TCR-γ expression in primary cutaneous T-cell lymphomas

American Journal of Surgical Pathology

Volumn 37, Issue 3, 2013, Pages 375-384

  Rodríguez Pinilla, Socorro Maria ^a,b   Ortiz Romero, Pablo L ^c   Monsalvez, Verónica ^c   Tomás, Itziar Eraña ^d   Almagro, Manuel ^h   Sevilla, Amparo ⁱ   Camacho, Gloria ^j   Longo, María Isabel ^e   Pulpillo, Águeda ^k   Diaz Pérez, Julio Alexander ^o   Montes Moreno, Santiago ^a,l   Castro, Yolanda ^e   Echevarría, Begoña ^m   Trébol, Izaskun ⁿ   Gonzalez, Carlos ^f   Sánchez, Lydia ^g   Otín, Alberto Puime ^b   Requena, Luis ^a   Rodríguez Peralto, Jose L ^d   Cerroni, Lorenzo ^p   Piris, Miguel Ángel ^a,l   more..

^a HOSPITAL UNIVERSITARIO FUNDACIÓN JIMÉNEZ DÍAZ   (Spain)

^b Hospital UniversitarioFundación Jiménez Díaz   (Spain)

^c HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^d Pathology Department   (Spain)

^e HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^f HOSPITAL UNIVERSITARIO DE GETAFE   (Spain)

^g Structural Biology and Biocomputing Programme   (Spain)

^h HOSPITAL JUAN CANALEJO   (Spain)

ⁱ HOSPITAL UNIVERSITARIO DE SAN JUAN   (Spain)

^j HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^k HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^l HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^m Hospital Virgen del Castillo   (Spain)

ⁿ HOSPITAL TXAGORRITXU   (Spain)

^o UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^p MEDICAL UNIVERSITY OF GRAZ   (Austria)

more..

Author keywords

CTCL; prognosis; TCR g

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR;

ADULT; AGED; ARTICLE; BIOSYNTHESIS; CUTANEOUS T CELL LYMPHOMA; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; POLYMERASE CHAIN REACTION; SKIN TUMOR; TISSUE MICROARRAY;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOMA, T-CELL, CUTANEOUS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SKIN NEOPLASMS; TISSUE ARRAY ANALYSIS;

EID: 84873987083     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e318275d1a2     Document Type: Article

References (67)

1. Aifantis I, Mandal M, Sawai K, et al. Regulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor. Immunol Rev. 2006;209:159-169.
2. Pechloff K, Holch J, Ferch U, et al. The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma. J Exp Med. 2010;207:1031-1044.
3. Serwold T, Hochedlinger K, Swindle J, et al. T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell. Proc Natl Acad Sci USA. 2010;107:18939-18943.
4. Wang X, Werneck MB, Wilson BG, et al. TCR-dependent transformation of mature memory phenotype T cells in mice. J Clin Invest. 2011;121:3834-3845.
5. Rojo JM, Bello R, Portoles P. T-cell receptor. Adv Exp Med Biol. 2008;640:1-11.
6. Lee SY, Stadanlick J, Kappes DJ, et al. Towards a molecular understanding of the differential signals regulating alphabeta/gammadelta T lineage choice. Semin Immunol. 2010;22:237-246.
7. Tripodo C, Iannitto E, Florena AM, et al. Gamma-delta T-cell lymphomas. Nat Rev Clin Oncol. 2009;6:707-717.
8. Swerdlow S, Campo E, Lee Harris N, et al. WHO classification of tumours of haematopoietic and ymphoid tissues. Mature T and NKcell Neoplasms. Lyon: IARC; 2008:269-321.
9. Aoyama Y, Yamane T, Hino M, et al. Nodal gamma/delta T cell lymphoma in complete remission following allogeneic bone marrow transplantation from an HLA-matched unrelated donor. Acta Haematol. 2001;105:49-52.
10. Arnulf B, Copie-Bergman C, Delfau-Larue MH, et al. Nonhepatosplenic gammadelta T-cell lymphoma: a subset of cytotoxic lymphomas with mucosal or skin localization. Blood. 1998;91: 1723-1731.
11. Chan JK, Chan AC, Cheuk W, et al. Type II enteropathy-associated T-cell lymphoma: a distinct aggressive lymphoma with frequent gammadelta T-cell receptor expression. Am J Surg Pathol. 2011;35:1557-1569.
12. Charton-Bain MC, Brousset P, Bouabdallah R, et al. Variation in the histological pattern of nodal involvement by gamma/delta T-cell lymphoma. Histopathology. 2000;36:233-239.
13. García-Herrera A, Song JY, Chuang SS, et al. Nonhepatosplenic gammadelta T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation. Am J Surg Pathol. 2011;35:1214-1225.
14. Gardner RV, Velez MC, Ode DL, et al. Gamma/delta T-cell lymphoma as a recurrent complication after transplantation. Leuk Lymphoma. 2004;45:2355-2359.
15. Harabuchi Y, Imai S, Wakashima J, et al. Nasal T-cell lymphoma causally associated with Epstein-Barr virus: clinicopathologic, phenotypic, and genotypic studies. Cancer. 1996;77:2137-2149.
16. Jaffe ES, Krenacs L, Kumar S, et al. Extranodal peripheral T-cell and NK-cell neoplasms. Am J Clin Pathol. 1999;111:S46-S55.
17. Kagami Y, Nakamura S, Suzuki R, et al. A nodal gamma/delta T-cell lymphoma with an association of Epstein-Barr virus. Am J Surg Pathol. 1997;21:729-736.
18. Ohshima K, Suzumiya J, Sugihara M, et al. Clinical, immunohistochemical and phenotypic features of aggressive nodal cytotoxic lymphomas, including alpha/beta, gamma/delta T-cell and natural killer cell types. Virchows Arch. 1999;435:92-100.
19. Wong KF, Chan JK, Matutes E, et al. Hepatosplenic gamma delta T-cell lymphoma. A distinctive aggressive lymphoma type. Am J Surg Pathol. 1995;19:718-726.
20. Yamaguchi M, Ohno T, Nakamine H, et al. Gamma delta T-cell lymphoma: a clinicopathologic study of 6 cases including extrahepatosplenic type. Int J Hematol. 1999;69:186-195.
21. Toro JR, Liewehr DJ, Pabby N, et al. Gamma-delta T-cell phenotype is associated with significantly decreased survival in cutaneous T-cell lymphoma. Blood. 2003;101:3407-3412.
22. Willemze R, Jansen PM, Cerroni L, et al. Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases. Blood. 2008;111:838-845.
23. Willemze R, Meijer CJ. Classification of cutaneous T-cell lymphoma: from Alibert to WHO-EORTC. J Cutan Pathol. 2006;33(suppl 1):18-26.
24. Ciofani M, Zuniga-Pflucker JC. Determining gammadelta versus alphabeta T cell development. Nat Rev Immunol. 2010;10:657-663.
25. Roullet M, Gheith SM, Mauger J, et al. Percentage of {gamma} {delta} T cells in panniculitis by paraffin immunohistochemical analysis. Am J Clin Pathol. 2009;131:820-826.
26. Willemze R, Jaffe ES, Burg G, et al. WHO-EORTC classification for cutaneous lymphomas. Blood. 2005;105:3768-3785.
27. Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours and Haematopoietic and Lymphoid Tissues. Lyon: IARC; 2008.
28. Saggini A, Gulia A, Argenyi Z, et al. A variant of lymphomatoid papulosis simulating primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma. Description of 9 cases. Am J Surg Pathol. 2010;34:1168-1175.
29. Garcia JF, Camacho FI, Morente M, et al. Hodgkin and Reed-Sternberg cells harbor alterations in the major tumor suppressor pathways and cell-cycle checkpoints: analyses using tissue microarrays. Blood. 2003;101:681-689.
30. Chang KL, Chen YY, Shibata D, et al. Description of an in situ hybridization methodology for detection of Epstein-Barr virus RNA in paraffin-embedded tissues, with a survey of normal and neoplastic tissues. Diagn Mol Pathol. 1992;1:246-255.
31. Kanavaros P, Lescs MC, Briere J, et al. Nasal T-cell lymphoma: a clinicopathologic entity associated with peculiar phenotype and with Epstein-Barr virus. Blood. 1993;81:2688-2695.
32. van Dongen JJ, Langerak AW, Bruggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia. 2003;17:2257-2317.
33. Groenen PJ, Langerak AW, van Dongen JJ, et al. Pitfalls in TCR gene clonality testing: teaching cases. J Hematop. 2008;1:97-109.
34. Bruggemann M, White H, Gaulard P, et al. Powerful strategy for polymerase chain reaction-based clonality assessment in T-cell malignancies Report of the BIOMED-2 Concerted Action BHM4 CT98-3936. Leukemia. 2007;21:215-221.
35. Berti E, Tomasini D, Vermeer MH, et al. Primary cutaneous CD8-positive epidermotropic cytotoxic T cell lymphomas. A distinct clinicopathological entity with an aggressive clinical behavior. Am J Pathol. 1999;155:483-492.
36. Berti E, Cerri A, Cavicchini S, et al. Primary cutaneous gamma/delta T-cell lymphoma presenting as disseminated pagetoid reticulosis. J Invest Dermatol. 1991;96:718-723. 35.
37. Huang Y, de Reynies A, de Leval L, et al. Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK/T-cell lymphoma, nasal type. Blood. 2010;115:1226-1237.
38. Iqbal J, Weisenburger DD, Chowdhury A, et al. Natural killer cell lymphoma shares strikingly similar molecular features with a group of non-hepatosplenic gammadelta T-cell lymphoma and is highly sensitive to a novel aurora kinase A inhibitor in vitro. Leukemia. 2011;25:348-358.
39. Caudron A, Bouaziz JD, Battistella M, et al. Two atypical cases of cutaneous gamma/delta T-cell lymphomas. Dermatology. 2011;222:297-303.
40. Chiang AK, Chan AC, Srivastava G, et al. Nasal T/natural killer (NK)-cell lymphomas are derived from Epstein-Barr virus-infected cytotoxic lymphocytes of both NK-and T-cell lineage. Int J Cancer. 1997;73:332-338.
41. Chiang AK, Srivastava G, Lau PW, et al. Differences in T-cellreceptor gene rearrangement and transcription in nasal lymphomas of natural killer and T-cell types: implications on cellular origin. Hum Pathol. 1996;27:701-707.
42. Ko YH, Ree HJ, Kim WS, et al. Clinicopathologic and genotypic study of extranodal nasal-type natural killer/T-cell lymphoma and natural killer precursor lymphoma among Koreans. Cancer. 2000;89:2106-2116.
43. Ng SB, Lai KW, Murugaya S, et al. Nasal-type extranodal natural killer/T-cell lymphomas: a clinicopathologic and genotypic study of 42 cases in Singapore. Mod Pathol. 2004;17:1097-1107.
44. Florell SR, Cessna M, Lundell RB, et al. Usefulness (or lack thereof) of immunophenotyping in atypical cutaneous T-cell infiltrates. Am J Clin Pathol. 2006;125:727-736.
45. Izban KF, Hsi ED, Alkan S. Immunohistochemical analysis of mycosis fungoides on paraffin-embedded tissue sections. Mod Pathol. 1998;11:978-982.
46. El-Shabrawi-Caelen L, Cerroni L, Medeiros LJ, et al. Hypopigmented mycosis fungoides: frequent expression of a CD8+ T-cell phenotype. Am J Surg Pathol. 2002;26:450-457.
47. Hodak E, David M, Maron L, et al. CD4/CD8 double-negative epidermotropic cutaneous T-cell lymphoma: an immunohistochemical variant of mycosis fungoides. J Am Acad Dermatol. 2006;55:276-284.
48. Lu D, Patel KA, Duvic M, et al. Clinical and pathological spectrum of CD8-positive cutaneous T-cell lymphomas. J Cutan Pathol. 2002;29:465-472.
49. Massone C, Crisman G, Kerl H, et al. The prognosis of early mycosis fungoides is not influenced by phenotype and T-cell clonality. Br J Dermatol. 2008;159:881-886.
50. Nikolaou VA, Papadavid E, Katsambas A, et al. Clinical characteristics and course of CD8+ cytotoxic variant of mycosis fungoides: a case series of seven patients. Br J Dermatol. 2009;161:826-830.
51. Pavlovsky L, Mimouni D, Amitay-Laish I, et al. Hyperpigmented mycosis fungoides: An unusual variant of cutaneous T-cell lymphoma with a frequent CD8+ phenotype. J Am Acad Dermatol. 2011;67: 69-75.
52. Vermeer MH, van Doorn R, Dukers D, et al. CD8+ T cells in cutaneous T-cell lymphoma: expression of cytotoxic proteins, Fas Ligand, and killing inhibitory receptors and their relationship with clinical behavior. J Clin Oncol. 2001;19:4322-4329.
53. Whittam LR, Calonje E, Orchard G, et al. CD8-positive juvenile onset mycosis fungoides: an immunohistochemical and genotypic analysis of six cases. Br J Dermatol. 2000;143:1199-1204.
54. Vermeer MH, Geelen FA, Kummer JA, et al. Expression of cytotoxic proteins by neoplastic T cells in mycosis fungoides increases with progression from plaque stage to tumor stage disease. Am J Pathol. 1999;154:1203-1210.
55. Barzilai A, Goldberg I, Shibi R, et al. Mycosis fungoides expressing gamma/delta T-cell receptors. J Am Acad Dermatol. 1996;34:301-302.
56. Munn SE, McGregor JM, Jones A, et al. Clinical and pathological heterogeneity in cutaneous gamma-delta T-cell lymphoma: a report of three cases and a review of the literature. Br J Dermatol. 1996;135:976-981.
57. Agar NS, Wedgeworth E, Crichton S, et al. Survival outcomes and prognostic factors in mycosis fungoides/Sezary syndrome: validation of the revised International Society for Cutaneous Lymphomas/European Organisation for Research and Treatment of Cancer staging proposal. J Clin Oncol. 2010;28:4730-4739.
58. Vergier B, de Muret A, Beylot-Barry M, et al. Transformation of mycosis fungoides: clinicopathological and prognostic features of 45 cases. French Study Group of Cutaneous Lymphomas. Blood. 2000;95:2212-2218.
59. Barberio E, Thomas L, Skowron F, et al. Transformed mycosis fungoides: clinicopathological features and outcome. Br J Dermatol. 2007;157:284-289.
60. Benner MF, Jansen PM, Vermeer MH, et al. Prognostic factors in transformed mycosis fungoides: a retrospective analysis of 100 cases. Blood. 2012;119:1643-1649.
61. KempfW, Pfaltz K, Vermeer MH, et al. EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. Blood. 2011;118:4024-4035.
62. Kinney MC, Jones D. Cutaneous T-cell and NK-cell lymphomas: the WHO-EORTC classification and the increasing recognition of specialized tumor types. Am J Clin Pathol. 2007;127: 670-686.
63. Whittaker S, Smith N, Jones RR, et al. Analysis of beta, gamma, and delta T-cell receptor genes in lymphomatoid papulosis: cellular basis of two distinct histologic subsets. J Invest Dermatol. 1991;96:786-791.
64. Pongpruttipan T, Sukpanichnant S, Assanasen T, et al. Extranodal NK/T-cell lymphoma, nasal type, includes cases of natural killer cell and alphabeta, gammadelta, and alphabeta/gammadelta T-cell origin: a comprehensive clinicopathologic and phenotypic study. Am J Surg Pathol. 2012;36:481-499.
65. Morgan NV, Goddard S, Cardno TS, et al. Mutation in the TCRalpha subunit constant gene (TRAC) leads to a human immunodeficiency disorder characterized by a lack of TCRalphabeta+ T cells. J Clin Invest. 2011;121:695-702.
66. Khor B, Wehrly TD, Sleckman BP. Chromosomal excision of TCRdelta chain genes is dispensable for alphabeta T cell lineage commitment. Int Immunol. 2005;17:225-232.
67. Gerber D, Boucontet L, Pereira P. Early expression of a functional TCRbeta chain inhibits TCRgamma gene rearrangements without altering the frequency of TCRgammadelta lineage cells. J Immunol. 2004;173:2516-2523.