Peritoneal adhesion index (PAI): Proposal of a score for the " ignored iceberg" of medicine and surgery

World Journal of Emergency Surgery

Volumn 8, Issue 1, 2013, Pages

  Coccolini, Federico ^a   Ansaloni, Luca ^a   Manfredi, Roberto ^a   Campanati, Luca ^a   Poiasina, Elia ^a   Bertoli, Paolo ^a   Capponi, Michela Giulii ^a   Sartelli, Massimo ^c   Saverio, Salomone Di ^b   Cucchi, Michele ^b   Lazzareschi, Daniel ^a   Pisano, Michele ^a   Catena, Fausto ^b  

^a PAPA GIOVANNI XXIII HOSPITAL   (Italy)

^b MAGGIORE HOSPITAL   (Italy)

^c Macerata Hospital   (Italy)

Author keywords

Abdominal; Adhesions; Classification; Occlusion; PAI; Peritoneal; Prevention; Surgery; Treatment

Indexed keywords

EID: 84873989803     PISSN: None     EISSN: 17497922     Source Type: Journal    
DOI: 10.1186/1749-7922-8-6     Document Type: Article

References (60)

1. Diamond MP, Freeman ML. Clinical implications of postsurgical adhesions. Hum Reprod Update 2001, 7:567-576. 10.1093/humupd/7.6.567, 11727865.
2. Arung W, Meurisse M, Detry O. Pathophysiology and prevention of postoperative peritoneal adhesions. World J Gastroenterol 2011, 17:4545-4553. 10.3748/wjg.v17.i41.4545, 3225091, 22147959.
3. Sulaiman H, Gabella G, Davis MSc C, Mutsaers SE, Boulos P, Laurent GJ, Herrick SE. Presence and distribution of sensory nerve fibers in human peritoneal adhesions. Ann Surg 2001, 234:256-261. 10.1097/00000658-200108000-00016, 1422013, 11505072.
4. Ellis H. The clinical significance of adhesions: focus on intestinal obstruction. Eur J Surg Suppl 1997, 577:5-9.
5. Pouly JL, Seak-San S. Adhesions: laparoscopy versus laparotomy. Peritoneal surgery 2000, 183-192. Springer, New York, DiZerega GS.
6. Diamond MP. Reduction of de novo postsurgical adhesions by intraoperative precoating with sepracoat (HAL-C) solution: a prospective, randomized, blinded, placebo-controlled multicenter study. The sepracoat adhesion study group. Fertil Steril 1998, 69:1067-1074. 10.1016/S0015-0282(98)00057-0, 9627294.
7. Zühlke HV, Lorenz EM, Straub EM, Savvas V. Pathophysiology and classification of adhesions. Langenbecks Arch Chir Verh Dtsch Ges Chir 1990, Suppl 2:1009-1016.
8. Parker MC, Wilson MS, van Goor H, Moran BJ, Jeekel J, Duron JJ, Menzies D, Wexner SD, Ellis H. Adhesions and colorectal surgery - call for action. Colorectal Dis 2007, 9(Suppl 2):66-72.
9. Liakakos T, Thomakos N, Fine PM, Dervenis C, Young RL. Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management. Dig Surg 2001, 18:260-273. 10.1159/000050149, 11528133.
10. Cheong YC, Laird SM, Li TC, Shelton JB, Ledger WL, Cooke ID. Peritoneal healing and adhesion formation/reformation. Hum Reprod Update 2001, 7:556-566. 10.1093/humupd/7.6.556, 11727864.
11. Kössi J, Salminen P, Rantala A, Laato M. Population-based study of the surgical workload and economic impact of bowel obstruction caused by postoperative adhesions. Br J Surg 2003, 90:1441-1444. 10.1002/bjs.4272, 14598429.
12. Menzies D, Ellis H. Intestinal obstruction from adhesions-how big is the problem?. Ann R Coll Surg Engl 1990, 72:60-63. 2499092, 2301905.
13. Gutt CN, Oniu T, Schemmer P, Mehrabi A, Büchler MW. Fewer adhesions induced by laparoscopic surgery?. Surg Endosc 2004, 18:898-906. 10.1007/s00464-003-9233-3, 15108105.
14. Krähenbühl L, Schäfer M, Kuzinkovas V, Renzulli P, Baer HU, Büchler MW. Experimental study of adhesion formation in open and laparoscopic fundoplication. Br J Surg 1998, 85:826-830. 10.1046/j.1365-2168.1998.00718.x, 9667717.
15. Garrard CL, Clements RH, Nanney L, Davidson JM, Richards WO. Adhesion formation is reduced after laparoscopic surgery. Surg Endosc 1999, 13:10-13. 10.1007/s004649900887, 9869679.
16. Polymeneas G, Theodosopoulos T, Stamatiadis A, Kourias E. A comparative study of postoperative adhesion formation after laparoscopic vs open cholecystectomy. Surg Endosc 2001, 15:41-43. 10.1007/s004640000269, 11178760.
17. Molinaro F, Kaselas C, Lacreuse I, Moog R, Becmeur F. Postoperative intestinal obstruction after laparoscopic versus open surgery in the pediatric population: A 15-year review. Eur J Pediatr Surg 2009, 19:160-162. 10.1055/s-0029-1202858, 19360547.
18. Dijkstra FR, Nieuwenhuijzen M, Reijnen MM, van Goor H. Recent clinical developments in pathophysiology, epidemiology, diagnosis and treatment of intra-abdominal adhesions. Scand J Gastroenterol Suppl 2000, 232:52-59.
19. Al-Jaroudi D, Tulandi T. Adhesion prevention in gynecologic surgery. Obstet Gynecol Surv 2004, 59:360-367. 10.1097/00006254-200405000-00024, 15097797.
20. Alpay Z, Saed GM, Diamond MP. Female infertility and free radicals: potential role in adhesions and endometriosis. J Soc Gynecol Investig 2006, 13:390-398. 10.1016/j.jsgi.2006.05.002, 16872846.
21. Trimbos-Kemper TC, Trimbos JB, van Hall EV. Adhesion formation after tubal surgery: results of the eighth-day laparoscopy in 188 patients. Fertil Steril 1985, 43:395-400.
22. Kresch AJ, Seifer DB, Sachs LB, Barrese I. Laparoscopy in 100 women with chronic pelvic pain. Obstet Gynecol 1984, 64:672-674.
23. Sutton C, MacDonald R. Laser laparoscopic adhesiolysis. J Gynecol Surg 1990, 6:155-159. 10.1089/gyn.1990.6.155, 10150017.
24. Ellis H, Moran BJ, Thompson JN, Parker MC, Wilson MS, Menzies D, McGuire A, Lower AM, Hawthorn RJ, O'Brien F, Buchan S, Crowe AM. Adhesion-related hospital readmissions after abdominal and pelvic surgery: a retrospective cohort study. Lancet 1999, 353:1476-1480. 10.1016/S0140-6736(98)09337-4, 10232313.
25. Diamond MP, Wexner SD, DiZerega GS, et al. Adhesion prevention and reduction: current status and future recommendations of a multinationalinter-disciplinary consensus conference. Surg Innov 2012, 17:183-188.
26. McEntee G, Pender D, Mulvin D, McCullough M, Naeeder S, Farah S, Badurdeen MS, Ferraro V, Cham C, Gillham N. Current spectrum of intestinal obstruction. Br J Surg 1987, 74:976-980. 10.1002/bjs.1800741105, 3690244.
27. Prushik SG, Stucchi AF, Matteotti R, Aarons CB, Reed KL, Gower AC, Becker JM. Open adhesiolysis is more effective in reducing adhesion reformation than laparoscopic adhesiolysis in an experimental model. Br J Surg 2010, 97:420-427. 10.1002/bjs.6899, 20101595.
28. Catena F, Di Saverio S, Kelly MD, Biffl WL, Ansaloni L, Mandalà V, et al. Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2010 evidence-based guidelines of the world society of emergency surgery. World J Emerg Surg 2011, 6:5. 21, 10.1186/1749-7922-6-5, 3037327, 21255429.
29. Ray NF, Larsen JW, Stillman RJ, Jacobs RJ. Economic impact of hospitalizations for lower abdominal adhesiolysis in the United States in 1988. Surg Gynecol Obstet 1993, 176:271-276.
30. Ray NF, Denton WG, Thamer M, Henderson SC, Perry S. Abdominal adhesiolysis: inpatient care and expenditures in the United States in 1994. J Am Coll Surg 1998, 186:1-9. 10.1016/S1072-7515(97)00127-0, 9449594.
31. Atta MH. Prevention of peritoneal adhesions: a promising role for gene therapy. World J Gastroenterol 2011, 17:5049-5058. 10.3748/wjg.v17.i46.5049, 3235588, 22171139.
32. Ellis H, Crowe A. Medico-legal consequences of post-operative intra-abdominal adhesions. Int J Surg 2009, 7:187-191. 10.1016/j.ijsu.2009.04.004, 19389492.
33. Wiseman DM, Trout JR, Diamond MP. The rates of adhesion adhesion development and the effects of crystalloid solutions on adhesion development in pelvic surgery. Fertil Steril 1998, 70:702-711. 10.1016/S0015-0282(98)00270-2, 9797102.
34. Holmdahl L, Eriksson E, Eriksson BI, Risberg B. Depression of peritoneal fibrinolysis during operation is a local response to trauma. Surgery 1998, 123:539-544. 10.1067/msy.1998.86984, 9591006.
35. Ivarsson ML, Bergström M, Eriksson E, Risberg B, Holmdahl L. Tissue markers as predictors of postoperative adhesions. Br J Surg 1998, 85:1549-1554. 10.1046/j.1365-2168.1998.00859.x, 9823923.
36. Holmdahl L, Kotseos K, Bergström M, Falk P, Ivarsson ML, Chegini N. Overproduction of transforming growth factorbeta1 (TGF-beta1) is associated with adhesion formation and peritoneal fibrinolytic impairment. Surgery 2001, 129:626-632. 10.1067/msy.2001.113039, 11331455.
37. Chegini N, Kotseos K, Zhao Y, Bennett B, McLean FW, Diamond MP, Holmdahl L, Burns J. Differential expression of TGF-beta1 and TGF-beta3 in serosal tissues of human intraperitoneal organs and peritoneal adhesions. Hum Reprod 2001, 16:1291-1300. 10.1093/humrep/16.6.1291, 11387308.
38. Cheong YC, Shelton JB, Laird SM, Li TC, Ledger WL, Cooke ID. Peritoneal fluid concentrations of matrix metalloproteinase- 9, tissue inhibitor of metalloproteinase-1, and transforming growth factor-beta in women with pelvic adhesions. Fertil Steril 2003, 79:1168-1175. 10.1016/S0015-0282(03)00079-7, 12738513.
39. Molinas CR, Campo R, Elkelani OA, Binda MM, Carmeliet P, Koninckx PR. Role of hypoxia inducible factors 1alpha and 2alpha in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice. Fertil Steril 2003, 80(Suppl 2):795-802.
40. Segura T, Schmokel H, Hubbell JA. RNA interference targeting hypoxia inducible factor 1alpha reduces post-operative adhesions in rats. J Surg Res 2007, 141:162-170. 10.1016/j.jss.2006.07.045, 17561118.
41. Cahill RA, Wang JH, Soohkai S, Redmond HP. Mast cells facilitate local VEGF release as an early event in the pathogenesis of postoperative peritoneal adhesions. Surgery 2006, 140:108-112. 10.1016/j.surg.2006.01.020, 16857448.
42. Avsar FM, Sahin M, Aksoy F, Avsar AF, Akoz M, Hengirmen S, Bilici S. Effects of diphenhydramine HCl and methylprednisolone in the prevention of abdominal adhesions. Am J Surg 2001, 181(6):512-515. 10.1016/S0002-9610(01)00617-1, 11513775.
43. Sahin M, Cakir M, Avsar FM, Tekin A, Kucukkartallar T, Akoz M. The effects of anti-adhesion materials in preventing postoperative adhesion in abdominal cavity (anti-adhesion materials for postoperative adhesions). Inflammation 2007, 30(6):244-249. 10.1007/s10753-007-9043-1, 17690965.
44. Muzii L, Marana R, Brunetti L, Margutti F, Vacca M, Mancuso S. Postoperative adhesion prevention with low-dose aspirin: effect through the selective inhibition of thromboxane production. Hum Reprod 1998, 13(6):1486-1489. 10.1093/humrep/13.6.1486, 9688377.
45. Oh SH, Kim JK, Song KS, Noh SM, Ghil SH, Yuk SH, Lee JH. Prevention of postsurgical tissue adhesion by anti-inflammatory drug-loaded pluronic mixtures with sol-gel transition behavior. J Biomed Mater Res A 2005, 72(3):306-316.
46. Rodgers KE, Johns DB, Girgis W, diZerega GS. Prevention of adhesion formation with intraperitoneal administration of tolmetin and hyaluronic acid. J Invest Surg 1997, 10(6):367-373. 10.3109/08941939709099600, 9654393.
47. Aldemir M, Ozturk H, Erten C, Buyukbayram H. The preventive effect of rofecoxib in postoperative Intraperitoneal adhesions. Acta Chir Belg 2004, 104(1):97-100.
48. Fukasawa M, Girgis W, diZerega GS. Inhibition of postsurgical adhesions in a standardized rabbit model: II. Intraperitoneal treatment with heparin. Int J Fertil 1991, 36(5):296-301.
49. Kutlay J, Ozer Y, Isik B, Kargici H. Comparative effectiveness of several agents for preventing postoperative adhesions. World J Surg 2004, 28(7):662-665. 10.1007/s00268-004-6825-6, 15184999.
50. Parsak CK, Satar S, Akcam T, Satar D, Sungur I. Effectiveness of treatment to prevent adhesions after abdominal surgery: an experimental evaluation in rats. Adv Ther 2007, 24(4):796-802. 10.1007/BF02849972, 17901028.
51. Aarons CB, Cohen PA, Gower A, Reed KL, Leeman SE, Stucchi AF, et al. Statins (HMG-CoA reductase inhibitors) decrease postoperative adhesions by increasing peritoneal fibrinolytic activity. Ann Surg 2007, 245:176-184. 10.1097/01.sla.0000236627.07927.7c, 1876993, 17245169.
52. Dorr PJ, Vemer HM, Brommer EJ, Willemsen WN, Veldhuizen RW, Rolland R. Prevention of postoperative adhesions by tissuetype plasminogen activator (t-PA) in the rabbit. Eur J Obstet Gynecol Reprod Biol 1990, 37(3):287-291. 10.1016/0028-2243(90)90037-2, 2121563.
53. Celepli{dotless} S, Kismet K, Kaptanoǧlu B, Erel S, Ozer S, Celepli{dotless} P, et al. The effect of oral honey and pollen on postoperative intraabdominal adhesions. Turk J Gastroenterol 2011, 22:65-72.
54. Fang CC, Chou TH, Lin GS, Yen ZS, Lee CC, Chen SC. Peritoneal infusion with cold saline decreased postoperative intra-abdominal adhesion formation. World J Surg 2010, 34:721-727. 10.1007/s00268-009-0378-7, 20049434.
55. Atta HM, Al-Hendy A, El-Rehany MA, Dewerchin M, Abdel Raheim SR, Abdel Ghany H, Fouad R. Adenovirusmediated overexpression of human tissue plasminogen activator prevents peritoneal adhesion formation/reformation in rats. Surgery 2009, 146:12-17. 10.1016/j.surg.2009.02.018, 19541005.
56. Guo H, Leung JC, Cheung JS, Chan LY, Wu EX, Lai KN. Non-viral Smad7 gene delivery and attenuation of postoperative peritoneal adhesion in an experimental model. Br J Surg 2009, 96:1323-1335. 10.1002/bjs.6722, 19847872.
57. Guo Q, Li QF, Liu HJ, Li R, Wu CT, Wang LS. Sphingosine kinase 1 gene transfer reduces postoperative peritoneal adhesion in an experimental model. Br J Surg 2008, 95:252-258.
58. Liu HJ, Wu CT, Duan HF, Wu B, Lu ZZ, Wang L. Adenoviral- mediated gene expression of hepatocyte growth factor prevents postoperative peritoneal adhesion in a rat model. Surgery 2006, 140:441-447. 10.1016/j.surg.2005.12.014, 16934607.
59. Brochhausen C, Schmitt VH, Planck CN, Rajab TK, Hollemann D, Tapprich C, et al. Current strategies and future perspectives for Intraperitoneal adhesion prevention. J Gastrointest Surg 2012, Epub ahead of print.
60. Hellebrekers BW, Kooistra T. Pathogenesis of postoperative adhesion formation. Br J Surg 2011, 98:1503-1516. 10.1002/bjs.7657, 21877324.