Effect of clustering of metabolic syndrome factors on capillary and cerebrovascular impairment

European Journal of Internal Medicine

Volumn 24, Issue 2, 2013, Pages 183-188

  Nazzaro, Pietro ^a   Schirosi, Gabriella ^a   Mezzapesa, Domenico ^a   Petruzzellis, Marco ^a   Pascazio, Lucia ^a   Serio, Gabriella ^a   De Benedittis, Lorenzo ^a   Federico, Francesco ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

Cerebral blood flow; Hypertension; Metabolic syndrome; Microcirculation

Indexed keywords

GLUCOSE; TRIACYLGLYCEROL;

ADULT; ARTICLE; BLOOD PRESSURE MONITORING; BODY MASS; BRAIN BLOOD FLOW; BRAIN DISEASE; BRAIN PERFUSION; BREATH HOLDING; CAPILLAROSCOPY; DIASTOLIC BLOOD PRESSURE; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; SKIN CAPILLARY; SYSTOLIC BLOOD PRESSURE; TRANSCRANIAL DOPPLER; TRIACYLGLYCEROL BLOOD LEVEL; VASODILATATION;

ADULT; BLOOD PRESSURE MONITORING, AMBULATORY; CEREBROVASCULAR CIRCULATION; CEREBROVASCULAR DISORDERS; DISEASE PROGRESSION; FEMALE; HUMANS; HYPERTENSION; MALE; METABOLIC SYNDROME X; MICROCIRCULATION; MICROSCOPIC ANGIOSCOPY; MIDDLE AGED; PROGNOSIS; REGIONAL BLOOD FLOW; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 84873739388     PISSN: 09536205     EISSN: 18790828     Source Type: Journal    
DOI: 10.1016/j.ejim.2012.08.017     Document Type: Article

References (43)

1. C. Ladenwall, K. Jood, C. Blomstrand, S. Nilsson, C. Jern, and P. Ladenwall Serum C-reactive protein concentration and genotype in relation to ischemic stroke subtype Stroke 37 2006 2018 2023
2. H. Markus, and M. Cullinane Severely impaired cerebrovascular reactivity predicts stroke and TIA risk in patients with carotid artery stenosis and occlusion Brain 124 2001 457 467
3. H. Yonas, and R.R. Pindzola Physiological determination of cerebrovascular reserve and its use in clinical management Cerebrovasc Brain Metab Rev 6 1994 325 340
4. S.M. Grundy, H.B. Brewer Jr., J.I. Cleeman, S.C. Smith Jr., and C. Lenfant Definition of metabolic syndrome: report of the National Heart, Lung and Blood Institute/American Heart Association conference of scientific issues related to definition Circulation 109 2004 433 438
5. M.J. Sorrentino Implication of the metabolic syndrome: the new epidemic Am J Cardiol 96 2005 3E 7E
6. V. Solfrizzi, E. Scafato, C. Capurso, A. D'Introno, A.M. Colacicco, and V. Frisardi Metabolic syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Ageing J Neurol Neurosurg Psychiatry 81 2010 433 440
7. N. Koren-Morag, U. Goldbourt, and D. Tanne Relation between the metabolic syndrome and ischemic stroke or transient ischemic attack: a prospective study in patients with atherosclerotic cardiovascular disease Stroke 36 2005 1366 1371
8. S.M. Grundy, B. Hansen, S.C. Smith, J.I. Cleeman, and R.A. Kahn Clinical management of metabolic syndrome: report of Am Heart Association/ National Heart, Lung, and Blood Institute / Am Diabetes Association Conference on scientific issue related to management Circulation 109 2004 551 556
9. K. Yaffe, A.L. Weston, T. Blackwell, and K.A. Krueger The metabolic syndrome and development of cognitive impairment among older women Arch Neurol 66 2009 324 328
10. E.H. Serne', R.O.B. Gans, J.C. ter Maaten, P.M. ter Wee, A.J. Donker, and C.D. Stehouwer Capillary recruitment is impaired in essential hypertension and relates to insulin's metabolic and vascular actions Cardiovasc Res 49 2001 161 168
11. J.P. Noon, B.R. Walker, D.J. Webb, A.C. Shore, D.W. Holton, and H.V. Edwards Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure J Clin Invest 99 1997 1873 1879
12. C.J. Lockhart, P.K. Hamilton, C.E. Quinn, and G.E. McVeigh End-organ dysfunction and cardiovascular outcomes: the role of microcirculation Clin Sci (Lond) 116 2009 175 190
13. A. Scuteri, P.M. Nilsson, C. Tzourio, J. Redon, and S. Laurent Microvascular brain damage with aging and hypertension: pathophysiological consideration and clinical implications J Hypertens 29 2011 1469 1477
14. G. Hu, Q. Qiao, J. Tuomilehto, B. Balkau, and K. Borch-Johnsen Pyorala K for the DECODE Study Group. Prevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in nondiabetic European men and women Arch Intern Med 164 2004 1066 1076
15. E.A. Francischetti, E. Tibirica, E. Goes da Silva, E. Rodriguez, B.M. Celoria, and V. Genelhu de Abreu Skin capillary density and microvascular reactivity in obese subjects with and without metabolic syndrome Microvasc Res 81 2011 325 330
16. G. Ciuffetti, G. Schillaci, S. Innocente, R. Lombardini, L. Pasqualini, and S. Notaristefano Capillary rarefaction and abnormal cardiovascular reactivity in hypertension J Hypertens 21 2003 2297 2303
17. T.F.T. Antonios, J.C. Kaski, K.M. Hasan, S.J. Brown, and D.R.J. Singer Rarefaction of skin capillaries in patients with anginal chest pain and normal coronary arteriograms Eur Heart J 22 2001 1144 1148
18. P. Nazzaro, G. Schirosi, R. Clemente, L. Battista, G. Serio, and E. Boniello Severe sleep apnoea exacerbates the microvascular impairment in very mild hypertensives Eur J Clin Invest 38 2008 766 773
19. S. Czernichow, J.R. Greenfield, P. Galan, F. Jellouli, M.E. Safar, and J. Blacher Macrovascular and microvascular dysfunction in the metabolic syndrome Hypertens Res 33 2010 293 297
20. T.G. Pickering, W.B. White, T.D. Giles, H.R. Black, J.L. Izzo, and B.J. Materson When and how to use self (home) and ambulatory blood pressure monitoring J Am Soc Hypertens 4 2010 56 61
21. L. Castilla-Guerra, C. Fernández-Moreno Mdel, A. Espino-Montoro, and J.M. López-Chozas Ambulatory blood pressure monitoring in stroke survivors: do we really control our patients? Eur J Intern Med 20 2009 760 763
22. P. Verdecchia Prognostic value of ambulatory blood pressure Hypertension 35 2000 844 851
23. L.M. Cupini, M. Diomedi, F. Placidi, M. Silvestrini, P. Giacomini, and L.M. Cupini Cerebrovascular reactivity and subcortical infarctions Arch Neurol 58 2001 577 581
24. H.S. Markus, and M.J.G. Harrison Estimation of cerebrovascular reactivity using transcranial Doppler, including the use of breath holding as the vasodilatory stimulus Stroke 23 1992 668 673
25. G. Settakis, A. Lengyel, C. Molnar, D. Bereczki, L. Csiba, and B. Fulesdi Transcranial Doppler study of cerebral hemodynamics changes during breath-holding and hyperventilation test J Neuroimaging 12 2002 252 258
26. J.B. Meigs, R.B. D'Agostino, P.W.F. Wilson, L.A. Cupples, D.M. Nathan, and D.E. Singer Risk variable clustering in the insulin resistance syndrome: the Framingham Offspring Study Diabetes 46 1997 1594 1600
27. H. Laine, H. Yki-Jarvinen, O. Kirvela, T. Tolvanen, M. Raitakari, and O. Solin Insulin resistance of glucose uptake in skeletal muscle cannot be ameliorated by enhancing endothelium-dependent blood flow in obesity J Clin Invest 101 1998 1156 1162
28. Julius S, Gudbrandsson T, Jamerson K, Shahab ST, Andersson O. The hemodynamic link between insulin resistance and hypertension. J Hypertens 1991;9:983-6.
29. G. Schillaci, M. Pirro, G. Vaudo, F. Gemelli, S. Marchesi, and C. Porcellati Prognostic value of the metabolic syndrome in essential hypertension J Am Coll Cardiol 43 2004 1817 1822
30. B. Iglseder, P. Cip, L. Malaimare, G. Ladurner, and B. Paulweber The metabolic syndrome is a stronger risk factor for early carotid atherosclerosis in women than in men Stroke 36 2005 1212 1217
31. A. Tenenbaum, M. Motro, E. Schwammenthal, and E.Z. Fisman Macrovascular complications of metabolic syndrome: an early intervention is imperative Int J Cardiol 97 2004 167 172
32. N. Straznicky, G. Grassi, M. Esler, G. Lambert, J. Dixon, and E. Lambert European Society of Hypertension Working Group on obesity antihypertensive effects of weight loss: myth or reality? J Hypertens 28 2010 637 643
33. S.M. Grundy Metabolic syndrome: connecting and reconciling cardiovascular and diabetes worlds J Am Coll Cardiol 47 2006 1093 1100
34. A. Towfighi, and B. Ovbiagele Metabolic syndrome and stroke Curr Diab Rep 8 2008 37 41
35. F. Feihl, L. Liaudet, B. Waeber, and B.I. Levy Hypertension: a disease of the microcirculation? Hypertension 48 2006 1012 1017
36. B.I. Levy, G. Ambrosio, A.R. Pries, and H.A. Struijiker-Boudier Microcirculation in hypertension: a new target for treatment? Circulation 104 2001 736 741
37. P. Nazzaro, V. Vulpis, G. Schirosi, G. Serio, L. Battista, and V. Lucivero Microvascular impairment is associated with insulin resistance in euglycemic mild hypertensives Am J Hypertens 21 2008 432 437
38. S.J. Cleland, J.R. Petrie, S. Ueda, H.L. Elliott, and J.M.C. Connell Insulin-mediated vasodilation and glucose up-take are functionally linked in humans Hypertension 33 1999 554 558
39. S.P. Whelton, H. Chin, X. Xin, and J. He Effect of aerobic exercise on blood pressure: a meta-analysis of randomized, controlled trials Ann Intern Med 136 2002 493 503
40. S. Kurl, J.A. Laukkanen, L. Niskanen, D. Laaksonen, J. Sivenius, and K. Nyyssönen Metabolic syndrome and the risk of stroke in middle-aged men Stroke 37 2006 806 811
41. G. Razay, A. Vreugdenhil, and G. Wilcock The metabolic syndrome and Alzheimer disease Arch Neurol 64 2007 93 96
42. E.A. Gale The myth of the metabolic syndrome Diabetologia 48 2005 1679 1683
43. H. Debbabi, L. Uzan, J.J. Mourad, M. Safar, B.I. Levy, and E.I. Tibirica Increased skin capillary density in treated essential hypertensive subjects Am J Hypertens 19 2006 477 483