Effects of mycophenolic acid alone and in combination with its metabolite mycophenolic acid glucuronide on rat embryos in vitro

Archives of Toxicology

Volumn 87, Issue 2, 2013, Pages 361-370

  Schmidt, Flavia ^a   Eckardt, Kathrin ^a   Shakibaei, Mehdi ^b   Glander, Petra ^a   Stahlmann, Ralf ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Apoptosis; Inosine 5 monophosphate dehydrogenase activity; Mycophenolic acid; Mycophenolic acid glucuronide; Whole immunostaining; Whole embryo culture

Indexed keywords

DRUG METABOLITE; INOSINATE DEHYDROGENASE; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID BETA D GLUCURONIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; EMBRYO; EMBRYO CULTURE; EMBRYO DEVELOPMENT; EMBRYOPATHY; EMBRYOTOXICITY; ENZYME ANALYSIS; FACIAL NERVE; FEMALE; GLOSSOPHARYNGEAL NERVE; IMMUNOHISTOCHEMISTRY; NERVOUS SYSTEM MALFORMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RAT; TERATOGENICITY; TRANSMISSION ELECTRON MICROSCOPY; TRIGEMINAL NERVE; VAGUS NERVE;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; CRANIAL NERVES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; EMBRYO CULTURE TECHNIQUES; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; GLUCURONIDES; IMMUNOSUPPRESSIVE AGENTS; IMP DEHYDROGENASE; MYCOPHENOLIC ACID; RATS; TERATOGENS; TOXICITY TESTS;

RATTUS;

EID: 84873731982     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-012-0922-3     Document Type: Article

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