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Volumn 8, Issue , 2013, Pages 495-504

Liposomes and nanotechnology in drug development: Focus on ocular targets

Author keywords

Age related macular degeneration; APRPG modified PEGylated liposome; DDS; Drug delivery system; Intravitreal injection

Indexed keywords

AFLIBERCEPT; AMIKACIN; AMPHOTERICIN B; AMPHOTERICIN B LIPID COMPLEX; ANGIOGENESIS INHIBITOR; BEVACIZUMAB; CYCLOSPORIN; DENDRIMER; FLOXURIDINE PHOSPHATE; FLUCONAZOLE; GANCICLOVIR; GENTAMICIN; LIPOSOME; MACROGOL; MICROSPHERE; NANOSPHERE; OFLOXACIN; OLIGONUCLEOTIDE; PEGAPTANIB; PHOSPHATIDYLGLYCEROL; POLYLACTIC ACID; PROTEIN TYROSINE KINASE INHIBITOR; RANIBIZUMAB; SEMAXANIB; TACROLIMUS; TILISOLOL; TOBRAMYCIN; UNINDEXED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE; VERTEPORFIN;

EID: 84873942340     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S30725     Document Type: Review
Times cited : (118)

References (67)
  • 1
    • 0346848865 scopus 로고    scopus 로고
    • Nanotech approaches to drug delivery and imaging
    • Sahoo SK, Labhasetwar V. Nanotech approaches to drug delivery and imaging. Drug Discov Today. 2003;8(24):1112-1120.
    • (2003) Drug Discov Today , vol.8 , Issue.24 , pp. 1112-1120
    • Sahoo, S.K.1    Labhasetwar, V.2
  • 3
    • 84860645250 scopus 로고    scopus 로고
    • Nanomaterials for ocular drug delivery
    • Liu S, Jones L, Gu FX. Nanomaterials for ocular drug delivery. Macromol Biosci. 2012;12(5):608-620.
    • (2012) Macromol Biosci , vol.12 , Issue.5 , pp. 608-620
    • Liu, S.1    Jones, L.2    Gu, F.X.3
  • 6
    • 0022362287 scopus 로고
    • Transport processes across the rabbit corneal epithelium: A review
    • Klyce SD, Crosson CE. Transport processes across the rabbit corneal epithelium: a review. Curr Eye Res. 1985;4(4):323-331.
    • (1985) Curr Eye Res , vol.4 , Issue.4 , pp. 323-331
    • Klyce, S.D.1    Crosson, C.E.2
  • 7
    • 45849137107 scopus 로고    scopus 로고
    • Ocular novel drug delivery: Impacts of membranes and barriers
    • Barar J, Javadzadeh AR, Omidi Y. Ocular novel drug delivery: impacts of membranes and barriers. Expert Opin Drug Deliv. 2008; 5(5):567-581.
    • (2008) Expert Opin Drug Deliv , vol.5 , Issue.5 , pp. 567-581
    • Barar, J.1    Javadzadeh, A.R.2    Omidi, Y.3
  • 8
    • 63949084823 scopus 로고    scopus 로고
    • Recent perspectives in ocular drug delivery
    • Gaudana R, Jwala J, Boddu SH, Mitra AK. Recent perspectives in ocular drug delivery. Pharm Res. 2009;26(5):1197-1216.
    • (2009) Pharm Res , vol.26 , Issue.5 , pp. 1197-1216
    • Gaudana, R.1    Jwala, J.2    Boddu, S.H.3    Mitra, A.K.4
  • 9
    • 0023025682 scopus 로고
    • Treatment of cytomegalovirus retinopathy in patients with acquired immunodeficiency syndrome. Use of the experimental drug 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine
    • Holland GN, Sakamoto MJ, Hardy D, Sidikaro Y, Kreiger AE, Frenkel LM. Treatment of cytomegalovirus retinopathy in patients with acquired immunodeficiency syndrome. Use of the experimental drug 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine. Arch Ophthalmol. 1986;104(12):1794-1800.
    • (1986) Arch Ophthalmol , vol.104 , Issue.12 , pp. 1794-1800
    • Holland, G.N.1    Sakamoto, M.J.2    Hardy, D.3    Sidikaro, Y.4    Kreiger, A.E.5    Frenkel, L.M.6
  • 11
    • 0031766152 scopus 로고    scopus 로고
    • Ocular neovascularization: An epidemiologic review
    • Lee P, Wang CC, Adamis AP. Ocular neovascularization: an epidemiologic review. Surv Ophthalmol. 1998;43(3):245-269.
    • (1998) Surv Ophthalmol , vol.43 , Issue.3 , pp. 245-269
    • Lee, P.1    Wang, C.C.2    Adamis, A.P.3
  • 12
    • 0019020390 scopus 로고
    • The Framingham Eye Study monograph: An ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973-1975
    • Leibowitz HM, Krueger DE, Maunder LR, etal. The Framingham Eye Study monograph: An ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973-1975. Surv Ophthalmol. 1980;24(Suppl):335-610.
    • (1980) Surv Ophthalmol , vol.24 , Issue.SUPPL. , pp. 335-610
    • Leibowitz, H.M.1    Krueger, D.E.2    Maunder, L.R.3    et al4
  • 14
    • 0029879849 scopus 로고    scopus 로고
    • Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes
    • Lopez PF, Sippy BD, Lambert HM, Thach AB, Hinton DR. Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes. Invest Ophthalmol Vis Sci. 1996;37(5):855-868.
    • (1996) Invest Ophthalmol Vis Sci , vol.37 , Issue.5 , pp. 855-868
    • Lopez, P.F.1    Sippy, B.D.2    Lambert, H.M.3    Thach, A.B.4    Hinton, D.R.5
  • 15
    • 0030999643 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression in choroidal neovascularization in rats
    • Yi X, Ogata N, Komada M, et al. Vascular endothelial growth factor expression in choroidal neovascularization in rats. Graefes Arch Clin Exp Ophthalmol. 1997;235(5):313-319.
    • (1997) Graefes Arch Clin Exp Ophthalmol , vol.235 , Issue.5 , pp. 313-319
    • Yi, X.1    Ogata, N.2    Komada, M.3
  • 16
    • 0024847652 scopus 로고
    • Long-term intravitreal ganciclovir therapy for cytomegalovirus retinopathy
    • Heinemann MH. Long-term intravitreal ganciclovir therapy for cytomegalovirus retinopathy. Arch Ophthalmol. 1989;107(12):1767-1772.
    • (1989) Arch Ophthalmol , vol.107 , Issue.12 , pp. 1767-1772
    • Heinemann, M.H.1
  • 17
    • 68249126178 scopus 로고    scopus 로고
    • Intravitreal injection of therapeutic agents
    • Peyman GA, Lad EM, Moshfeghi DM. Intravitreal injection of therapeutic agents. Retina. 2009;29(7):875-912.
    • (2009) Retina , vol.29 , Issue.7 , pp. 875-912
    • Peyman, G.A.1    Lad, E.M.2    Moshfeghi, D.M.3
  • 18
    • 1642362625 scopus 로고    scopus 로고
    • Drug delivery systems: Entering the mainstream
    • Allen TM, Cullis PR. Drug delivery systems: entering the mainstream. Science. 2004;303(5665):1818-1822.
    • (2004) Science , vol.303 , Issue.5665 , pp. 1818-1822
    • Allen, T.M.1    Cullis, P.R.2
  • 19
    • 0000631893 scopus 로고
    • Negative staining of phospholipids and their structural modification by surface-active agents as observed in the electron microscope
    • Bangham AD, Horne RW. Negative staining of phospholipids and their structural modification by surface-active agents as observed in the electron microscope. J Mol Biol. 1964;8:660-668.
    • (1964) J Mol Biol , vol.8 , pp. 660-668
    • Bangham, A.D.1    Horne, R.W.2
  • 20
    • 0032853891 scopus 로고    scopus 로고
    • Anticancer therapy using glucuronate modified long-circulating liposomes
    • Oku N. Anticancer therapy using glucuronate modified long-circulating liposomes. Adv Drug Deliv Rev. 1999;40(1-2):63-73.
    • (1999) Adv Drug Deliv Rev , vol.40 , Issue.1-2 , pp. 63-73
    • Oku, N.1
  • 21
    • 24644437854 scopus 로고    scopus 로고
    • Ligand-targeted liposomes for cancer treatment
    • Sapra P, Tyagi P, Allen TM. Ligand-targeted liposomes for cancer treatment. Curr Drug Deliv. 2005;2(4):369-381.
    • (2005) Curr Drug Deliv , vol.2 , Issue.4 , pp. 369-381
    • Sapra, P.1    Tyagi, P.2    Allen, T.M.3
  • 22
    • 84907106198 scopus 로고
    • Liposomes in immunology: Multilamellar phosphatidylcholine liposomes as a simple, biodegradable and harmless adjuvant without any immunogenic activity of its own
    • van Rooijen N, van Nieuwmegen R. Liposomes in immunology: multilamellar phosphatidylcholine liposomes as a simple, biodegradable and harmless adjuvant without any immunogenic activity of its own. Immunol Commun. 1980;9(3):243-256.
    • (1980) Immunol Commun , vol.9 , Issue.3 , pp. 243-256
    • van Rooijen, N.1    van Nieuwmegen, R.2
  • 23
    • 0020979967 scopus 로고
    • Effects of sterols on the therapeutic efficacy of liposomal amphotericin B in murine candidiasis
    • Lopez-Berestein G, Mehta R, Hopfer R, Mehta K, Hersh EM, Juliano R. Effects of sterols on the therapeutic efficacy of liposomal amphotericin B in murine candidiasis. Cancer Drug Deliv. 1983;1(1): 37-42.
    • (1983) Cancer Drug Deliv , vol.1 , Issue.1 , pp. 37-42
    • Lopez-Berestein, G.1    Mehta, R.2    Hopfer, R.3    Mehta, K.4    Hersh, E.M.5    Juliano, R.6
  • 24
    • 0018863684 scopus 로고
    • Selective release of non-electrolytes from liposomes upon perturbation of bilayers by temperature change or polyene antibiotics
    • Oku N, Nojima S, Inoue K. Selective release of non-electrolytes from liposomes upon perturbation of bilayers by temperature change or polyene antibiotics. Biochim Biophys Acta. 1980;595(2):277-290.
    • (1980) Biochim Biophys Acta , vol.595 , Issue.2 , pp. 277-290
    • Oku, N.1    Nojima, S.2    Inoue, K.3
  • 25
    • 0025341615 scopus 로고
    • Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
    • Klibanov AL, Maruyama K, Torchilin VP, Huang L. Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett. 1990;268(1):235-237.
    • (1990) FEBS Lett , vol.268 , Issue.1 , pp. 235-237
    • Klibanov, A.L.1    Maruyama, K.2    Torchilin, V.P.3    Huang, L.4
  • 26
    • 0021798066 scopus 로고
    • Reduced toxicity of liposome-associated amphotericin B injected intravitreally in rabbits
    • Tremblay C, Barza M, Szoka F, Lahav M, Baum J. Reduced toxicity of liposome-associated amphotericin B injected intravitreally in rabbits. Invest Ophthalmol Vis Sci. 1985;26(5):711-718.
    • (1985) Invest Ophthalmol Vis Sci , vol.26 , Issue.5 , pp. 711-718
    • Tremblay, C.1    Barza, M.2    Szoka, F.3    Lahav, M.4    Baum, J.5
  • 27
    • 0022000969 scopus 로고
    • Ocular toxicity of intravitreally injected liposomal amphotericin B in rhesus monkeys
    • Barza M, Baum J, Tremblay C, Szoka F, D'Amico DJ. Ocular toxicity of intravitreally injected liposomal amphotericin B in rhesus monkeys. Am J Ophthalmol. 1985;100(2):259-263.
    • (1985) Am J Ophthalmol , vol.100 , Issue.2 , pp. 259-263
    • Barza, M.1    Baum, J.2    Tremblay, C.3    Szoka, F.4    D'Amico, D.J.5
  • 28
    • 0022532408 scopus 로고
    • Intravitreal liposome-encapsulated gentamicin in a rabbit model. Prolonged therapeutic levels
    • Fishman PH, Peyman GA, Lesar T. Intravitreal liposome-encapsulated gentamicin in a rabbit model. Prolonged therapeutic levels. Invest Ophthalmol Vis Sci. 1986;27(7):1103-1106.
    • (1986) Invest Ophthalmol Vis Sci , vol.27 , Issue.7 , pp. 1103-1106
    • Fishman, P.H.1    Peyman, G.A.2    Lesar, T.3
  • 29
    • 0023622893 scopus 로고
    • Intravitreal injection of liposome-encapsulated ganciclovir in a rabbit model
    • Peyman GA, Khoobehi B, Tawakol M, et al. Intravitreal injection of liposome-encapsulated ganciclovir in a rabbit model. Retina. 1987;7(4):227-229.
    • (1987) Retina , vol.7 , Issue.4 , pp. 227-229
    • Peyman, G.A.1    Khoobehi, B.2    Tawakol, M.3
  • 30
    • 0024460077 scopus 로고
    • Toxicity and clearance of a combination of liposome-encapsulated ganciclovir and trifluridine
    • Peyman GA, Schulman JA, Khoobehi B, Alkan HM, Tawakol ME, Mani H. Toxicity and clearance of a combination of liposome-encapsulated ganciclovir and trifluridine. Retina. 1989;9(3):232-236.
    • (1989) Retina , vol.9 , Issue.3 , pp. 232-236
    • Peyman, G.A.1    Schulman, J.A.2    Khoobehi, B.3    Alkan, H.M.4    Tawakol, M.E.5    Mani, H.6
  • 31
    • 0036139020 scopus 로고    scopus 로고
    • Intravitreal delivery of oligonucleotides by sterically stabilized liposomes
    • Bochot A, Fattal E, Boutet V, etal. Intravitreal delivery of oligonucleotides by sterically stabilized liposomes. Invest Ophthalmol Vis Sci. 2002;43(1):253-259.
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , Issue.1 , pp. 253-259
    • Bochot, A.1    Fattal, E.2    Boutet, V.3
  • 32
    • 0026974894 scopus 로고
    • Liposomally-entrapped ganciclovir for the treatment of cytomegalovirus retinitis in AIDS patients. Experimental toxicity and pharmacokinetics, and clinical trial
    • Díaz-Llopis M, Martos MJ, España E, et al. Liposomally-entrapped ganciclovir for the treatment of cytomegalovirus retinitis in AIDS patients. Experimental toxicity and pharmacokinetics, and clinical trial. Doc Ophthalmol. 1992;82(4):297-305.
    • (1992) Doc Ophthalmol , vol.82 , Issue.4 , pp. 297-305
    • Díaz-Llopis, M.1    Martos, M.J.2    España, E.3
  • 33
    • 0028030593 scopus 로고
    • Treatment of cytomegalovirus retinitis with intravitreal injection of liposome encapsulated ganciclovir in a patient with AIDS
    • Akula SK, Ma PE, Peyman GA, et al. Treatment of cytomegalovirus retinitis with intravitreal injection of liposome encapsulated ganciclovir in a patient with AIDS. Br J Ophthalmol. 1994;78(9):677-680.
    • (1994) Br J Ophthalmol , vol.78 , Issue.9 , pp. 677-680
    • Akula, S.K.1    Ma, P.E.2    Peyman, G.A.3
  • 34
    • 0027366709 scopus 로고
    • Intravitreal pharmacokinetics of liposome-encapsulated amikacin in a rabbit model
    • Zeng S, Hu C, Wei H, et al. Intravitreal pharmacokinetics of liposome-encapsulated amikacin in a rabbit model. Ophthalmology. 1993;100(11):1640-1644.
    • (1993) Ophthalmology , vol.100 , Issue.11 , pp. 1640-1644
    • Zeng, S.1    Hu, C.2    Wei, H.3
  • 35
    • 0037406802 scopus 로고    scopus 로고
    • Comparative toxicity and concentrations of intravitreal amphotericin B formulations in a rabbit model
    • Cannon JP, Fiscella R, Pattharachayakul S, et al. Comparative toxicity and concentrations of intravitreal amphotericin B formulations in a rabbit model. Invest Ophthalmol Vis Sci. 2003;44(5): 2112-2117.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , Issue.5 , pp. 2112-2117
    • Cannon, J.P.1    Fiscella, R.2    Pattharachayakul, S.3
  • 36
    • 0033991421 scopus 로고    scopus 로고
    • Intravitreal administration of antisense oligonucleotides: Potential of liposomal delivery
    • Bochot A, Couvreur P, Fattal E. Intravitreal administration of antisense oligonucleotides: potential of liposomal delivery. Prog Retin Eye Res. 2000;19(2):131-147.
    • (2000) Prog Retin Eye Res , vol.19 , Issue.2 , pp. 131-147
    • Bochot, A.1    Couvreur, P.2    Fattal, E.3
  • 37
    • 66349109049 scopus 로고    scopus 로고
    • Preparation, characterization, and in vivo evaluation of nanoliposomes-encapsulated bevacizumab (avastin) for intravitreal administration
    • Abrishami M, Zarei-Ghanavati S, Soroush D, Rouhbakhsh M, Jaafari MR, Malaekeh-Nikouei B. Preparation, characterization, and in vivo evaluation of nanoliposomes-encapsulated bevacizumab (avastin) for intravitreal administration. Retina. 2009;29(5):699-703.
    • (2009) Retina , vol.29 , Issue.5 , pp. 699-703
    • Abrishami, M.1    Zarei-Ghanavati, S.2    Soroush, D.3    Rouhbakhsh, M.4    Jaafari, M.R.5    Malaekeh-Nikouei, B.6
  • 38
    • 0024241153 scopus 로고
    • Liposome-bound cyclosporine: Retinal toxicity after intravitreal injection
    • Alghadyan AA, Peyman GA, Khoobehi B, Liu KR. Liposome-bound cyclosporine: retinal toxicity after intravitreal injection. Int Ophthalmol. 1988;12(2):105-107.
    • (1988) Int Ophthalmol , vol.12 , Issue.2 , pp. 105-107
    • Alghadyan, A.A.1    Peyman, G.A.2    Khoobehi, B.3    Liu, K.R.4
  • 39
    • 0025988184 scopus 로고
    • Liposome suppression of proliferative vitreoretinopathy. Rabbit model using antimetabolite encapsulated liposomes
    • Assil KK, Hartzer M, Weinreb RN, Nehorayan M, Ward T, Blumenkranz M. Liposome suppression of proliferative vitreoretinopathy. Rabbit model using antimetabolite encapsulated liposomes. Invest Ophthalmol Vis Sci. 1991;32(11):2891-2897.
    • (1991) Invest Ophthalmol Vis Sci , vol.32 , Issue.11 , pp. 2891-2897
    • Assil, K.K.1    Hartzer, M.2    Weinreb, R.N.3    Nehorayan, M.4    Ward, T.5    Blumenkranz, M.6
  • 40
    • 0028298046 scopus 로고
    • Retinal toxicity of the antimetabolite 5-fluorouridine 5′-monophosphate administered intravitreally using multivesicular liposomes
    • Gariano RF, Assil KK, Wiley CA, Munguia D, Weinreb RN, Freeman WR. Retinal toxicity of the antimetabolite 5-fluorouridine 5′-monophosphate administered intravitreally using multivesicular liposomes. Retina. 1994;14(1):75-80.
    • (1994) Retina , vol.14 , Issue.1 , pp. 75-80
    • Gariano, R.F.1    Assil, K.K.2    Wiley, C.A.3    Munguia, D.4    Weinreb, R.N.5    Freeman, W.R.6
  • 41
    • 0033637620 scopus 로고    scopus 로고
    • Intravitreal pharmacokinetics of plain and liposome-entrapped fluconazole in rabbit eyes
    • Gupta SK, Velpandian T, Dhingra N, Jaiswal J. Intravitreal pharmacokinetics of plain and liposome-entrapped fluconazole in rabbit eyes. J Ocul Pharmacol Ther. 2000;16(6):511-518.
    • (2000) J Ocul Pharmacol Ther , vol.16 , Issue.6 , pp. 511-518
    • Gupta, S.K.1    Velpandian, T.2    Dhingra, N.3    Jaiswal, J.4
  • 42
    • 77955537470 scopus 로고    scopus 로고
    • Treatment of experimental autoimmune uveoretinitis with intravitreal injection of tacrolimus (FK506) encapsulated in liposomes
    • Zhang R, He R, Qian J, Guo J, Xue K, Yuan YF. Treatment of experimental autoimmune uveoretinitis with intravitreal injection of tacrolimus (FK506) encapsulated in liposomes. Invest Ophthalmol Vis Sci. 2010;51(7):3575-3582.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , Issue.7 , pp. 3575-3582
    • Zhang, R.1    He, R.2    Qian, J.3    Guo, J.4    Xue, K.5    Yuan, Y.F.6
  • 43
    • 0025679393 scopus 로고
    • Pharmacokinetics of intravitreally injected liposome-encapsulated tobramycin in normal rabbits
    • Kim EK, Kim HB. Pharmacokinetics of intravitreally injected liposome-encapsulated tobramycin in normal rabbits. Yonsei Med J. 1990;31(4):308-314.
    • (1990) Yonsei Med J , vol.31 , Issue.4 , pp. 308-314
    • Kim, E.K.1    Kim, H.B.2
  • 44
    • 34548057327 scopus 로고    scopus 로고
    • Downregulation of endotoxin-induced uveitis by intravitreal injection of vasoactive intestinal Peptide encapsulated in liposomes
    • Lajavardi L, Bochot A, Camelo S, et al. Downregulation of endotoxin-induced uveitis by intravitreal injection of vasoactive intestinal Peptide encapsulated in liposomes. Invest Ophthalmol Vis Sci. 2007;48(7):3230-3238.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , Issue.7 , pp. 3230-3238
    • Lajavardi, L.1    Bochot, A.2    Camelo, S.3
  • 45
    • 79952605798 scopus 로고    scopus 로고
    • Suppression of choroidal neovascularization by intravitreal injection of liposomal SU5416
    • Honda M, Asai T, Umemoto T, Araki Y, Oku N, Tanaka M. Suppression of choroidal neovascularization by intravitreal injection of liposomal SU5416. Arch Ophthalmol. 2011;129(3):317-321.
    • (2011) Arch Ophthalmol , vol.129 , Issue.3 , pp. 317-321
    • Honda, M.1    Asai, T.2    Umemoto, T.3    Araki, Y.4    Oku, N.5    Tanaka, M.6
  • 46
    • 0034863374 scopus 로고    scopus 로고
    • Sustained ocular delivery of tilisolol to rabbits after topical administration or intravitreal injection of lipophilic prodrug incorporated in liposomes
    • Kawakami S, Yamamura K, Mukai T, et al. Sustained ocular delivery of tilisolol to rabbits after topical administration or intravitreal injection of lipophilic prodrug incorporated in liposomes. J Pharm Pharmacol. 2001;53(8):1157-1161.
    • (2001) J Pharm Pharmacol , vol.53 , Issue.8 , pp. 1157-1161
    • Kawakami, S.1    Yamamura, K.2    Mukai, T.3
  • 47
    • 0032237799 scopus 로고    scopus 로고
    • Retinal toxicity of liposome-incorporated and free ofloxacin after intravitreal injection in rabbit eyes
    • Wiechens B, Neumann D, Grammer JB, Pleyer U, Hedderich J, Duncker GI. Retinal toxicity of liposome-incorporated and free ofloxacin after intravitreal injection in rabbit eyes. Int Ophthalmol. 1998-1999;22(3):133-143.
    • (1998) Int Ophthalmol , vol.22 , Issue.3 , pp. 133-143
    • Wiechens, B.1    Neumann, D.2    Grammer, J.B.3    Pleyer, U.4    Hedderich, J.5    Duncker, G.I.6
  • 48
    • 18344369540 scopus 로고    scopus 로고
    • Anti-neovascular therapy using novel peptides homing to angiogenic vessels
    • Oku N, Asai T, Watanabe K, et al. Anti-neovascular therapy using novel peptides homing to angiogenic vessels. Oncogene. 2002; 21(17):2662-2669.
    • (2002) Oncogene , vol.21 , Issue.17 , pp. 2662-2669
    • Oku, N.1    Asai, T.2    Watanabe, K.3
  • 49
    • 52149099655 scopus 로고    scopus 로고
    • Antiangiogenic cancer therapy using tumor vasculature-targeted liposomes encapsulating 3-(3,5-dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one, SU5416
    • Katanasaka Y, Ida T, Asai T, et al. Antiangiogenic cancer therapy using tumor vasculature-targeted liposomes encapsulating 3-(3,5-dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one, SU5416. Cancer Lett. 2008;270(2):260-268.
    • (2008) Cancer Lett , vol.270 , Issue.2 , pp. 260-268
    • Katanasaka, Y.1    Ida, T.2    Asai, T.3
  • 50
    • 2942583144 scopus 로고    scopus 로고
    • In vivo gene transfection via intravitreal injection of cationic liposome/plasmid DNA complexes in rabbits
    • Kawakami S, Harada A, Sakanaka K, et al. In vivo gene transfection via intravitreal injection of cationic liposome/plasmid DNA complexes in rabbits. Int J Pharm. 2004;278(2):255-262.
    • (2004) Int J Pharm , vol.278 , Issue.2 , pp. 255-262
    • Kawakami, S.1    Harada, A.2    Sakanaka, K.3
  • 51
    • 0029100424 scopus 로고
    • Biodegradation and tissue reaction to intravitreous biodegradable poly(D,L-lactic-coglycolic)acid microspheres
    • Giordano GG, Chevez-Barrios P, Refojo MF, Garcia CA. Biodegradation and tissue reaction to intravitreous biodegradable poly(D,L-lactic-coglycolic)acid microspheres. Curr Eye Res. 1995;14(9):761-768.
    • (1995) Curr Eye Res , vol.14 , Issue.9 , pp. 761-768
    • Giordano, G.G.1    Chevez-Barrios, P.2    Refojo, M.F.3    Garcia, C.A.4
  • 52
  • 53
    • 0031563023 scopus 로고    scopus 로고
    • Treatment of cytomegalovirus retinitis with a sustained-release ganciclovir implant
    • The Ganciclovir Implant Study Group
    • Musch DC, Martin DF, Gordon JF, Davis MD, Kuppermann BD. Treatment of cytomegalovirus retinitis with a sustained-release ganciclovir implant. The Ganciclovir Implant Study Group. N Engl J Med. 1997;337(2):83-90.
    • (1997) N Engl J Med , vol.337 , Issue.2 , pp. 83-90
    • Musch, D.C.1    Martin, D.F.2    Gordon, J.F.3    Davis, M.D.4    Kuppermann, B.D.5
  • 55
    • 77952882990 scopus 로고    scopus 로고
    • Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion
    • for the Ozurdex GENEVA Study Group
    • Haller JA, Bandello F, Belfort R Jr, etal; for the Ozurdex GENEVA Study Group. Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion. Ophthalmology. 2010;117(6):1134-1146.
    • (2010) Ophthalmology , vol.117 , Issue.6 , pp. 1134-1146
    • Haller, J.A.1    Bandello, F.2    Belfort Jr., R.3    et al4
  • 56
    • 79952947252 scopus 로고    scopus 로고
    • Dexamethasone intravitreal implant for noninfectious intermediate or posterior uveitis
    • For the Ozurdex HURON Study Group
    • Lowder C, Belfort R Jr, Lightman S, et al; for the Ozurdex HURON Study Group. Dexamethasone intravitreal implant for noninfectious intermediate or posterior uveitis. Arch Ophthalmol. 2011;129(5):545-553.
    • (2011) Arch Ophthalmol , vol.129 , Issue.5 , pp. 545-553
    • Lowder, C.1    Belfort Jr., R.2    Lightman, S.3
  • 57
    • 79955558683 scopus 로고    scopus 로고
    • Dexamethasone intravitreal implant for treatment of diabetic macular edema in vitrectomized patients
    • for the Ozurdex CHAMPLAIN Study Group
    • Boyer DS, Faber D, Gupta S, et al; for the Ozurdex CHAMPLAIN Study Group. Dexamethasone intravitreal implant for treatment of diabetic macular edema in vitrectomized patients. Retina. 2011;31(5):915-923.
    • (2011) Retina , vol.31 , Issue.5 , pp. 915-923
    • Boyer, D.S.1    Faber, D.2    Gupta, S.3
  • 58
    • 0028316563 scopus 로고
    • In vitro phagocytosis of polylactide microspheres by retinal pigment epithelial cells and intracellular drug release
    • Kimura H, Ogura Y, Moritera T, Honda Y, Tabata Y, Ikada Y. In vitro phagocytosis of polylactide microspheres by retinal pigment epithelial cells and intracellular drug release. Curr Eye Res. 1994;13(5):353-360.
    • (1994) Curr Eye Res , vol.13 , Issue.5 , pp. 353-360
    • Kimura, H.1    Ogura, Y.2    Moritera, T.3    Honda, Y.4    Tabata, Y.5    Ikada, Y.6
  • 59
    • 0042844771 scopus 로고    scopus 로고
    • Ocular drug delivery targeting the retina and retinal pigment epithelium using polylactide nanoparticles
    • Bourges JL, Gautier SE, Delie F, et al. Ocular drug delivery targeting the retina and retinal pigment epithelium using polylactide nanoparticles. Invest Ophthalmol Vis Sci. 2003;44(8):3562-3569.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , Issue.8 , pp. 3562-3569
    • Bourges, J.L.1    Gautier, S.E.2    Delie, F.3
  • 60
    • 0035211330 scopus 로고    scopus 로고
    • Effect of particle size of polymeric nanospheres on intravitreal kinetics
    • Sakurai E, Ozeki H, Kunou N, Ogura Y. Effect of particle size of polymeric nanospheres on intravitreal kinetics. Ophthalmic Res. 2001;33(1):31-36.
    • (2001) Ophthalmic Res , vol.33 , Issue.1 , pp. 31-36
    • Sakurai, E.1    Ozeki, H.2    Kunou, N.3    Ogura, Y.4
  • 62
    • 42449098583 scopus 로고    scopus 로고
    • Microemulsions as potential drug delivery systems: A review
    • Ansari MJ, Kohli K, Dixit N. Microemulsions as potential drug delivery systems: a review. PDA J Pharm Sci Technol. 2008;62(1):66-79.
    • (2008) PDA J Pharm Sci Technol , vol.62 , Issue.1 , pp. 66-79
    • Ansari, M.J.1    Kohli, K.2    Dixit, N.3
  • 63
    • 0036130360 scopus 로고    scopus 로고
    • Microemulsions as ocular drug delivery systems: Recent developments and future challenges
    • Vandamme TF. Microemulsions as ocular drug delivery systems: recent developments and future challenges. Prog Retin Eye Res. 2002;21(1):15-34.
    • (2002) Prog Retin Eye Res , vol.21 , Issue.1 , pp. 15-34
    • Vandamme, T.F.1
  • 64
    • 11444263514 scopus 로고    scopus 로고
    • New vehicle based on a microemulsion for topical ocular administration of dexamethasone
    • Fialho SL, da Silva-Cunha A. New vehicle based on a microemulsion for topical ocular administration of dexamethasone. Clin Experiment Ophthalmol. 2004;32(6):626-632.
    • (2004) Clin Experiment Ophthalmol , vol.32 , Issue.6 , pp. 626-632
    • Fialho, S.L.1    da Silva-Cunha, A.2
  • 65
    • 0036744856 scopus 로고    scopus 로고
    • Design and function of a dendrimer-based therapeutic nanodevice targeted to tumor cells through the folate receptor
    • Quintana A, Raczka E, Piehler L, et al. Design and function of a dendrimer-based therapeutic nanodevice targeted to tumor cells through the folate receptor. Pharm Res. 2002;19(9):1310-1316.
    • (2002) Pharm Res , vol.19 , Issue.9 , pp. 1310-1316
    • Quintana, A.1    Raczka, E.2    Piehler, L.3
  • 66
    • 38349134916 scopus 로고    scopus 로고
    • Dendrimers as drug carriers: Applications in different routes of drug administration
    • Cheng Y, Xu Z, Ma M, Xu T. Dendrimers as drug carriers: applications in different routes of drug administration. J Pharm Sci. 2008;97(1):123-143.
    • (2008) J Pharm Sci , vol.97 , Issue.1 , pp. 123-143
    • Cheng, Y.1    Xu, Z.2    Ma, M.3    Xu, T.4
  • 67
    • 4544332801 scopus 로고    scopus 로고
    • Inhibition of in vitro VEGF expression and choroidal neovascularization by synthetic dendrimer peptide mediated delivery of a sense oligonucleotide
    • Marano RJ, Wimmer N, Kearns PS, et al. Inhibition of in vitro VEGF expression and choroidal neovascularization by synthetic dendrimer peptide mediated delivery of a sense oligonucleotide. Exp Eye Res. 2004;79(4):525-535.
    • (2004) Exp Eye Res , vol.79 , Issue.4 , pp. 525-535
    • Marano, R.J.1    Wimmer, N.2    Kearns, P.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.