Human Cytomegalovirus Infection Enhances NF-κB/p65 Signaling in Inflammatory Breast Cancer Patients

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  El Shinawi, Mohamed ^a   Mohamed, Hossam Taha ^b   El Ghonaimy, Eslam A ^b   Tantawy, Marwa ^b   Younis, Amal ^b   Schneider, Robert J ^c   Mohamed, Mona Mostafa ^b  

^a AIN SHAMS UNIVERSITY   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; TRANSCRIPTION FACTOR RELA; VIRUS ANTIBODY; VIRUS DNA;

ADULT; AGED; ANTIBODY SCREENING; ANTIBODY TITER; ARTICLE; BREAST CARCINOMA; CANCER PATIENT; CANCER TISSUE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; FEMALE; HUMAN; HUMAN CYTOMEGALOVIRUS INFECTION; HUMAN TISSUE; INFLAMMATORY BREAST CANCER; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; VIRUS STRAIN;

ADULT; AGED; CYTOMEGALOVIRUS INFECTIONS; FEMALE; GENE EXPRESSION PROFILING; HUMANS; INFLAMMATORY BREAST NEOPLASMS; MIDDLE AGED; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, MESSENGER; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84873895508     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0055755     Document Type: Article

References (55)

1. Amarante MK, Watanabe MA, (2009) The possible involvement of virus in breast cancer. J Cancer Res Clin Oncol 135: 329-337.
2. Zamora MR, (2011) DNA viruses (CMV, EBV, and the herpesviruses). Semin Respir Crit Care Med 32: 454-470.
3. Niedobitek G, Meru N, Delecluse HJ, (2001) Epstein-Barr virus infection and human malignancies. Int J Exp Pathol 82: 149-170.
4. Fawzy S, Sallam M, Awad NM, (2008) Detection of Epstein-Barr virus in breast carcinoma in Egyptian women. Clin Biochem 41: 486-492.
5. Hachana M, Amara K, Ziadi S, Romdhane E, Gacem RB, et al. (2011) Investigation of Epstein-Barr virus in breast carcinomas in Tunisia. Pathol Res Pract 207: 695-700.
6. Soroceanu L, Cobbs CS, (2011) Is HCMV a tumor promoter? Virus Res 157: 193-203.
7. Harkins L, Volk AL, Samanta M, Mikolaenko I, Britt WJ, et al. (2002) Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer. Lancet 360: 1557-1563.
8. Samanta M, Harkins L, Klemm K, Britt WJ, Cobbs CS, (2003) High prevalence of human cytomegalovirus in prostatic intraepithelial neoplasia and prostatic carcinoma. J Urol 170: 998-1002.
9. Tsai JH, Hsu CS, Tsai CH, Su JM, Liu YT, et al. (2007) Relationship between viral factors, axillary lymph node status and survival in breast cancer. J Cancer Res Clin Oncol 133: 13-21.
10. Harkins LE, Matlaf LA, Soroceanu L, Klemm K, Britt WJ, et al. (2010) Detection of human cytomegalovirus in normal and neoplastic breast epithelium. Herpesviridae 1: 8.
11. Melnick M, Sedghizadeh PP, Allen CM, Jaskoll T, (2011) Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: Cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship. Exp Mol Pathol 92: 118-125.
12. Cobbs CS, (2011) Evolving evidence implicates cytomegalovirus as a promoter of malignant glioma pathogenesis. Herpesviridae 2: 10.
13. Soroceanu L, Matlaf L, Bezrookove V, Harkins L, Martinez R, et al. (2011) Human cytomegalovirus US28 found in glioblastoma promotes an invasive and angiogenic phenotype. Cancer Res 71: 6643-6653.
14. Baryawno N, Rahbar A, Wolmer-Solberg N, Taher C, Odeberg J, et al. (2011) Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target. J Clin Invest 121: 4043-4055.
15. Cobbs CS, Harkins L, Samanta M, Gillespie GY, Bharara S, et al. (2002) Human cytomegalovirus infection and expression in human malignant glioma. Cancer Res 62: 3347-3350.
16. Maussang D, Verzijl D, van Walsum M, Leurs R, Holl J, et al. (2006) Human cytomegalovirus-encoded chemokine receptor US28 promotes tumorigenesis. Proc Natl Acad Sci U S A 103: 13068-13073.
17. Chan G, Bivins-Smith ER, Smith MS, Yurochko AD, (2008) Transcriptome analysis of NF-kappaB- and phosphatidylinositol 3-kinase-regulated genes in human cytomegalovirus-infected monocytes. J Virol 82: 1040-1046.
18. Chan G, Bivins-Smith ER, Smith MS, Yurochko AD (2009) NF-kappaB and phosphatidylinositol 3-kinase activity mediates the HCMV-induced atypical M1/M2 polarization of monocytes. Virus Res.
19. Juckem LK, Boehme KW, Feire AL, Compton T, (2008) Differential initiation of innate immune responses induced by human cytomegalovirus entry into fibroblast cells. J Immunol 180: 4965-4977.
20. Dumortier J, Streblow DN, Moses AV, Jacobs JM, Kreklywich CN, et al. (2008) Human cytomegalovirus secretome contains factors that induce angiogenesis and wound healing. J Virol 82: 6524-6535.
21. Fiorentini S, Luganini A, Dell'Oste V, Lorusso B, Cervi E, et al. (2011) Human cytomegalovirus productively infects lymphatic endothelial cells and induces a secretome that promotes angiogenesis and lymphangiogenesis through interleukin-6 and granulocyte-macrophage colony-stimulating factor. J Gen Virol 92: 650-660.
22. Allart S, Martin H, Detraves C, Terrasson J, Caput D, et al. (2002) Human cytomegalovirus induces drug resistance and alteration of programmed cell death by accumulation of deltaN-p73alpha. J Biol Chem 277: 29063-29068.
23. Van Laere SJ, Van den Eynden GG, Van der Auwera I, Vandenberghe M, van Dam P, et al. (2006) Identification of cell-of-origin breast tumor subtypes in inflammatory breast cancer by gene expression profiling. Breast Cancer Res Treat 95: 243-255.
24. Labidi SI, Mrad K, Mezlini A, Ouarda MA, Combes JD, et al. (2008) Inflammatory breast cancer in Tunisia in the era of multimodality therapy. Ann Oncol 19: 473-480.
25. Lo AC, Georgopoulos A, Kleer CG, Banerjee M, Omar S, et al. (2009) Analysis of RhoC expression and lymphovascular emboli in inflammatory vs non-inflammatory breast cancers in Egyptian patients. Breast 18: 55-59.
26. Soliman AS, Banerjee M, Lo AC, Ismail K, Hablas A, et al. (2009) High proportion of inflammatory breast cancer in the Population-based Cancer Registry of Gharbiah, Egypt. Breast J 15: 432-434.
27. Duke TJ, Jahed NC, Veneroso CC, Da Roza R, Johnson O, et al. (2010) A cluster of inflammatory breast cancer (IBC) in an office setting: additional evidence of the importance of environmental factors in IBC etiology. Oncol Rep 24: 1277-1284.
28. Al-Raawi D, Abu-El-Zahab H, El-Shinawi M, Mohamed MM, (2011) Membrane type-1 matrix metalloproteinase (MT1-MMP) correlates with the expression and activation of matrix metalloproteinase-2 (MMP-2) in inflammatory breast cancer. Int J Clin Exp Med 4: 265-275.
29. Nouh MA, Mohamed MM, El-Shinawi M, Shaalan MA, Cavallo-Medved D, et al. (2011) Cathepsin B: a potential prognostic marker for inflammatory breast cancer. J Transl Med 9: 1.
30. Zhang S, Zhou YH, Li L, Hu Y, (2010) Monitoring human cytomegalovirus infection with nested PCR: comparison of positive rates in plasma and leukocytes and with quantitative PCR. Virol J 7: 73.
31. Toi M, Ohashi Y, Seow A, Moriya T, Tse G, et al. (2010) The Breast Cancer Working Group presentation was divided into three sections: the epidemiology, pathology and treatment of breast cancer. Jpn J Clin Oncol 40Suppl 1: i13-18.
32. Bonnier P, Charpin C, Lejeune C, Romain S, Tubiana N, et al. (1995) Inflammatory carcinomas of the breast: a clinical, pathological, or a clinical and pathological definition? Int J Cancer 62: 382-385.
33. Gong Y, (2008) Pathologic aspects of inflammatory breast cancer: part 2. Biologic insights into its aggressive phenotype. Semin Oncol 35: 33-40.
34. Richardson AK, Cox B, McCredie MR, Dite GS, Chang JH, et al. (2004) Cytomegalovirus, Epstein-Barr virus and risk of breast cancer before age 40 years: a case-control study. Br J Cancer 90: 2149-2152.
35. Retiere C, Imbert BM, David G, Courcoux P, Hallet MM, (1998) A polymorphism in the major immediate-early gene delineates groups among cytomegalovirus clinical isolates. Virus Res 57: 43-51.
36. Sowmya P, Madhavan HN, (2009) Analysis of mixed infections by multiple genotypes of human cytomegalovirus in immunocompromised patients. J Med Virol 81: 861-869.
37. Van Laere S, Van der Auwera I, Van den Eynden GG, Fox SB, Bianchi F, et al. (2005) Distinct molecular signature of inflammatory breast cancer by cDNA microarray analysis. Breast Cancer Res Treat 93: 237-246.
38. Van Laere SJ, Van der Auwera I, Van den Eynden GG, Elst HJ, Weyler J, et al. (2006) Nuclear factor-kappaB signature of inflammatory breast cancer by cDNA microarray validated by quantitative real-time reverse transcription-PCR, immunohistochemistry, and nuclear factor-kappaB DNA-binding. Clin Cancer Res 12: 3249-3256.
39. Lerebours F, Vacher S, Andrieu C, Espie M, Marty M, et al. (2008) NF-kappa B genes have a major role in inflammatory breast cancer. BMC Cancer 8: 41.
40. Yurochko AD, Kowalik TF, Huong SM, Huang ES, (1995) Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105/p50 and p65 promoters. J Virol 69: 5391-5400.
41. Smith MS, Bivins-Smith ER, Tilley AM, Bentz GL, Chan G, et al. (2007) Roles of phosphatidylinositol 3-kinase and NF-kappaB in human cytomegalovirus-mediated monocyte diapedesis and adhesion: strategy for viral persistence. J Virol 81: 7683-7694.
42. Michaelis M, Doerr HW, Cinatl J, (2009) The story of human cytomegalovirus and cancer: increasing evidence and open questions. Neoplasia 11: 1-9.
43. Soderberg-Naucler C, (2008) HCMV microinfections in inflammatory diseases and cancer. J Clin Virol 41: 218-223.
44. Fagundes CP, Glaser R, Alfano CM, Bennett JM, Povoski SP, et al. (2011) Fatigue and herpesvirus latency in women newly diagnosed with breast cancer. Brain Behav Immun.
45. Breathnach O, Donnellan P, Collins D, McNicholas W, Crown J, (1999) Cytomegalovirus pneumonia in a patient with breast cancer on chemotherapy: case report and review of the literature. Ann Oncol 10: 461-465.
46. Chang S, Parker SL, Pham T, Buzdar AU, Hursting SD, (1998) Inflammatory breast carcinoma incidence and survival: the surveillance, epidemiology, and end results program of the National Cancer Institute, 1975-1992. Cancer 82: 2366-2372.
47. Cheeran MC, Hu S, Yager SL, Gekker G, Peterson PK, et al. (2001) Cytomegalovirus induces cytokine and chemokine production differentially in microglia and astrocytes: antiviral implications. J Neurovirol 7: 135-147.
48. Zhang Y, Wang YL, Liu YW, Li Q, Yuan YH, et al. (2009) Change of peripheral blood mononuclear cells IFN-gamma, IL-10, and TGF-beta1 mRNA expression levels with active human cytomegalovirus infection in orthotopic liver transplantation. Transplant Proc 41: 1767-1769.
49. Shimamura M, Murphy-Ullrich JE, Britt WJ, (2010) Human cytomegalovirus induces TGF-beta1 activation in renal tubular epithelial cells after epithelial-to-mesenchymal transition. PLoS Pathog 6: e1001170.
50. Blaheta RA, Beecken WD, Engl T, Jonas D, Oppermann E, et al. (2004) Human cytomegalovirus infection of tumor cells downregulates NCAM (CD56): a novel mechanism for virus-induced tumor invasiveness. Neoplasia 6: 323-331.
51. Blaheta RA, Weich E, Marian D, Bereiter-Hahn J, Jones J, et al. (2006) Human cytomegalovirus infection alters PC3 prostate carcinoma cell adhesion to endothelial cells and extracellular matrix. Neoplasia 8: 807-816.
52. Cinatl J Jr, Cinatl J, Vogel JU, Kotchetkov R, Driever PH, et al. (1998) Persistent human cytomegalovirus infection induces drug resistance and alteration of programmed cell death in human neuroblastoma cells. Cancer Res 58: 367-372.
53. Robertson FM, Bondy M, Yang W, Yamauchi H, Wiggins S, et al. (2010) Inflammatory breast cancer: the disease, the biology, the treatment. CA Cancer J Clin 60: 351-375.
54. Vermeulen PB, van Golen KL, Dirix LY, (2010) Angiogenesis, lymphangiogenesis, growth pattern, and tumor emboli in inflammatory breast cancer: a review of the current knowledge. Cancer 116: 2748-2754.
55. Soderberg-Naucler C, Johnsen JI, (2012) Cytomegalovirus infection in brain tumors: A potential new target for therapy? Oncoimmunology 1: 739-740.