Advances in the bioconversion mechanism of lovastatin to wuxistatin by Amycolatopsis sp. CGMCC 1149

Applied Microbiology and Biotechnology

Volumn 97, Issue 2, 2013, Pages 599-609

  Zong, Hong ^a   Zhuge, Bin ^a   Fang, Huiying ^a   Cao, Yanhui ^a   Mu, Lin ^a   Fu, Weilai ^a   Song, Jian ^a   Zhuge, Jian ^a  

^a JIANGNAN UNIVERSITY   (China)

Author keywords

Biconversion; Cytochrome P450; Hydroxylation; Lovastatin; Product I; Wuxistatin

Indexed keywords

BICONVERSION; CELL-FREE SYSTEM; CYTOCHROME P450; FERMENTATION BROTHS; GTP-BINDING PROTEINS; HYDROXYL GROUPS; HYDROXYLASES; HYDROXYLATION REACTIONS; INTEGRAL MEMBRANE PROTEINS; INTERMEDIATE PRODUCT; INTRAMOLECULAR TRANSFER; ISOMERASES; ISOTOPE TRACING; LOVASTATIN; METHYL GROUP; OXIDOREDUCTASES; PROTEOMICS; STRUCTURE ANALYSIS; WUXISTATIN;

BIOLOGICAL MEMBRANES; FUNCTIONAL GROUPS; HYDROXYLATION; ISOTOPES; MOLECULAR BIOLOGY; ORGANIC ACIDS;

PROTEINS;

ASCORBIC ACID; CARBON DIOXIDE; CYTOCHROME P450; GUANINE NUCLEOTIDE BINDING PROTEIN; HYDROXYL GROUP; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEMBRANE PROTEIN; MEVINOLIN; NUCLEOTIDE BINDING PROTEIN; OXYGENASE; UNCLASSIFIED DRUG; WUXISTATIN;

ASCORBIC ACID; BACTERIUM; CYTOCHROME; DRUG; ENZYME ACTIVITY; FERMENTATION; INHIBITION; MEMBRANE; PROTEIN;

AMYCOLATOPSIS; ARTICLE; BACTERIUM; CELL FREE SYSTEM; DRUG HYDROXYLATION; DRUG TRANSFORMATION; ELECTROSPRAY MASS SPECTROMETRY; FERMENTATION MEDIUM; ISOTOPE TRACING; NONHUMAN; PROTEOMICS;

ACTINOMYCETALES; BUTYRATES; CYTOCHROME P-450 ENZYME SYSTEM; HYDROXYLATION; LOVASTATIN;

AMYCOLATOPSIS SP.;

EID: 84873988486     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-012-4341-4     Document Type: Article

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