (TKI) therapies for chronic myeloid leukemia (CML). ASH Annual Meeting Abstr 2010, 116(21):1514.
    • (2010) ASH Annual Meeting Abstr , vol.116 , Issue.21 , pp. 1514
    • Guilhot, F.1    Coombs, J.2    Zernovak, O.3    Szczudlo, T.4    Rosti, G.5
  • 53
    • 79954585749 scopus 로고    scopus 로고
    • Exploring chronic myeloid leukemia patients' reasons for not adhering to the oral anticancer drug imatinib as prescribed
    • Eliasson L., Clifford S., Barber N., Marin D. Exploring chronic myeloid leukemia patients' reasons for not adhering to the oral anticancer drug imatinib as prescribed. Leuk Res 2011, 35(5):626-630.
    • (2011) Leuk Res , vol.35 , Issue.5 , pp. 626-630
    • Eliasson, L.1    Clifford, S.2    Barber, N.3    Marin, D.4
  • 54
    • 84868371245 scopus 로고    scopus 로고
    • East Hanover, NJ: Novartis Pharmaceuticals Corporation
    • Gleevec (imatinib) [prescribing information]. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2011.
    • (2011) Gleevec (imatinib) [prescribing information]
  • 55
    • 78649635342 scopus 로고    scopus 로고
    • Predictors of treatment non-adherence in patients treated with imatinib mesylate for chronic myeloid leukemia
    • St.Charles M., Bollu V.K., Hornyak E., Coombs J., Blanchette C.M., DeAngelo D.J. Predictors of treatment non-adherence in patients treated with imatinib mesylate for chronic myeloid leukemia. ASH Annual Meeting Abstr 2009, 114(22):2209.
    • (2009) ASH Annual Meeting Abstr , vol.114 , Issue.22 , pp. 2209
    • St.Charles, M.1    Bollu, V.K.2    Hornyak, E.3    Coombs, J.4    Blanchette, C.M.5    DeAngelo, D.J.6
  • 56
    • 33947280081 scopus 로고    scopus 로고
    • Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy
    • Hochhaus A., Kantarjian H.M., Baccarani M., Lipton J.H., Apperley J.F., Druker B.J., et al. Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy. Blood 2007, 109(6):2303-2309.
    • (2007) Blood , vol.109 , Issue.6 , pp. 2303-2309
    • Hochhaus, A.1    Kantarjian, H.M.2    Baccarani, M.3    Lipton, J.H.4    Apperley, J.F.5    Druker, B.J.6
  • 57
    • 36348968931 scopus 로고    scopus 로고
    • Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance
    • Kantarjian H.M., Giles F., Gattermann N., Bhalla K., Alimena G., Palandri F., et al. Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance. Blood 2007, 110(10):3540-3546.
    • (2007) Blood , vol.110 , Issue.10 , pp. 3540-3546
    • Kantarjian, H.M.1    Giles, F.2    Gattermann, N.3    Bhalla, K.4    Alimena, G.5    Palandri, F.6
  • 58
    • 49249121723 scopus 로고    scopus 로고
    • Intermittent target inhibition with dasatinib 100mg once daily preserves efficacy and improves tolerability in imatinib-resistant and -intolerant chronic-phase chronic myeloid leukemia
    • Shah N.P., Kantarjian H.M., Kim D.W., Rea D., Dorlhiac-Llacer P.E., Milone J.H., et al. Intermittent target inhibition with dasatinib 100mg once daily preserves efficacy and improves tolerability in imatinib-resistant and -intolerant chronic-phase chronic myeloid leukemia. J Clin Oncol 2008, 26(19):3204-3212.
    • (2008) J Clin Oncol , vol.26 , Issue.19 , pp. 3204-3212
    • Shah, N.P.1    Kantarjian, H.M.2    Kim, D.W.3    Rea, D.4    Dorlhiac-Llacer, P.E.5    Milone, J.H.6
  • 59
    • 43549086415 scopus 로고    scopus 로고
    • Therapy options in imatinib failures
    • Ramirez P., DiPersio J.F. Therapy options in imatinib failures. Oncologist 2008, 13(4):424-434.
    • (2008) Oncologist , vol.13 , Issue.4 , pp. 424-434
    • Ramirez, P.1    DiPersio, J.F.2
  • 60
    • 84873989986 scopus 로고    scopus 로고
    • ClinicalTrials.gov. NCT01220648. Determining the maximum tolerated dose of low dose interferon-alfa in conjunction with nilotinib in imatinib resistant and/or intolerant Philadelphia chromosome positive (Ph+) chronic myeloid leukemia patients in chronic phase (CML-CP) (NICOLI).[accessed 14.11.2011]
    • ClinicalTrials.gov. NCT01220648. Determining the maximum tolerated dose of low dose interferon-alfa in conjunction with nilotinib in imatinib resistant and/or intolerant Philadelphia chromosome positive (Ph+) chronic myeloid leukemia patients in chronic phase (CML-CP) (NICOLI). <>; 2010 [accessed 14.11.2011]. http://www.clinicaltrials.gov/ct2/show/NCT01220648?term=NCT01220648&rank=1.
    • (2010)
  • 61
    • 84873999289 scopus 로고    scopus 로고
    • ClinicalTrials.gov. NCT00866736. A study of dasatinib in patients with imatinib resistant or intolerant chronic myeloid leukemia. [accessed 14.11.2011]
    • ClinicalTrials.gov. NCT00866736. A study of dasatinib in patients with imatinib resistant or intolerant chronic myeloid leukemia.
    • (2009)
  • 62
    • 84873987425 scopus 로고    scopus 로고
    • ClinicalTrials.gov. NCT01426334. Dasatinib and cyclosporine in treating patients with chronic myelogenous leukemia refractory or intolerant to imatinib mesylate.[accessed 17.01.2012]
    • ClinicalTrials.gov. NCT01426334. Dasatinib and cyclosporine in treating patients with chronic myelogenous leukemia refractory or intolerant to imatinib mesylate. <>; 2011 [accessed 17.01.2012]. http://www.clinicaltrials.gov/ct2/show/NCT01426334?term=NCT01426334&rank=1.
    • (2011)
  • 63
    • 84873995407 scopus 로고    scopus 로고
    • Study of treatment with nilotinib in adult patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis
    • ClinicalTrials.gov. NCT00786812.[accessed 17.01.2012]
    • ClinicalTrials.gov. NCT00786812. Study of treatment with nilotinib in adult patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis, accelerated phase or chronic phase (ENACT). <>; 2008 [accessed 17.01.2012]. http://www.clinicaltrials.gov/ct2/show/NCT00786812?term=NCT00786812&rank=1.
    • (2008) accelerated phase or chronic phase (ENACT)
  • 64
    • 84874000893 scopus 로고    scopus 로고
    • ClinicalTrials.gov. NCT00538109 expanded access study of oral AMN 107 in adult patients with imatinib (Glivec®/Gleevec®) - resistant or intolerant chronic myeloid leukemia in blast crisis, accelerated phase or chronic phase.[accessed 17.01.2012]
    • ClinicalTrials.gov. NCT00538109. An open-label, multicenter, expanded access study of oral AMN 107 in adult patients with imatinib (Glivec®/Gleevec®) - resistant or intolerant chronic myeloid leukemia in blast crisis, accelerated phase or chronic phase. <>; 2007 [accessed 17.01.2012]. http://www.clinicaltrials.gov/ct2/show/NCT00538109?term=NCT00538109&rank=1.
    • (2007) An open-label, multicenter
  • 65
    • 84873987905 scopus 로고    scopus 로고
    • ClinicalTrials.gov. NCT00777036. A phase II study of dasatinib in children and adolescents with newly diagnosed chronic phase CML or with Ph+ leukemias resistant or intolerant to imatinib.[accessed 14.11.2011]
    • ClinicalTrials.gov. NCT00777036. A phase II study of dasatinib in children and adolescents with newly diagnosed chronic phase CML or with Ph+ leukemias resistant or intolerant to imatinib. <>; 2008 [accessed 14.11.2011]. http://www.clinicaltrials.gov/ct2/show/NCT00777036?term=NCT00777036&rank=1.
    • (2008)
  • 66
    • 84873999250 scopus 로고    scopus 로고
    • An exploratory trial to assess the improvement of adverse events in chronic myelogenous leukemia patients treated with imatinib when switched to nilotinib ClinicalTrials.gov. NCT00980018. treatment.[accessed 17.01.2012]
    • ClinicalTrials.gov. NCT00980018. An exploratory trial to assess the improvement of adverse events in chronic myelogenous leukemia patients treated with imatinib when switched to nilotinib treatment. <>; 2009 [accessed 17.01.2012]. http://www.clinicaltrials.gov/ct2/show/NCT00980018?term=NCT00980018&rank=1.
    • (2009)
  • 67
    • 63249106852 scopus 로고    scopus 로고
    • Dasatinib lack of cross intolerance to imatinib in patients (pts) with chronic myelogenous leukemia chronic phase (CML-CP) intolerant to imatinib: a retrospective analysis of safety
    • Khoury H.J., Goldberg S.L., Mauro M.J., Stone R.M., Matloub Y., Chen T., et al. Dasatinib lack of cross intolerance to imatinib in patients (pts) with chronic myelogenous leukemia chronic phase (CML-CP) intolerant to imatinib: a retrospective analysis of safety. J Clin Oncol 2008, 26(Suppl.):7015.
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL. , pp. 7015
    • Khoury, H.J.1    Goldberg, S.L.2    Mauro, M.J.3    Stone, R.M.4    Matloub, Y.5    Chen, T.6
  • 68
    • 79960107896 scopus 로고    scopus 로고
    • Lack of non-hematological cross intolerance of dasatinib to imatinib in imatinib-intolerant patients with Philadelphia chromosome positive chronic myeloid leukemia or acute lymphatic leukemia: a retrospective safety analysis
    • Kobayashi Y., Sakamaki H., Fujisawa S., Ando K., Yamamoto K., Okada M., et al. Lack of non-hematological cross intolerance of dasatinib to imatinib in imatinib-intolerant patients with Philadelphia chromosome positive chronic myeloid leukemia or acute lymphatic leukemia: a retrospective safety analysis. Int J Hematol 2011, 93(6):745-749.
    • (2011) Int J Hematol , vol.93 , Issue.6 , pp. 745-749
    • Kobayashi, Y.1    Sakamaki, H.2    Fujisawa, S.3    Ando, K.4    Yamamoto, K.5    Okada, M.6
  • 69
    • 79957616017 scopus 로고    scopus 로고
    • Minimal cross-intolerance with nilotinib in patients with chronic myeloid leukemia in chronic or accelerated phase who are intolerant to imatinib
    • Cortes J.E., Hochhaus A., le Coutre P.D., Rosti G., Pinilla-Ibarz J., Jabbour E., et al. Minimal cross-intolerance with nilotinib in patients with chronic myeloid leukemia in chronic or accelerated phase who are intolerant to imatinib. Blood 2011, 117(21):5600-5606.
    • (2011) Blood , vol.117 , Issue.21 , pp. 5600-5606
    • Cortes, J.E.1    Hochhaus, A.2    le Coutre, P.D.3    Rosti, G.4    Pinilla-Ibarz, J.5    Jabbour, E.6
  • 70
    • 84873994280 scopus 로고    scopus 로고
    • Open-label study evaluating change in chronic low-grade (LG) non-hematologic (heme) adverse events (AEs) in Philadelphia positive (Ph+) CML-CP patients (pts) switched from imatinib (IM) to nilotinib (NL)
    • Cortes J.E., Miller C.B., Lipton J.H., Busque L., Akard L.P., Pinilla-Ibarz J., et al. Open-label study evaluating change in chronic low-grade (LG) non-hematologic (heme) adverse events (AEs) in Philadelphia positive (Ph+) CML-CP patients (pts) switched from imatinib (IM) to nilotinib (NL). J Clin Oncol 2011, 29(Suppl.):6615.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL. , pp. 6615
    • Cortes, J.E.1    Miller, C.B.2    Lipton, J.H.3    Busque, L.4    Akard, L.P.5    Pinilla-Ibarz, J.6
  • 71
    • 79251546724 scopus 로고    scopus 로고
    • Nilotinib is effective in patients with chronic myeloid leukemia in chronic phase after imatinib resistance or intolerance. 24-month follow-up results
    • Kantarjian H.M., Giles F.J., Bhalla K.N., Pinilla-Ibarz J., Larson R.A., Gattermann N., et al. Nilotinib is effective in patients with chronic myeloid leukemia in chronic phase after imatinib resistance or intolerance. 24-month follow-up results. Blood 2011, 117(4):1141-1145.
    • (2011) Blood , vol.117 , Issue.4 , pp. 1141-1145
    • Kantarjian, H.M.1    Giles, F.J.2    Bhalla, K.N.3    Pinilla-Ibarz, J.4    Larson, R.A.5    Gattermann, N.6
  • 72
    • 67649624660 scopus 로고    scopus 로고
    • Dasatinib early intervention after cytogenetic or hematologic resistance to imatinib in patients with chronic myeloid leukemia
    • Quintas-Cardama A., Cortes J.E., O'Brien S., Ravandi F., Borthakur G., Liu D., et al. Dasatinib early intervention after cytogenetic or hematologic resistance to imatinib in patients with chronic myeloid leukemia. Cancer 2009, 115(13):2912-2921.
    • (2009) Cancer , vol.115 , Issue.13 , pp. 2912-2921
    • Quintas-Cardama, A.1    Cortes, J.E.2    O'Brien, S.3    Ravandi, F.4    Borthakur, G.5    Liu, D.6
  • 73
    • 84873986657 scopus 로고    scopus 로고
    • Outcome after failure to second generation tyrosine kinase inhibitors (TKI) treatment as frontline therapy for patients with chronic myeloid leukemia (CML) in chronic phase (CP)
    • Eghtedar A., Kantarjian H., Jabbour E., O'Brien S., Quintas-Cardama A., Burton E., et al. Outcome after failure to second generation tyrosine kinase inhibitors (TKI) treatment as frontline therapy for patients with chronic myeloid leukemia (CML) in chronic phase (CP). ASH Annual Meeting Abstr 2010, 116(21):3442.
    • (2010) ASH Annual Meeting Abstr , vol.116 , Issue.21 , pp. 3442
    • Eghtedar, A.1    Kantarjian, H.2    Jabbour, E.3    O'Brien, S.4    Quintas-Cardama, A.5    Burton, E.6
  • 74
    • 1342343033 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance of leukemia to imatinib mesylate
    • Tauchi T., Ohyashiki K. Molecular mechanisms of resistance of leukemia to imatinib mesylate. Leuk Res 2004, 28(Suppl. 1):S39-45.
    • (2004) Leuk Res , vol.28 , Issue.1 SUPPL.
    • Tauchi, T.1    Ohyashiki, K.2
  • 75
    • 77749288978 scopus 로고    scopus 로고
    • Mechanisms of resistance to tyrosine kinase inhibitors in chronic myeloid leukemia and recent therapeutic strategies to overcome resistance
    • Bixby D., Talpaz M. Mechanisms of resistance to tyrosine kinase inhibitors in chronic myeloid leukemia and recent therapeutic strategies to overcome resistance. Hematology Am Soc Hematol Educ Program 2009, 23:461-476.
    • (2009) Hematology Am Soc Hematol Educ Program , vol.23 , pp. 461-476
    • Bixby, D.1    Talpaz, M.2
  • 76
    • 70349245253 scopus 로고    scopus 로고
    • Long-term outcome of patients with chronic myeloid leukemia treated with second-generation tyrosine kinase inhibitors after imatinib failure is predicted by the in vitro sensitivity of BCR-ABL kinase domain mutations
    • Jabbour E., Jones D., Kantarjian H.M., O'Brien S., Tam C., Koller C., et al. Long-term outcome of patients with chronic myeloid leukemia treated with second-generation tyrosine kinase inhibitors after imatinib failure is predicted by the in vitro sensitivity of BCR-ABL kinase domain mutations. Blood 2009, 114(10):2037-2043.
    • (2009) Blood , vol.114 , Issue.10 , pp. 2037-2043
    • Jabbour, E.1    Jones, D.2    Kantarjian, H.M.3    O'Brien, S.4    Tam, C.5    Koller, C.6
  • 77
    • 23044458596 scopus 로고    scopus 로고
    • ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: a study by the GIMEMA Working Party on Chronic Myeloid Leukemia
    • Soverini S., Martinelli G., Rosti G., Bassi S., Amabile M., Poerio A., et al. ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: a study by the GIMEMA Working Party on Chronic Myeloid Leukemia. J Clin Oncol 2005, 23(18):4100-4109.
    • (2005) J Clin Oncol , vol.23 , Issue.18 , pp. 4100-4109
    • Soverini, S.1    Martinelli, G.2    Rosti, G.3    Bassi, S.4    Amabile, M.5    Poerio, A.6
  • 78
    • 80051573352 scopus 로고    scopus 로고
    • BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet
    • Soverini S., Hochhaus A., Nicolini F.E., Gruber F., Lange T., Saglio G., et al. BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet. Blood 2011, 118(5):1208-1215.
    • (2011) Blood , vol.118 , Issue.5 , pp. 1208-1215
    • Soverini, S.1    Hochhaus, A.2    Nicolini, F.E.3    Gruber, F.4    Lange, T.5    Saglio, G.6
  • 79
    • 0038375012 scopus 로고    scopus 로고
    • Several BCR-ABL kinase domain mutants associated with imatinib mesylate resistance remain sensitive to imatinib
    • Corbin A.S., La Rosee P., Stoffregen E.P., Druker B.J., Deininger M.W. Several BCR-ABL kinase domain mutants associated with imatinib mesylate resistance remain sensitive to imatinib. Blood 2003, 101(11):4611-4614.
    • (2003) Blood , vol.101 , Issue.11 , pp. 4611-4614
    • Corbin, A.S.1    La Rosee, P.2    Stoffregen, E.P.3    Druker, B.J.4    Deininger, M.W.5
  • 80
    • 84873997570 scopus 로고    scopus 로고
    • The incidence of BCR-ABL mutations in patients (pts) with newly diagnosed chronic myeloid leukemia (CML) in chronic phase (CP) treated with nilotinib or imatinib in ENESTnd: 24-month follow-up
    • Saglio G., Kantarjian H., Reiffers J., Jootar S., Kalaycio M.E., Shibayama H., et al. The incidence of BCR-ABL mutations in patients (pts) with newly diagnosed chronic myeloid leukemia (CML) in chronic phase (CP) treated with nilotinib or imatinib in ENESTnd: 24-month follow-up. J Clin Oncol 2011, 29(Suppl.):6502.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL. , pp. 6502
    • Saglio, G.1    Kantarjian, H.2    Reiffers, J.3    Jootar, S.4    Kalaycio, M.E.5    Shibayama, H.6
  • 81
    • 3142676436 scopus 로고    scopus 로고
    • Overriding imatinib resistance with a novel ABL kinase inhibitor
    • Shah N.P., Tran C., Lee F.Y., Chen P., Norris D., Sawyers C.L. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 2004, 305(5682):399-401.
    • (2004) Science , vol.305 , Issue.5682 , pp. 399-401
    • Shah, N.P.1    Tran, C.2    Lee, F.Y.3    Chen, P.4    Norris, D.5    Sawyers, C.L.6
  • 82
    • 58149380741 scopus 로고    scopus 로고
    • Characteristics and outcome of chronic myeloid leukemia patients with F317L BCR-ABL kinase domain mutation after therapy with tyrosine kinase inhibitors
    • Jabbour E., Kantarjian H.M., Jones D., Reddy N., O'Brien S., Garcia-Manero G., et al. Characteristics and outcome of chronic myeloid leukemia patients with F317L BCR-ABL kinase domain mutation after therapy with tyrosine kinase inhibitors. Blood 2008, 112(13):4839-4842.
    • (2008) Blood , vol.112 , Issue.13 , pp. 4839-4842
    • Jabbour, E.1    Kantarjian, H.M.2    Jones, D.3    Reddy, N.4    O'Brien, S.5    Garcia-Manero, G.6
  • 83
    • 21144451094 scopus 로고    scopus 로고
    • In vitro activity of BCR-ABL inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant ABL kinase domain mutants
    • O'Hare T., Walters D.K., Stoffregen E.P., Jia T., Manley P.W., Mestan J., et al. In vitro activity of BCR-ABL inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant ABL kinase domain mutants. Cancer Res 2005, 65(11):4500-4505.
    • (2005) Cancer Res , vol.65 , Issue.11 , pp. 4500-4505
    • O'Hare, T.1    Walters, D.K.2    Stoffregen, E.P.3    Jia, T.4    Manley, P.W.5    Mestan, J.6
  • 85
    • 70249105789 scopus 로고    scopus 로고
    • Impact of baseline BCR-ABL mutations on response to nilotinib in patients with chronic myeloid leukemia in chronic phase
    • Hughes T., Saglio G., Branford S., Soverini S., Kim D.-W., Müller M.C., et al. Impact of baseline BCR-ABL mutations on response to nilotinib in patients with chronic myeloid leukemia in chronic phase. J Clin Oncol 2009, 27(25):4204-4210.
    • (2009) J Clin Oncol , vol.27 , Issue.25 , pp. 4204-4210
    • Hughes, T.1    Saglio, G.2    Branford, S.3    Soverini, S.4    Kim, D.-W.5    Müller, M.C.6
  • 86
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre M.E., Mohammed M., Ellwood K., Hsu N., Paquette R., Rao P.N., et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001, 293(5531):876-880.
    • (2001) Science , vol.293 , Issue.5531 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3    Hsu, N.4    Paquette, R.5    Rao, P.N.6
  • 87
    • 47249123747 scopus 로고    scopus 로고
    • Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation following failure of imatinib mesylate therapy
    • Jabbour E., Kantarjian H., Jones D., Breeden M., Garcia-Manero G., O'Brien S., et al. Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation following failure of imatinib mesylate therapy. Blood 2008, 112(1):53-55.
    • (2008) Blood , vol.112 , Issue.1 , pp. 53-55
    • Jabbour, E.1    Kantarjian, H.2    Jones, D.3    Breeden, M.4    Garcia-Manero, G.5    O'Brien, S.6
  • 88
    • 33947673579 scopus 로고    scopus 로고
    • Defining and managing imatinib resistance
    • Mauro M.J. Defining and managing imatinib resistance. Hematology 2006, 2006(1):219-225.
    • (2006) Hematology , vol.2006 , Issue.1 , pp. 219-225
    • Mauro, M.J.1
  • 89
    • 78650159009 scopus 로고    scopus 로고
    • Structural mechanism of the pan-BCR-ABL inhibitor ponatinib (AP24534): lessons for overcoming kinase inhibitor resistance
    • Zhou T., Commodore L., Huang W.S., Wang Y., Thomas M., Keats J., et al. Structural mechanism of the pan-BCR-ABL inhibitor ponatinib (AP24534): lessons for overcoming kinase inhibitor resistance. Chem Biol Drug Des 2011, 77(1):1-11.
    • (2011) Chem Biol Drug Des , vol.77 , Issue.1 , pp. 1-11
    • Zhou, T.1    Commodore, L.2    Huang, W.S.3    Wang, Y.4    Thomas, M.5    Keats, J.6
  • 90
    • 70350507997 scopus 로고    scopus 로고
    • AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance
    • O'Hare T., Shakespeare W.C., Zhu X., Eide C.A., Rivera V.M., Wang F., et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell 2009, 16(5):401-412.
    • (2009) Cancer Cell , vol.16 , Issue.5 , pp. 401-412
    • O'Hare, T.1    Shakespeare, W.C.2    Zhu, X.3    Eide, C.A.4    Rivera, V.M.5    Wang, F.6
  • 91
    • 84873987112 scopus 로고    scopus 로고
    • Subset analysis of response to treatment of chronic phase cml in a phase 1 study of ponatinib in refractory hematologic malignancies.
    • December 12,San Diego, CA. Abstract 602
    • Cortes JE, Kantarjian HM, Shah N, Bixby D, Mauro MJ, Flinn IW, et al. Subset analysis of response to treatment of chronic phase cml in a phase 1 study of ponatinib in refractory hematologic malignancies. Presented at: 53rd ASH Annual Meeting and Exposition, December 12, 2011; San Diego, CA. Abstract 602.
    • (2011) Presented at: 53rd ASH Annual Meeting and Exposition
    • Cortes, J.E.1    Kantarjian, H.M.2    Shah, N.3    Bixby, D.4    Mauro, M.J.5    Flinn, I.W.6
  • 92
    • 79955485779 scopus 로고    scopus 로고
    • The ABL switch control inhibitor DCC-2036 is active against the chronic myeloid leukemia mutant BCR-ABLT315I and exhibits a narrow resistance profile
    • Eide C.A., Adrian L.T., Tyner J.W., Mac Partlin M., Anderson D.J., Wise S.C., et al. The ABL switch control inhibitor DCC-2036 is active against the chronic myeloid leukemia mutant BCR-ABLT315I and exhibits a narrow resistance profile. Cancer Res 2011, 71(9):3189-3195.
    • (2011) Cancer Res , vol.71 , Issue.9 , pp. 3189-3195
    • Eide, C.A.1    Adrian, L.T.2    Tyner, J.W.3    Mac Partlin, M.4    Anderson, D.J.5    Wise, S.C.6
  • 93
    • 84873986320 scopus 로고    scopus 로고
    • A phase 1 study of DCC-2036
    • in patients with Philadelphia chromosome positive (Ph+) leukemias including patients with T315I mutation. Presented at: 53rd ASH Annual Meeting and Exposition, December 12,San Diego, CA. Abstract 601
    • Cortes JE, Talpaz M, Kantarjian HM, Smith H, Bixby D, Rafferty U, et al. A phase 1 study of DCC-2036, a novel oral inhibitor of BCR-ABL kinase, in patients with Philadelphia chromosome positive (Ph+) leukemias including patients with T315I mutation. Presented at: 53rd ASH Annual Meeting and Exposition, December 12, 2011, San Diego, CA. Abstract 601.
    • (2011) a novel oral inhibitor of BCR-ABL kinase
    • Cortes, J.E.1    Talpaz, M.2    Kantarjian, H.M.3    Smith, H.4    Bixby, D.5    Rafferty, U.6
  • 94
    • 43249111278 scopus 로고    scopus 로고
    • Simultaneous targeting of Aurora kinases and BCR-ABL kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I
    • Gontarewicz A., Balabanov S., Keller G., Colombo R., Graziano A., Pesenti E., et al. Simultaneous targeting of Aurora kinases and BCR-ABL kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I. Blood 2008, 111(8):4355-4364.
    • (2008) Blood , vol.111 , Issue.8 , pp. 4355-4364
    • Gontarewicz, A.1    Balabanov, S.2    Keller, G.3    Colombo, R.4    Graziano, A.5    Pesenti, E.6
  • 95
    • 77950919574 scopus 로고    scopus 로고
    • Danusertib hydrochloride (PHA-739358), a multi-kinase aurora inhibitor, elicits clinical benefit in advanced chronic myeloid leukemia and Philadelphia chromosome positive acute lymphoblastic leukemia
    • Cortes-Franco J., Dombret H., Schafhausen P., Brummendorf T.H., Boissel N., Latini F., et al. Danusertib hydrochloride (PHA-739358), a multi-kinase aurora inhibitor, elicits clinical benefit in advanced chronic myeloid leukemia and Philadelphia chromosome positive acute lymphoblastic leukemia. Blood (ASH Annual Meeting Abstracts) 2009, 114:864.
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , pp. 864
    • Cortes-Franco, J.1    Dombret, H.2    Schafhausen, P.3    Brummendorf, T.H.4    Boissel, N.5    Latini, F.6
  • 96
    • 72249090201 scopus 로고    scopus 로고
    • Homoharringtonine, omacetaxine mepesuccinate, and chronic myeloid leukemia circa 2009
    • Quintas-Cardama A., Kantarjian H., Cortes J. Homoharringtonine, omacetaxine mepesuccinate, and chronic myeloid leukemia circa 2009. Cancer 2009, 115(23):5382-5393.
    • (2009) Cancer , vol.115 , Issue.23 , pp. 5382-5393
    • Quintas-Cardama, A.1    Kantarjian, H.2    Cortes, J.3
  • 97
    • 68749110580 scopus 로고    scopus 로고
    • Inhibitory effects of omacetaxine on leukemic stem cells and BCR-ABL-induced chronic myeloid leukemia and acute lymphoblastic leukemia in mice
    • Chen Y., Hu Y., Michaels S., Segal D., Brown D., Li S. Inhibitory effects of omacetaxine on leukemic stem cells and BCR-ABL-induced chronic myeloid leukemia and acute lymphoblastic leukemia in mice. Leukemia 2009, 23(8):1446-1454.
    • (2009) Leukemia , vol.23 , Issue.8 , pp. 1446-1454
    • Chen, Y.1    Hu, Y.2    Michaels, S.3    Segal, D.4    Brown, D.5    Li, S.6
  • 98
    • 84865196136 scopus 로고    scopus 로고
    • Subcutaneous omacetaxine in chronic or accelerated chronic myeloid leukemia resistant to two or more tyrosine-kinase inhibitors including imatinib
    • Cortes J.E., Nicolini F.E., Wetzler M., Lipton J.H., Akard L.P., Craig A., et al. Subcutaneous omacetaxine in chronic or accelerated chronic myeloid leukemia resistant to two or more tyrosine-kinase inhibitors including imatinib. Blood (ASH Annual Meeting Abstracts) 2011, 118:3761.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , pp. 3761
    • Cortes, J.E.1    Nicolini, F.E.2    Wetzler, M.3    Lipton, J.H.4    Akard, L.P.5    Craig, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.