Cognitive enhancement effects of Bacopa Monnieri (Brahmi) on novel object recognition and NMDA receptor immunodensity in the prefrontal cortex and hippocampus of sub-chronic phencyclidine rat model of schizophrenia

Journal of the Medical Association of Thailand

Volumn 96, Issue 2, 2013, Pages 231-238

  Piyabhan, Pritsana ^a   Wetchateng, Thanitsara ^a   Sirseeratawong, Seewaboon ^a  

^a THAMMASAT UNIVERSITY   (Thailand)

Author keywords

Animal model; Brahmi; NMDA receptor; Novel object recognition; Schizophrenia

Indexed keywords

BACOPA MONNIERI EXTRACT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PLANETARY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DENTATE GYRUS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NONHUMAN; PREFRONTAL CORTEX; RAT; RECOGNITION; SCHIZOPHRENIA; TASK PERFORMANCE; UPREGULATION;

ANIMALS; BACOPA; COGNITION; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; HALLUCINOGENS; HIPPOCAMPUS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; MALE; NOOTROPIC AGENTS; PHENCYCLIDINE; PHYTOTHERAPY; PREFRONTAL CORTEX; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; SCHIZOPHRENIA;

EID: 84873907503     PISSN: 01252208     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Allen RM, Young SJ. Phencyclidine-induced psychosis. Am J Psychiatry 1978; 135: 1081-1084.
2. Javitt DC, Zukin SR. Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry 1991; 148: 1301-1308.
3. Lipska BK, Weinberger DR. To model a psychiatric disorder in animals: schizophrenia as a reality test. Neuropsychopharmacology 2000; 23: 223-239.
4. Abdul-Monim Z, Reynolds GP, Neill JC. The atypical antipsychotic ziprasidone, but not haloperidol, improves phencyclidine-induced cognitive deficits in a reversal learning task in the rat. J Psychopharmacol 2003; 17: 57-65.
5. Grayson B, Idris NF, Neill JC. Atypical anti-psychotics attenuate a sub-chronic PCP-induced cognitive deficit in the novel object recognition task in the rat. Behav Brain Res 2007; 184: 31-38.
6. Anastasio NC, Johnson KM. Differential regulation of the NMDA receptor by acute and sub-chronic phencyclidine administration in the developing rat. J Neurochem 2008; 104: 1210-1218.
7. Wang C, Fridley J, Johnson KM. The role of NMDA receptor upregulation in phencyclidine-induced cortical apoptosis in organotypic culture. Biochem Pharmacol 2005; 69: 1373-1383.
8. Nudmamud S, Reynolds GP. Increased density of glutamate/N-methyl-D-aspartate receptors in superior temporal cortex in schizophrenia. Neurosci Lett 2001; 304: 9-12.
9. Kawanishi Y, Tachikawa H, Suzuki T. Pharma-cogenomics and schizophrenia. Eur J Pharmacol 2000; 410: 227-241.
10. Coffey I. Options for the treatment of negative symptoms of schizophrenia. CNS Drugs 1994; 1: 107-118.
11. Kirk SL, Cahir M, Reynolds GP. Clozapine, but not haloperidol, increases neuropeptide Y neuronal expression in the rat hypothalamus. J Psychopharmacol 2006; 20: 577-579.
12. Shinomol GK, Muralidhara, Bharath MM. Exploring the role of "Brahmi" (Bocopa monnieri and Centella asiatica) in brain function and therapy. Recent Pat Endocr Metab Immune Drug Discov 2011; 5: 33-49.
13. Rastogi M, Ojha RP, Prabu PC, Devi BP, Agrawal A, Dubey GP. Prevention of age-associated neurodegeneration and promotion of healthy brain ageing in female Wistar rats by long term use of bacosides. Biogerontology 2012; 13: 183-195.
14. Dhanasekaran M, Tharakan B, Holcomb LA, Hitt AR, Young KA, Manyam BV. Neuroprotective mechanisms of ayurvedic antidementia botanical Bacopa monniera. Phytother Res 2007; 21: 965-969.
15. Calabrese C, Gregory WL, Leo M, Kraemer D, Bone K, Oken B. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. J Altern Complement Med 2008; 14: 707-713.
16. th ed. New York: Academic Press; 1998.
17. McKibben CE, Jenkins TA, Adams HN, Harte MK, Reynolds GP. Effect of pretreatment with risperidone on phencyclidine-induced disruptions in object recognition memory and prefrontal cortex parvalbumin immunoreactivity in the rat. Behav Brain Res 2010; 208: 132-136.
18. Abdul-Monim Z, Neill JC, Reynolds GP. Sub-chronic psychotomimetic phencyclidine induces deficits in reversal learning and alterations in parvalbumin-immunoreactive expression in the rat. J Psychopharmacol 2007; 21: 198-205.
19. McLean SL, Beck JP, Woolley ML, Neill JC. A preliminary investigation into the effects of antipsychotics on sub-chronic phencyclidine-induced deficits in attentional set-shifting in female rats. Behav Brain Res 2008; 189: 152-158.
20. Stough C, Lloyd J, Clarke J, Downey LA, Hutchison CW, Rodgers T, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl) 2001; 156: 481-484.
21. Kishore K, Singh M. Effect of bacosides, alcoholic extract of Bacopa monniera Linn. (brahmi), on experimental amnesia in mice. Indian J Exp Biol 2005; 43: 640-645.
22. Uabundit N, Wattanathorn J, Mucimapura S, Ingkaninan K. Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer's disease model. J Ethnopharmacol 2010; 127: 26-31.
23. Gao XM, Tamminga CA. An increase in NMDA-sensitive [3H]glutamate and [3H]kainate binding in hippocampus 24 hours after PCP. Neurosci Lett 1994; 174: 149-153.
24. Slikker W, Xu Z, Wang C. Application of a systems biology approach to developmental neurotoxicology. Reprod Toxicol 2005; 19: 305-319.
25. Itzhak Y. Modulation of the PCP/NMDA receptor complex and sigma binding sites by psychostimulants. Neurotoxicol Teratol 1994; 16: 363-368.