Expression of cytotoxic proteins by neoplastic T cells in mycosis fungoides increases with progression from plaque stage to tumor stage disease

American Journal of Pathology

Volumn 154, Issue 4, 1999, Pages 1203-1210

  Vermeer, Maarten H ^a   Geelen, Francoise A M J ^a   Kummer, J Alain ^a   Meijer, Chris J L M ^a   Willemze, Rein ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC FACTOR; GRANZYME B; T LYMPHOCYTE ANTIGEN;

ARTICLE; BLAST TRANSFORMATION; CANCER CELL; CANCER STAGING; CYTOTOXIC T LYMPHOCYTE; DISEASE ASSOCIATION; DISEASE COURSE; HUMAN; MAJOR CLINICAL STUDY; MYCOSIS FUNGOIDES; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SKIN TUMOR; SURVIVAL RATE; T CELL LYMPHOMA; TUMOR BIOPSY; TUMOR GROWTH;

EID: 0032921874     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65372-2     Document Type: Article

References (37)

1. Lichtenheld MG, Olsen KJ, Lu P, Lowrey DM, Hameed A, Hengartner H, Podack ER: Structure and function of human perforin. Nature 1988, 335:448-451
2. Krahenbuhl O, Rey C, Jenne D, Lanzavecchia A, Groscurth P, Carrel S, Tschopp J: Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes. J Immunol 1988, 141:3471-3477
3. Griffiths GM, Mueller C: Expression of perforin and granzymes in vivo: potential diagnostic markers for activated cytotoxic cells. Immunol Today 1991, 12:415-419
4. Anderson P, Nagler-Anderson C, O'Brien C, Levine H, Watkins S, Slayter HS, Blue ML, Schlossman SF: A monoclonal antibody reactive with a 15-kDa cytoplasmic granule-associated protein defines a sub-population of CD8+ T lymphocytes. J Immunol 1990, 144:574-582
5. Anderson P: TIA-1: structural and functional studies on a new class of cytolytic effector molecule. Curr Top Microbiol Immunol 1995, 198: 131-143
6. Froelich CJ, Hanna WL, Poirier GG, Duriez PJ, Damours D, Salvesen GS, Alnemri ES, Earnshaw WC, Shah GM: Granzyme B perforin-mediated apoptosis of Jurkat cells results in cleavage of poly (ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment. Biochem Biophys Res Commun 1996, 227: 658-665
7. Froelich CJ, Orth K, Turbov J, Seth P, Gottlieb R, Babior B, Shah GM, Bleackley RC, Dixit VM, Hanna W: New paradigm for lymphocyte granule-mediated cytotoxicity: target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis. J Biol Chem 1996, 271:29073-29079
8. Froelich CJ, Dixit VM, Yang XH: Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases. Immunol Today 1998, 19:30-36
9. Shi LF, Chen G, He DL, Bosc DG, Litchfield DW, Greenberg AH: Granzyme B induces apoptosis and cyclin A-associated cyclin-dependent kinase activity in all stages of the cell cycle. J Immunol 1996, 157:2381-2385
10. Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW, Yuan JY: Human ICE/CED-3 protease nomenclature. Cell 1996, 87:171
11. Zou H, Henzel WJ, Liu XS, Lutschg A, Wang XD: APAF-1, a human protein homologous to c-elegans CED-4, participates in cytochrome C-dependent activation of caspase-3. Cell 1997, 90:405-413
12. De Bruin PC, Kummer JA, Van der Valk P, Van Heerde P, Kluin PM, Willemze R, Ossenkoppele GJ, Radaszkiewicz T, Meijer CJ: Granzyme B-expressing peripheral T-cell lymphomas: neoplastic equivalents of activated cytotoxic T cells with preference for mucosa-associated lymphoid tissue localization. Blood 1994, 84:3785-3791
13. De Bruin PC, Connolly CE, Oudejans JJ, Kummer JA, Jansen W, McCarthy CF, Meijer CM: Enteropathy-associated T-cell lymphomas have a cytotoxic T-cell phenotype. Histopathology 1997, 31:313-317
14. Daum S, Foss HD, Anagnostopoulos I, Dederke B, Demel G, Araujo I, Riecken EO, Stein H: Expression of cytotoxic molecules in intestinal T-cell lymphomas: the German Study Group on intestinal non-Hodgkin lymphoma. J Pathol 1997, 182:311-317
15. Van Gorp J, De Bruin PC, Siego DS, Van Heerde P, Ossenkoppele GJ, Rademakers LM, Meijer CM, Vandentweel JG: Nasal T-cell lymphoma: a clinicopathological and immunophenotypic analysis of 13 cases. Histopathology 1995, 27:139-148
16. Ohshima K, Suzumiya J, Shimazaki K, Kato A, Tanaka T, Kanda M, Kikuchi M: Nasal T/NK cell lymphomas commonly express perforin and Fas ligand: important mediators of tissue damage. Histopathology 1997, 31:444-450
17. Foss HD, Anagnostopoulos I, Araujo I, Assaf C, Demel G, Kummer JA, Hummel M, Stein H: Anaplastic large-cell lymphomas of T-cell and null-cell phenotype express cytotoxic molecules. Blood 1996, 88:4005-4011
18. Oudejans JJ, Kummer JA, Jiwa M, Van der Valk P, Ossenkoppele GJ, Kluin PM, Kluin-Nelemans JC, Meijer CM: Granzyme B expression in Reed-Sternberg cells of Hodgkins disease. Am J Pathol 1996, 148: 233-240
19. Krenacs L, Wellmann A, Sorbara L, Himmelmann AW, Bagdi E, Jaffe ES, Raffeld M: Cytotoxic cell antigen expression in anaplastic large cell lymphomas of T- and null-cell type and Hodgkin's disease: evidence for distinct cellular origin. Blood 1997, 89:980-989
20. Kummer JA, Vermeer MH, Dukers D, Meijer CJ, Willemze R: Most primary cutaneous CD30-positive lymphoproliferative disorders have a CD4-positive cytotoxic T-cell phenotype. J Invest Dermatol 1997, 109:636-640
21. Willemze R, Kerl H, Sterry W, Berti E, Cerroni L, Chimenti S, Diazperez JL, Geerts ML, Goos M, Knobler R, Ralfkiaer E, Santucci M, Smith N, Wechsler J, Van Vloten WA, Meijer CM: EORTC classification for primary cutaneous lymphomas: a proposal from the cutaneous lymphoma study group of the European organization for research and treatment of cancer. Blood 1997, 90:354-371
22. Diamandidou E, Cohen PR, Kurzrock R: Mycosis fungoides and Sezary syndrome. Blood 1996, 88:2385-2409
23. Dmitrovsky E, Matthews MJ, Bunn PA, Schechter GP, Makuch RW, Winkler CF, Eddy J, Sausville EA, Ihde DC: Cytologic transformation in cutaneous T cell lymphoma: a clinicopathologic entity associated with poor prognosis. J Clin Oncol 1987, 5:208-215
24. Greer JP, Salhany KE, Cousar JB, Fields JP, King LE, Graber SE, Flexner JM, Stein RS, Collins RD: Clinical features associated with transformation of ceribriform T-cell lymphoma to a large cell process. Hematol Oncol 1990, 8:215-227
25. Kummer JA, Kamp AM, Van Katwijk M, Brakenhoff JP, Radosevic K, van Leeuwen AM, Borst J, Verweij CL, Hack CE: Production and characterization of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins. J Immunol Methods 1993, 163:77-83
26. Kummer JA, Kamp AM, Tadema TM, Vos W, Meijer CJ, Hack CE: Localization and identification of granzymes A and B-expressing cells in normal human lymphoid tissue and peripheral blood. Clin Exp Immunol 1995, 100:164-172
27. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958, 53:457-481
28. Hanson RD, Sclar GM, Kanagawa O, Ley TJ: The 5′-flanking region of the human CGL-1/granzyme B gene targets expression of a reporter gene to activated T-lymphocytes in transgenic mice. J Biol Chem 1991, 266:24433-24438
29. Russell GJ, Nagler-Anderson C, Anderson P, Bhan AK: Cytotoxic potential of intraepithelial lymphocytes (IELs): presence of TIA-1, the cytolytic granule-associated protein, in human IELs in normal and diseased intestine. Am J Pathol 1993, 143:350-354
30. Asadullah K, Friderich M, Haeussler A, Sterry W, Docke WD, Volk HD: Granzyme A mRNA expression in mycosis fungoides progression. Blood 1997, 90:3810-3811
31. Hoppe RT, Medeiros LJ, Warnke RA, Wood GS: CD8-positive tumor-infiltrating lymphocytes influence the long-term survival of patients with mycosis fungoides. J Am Acad Dermatol 1995, 32:448-453
32. Muller C, Tschopp J: Resistance of CTL to perforin-mediated lysis: evidence for a lymphocyte membrane protein interacting with perforin. J Immunol 1994, 153:2470-2478
33. Sun JR, Bird CH, Sutton V, Mcdonald L, Coughlin PB, Dejong TA, Trapani JA, Bird PI: A Cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier a is present in cytotoxic lymphocytes. J Biol Chem 1996, 271:27802-27809
34. Fleischer B: Acquisition of specific cytotoxic activity by human T4+ T lymphocytes in culture. Nature 1984, 308:365-367
35. Susskind B, Shornick MD, Iannotti MR, Duffy B, Mehrotra PT, Siegel JP, Mohanakumar T: Cytolytic effector mechanisms of human CD4+ cytotoxic T lymphocytes. Hum Immunol 1996, 45:64-75
36. Williams NS, Engelhard VH: Perforin-dependent cytotoxic activity and lymphokine secretion by CD4+ T cells are regulated by CD8+ T cells. J Immunol 1997, 159:2091-2099
37. Kim YH, Bishop K, Varghese A, Hoppe RT: Prognostic factors in erythrodermic mycosis fungoides and the Sezary syndrome. Arch Dermatol 1995, 131:1003-1008