Prevention of adhesion formation with intraperitoneal administration of tolmetin and hyaluronic acid

Journal of Investigative Surgery

Volumn 10, Issue 6, 1997, Pages 367-373

  Rodgers, Kathleen E ^a,c   Johns, Douglas B ^b   Girgis, Wefki ^a   DiZerega, Gere S ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b ETHICON INC   (United States)

^c Livingston Repro Biology Laboratory   (United States)

Author keywords

Adhesions; Nonsteroidal anti inflammatory drugs; Peritoneal healing

Indexed keywords

GLYCOSAMINOGLYCAN; HYALURONIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; TOLMETIN;

ABDOMINAL SURGERY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; LAPAROTOMY; MOLECULAR WEIGHT; NONHUMAN; PERITONEUM ADHESION; PRIORITY JOURNAL; RABBIT; VISCOSITY;

EID: 0031395544     PISSN: 08941939     EISSN: None     Source Type: Journal    
DOI: 10.3109/08941939709099600     Document Type: Article

References (25)

1. diZerega GS, Rodgers KE. Intraperitoneal adhesions. In: The Peritoneum. New York: Springer-Verlag, 1992:274-306.
2. Thorton M, diZerega GS. Using barriers to prevent adhesions. Cont Ob/Gyn. 1996;41:107-128.
3. Strickler B, Blanco J, Fox HE. The gynecologic contribution to intestinal obstruction in females. J Am Coll Surg. 1994;178:617-621.
4. Howard FM. The role of laparoscopy in chronic pelvic pain: Promise and pitfalls. Obstet Gynecol Surv. 1993;48: 357-361.
5. Peters AAW, Trimbos-Kemper TCM, Admiraal C, et al. A randomized clinical trial on the benefit of adhesiolysis in patients with intraperitoneal adhesions and chronic pelvic pain. Br J Obstet Gynecol. 1992;99:59-67.
6. DeCherney AH, Mezer HC. The nature of post-tuboplasty pelvic adhesions determined by early and late laparoscopy. Fertil Steril. 1984;41:643-646.
7. Trimbos-Kemper TCM, Trimbos JB, van Hall EV. Adhesion formation after tubal surgery results of the eight-day laparoscopy in 188 patients. Fertil Steril. 1985;43:395-400.
8. Randall RW, Eakins KE, Higgs GA. Inhibition of arachidonic acid cyclo-oxygenase and lipo-oxygenase activities by indomethacin and compound BW755. Agents Actions. 1980;10:553-555.
9. Nishimura K, Nakamura RM, diZerega GS. Ibuprofen inhibition of postsurgical adhesion formation: A time and dose response biochemical evaluation in rabbits. J Surg Res. 1984;36:115-124.
10. Rodgers KE, Girgis W, Johns D, diZerega GS. Intraperitoneal tolmetin prevents postsurgical adhesions formation in rabbits. Int J Infert. 1990;35:40-45.
11. Rodgers KE, Bracken K, Cox G, Richer L, Girgis W, diZerega GS. Inhibition of post-surgical adhesions by liposomes containing anti-inflammatory drugs. Int J Infert. 1990;35:315-320.
12. Urman B, Gomel V. Effect of hyaluronic acid on postoperative intraperitoneal adhesion formation and reformation in the rat model. Fertil Steril. 1991;56:568-570.
13. Urman B, Gomel V. Effect of hyaluronic acid on postoperative intraperitoneal adhesion formation in the rat model. Fertil Steril. 1991;56:563-567.
14. Rodgers KE. Nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of postsurgical adhesions. In: GS diZerega, LR Malinak, MD Diamond, C Linsky, eds. Treatment of Postsurgical Adhesions. New York: Wiley Liss, 1990:119-129.
15. Wiseman DM, Huang WJ, Johns DB, Rodgers KE, diZerega GS. Time-dependent effect of tolmetin sodium in a rabbit uterine horn adhesion model. J Invest Surg. 1994;7:527-532.
16. LeGrand EK, Rodgers KE, Girgis W, Struck K, Campeau JD, diZerega GS, Kiorpes TC. Efficacy of tolmetin sodium for adhesion prevention in rabbit and rat models. J Surg Res. 1994;56:67-71.
17. Comper WD, Larent TC. Physiologic functions of connective tissue polysaccharides. Physiol Rev. 1978;4:255-262.
18. Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature. 1976;238: 104-107.
19. Bonney RJ, Davies P. Possible autoregulatory functions of the secretory products of mononuclear phagocytes. Contemp Topics Immunol. 1984;10:199-223.
20. Rodgers KE, Ellefson DD, Girgis W, Scott L, diZerega GS. Effects of tolmetin sodium dihydrate on normal and post-surgical peritoneal cell function. Int J Immunopharmacol. 1988;10:111-120.
21. Rodgers KE, Ellefson DD, Girgis W, diZerega GS. Protease and protease inhibitor secretion by postsurgical macrophages following in vitro exposure to tolmetin. Agents Actions. 1992;36: 248-255.
22. Rodgers KE, Ellefson DD, Girgis W, diZerega GS. Modulation of postsurgical cell infiltration and fibrinolytic activity by tolmetin in two species. J Surg Res. 1994;56:314-325.
23. Abe H, Rodgers KE, Campeau JD, Girgis W, Ellefson D, diZerega GS. The effect of intraperitoneal administration of sodium tolmetin-hyaluronic acid on the postsurgical cell infiltration in vivo. J Surg Res. 1990;49:322-327.
24. Abe H, Campeau JD, Rodgers KE, Ellefson DD, Girgis W, diZerega GS. Peritoneal lavage fluid protease levels after in vivo administration of tolmetin in hyaluronic acid. J Surg Res. 1993;55:1-6.
25. Rodgers KE, Abe H, Campeau JD, Ellefson D, Girgis W, diZerega GS. In vivo administration of tolmetin in hyaluronic acid modulates protease levels in post-surgical macrophage conditioned media. J Invest Surg. 1992;5: 285-291.