Molecular dynamics simulation of PNPLA3 I148M polymorphism reveals reduced substrate access to the catalytic cavity

Proteins: Structure, Function and Bioinformatics

Volumn 81, Issue 3, 2013, Pages 406-414

  Xin, Yong Ning ^a,b   Zhao, Yuqi ^c   Lin, Zhong Hua ^b   Jiang, Xiangjun ^b   Xuan, Shi Ying ^a,b   Huang, Jingfei ^c  

^a OCEAN UNIVERSITY OF CHINA   (China)

^b QINGDAO MUNICIPAL HOSPITAL   (China)

^c KUNMING INSTITUTE OF ZOOLOGY   (China)

Author keywords

Missense mutation; Molecular dynamics simulations; Nonalcoholic fatty liver disease; PNPLA3

Indexed keywords

ENZYME; PALMITIC ACID; PATATIN LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; ENTROPY; ENZYME ACTIVITY; ENZYME CONFORMATION; MISSENSE MUTATION; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN BINDING; WILD TYPE;

CATALYTIC DOMAIN; COMPUTATIONAL BIOLOGY; ENZYME ACTIVATION; ENZYME STABILITY; HUMANS; ISOLEUCINE; LIPASE; MEMBRANE PROTEINS; MOLECULAR DYNAMICS SIMULATION; MULTIPROTEIN COMPLEXES; MUTATION, MISSENSE; PALMITIC ACID; POLYMORPHISM, GENETIC; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84873851948     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24199     Document Type: Article

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