Changes in vitamin D and parathyroid hormone metabolism in incident pediatric Crohn's disease

Inflammatory Bowel Diseases

Volumn 19, Issue 1, 2013, Pages 45-53

  Prosnitz, Aaron R ^a   Leonard, Mary B ^b,c   Shults, Justine ^c   Zeme, Babette S ^b   Hollis, Bruce W ^d   Denson, Lee A ^e   Baldassano, Robert N ^b   Cohen, Aaron B ^b   Thayu, Meena ^b,c  

^a YALE NEW HAVEN CHILDREN S HOSPITAL   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^e CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

1,25(OH)2D; 25(OH)D; Children; Crohn's disease; Parathyroid hormone

Indexed keywords

25 HYDROXYVITAMIN D; ALBUMIN; CALCITRIOL; INTERLEUKIN 6; PARATHYROID HORMONE; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; ARTICLE; BODY HEIGHT; BODY MASS; CHILD; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATIONAL STUDY; CROHN DISEASE; DISEASE ACTIVITY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; GLOMERULUS FILTRATION RATE; GROWTH DISORDER; HEMATOCRIT; HUMAN; INCIDENCE; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; PARATHYROID HORMONE BLOOD LEVEL; PRESCHOOL CHILD; PRIORITY JOURNAL; RACE; SCHOOL CHILD; SEASON; THYROID HORMONE METABOLISM; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN D METABOLISM; VITAMIN SUPPLEMENTATION;

ADOLESCENT; ADULT; BODY COMPOSITION; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; CROHN DISEASE; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; PARATHYROID HORMONE; PROGNOSIS; SOUTH CAROLINA; TUMOR NECROSIS FACTOR-ALPHA; VITAMIN D; VITAMIN D DEFICIENCY; YOUNG ADULT;

EID: 84873741229     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.22969     Document Type: Article

References (47)

1. Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr. 2004;80:1678S-1688S.
2. Institute of Medicine. Dietary reference intakes for calcium and vitamin D. Washington, DC: National Academies Press; 2011.
3. Norman AW. From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr. 2008;88: 491S-499S.
4. Zehnder D, Bland R, Chana RS, et al. Synthesis of 1,25-dihydroxyvitamin D(3) by human endothelial cells is regulated by inflammatory cytokines: a novel autocrine determinant of vascular cell adhesion. J Am Soc Nephrol. 2002;13:621-629.
5. Lim WC, Hanauer SB, Li YC. Mechanisms of disease: vitamin D and inflammatory bowel disease. Nat Clin Pract Gastroenterol Hepatol. 2005;2:308-315.
6. Wang TT, Dabbas B, Laperriere D, et al. Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn disease. J Biol Chem. 2010;285:2227-2231.
7. Liu N, Nguyen L, Chun RF, et al. Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation. Endocrinology. 2008;149:4799-4808.
8. Abreu MT, Kantorovich V, Vasiliauskas EA, et al. Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn's disease patients with elevated 1,25-dihydroxyvitamin D and low bone mineral density. Gut. 2004;53:1129-1136.
9. Canaff L, Hendy GN. Calcium-sensing receptor gene transcription is upregulated by the proinflammatory cytokine, interleukin-1beta. Role of the NF-kappa B PATHWAY and kappaB elements. J Biol Chem. 2005;280: 14177-14188.
10. Canaff L, Zhou X, Hendy GN. The proinflammatory cytokine, interleukin-6, up-regulates calcium-sensing receptor gene transcription via Stat1/3 and Sp1/3. J Biol Chem. 2008;283:13586-13600.
11. Issenman R, Atkinson S, Radoja C, et al. Longitudinal assessment of growth, mineral metabolism, and bone mass in pediatric Crohn's disease. J Pediatr Gastroenterol Nutr. 1993;17:401-406.
12. Gokhale R, Favus MJ, Karrison T, et al. Bone mineral density assessment in children with inflammatory bowel disease. Gastroenterology. 1998; 114:902-911.
13. Sentongo T, Semeao EJ, Stettler N, et al. Vitamin D status in childen, adolescent, and young adults with Crohn disease. Am J Clin Nutr. 2002; 76:1077-1081.
14. Pappa HM, Gordon CM, Saslowsky TM, et al. Vitamin D status in children and young adults with inflammatory bowel disease. Pediatrics. 2006; 118:1950-1961.
15. Sylvester FA, Wyzga N, Hyams JS, et al. Natural history of bone metabolism and bone mineral density in children with inflammatory bowel disease. Inflamm Bowel Dis. 2007;13:42-50.
16. Levin AD, Wadhera V, Leach ST, et al. Vitamin d deficiency in children with inflammatory bowel disease. Dig Dis Sci. 2011;56:830-836.
17. Weng FL, Shults J, Leonard MB, et al. Risk factors for low serum 25-hydroxyvitamin D concentrations in otherwise healthy children and adolescents. Am J Clin Nutr. 2007;86:150-158.
18. Thayu M, Shults J, Burnham JM, et al. Gender differences in body composition deficits at diagnosis in children and adolescents with Crohn's disease. Inflamm Bowel Dis. 2007;13:1121-1128.
19. Dubner SE, Shults J, Baldassano RN, et al. Longitudinal assessment of bone density and structure in an incident cohort of children with Crohn's disease. Gastroenterology. 2009;136:123-130.
20. Thayu M, Denson LA, Shults J, et al. Determinants of changes in linear growth and body composition in incident pediatric Crohn's disease. Gastroenterology. 2010;139:430-438.
21. Hyams JS, Ferry GD, Mandel FS, et al. Development and validation of a pediatric Crohn's disease activity index. J Pediatr Gastroenterol Nutr. 1991;12:439-447.
22. Morris NN, Udry JR. Validation of a self-administered instrument to assess stage of adolescent development. J Youth Adolesc. 1980;271-280.
23. Tanner JM. Growth at Adolescence. London: Blackwell Scientific; 1962.
24. Burnham JM, Shults J, Semeao E, et al. Body-composition alterations consistent with cachexia in children and young adults with Crohn disease. Am J Clin Nutr. 2005;82:413-420.
25. Schwartz GJ, Brion LP, Spitzer A. The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents. Pediatr Clin North Am. 1987;34:571-590.
26. Hollis BW. Quantitation of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D by radioimmunoassay using radioiodinated tracers. Methods Enzymol. 1997;282:174-186.
27. Clive DR, Sudhaker D, Giacherio D, et al. Analytical and clinical validation of a radioimmunoassay for the measurement of 1,25 dihydroxyvitamin D. Clin Biochem. 2002;35:517-521.
28. Ogden CL, Kuczmarski RJ, Flegal KM, et al. Centers for Disease Control and Prevention 2000 growth charts for the United States: improvements to the 1977 National Center for Health Statistics version. Pediatrics. 2002; 109:45-60.
29. Cole TJ. The LMS method for constructing normalized growth standards. Eur J Clin Nutr. 1990;44:45-60.
30. Terpstra AM, Kalkwarf HJ, Shults J, et al. Bone density and cortical structure after pediatric renal transplantation. J Am Soc Nephrol. 2012; 23:715-726.
31. Tuchman S, Thayu M, Shults J, et al. Interpretation of biomarkers of bone metabolism in children: impact of growth velocity and body size in healthy children and chronic disease. J Pediatr. 2008;153:484-490.
32. Gordon CM, DePeter KC, Feldman HA, et al. Prevalence of vitamin D deficiency among healthy adolescents. Arch Pediatr Adolesc Med. 2004; 158:531-537.
33. Rockell JE, Green TJ, Skeaff CM, et al. Season and ethnicity are determinants of serum 25-hydroxyvitamin D concentrations in New Zealand children aged 5-14 y. J Nutr. 2005;135:2602-2608.
34. Alemzadeh R, Kichler J, Babar G, et al. Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season. Metabolism. 2008;57:183-191.
35. Snijder MB, van Dam RM, Visser M, et al. Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. J Clin Endocrinol Metab. 2005;90:4119-4123.
36. Malabanan A, Veronikis IE, Holick MF. Redefining vitamin D insufficiency. Lancet. 1998;351:805-806.
37. McKenna MJ, Freaney R. Secondary hyperparathyroidism in the elderly: means to defining hypovitaminosis D. Osteoporos Int. 1998;(8 Suppl 2): S3-6.
38. Shults J, Ratcliffe SJ, Leonard MB. Improved generalized estimating equation analysis via xtqls for implementation of quali-least squares in Stata. STATA J. 2007;7:147-166.
39. Haddad JG. Plasma vitamin D-binding protein (Gc-globulin): multiple tasks. J Steroid Biochem Mol Biol. 1995;53:579-582.
40. Andres PG, Friedman LS. Epidemiology and the natural course of inflammatory bowel disease. Gastroenterol Clin North Am. 1999;28:255-281, vii.
41. Kremer R, Campbell PP, Reinhardt T, et al. Vitamin D status and its relationship to body fat, final height, and peak bone mass in young women. J Clin Endocrinol Metab. 2009;94:67-73.
42. Absoud M, Cummins C, Lim MJ, et al. Prevalence and predictors of vitamin D insufficiency in children: a Great Britain population based study. PLoS One. 2011;6:e22179.
43. Maruotti N, Cantatore FP. Vitamin D and the immune system. J Rheumatol. 2010;37:491-495.
44. Liu PT, Stenger S, Li H, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006;311: 1770-1773.
45. White JH. Vitamin D signaling, infectious diseases, and regulation of innate immunity. Infect Immun. 2008;76:3837-3843.
46. Schonau E, Rauch F. Biochemical markers of bone metabolism. In: Glorieux FH, ed. Pediatric Bone: Biology and Diseases. San Diego: Academic Press; 2003. p 339-357.
47. Lee SE, Chung WJ, Kwak HB, et al. Tumor necrosis factor-alpha supports the survival of osteoclasts through the activation of Akt and ERK. J Biol Chem. 2001;276:49343-49349.