-
2
-
-
0029847929
-
Anti-peptide aptamers recognize amino sequence and bind a protein epitope
-
Xu W, Ellington AD, (1996) Anti-peptide aptamers recognize amino sequence and bind a protein epitope. Proc Natl Acad Sci USA 93: 7475-7480.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 7475-7480
-
-
Xu, W.1
Ellington, A.D.2
-
3
-
-
0029758369
-
Mirror-image RNA that binds D-adenosine
-
Klussmann S, Nolte A, Bald R, Erdmann VA, Fürste JP, (1996) Mirror-image RNA that binds D-adenosine. Nat Biotechnol 14: 1112-1115.
-
(1996)
Nat Biotechnol
, vol.14
, pp. 1112-1115
-
-
Klussmann, S.1
Nolte, A.2
Bald, R.3
Erdmann, V.A.4
Fürste, J.P.5
-
4
-
-
0029758370
-
Mirror-design of L-oligonucleotide ligands binding to L-arginine
-
Nolte A, Klussmann S, Bald R, Erdmann VA, Fürste JP, (1996) Mirror-design of L-oligonucleotide ligands binding to L-arginine. Nat Biotechnol 14: 1116-1119.
-
(1996)
Nat Biotechnol
, vol.14
, pp. 1116-1119
-
-
Nolte, A.1
Klussmann, S.2
Bald, R.3
Erdmann, V.A.4
Fürste, J.P.5
-
5
-
-
84868475728
-
MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles
-
van Rooij E, Olson EN, (2012) MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles. Nat Rev Drug Discov 11: 860-872.
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 860-872
-
-
van Rooij, E.1
Olson, E.N.2
-
6
-
-
77955931767
-
Recent progress in chemically modified siRNAs
-
Gaglione M, Messere A, (2010) Recent progress in chemically modified siRNAs. Mini Rev Med Chem 10: 578-595.
-
(2010)
Mini Rev Med Chem
, vol.10
, pp. 578-595
-
-
Gaglione, M.1
Messere, A.2
-
7
-
-
46649107904
-
Spiegelmers for Therapeutic Applications
-
Ed. S. Klussmann, Wiley-VCH Weinheim
-
Eulberg D, Jarosch F, Vonhoff S, Klussmann S (2006) Spiegelmers for Therapeutic Applications. In: The Aptamer Handbook, Functional Oligonucleotides and Their Applications, Ed. S. Klussmann, Wiley-VCH Weinheim.
-
(2006)
The Aptamer Handbook, Functional Oligonucleotides and Their Applications
-
-
Eulberg, D.1
Jarosch, F.2
Vonhoff, S.3
Klussmann, S.4
-
8
-
-
70350571814
-
Development of universal antidotes to control aptamer activity
-
Oney S, Lam RT, Bompiani KM, Blake CM, Quick G, et al. (2009) Development of universal antidotes to control aptamer activity. Nat Med 15: 1224-1228.
-
(2009)
Nat Med
, vol.15
, pp. 1224-1228
-
-
Oney, S.1
Lam, R.T.2
Bompiani, K.M.3
Blake, C.M.4
Quick, G.5
-
9
-
-
0025332385
-
Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA
-
Robertson DL, Joyce GF, (1990) Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA. Nature 344: 467-468.
-
(1990)
Nature
, vol.344
, pp. 467-468
-
-
Robertson, D.L.1
Joyce, G.F.2
-
10
-
-
0025194307
-
Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
-
Tuerk C, Gold L, (1990) Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 249: 505-510.
-
(1990)
Science
, vol.249
, pp. 505-510
-
-
Tuerk, C.1
Gold, L.2
-
11
-
-
0025074907
-
In vitro selection of RNA molecules that bind specific ligands
-
Ellington AD, Szostak JW, (1990) In vitro selection of RNA molecules that bind specific ligands. Nature 346: 818-822.
-
(1990)
Nature
, vol.346
, pp. 818-822
-
-
Ellington, A.D.1
Szostak, J.W.2
-
12
-
-
59649089797
-
Anti-Ccl2 Spiegelmer permits 75% dose reduction of cyclophosphamide to control diffuse proliferative lupus nephritis and pneumonitis in MRL-Fas(lpr) mice
-
Kulkarni O, Eulberg D, Selve N, Zöllner S, Allam R, et al. (2009) Anti-Ccl2 Spiegelmer permits 75% dose reduction of cyclophosphamide to control diffuse proliferative lupus nephritis and pneumonitis in MRL-Fas(lpr) mice. J Pharmacol Exp Ther 328: 371-377.
-
(2009)
J Pharmacol Exp Ther
, vol.328
, pp. 371-377
-
-
Kulkarni, O.1
Eulberg, D.2
Selve, N.3
Zöllner, S.4
Allam, R.5
-
13
-
-
40449140901
-
Late onset of Ccl2 blockade with the Spiegelmer mNOX-E36-3′PEG prevents glomerulosclerosis and improves glomerular filtration rate in db/db mice
-
Ninichuk VS, Clauss S, Kulkarni O, Schmid H, Segerer S, et al. (2008) Late onset of Ccl2 blockade with the Spiegelmer mNOX-E36-3′PEG prevents glomerulosclerosis and improves glomerular filtration rate in db/db mice. Am J Pathol. 172: 628-637.
-
(2008)
Am J Pathol
, vol.172
, pp. 628-637
-
-
Ninichuk, V.S.1
Clauss, S.2
Kulkarni, O.3
Schmid, H.4
Segerer, S.5
-
14
-
-
84873804899
-
Noxxon Pharma AG Presentation at Bio-Europe Sprong 2011
-
Milan, Italy. See also press release by Noxxon Pharma AG, July, 2012
-
Mangasarian A (2011) Noxxon Pharma AG Presentation at Bio-Europe Sprong 2011, 5th Annual International Partnering Conference, Milan, Italy. See also press release by Noxxon Pharma AG, July, 2012.
-
(2011)
5th Annual International Partnering Conference
-
-
Mangasarian, A.1
-
15
-
-
0023643095
-
Self-cleavage of virusoid RNA is performed by the proposed 55-nucleotide active site
-
Foster AC, Symons RH, (1987) Self-cleavage of virusoid RNA is performed by the proposed 55-nucleotide active site. Cell 50: 9-16.
-
(1987)
Cell
, vol.50
, pp. 9-16
-
-
Foster, A.C.1
Symons, R.H.2
-
16
-
-
0024435363
-
Studies on the hammerhead RNA self-cleaving domain
-
Ruffner DE, Dahm SC, Uhlenbeck OC, (1989) Studies on the hammerhead RNA self-cleaving domain. Gene 82: 31-41.
-
(1989)
Gene
, vol.82
, pp. 31-41
-
-
Ruffner, D.E.1
Dahm, S.C.2
Uhlenbeck, O.C.3
-
17
-
-
0026771509
-
Numbering system for the hammerhead
-
Hertel KJ, Pardi A, Uhlenbeck OC, Koizumi M, Ohtsuka E, et al. (1992) Numbering system for the hammerhead. Nucleic Acids Res 20: 3252.
-
(1992)
Nucleic Acids Res
, vol.20
, pp. 3252
-
-
Hertel, K.J.1
Pardi, A.2
Uhlenbeck, O.C.3
Koizumi, M.4
Ohtsuka, E.5
-
18
-
-
0031860104
-
Crystallographic structures of the hammerhead ribozyme: relationship to ribozyme folding and catalysis
-
Wedekind JE, McKay DB, (1998) Crystallographic structures of the hammerhead ribozyme: relationship to ribozyme folding and catalysis. Annu Rev Biophys Biomol Struct 27: 475-502.
-
(1998)
Annu Rev Biophys Biomol Struct
, vol.27
, pp. 475-502
-
-
Wedekind, J.E.1
McKay, D.B.2
-
19
-
-
0036903567
-
Folding and activity of the hammerhead ribozyme
-
Hammann C, Lilley DM, (2002) Folding and activity of the hammerhead ribozyme. ChemBioChem 3: 690-700.
-
(2002)
ChemBioChem
, vol.3
, pp. 690-700
-
-
Hammann, C.1
Lilley, D.M.2
-
20
-
-
67349123194
-
Comparative enzymology and structural biology of RNA self-cleavage
-
Fedor MJ, (2009) Comparative enzymology and structural biology of RNA self-cleavage. Annu Rev Biophys 38: 271-299.
-
(2009)
Annu Rev Biophys
, vol.38
, pp. 271-299
-
-
Fedor, M.J.1
-
21
-
-
85145201693
-
What can the new hammerhead ribozyme structures teach us about design?
-
Eds: V.A. Erdmann, Jan Barciszewski, Springer
-
Scott WG (2010) What can the new hammerhead ribozyme structures teach us about design? in RNA Technologies and Their Applications, Eds: V.A. Erdmann, Jan Barciszewski, Springer, 305-324.
-
(2010)
RNA Technologies and Their Applications
, pp. 305-324
-
-
Scott, W.G.1
-
22
-
-
39749165700
-
DNAzyme technology and cancer therapy: Cleave and let die
-
Dass CR, Choong PF, Khachigian LM, (2008) DNAzyme technology and cancer therapy: Cleave and let die. Mol Cancer Ther 7: 243-251.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 243-251
-
-
Dass, C.R.1
Choong, P.F.2
Khachigian, L.M.3
-
23
-
-
84862841985
-
DNAzyme targeting c-jun suppresses skin cancer growth
-
Cai H, Santiago FS, Prado-Lourenco L, Wang B, Patrikakis M, et al. (2012) DNAzyme targeting c-jun suppresses skin cancer growth. Sci Transl Med 4: 139ra82.
-
(2012)
Sci Transl Med
, vol.4
-
-
Cai, H.1
Santiago, F.S.2
Prado-Lourenco, L.3
Wang, B.4
Patrikakis, M.5
-
24
-
-
11844276654
-
Deletion analysis in the catalytic region of the 10-23 DNA enzyme
-
Zaborowska Z, Schubert S, Kurreck J, Erdmann VA, (2005) Deletion analysis in the catalytic region of the 10-23 DNA enzyme. FEBS Lett. 579: 554-558.
-
(2005)
FEBS Lett
, vol.579
, pp. 554-558
-
-
Zaborowska, Z.1
Schubert, S.2
Kurreck, J.3
Erdmann, V.A.4
-
25
-
-
4344627896
-
First look at RNA in L-configuration
-
Vallazzza M, Perbandt M, Klussmann S, Einspahr HM, Erdmann VA, et al. (2004) First look at RNA in L-configuration. Acta Crystallogr.D 60, 1-7.
-
(2004)
Acta Crystallogr.D
, vol.60
, pp. 1-7
-
-
Vallazzza, M.1
Perbandt, M.2
Klussmann, S.3
Einspahr, H.M.4
Erdmann, V.A.5
-
26
-
-
33744487133
-
The first crystal structure of an RNA racemate
-
Rypniewski W, Vallazza M, Perbandt M, Klussmann S, Delucas LJ, et al. (2006) The first crystal structure of an RNA racemate. Acta Cryst. D62: 659-664.
-
(2006)
Acta Cryst
, vol.D62
, pp. 659-664
-
-
Rypniewski, W.1
Vallazza, M.2
Perbandt, M.3
Klussmann, S.4
Delucas, L.J.5
-
27
-
-
35548929411
-
First experimental evidence for the preferential stabilization of the natural D- over the nonnatural L-confirmation of nucleic acids
-
Bolik S, Rübhausen M, Binder S, Schultz B, Perbandt M, et al. (2007) First experimental evidence for the preferential stabilization of the natural D- over the nonnatural L-confirmation of nucleic acids. RNA 13: 877-880.
-
(2007)
RNA
, vol.13
, pp. 877-880
-
-
Bolik, S.1
Rübhausen, M.2
Binder, S.3
Schultz, B.4
Perbandt, M.5
-
28
-
-
38749106637
-
Nucleic acid aptamers and their complimentary antidotes
-
Becker RC, Oney S, Becker KC, Rusconi CP, Sullenger B, (2007) Nucleic acid aptamers and their complimentary antidotes. Heamostaseologie 27: 378-382.
-
(2007)
Heamostaseologie
, vol.27
, pp. 378-382
-
-
Becker, R.C.1
Oney, S.2
Becker, K.C.3
Rusconi, C.P.4
Sullenger, B.5
-
29
-
-
0037026484
-
RNA aptamers as reversible antagonists of coagulation factor IXa
-
Rusconi CP, Scardino E, Layzer J, Pitoc GA, Ortel TL, et al. (2002) RNA aptamers as reversible antagonists of coagulation factor IXa. Nature 419: 90-94.
-
(2002)
Nature
, vol.419
, pp. 90-94
-
-
Rusconi, C.P.1
Scardino, E.2
Layzer, J.3
Pitoc, G.A.4
Ortel, T.L.5
-
30
-
-
33746867177
-
A novel antidote-controlled anticoagulant reduces thrombin generation and inflammation and improves cardiac function in cardiopulmonary bypass surgery
-
Nimjee SM, Keys JR, Pitoc GA, Quick G, Rusconi CP, et al. (2006) A novel antidote-controlled anticoagulant reduces thrombin generation and inflammation and improves cardiac function in cardiopulmonary bypass surgery. Mol Ther 14: 408-415.
-
(2006)
Mol Ther
, vol.14
, pp. 408-415
-
-
Nimjee, S.M.1
Keys, J.R.2
Pitoc, G.A.3
Quick, G.4
Rusconi, C.P.5
-
31
-
-
70349387406
-
Regulation of thrombin activity with a bifunctional aptamer and hemin: development of a new anticoagulant and antidote pair
-
Wang J, Cao Y, Chen G, Li G, (2009) Regulation of thrombin activity with a bifunctional aptamer and hemin: development of a new anticoagulant and antidote pair. ChemBioChem 10: 2171-2176.
-
(2009)
ChemBioChem
, vol.10
, pp. 2171-2176
-
-
Wang, J.1
Cao, Y.2
Chen, G.3
Li, G.4
-
32
-
-
0030898510
-
A general purpose RNA-cleaving DNA enzyme
-
Santoro SW, Joyce GF, (1997) A general purpose RNA-cleaving DNA enzyme. Proc Natl Acad Sci USA 94: 4262-4266.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4262-4266
-
-
Santoro, S.W.1
Joyce, G.F.2
-
33
-
-
84864376913
-
Therapeutics: Antitumour potential of catalytic DNA
-
Burgess DJ, (2012) Therapeutics: Antitumour potential of catalytic DNA. Nature Rev Cancer 12: 508-509.
-
(2012)
Nature Rev Cancer
, vol.12
, pp. 508-509
-
-
Burgess, D.J.1
-
34
-
-
33746228126
-
Tertiary contacts distant from the active site prime a ribozyme for catalysis
-
Martick M, Scott WG (2006) Tertiary contacts distant from the active site prime a ribozyme for catalysis. Cell: 126, 309-320.
-
(2006)
Cell
, vol.126
, pp. 309-320
-
-
Martick, M.1
Scott, W.G.2
|