Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin

Journal of Controlled Release

Volumn 166, Issue 3, 2013, Pages 307-315

  Park, Tae Yoon ^a   Kim, Seung Hyung ^b   Shin, Yoon Chul ^a   Lee, Nae Hyun ^a   Lee, Rae Kyung Christina ^c   Shim, Jae Hyuck ^c   Glimcher, Laurie H ^c   Mook Jung, Inhee ^d   Cheong, Eunji ^a   Kim, Won Ki ^e   Honda, Fumiko ^f   Morio, Tomohiro ^f   Lim, Jong Soon ^b   Lee, Sang Kyou ^a  

^a Yonsei University   (South Korea)

^b Daejeon University   (South Korea)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d Seoul National University   (South Korea)

^e Korea University College of Medicine   (South Korea)

^f TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Alzheimer; Apoptosis; Drug delivery; Inflammation; Neuroprotection

Indexed keywords

ALZHEIMER; ALZHEIMER'S DISEASE; AMYLOID BETAS; ANIMAL MODEL; ANTI-APOPTOTIC PROTEIN; BLOOD-BRAIN BARRIER; BRAIN INJURY; CASPASE-3; CASPASE-3 ACTIVATION; COGNITIVE MEMORY; CYTOPLASMIC DELIVERY; HUMANIN; INFLAMMATION; INFLAMMATORY CELLS; LATE STAGE; MIDDLE CEREBRAL ARTERY OCCLUSIONS; NEURODEGENERATION; NEURODEGENERATIVE; NEURONAL CELL; NEUROPROTECTION; TARGETED DELIVERY; THERAPEUTIC FUNCTIONS;

DRUG DELIVERY; NEURONS;

CELL DEATH;

AMYLOID BETA PROTEIN; CASPASE 3; CENTRAL NERVOUS SYSTEM AGENTS; DONEPEZIL; HUMANIN; PROTEIN BAX; TRANSDUCIBLE HUMANIN WITH AN EXTENDED CASPASE 3; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; BRAIN INJURY; CELL INFILTRATION; CELL PROTECTION; COGNITION; CONTROLLED STUDY; CYTOPLASM; DISEASE COURSE; DRUG DELIVERY SYSTEM; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVE CELL; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CASPASE 3; CELL DEATH; CELL LINE, TUMOR; CYTOPLASM; CYTOPROTECTION; DISEASE MODELS, ANIMAL; FEMALE; FLOW CYTOMETRY; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURODEGENERATIVE DISEASES; NEURONS; NEUROPROTECTIVE AGENTS; RATS;

EID: 84873739212     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.12.022     Document Type: Article

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