Analysis of mixed infections by multiple genotypes of human cytomegalovirus in immunocompromised patients

Journal of Medical Virology

Volumn 81, Issue 5, 2009, Pages 861-869

  Sowmya, P ^a   Madhavan, H N ^a  

^a VISION RESEARCH FOUNDATION   (India)

Author keywords

Genotypes; Human cytomegalovirus; Nucleic acid based techniques; Viral load

Indexed keywords

AQUEOUS HUMOR; ARTICLE; BLOOD; CONTROLLED STUDY; DISEASE MARKER; GENE FREQUENCY; GENOTYPE; HUMAN; HUMAN CYTOMEGALOVIRUS; IMMUNOCOMPROMISED PATIENT; MAJOR CLINICAL STUDY; MIXED INFECTION; MULTIPLEX POLYMERASE CHAIN REACTION; NONHUMAN; POLYMERASE CHAIN REACTION; REAL TIME POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; URINE; VIRUS GENOME; VIRUS LOAD;

CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; GENOTYPE; HUMANS; IMMUNOCOMPROMISED HOST; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; VIRAL LOAD;

HUMAN HERPESVIRUS 5;

EID: 65649117676     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.21459     Document Type: Article

References (27)

1. Aquino VH, Figueiredo LTM. 2000. High prevalence of renal transplant recipients infected with more than one cytomegalovirus glycoprotein B genotype. J Med Virol 61:138-142.
2. Bongarts A, Von Laer D, Vogelberg C, Ebert K, Van Lunzen J, Garweg J, Vaith P, Hufert FT, Haller O, Meyer-König U. 1996. Glycoprotein B genotype of human cytomegalovirus: Distribution in HIV-infected patients. Scand J Infect Dis 28:447-449.
3. Chou S. 1992. Molecular epidemiology of envelope glycoprotein H of human cytomegalovirus. J Infect Dis 166:604-607.
4. Chou S, Dennison KM. 1991. Analysis of interstrain variation in cytomegalovirus glycoprotein B sequences encoding neutralization related epitopes. J Infect Dis 163:1229-1234.
5. Cicin-Sain L, Podlech J, Messerle M, Reddehase MJ, Koszinowski UH. 2005. Frequent coinfection of cells explains functional in vivo complementation between cytomegalovirus variants in the multiply infected host. J Virol 79:9492-9502.
6. Coaquette A, Bourgeois A, Dirand C, Varin A, Chen W, Herbein G. 2004. Mixed cytomegalovirus glycoprotein B genotypes in immunocompromised patients. Clin Infect Dis 39:155-161.
7. Gorzer I, Kerschner H, Jaksch P, Bauer C, Seebacher G, Klepetko W, Puchhammer-Stöckl E. 2008. Virus load dynamics of individual CMV-genotypes in lung transplant recipients with mixed-genotype infections. J Med Virol 80:1405-1414.
8. Humar A, Kumar D, Gilbert C, Boivin G. 2003. Cytomegalovirus (CMV) glycoprotein Bgenotypes and response to antiviral therapy in solidorgantransplant recipients with CMV disease. J Infect Dis 188:581-584.
9. LangDJ,KovacsAA,ZaiaJA,DoelkinG,NilandJC,AledortL,AzenSP,FletcherMA, GaudermanJ,GjersetGJ.1989.SeroepidemiologicstudiesofcytomegalovirusandEpstein- Barrvirusinfectionsinrelation- humanimmunodeficiencyvirustype1infectioninselectedrecipientpopulations. TransfusionSafetyStudyGrouJAcquirImmuneDeficSyndr2:540-549.(Pubitemid20017257)
10. Madhavan HN, Sowmya P, Therese KL, Malathi J. 2007. Development and application of a novel multiplex polymerase chain reaction for semi-quantitation of human cytomegalovirus in clinical specimens. J Virol Meth 141:166-172.
11. Mattick C, Dewin D, Polley S, Sevilla-Reyes E, Pignatelli S, Rawlinson W, Wilkinson G, Dal Monte P, Gompels UA. 2004. Linkage of human cytomegalovirus glycoprotein gO variant groups identified from worldwide clinical isolates with gN genotypes, implications for disease associations and evidence for N-terminal sites of positive selection. Virology 318:582-597.
12. Mengelle C, Sandres-Saune K, Pasquier C, Rostaing L, Mansuy JM, Marty M, Da Silva I, Attal M, Massip P, Izopet J. 2003. Automated extraction and quantification of human cytomegalovirus DNA in whole blood by real-time PCR assay. J Clin Microbiol 41:3840-3845.
13. Pass RF. 2001. Cytomegalovirus. In: Knipe DM, Howley PM, editors. Field's virology. 4th edition. Philadelphia: Lippincott, Williams and Wilkins. pp 2675-2706.
14. Peek R, Verbraak F, Bruinenberg M, Van der Lelij A, Van den Horn G, Kijlstra A. 1998. Cytomegalovirus glycoprotein B genotyping in ocular fluids and blood of AIDS patients with cytomegalovirus retinitis. Invest Ophthalmol Vis Sci 39:1183-1187.
15. PignatelliS,DalMonteP,LandiniMP.2001.gpUL73(gN) genomicvariantsofhumancytomegalovirusisolatesareclusteredintofourdistinct genotypes.JGenVirol82:2777-2784.(Pubitemid32998655)
16. Pignatelli S, Dal Monte P, Rossini G, Chou S, Gojobori T, Hanada K, Guo JJ, Rawlinson W, Britt W, Mach M, Landini MP. 2003. Human Cytomegalovirus glycoprotein N (gpUL73-gN) genomic variants: Identification of a novel subgroup, geographical distribution and evidence of positive selective pressure. J Gen Virol 84:647-655.
17. Puchhammer-Stöckl E, Görzer I, Zoufaly A, Jaksch P, Bauer CC, Klepetko W, Popow-Kraupp T. 2006. Emergence of multiple cytomegalovirus strains in blood and lung of lung transplant recipients. Transplantation 81:187-194.
18. Rasmussen L. 1999. Molecular pathogenesis of human cytomegalovirus infection. Transpl Infect Dis 1:127-134.
19. Rasmussen L, Geissler A, Cowan C, Chase A, Winters M. 2002. The genes encoding the gCIII complex of human cytomegalovirus exist in highly diverse combinations in clinical isolates. J Virol 76:10841-10848.
20. Razonable RR, Brown RA, Wilson J, Groettum C, Kremers W, Espy M, Smith TF, Paya CV. 2002. The clinical use of various blood compartments for cytomegalovirus (CMV) DNA quantitation in transplant recipients with CMV disease. Transplantation 73:968-973.
21. Shepp DH, Match ME, Lipson SM, Pergolizzi RG. 1998. A fifth human cytomegalovirus glycoprotein B genotype. Res Virol 149:109-114.
22. Sowmya P, Madhavan HN, Therese KL. 2006. Evaluation of three polymerase chain reaction tests targeting morphological transforming region II, UL 83 gene and glycoprotein O gene for the detection of human cytomegalovirus genome in clinical specimens of immunocompromised patients in Chennai, India. Virol J 3:20.
23. Sowmya P, Dhanya V, Madhavan HN, Therese KL. 2007. Comparative efficacy of PCR-based restriction fragment length polymorphism (RFLP) and multiplex PCR for glycoprotein B (gB) genotyping of human cytomegalovirus. Indian J Med Res 126:122-127.
24. Spector SA, Hirata KK, Newman TR. 1984. Identification of multiple cytomegalovirus strains in homosexual men with acquired immunodeficiency syndrome. J Infect Dis 150:953-956.
25. Steininger C, Schmied B, Sarcletti M, Geit M, Puchhammer-Stockl E. 2005. Cytomegalovirus genotypes present in cerebrospinal fluid of HIV infected patients. AIDS 18:273-278.
26. Steininger C, Puchhammer-Stockl E, Popow-Kraupp T. 2006. Cytomegalovirus disease in the era of highly active antiretroviral therapy (HAART). J Clin Virol 37:1-9.
27. Verbraak FD, Bruinenberg M, van den Horn GJ, Meenken C, van der Lelij A, Hoyng CB, Kijlstra A, Peek R. 1998. Cytomegalovirus (CMV) strain differences between the eye and blood in AIDS patients with CMV retinitis. AIDS 12:713-718.