The V499G/Y501H mutation impairs fast motor kinetics of prestin and has significance for defining functional independence of individual prestin subunits

Journal of Biological Chemistry

Volumn 288, Issue 4, 2013, Pages 2452-2463

  Homma, Kazuaki ^a   Duan, Chongwen ^a   Zheng, Jing ^a,b   Cheatham, Mary Ann ^b   Dallos, Peter ^b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COCHLEAR AMPLIFICATION; ELECTRICAL ENERGY; ENERGY TRANSDUCTION MECHANISM; MECHANICAL DISPLACEMENTS; MOLECULAR MECHANISM; MOTOR ACTIVITY; MOTOR FUNCTION; OPERATING RANGES; OUTER HAIR CELL; SOUND ENERGY; VISCOUS DAMPING; WILD TYPES;

MAMMALS;

KINETICS;

GLYCINE; HISTIDINE; PRESTIN; TYROSINE; VALINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ELECTRIC CAPACITANCE; ELECTRIC POTENTIAL; HAIR CELL; MOLECULAR MODEL; MOTOR PERFORMANCE; MOUSE; MUTAGENESIS; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SUBUNIT; SIGNAL TRANSDUCTION;

ALGORITHMS; AMINO ACID SEQUENCE; ANIMALS; ANION TRANSPORT PROTEINS; ELECTROPHYSIOLOGY; HAIR CELLS, AUDITORY, OUTER; HEK293 CELLS; HUMANS; IMMUNOPRECIPITATION; KINETICS; MICE; MOLECULAR MOTOR PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TYROSINE; VALINE;

EID: 84873879363     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.411579     Document Type: Article

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