Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition

Journal of Structural Biology

Volumn 181, Issue 3, 2013, Pages 243-251

  Alicea Velázquez, Nilda L ^a   Jakoncic, Jean ^b   Boggon, Titus J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

Crystal structure; Cytokine signaling; JAK STAT; Phosphatase; Protein protein interaction; PTP1B

Indexed keywords

JANUS KINASE 1; PHOSPHATASE; PHOSPHATE; PHOSPHOTYROSINE; PROTEIN TYROSINE PHOSPHATASE SHP 1; SULFATE;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; THERMODYNAMICS;

CALORIMETRY; CATALYTIC DOMAIN; JANUS KINASE 1; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6; X-RAY DIFFRACTION;

EID: 84873987697     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2012.12.009     Document Type: Article

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