Synthesis of kojic acid-derived copper-chelating apoptosis inducing agents

Medicinal Chemistry Research

Volumn 22, Issue 2, 2013, Pages 995-1003

  Chen, Yu Hua ^a   Lu, Pei Jung ^b   Hulme, Christopher ^c   Shaw, Arthur Y ^c  

^a TAMKANG UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

Apoptosis inducing agents; Copper chelating effect; Kojic acid; Mitogen activated protein (MAP) kinases

Indexed keywords

2 (3,4 DIHYDROXYSTYRYL) 5 HYDROXY 4H PYRAN 4 ONE; 2 (HYDROXYMETHYL) 5 (4 METHOXYBENZYLOXY) 4H PYRAN 4 ONE; 5 (4 METHOXYBENZYLOXY) 2 [(QUINOLIN 8 YLOXY)METHYL] 4H PYRAN 4 ONE; 5 (4 METHOXYBENZYLOXY) 2 BROMOMETHYL 4H PYRAN 4 ONE; 5 (BENZYLOXY) 2 (3,4 DIMETHOXYSTYRYL) 4H PYRAN 4 ONE; 5 (BENZYLOXY) 2 (BROMOMETHYL) 4H PYRAN 4 ONE; 5 (BENZYLOXY) 2 (HYDROXYMETHYL) 4H PYRAN 4 ONE; 5 (BENZYLOXY) 2 [(3 HYDROXYPHENOXY)METHYL] 4H PYRAN 4 ONE; 5 (BENZYLOXY) 2 [[4 (PHENYLSULFONYL)PIPERAZIN 1 YL]METHYL] 4H PYRAN 4 ONE; 5 (BENZYLOXY) 2 STYRYL 4H PYRAN 4 ONE; 5 HYDROXY 2 [(3 HYDROXYPHENOXY)METHYL] 4H PYRAN 4 ONE; 5 HYDROXY 2 [(QUINOLIN 8 YLOXY)METHYL] 4H PYRAN 4 ONE; 5 HYDROXY 2 [[4 (PHENYLSULFONYL)PIPERAZIN 1 YL]METHYL] 4H PYRAN 4 ONE; 5 HYDROXY 2 STYRYL 4H PYRAN 4 ONE; [5 (4 METHOXYBENZYLOXY) 4 OXO 4H PYRAN 2 YL]METHYL METHANESULFONATE; [5 (BENZYLOXY) 4 OXO 4H PYRAN 2 YL]METHYL METHANESULFONATE; CASPASE 3; CHELATING AGENT; COPPER ION; DIETHYL [5 (BENZYLOXY) 4 OXO 4H PYRAN 2 YL]METHYLPHOSPHONATE; DIETHYL [[5 [(4 METHOXYBENZYL)OXY] 4 OXO 4H PYRAN 2 YL]METHYL]PHOSPHONATE; KOJIC ACID; MITOGEN ACTIVATED PROTEIN KINASE P38; POLY(ADENOSINE DIPHOSPHATE RIBOSE); UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CYTOSOL; DNA FRAGMENTATION; DOSE RESPONSE; DRUG SYNTHESIS; ENZYME ACTIVATION; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; GROWTH INHIBITION; HELA CELL; HYDROPHOBICITY; OXIDATIVE STRESS; PROTEIN CLEAVAGE; WESTERN BLOTTING;

EID: 84873989368     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-012-0094-y     Document Type: Article

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