Haptoglobin genotype is a consistent marker of coronary heart disease risk among individuals with elevated glycosylated hemoglobin

Journal of the American College of Cardiology

Volumn 61, Issue 7, 2013, Pages 728-737

  Cahill, Leah E ^a   Levy, Andrew P ^b   Chiuve, Stephanie E ^a,c   Jensen, Majken K ^a   Wang, Hong ^d   Shara, Nawar M ^d   Blum, Shany ^b   Howard, Barbara V ^d   Pai, Jennifer K ^a,c   Mukamal, Kenneth J ^e   Rexrode, Kathryn M ^c   Rimm, Eric B ^a,c  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d Delaware   (United States)

^e BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

acute myocardial infarction; coronary disease; epidemiology; genetic association; genotype; glycoproteins

Indexed keywords

ALPHA TOCOPHEROL; HAPTOGLOBIN; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; ORAL ANTIDIABETIC AGENT;

ADULT; AGED; ARTICLE; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENOTYPE; GLYCEMIC CONTROL; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; ISCHEMIC HEART DISEASE; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; NATIONAL HEALTH SERVICE; NON INSULIN DEPENDENT DIABETES MELLITUS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; PROTEIN PROTEIN INTERACTION; RISK ASSESSMENT; RISK FACTOR;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; COHORT STUDIES; CORONARY DISEASE; FEMALE; GENOTYPE; GLYCOSYLATION; HAPTOGLOBINS; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RISK FACTORS; UP-REGULATION; YOUNG ADULT;

EID: 84873731913     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2012.09.063     Document Type: Article

References (35)

1. J.M. Gutteridge The antioxidant activity of haptoglobin towards haemoglobin-stimulated lipid peroxidation Biochim Biophys Acta 917 1987 219 223
2. A.P. Levy, R. Asleh, S. Blum Haptoglobin: basic and clinical aspects Antioxid Redox Signal 12 2010 293 304
3. M.R. Langlois, J.R. Delanghe Biological and clinical significance of haptoglobin polymorphism in humans Clin Chem 42 1996 1589 1600
4. A.P. Levy, J.E. Levy, S. Kalet-Litman Haptoglobin genotype is a determinant of iron, lipid peroxidation, and macrophage accumulation in the atherosclerotic plaque Arterioscler Thromb Vasc Biol 27 2007 134 140
5. M. Melamed-Frank, O. Lache, B.I. Enav Structure-function analysis of the antioxidant properties of haptoglobin Blood 98 2001 3693 3698
6. R. Asleh, S. Marsh, M. Shilkrut Genetically determined heterogeneity in hemoglobin scavenging and susceptibility to diabetic cardiovascular disease Circ Res 92 2003 1193 1200
7. J. Guetta, M. Strauss, N.S. Levy, L. Fahoum, A.P. Levy Haptoglobin genotype modulates the balance of Th1/Th2 cytokines produced by macrophages exposed to free hemoglobin Atherosclerosis 191 2007 48 53
8. R. Asleh, J. Guetta, S. Kalet-Litman, R. Miller-Lotan, A.P. Levy Haptoglobin genotype- and diabetes-dependent differences in iron-mediated oxidative stress in vitro and in vivo Circ Res 96 2005 435 441
9. A.P. Levy, M.G. Larson, D. Corey, R. Lotan, J.A. Vita, E.J. Benjamin Haptoglobin phenotype and prevalent coronary heart disease in the Framingham offspring cohort Atherosclerosis 172 2004 361 365
10. D. De Bacquer, G. De Backer, M. Langlois, J. Delanghe, H. Kesteloot, M. Kornitzer Haptoglobin polymorphism as a risk factor for coronary heart disease mortality Atherosclerosis 157 2001 161 166
11. A. Patel, S. MacMahon, J. Chalmers Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes N Engl J Med 358 2008 2560 2572
12. H.C. Gerstein, M.E. Miller, S. Genuth Long-term effects of intensive glucose lowering on cardiovascular outcomes N Engl J Med 364 2011 818 828
13. A. Cassidy, S.E. Chiuve, J.E. Manson, K.M. Rexrode, C.J. Girman, E.B. Rimm Potential role for plasma placental growth factor in predicting coronary heart disease risk in women Arterioscler Thromb Vasc Biol 29 2009 134 139
14. G.A. Colditz, S.E. Hankinson The Nurses' Health Study: lifestyle and health among women Nature reviews 5 2005 388 396
15. W.C. Willett, M.J. Stampfer, G.A. Colditz, B.A. Rosner, C.H. Hennekens, F.E. Speizer Dietary fat and the risk of breast cancer N Engl J Med 316 1987 22 28
16. U. Milman, S. Blum, C. Shapira Vitamin E supplementation reduces cardiovascular events in a subgroup of middle-aged individuals with both type 2 diabetes mellitus and the haptoglobin 2-2 genotype: a prospective double-blinded clinical trial Arterioscler Thromb Vasc Biol 28 2008 341 347
17. Database of Single Nucleotide Polymorphisms (dbSNP) Bethesda, MD: National Center for Biotechnology Information, National Library of Medicine. dbSNP accession:{ss1 or ss1 - ss100}, (dbSNP Build ID: {build ID}) http://www.ncbi.nlm.nih.gov/SNP/ Accessed May 15, 2012
18. I. Hochberg, A. Roguin, E. Nikolsky, P.V. Chanderashekhar, S. Cohen, A.P. Levy Haptoglobin phenotype and coronary artery collaterals in diabetic patients Atherosclerosis 161 2002 441 446
19. W. Koch, W. Latz, M. Eichinger Genotyping of the common haptoglobin Hp 1/2 polymorphism based on PCR Clin Chem 48 2002 1377 1382
20. J.K. Pai, T. Pischon, J. Ma Inflammatory markers and the risk of coronary heart disease in men and women N Engl J Med 351 2004 2599 2610
21. G.A. Rose, H. Blackburn Cardiovascular Survey Methods monograph series no. 58 2nd ed 1982 World Health Organization Geneva, Switzerland
22. International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes Diabetes Care 32 2009 1327 1334
23. R. DerSimonian, N. Laird Meta-analysis in clinical trials Control Clin Trials 7 1986 177 188
24. A.P. Levy, I. Hochberg, K. Jablonski Haptoglobin phenotype is an independent risk factor for cardiovascular disease in individuals with diabetes: the Strong Heart Study J Am Coll Cardiol 40 2002 1984 1990
25. H. Wang, N.M. Shara, E.T. Lee Hemoglobin A1c, fasting glucose, and cardiovascular risk in a population with high prevalence of diabetes: the Strong Heart Study Diabetes Care 34 2011 1952 1958
26. M.K. Jensen, K.J. Mukamal, K. Overvad, E.B. Rimm Alcohol consumption, TaqIB polymorphism of cholesteryl ester transfer protein, high-density lipoprotein cholesterol, and risk of coronary heart disease in men and women Eur Heart J 29 2008 104 112
27. R. Asleh, S. Blum, S. Kalet-Litman Correction of HDL dysfunction in individuals with diabetes and the haptoglobin 2-2 genotype Diabetes 57 2008 2794 2800
28. M.C. Cid, D.S. Grant, G.S. Hoffman, R. Auerbach, A.S. Fauci, H.K. Kleinman Identification of haptoglobin as an angiogenic factor in sera from patients with systemic vasculitis J Clin Invest 91 1993 977 985
29. J.P. Chapelle, A. Albert, J.P. Smeets, C. Heusghem, H.E. Kulbertus Effect of the haptoglobin phenotype on the size of a myocardial infarct N Engl J Med 307 1982 457 463
30. L. Braeckman, D. De Bacquer, J. Delanghe, L. Claeys, G. De Backer Associations between haptoglobin polymorphism, lipids, lipoproteins and inflammatory variables Atherosclerosis 143 1999 383 388
31. J. Delanghe, M. Langlois, D. Duprez, M. De Buyzere, D. Clement Haptoglobin polymorphism and peripheral arterial occlusive disease Atherosclerosis 145 1999 287 292
32. D. Maglott, J. Ostell, K.D. Pruitt, T. Tatusova Entrez gene: gene-centered information at NCBI Nucleic Acids Res 39 2011 D52 D57
33. W. Duckworth, C. Abraira, T. Moritz Glucose control and vascular complications in veterans with type 2 diabetes N Engl J Med 360 2009 129 139
34. K.K. Ray, S.R. Seshasai, S. Wijesuriya Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials Lancet 373 2009 1765 1772
35. K. Carter, M. Worwood Haptoglobin: a review of the major allele frequencies worldwide and their association with diseases Int J Lab Hematol 29 2007 92 110