S100A4 promotes invasion and angiogenesis in breast cancer MDA-MB-231 cells by upregulating matrix metalloproteinase-13

Acta Biochimica Polonica

Volumn 59, Issue 4, 2012, Pages 593-598

  Wang, Lin ^a   Wang, Xingang ^b   Liang, Yu ^c   Diao, Xinying ^c   Chen, Qingfeng ^b  

^a Institute of Oncology Tianjin Union Medicine Centre   (China)

^b QINGDAO UNIVERSITY   (China)

^c The Second Affiliated Hospital of Tianjin Medical Uiversity   (China)

Author keywords

Breast cancer; Metastasis; MMP 13; S100A4

Indexed keywords

EID: 84873726489     PISSN: 0001527X     EISSN: 1734154X     Source Type: Journal    
DOI: 10.18388/abp.2012_2097     Document Type: Article

References (27)

1. Ambartsumian N, Klingelhöfer J, Grigorian M, Christensen C, Kriajevska M, Tulchinsky E, Georgiev G, Berezin V, Bock E, Rygaard J, Cao R, Cao Y, Lukanidin E (2001) The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor. Oncogene 20: 4685-4695.
2. Ambartsumian NS, Grigorian MS, Larsen IF, Karlstrøm O, Sidenius N, Rygaard J, Georgiev G, Lukanidin E (1996) Metastasis of mammary carcinomas in GRS/A hybrid mice transgenic for the mts1 gene. Oncogene 13: 1621-1630.
3. Acuff HB, Carter KJ, Fingleton B, Gorden DL, Matrisian LM (2006) Matrix metalloproteinase-9 from bone marrow-derived cells contributes to survival but not growth of tumor cells in the lung microenvironment. Cancer Res 66: 259-266.
4. Duarte WR, Shibata T, Takenaga K, Takahashi E, Kubota K, Ohya K, Ishikawa I, Yamauchi M, Kasugai S (2003) S100A4: a novel negative regulator of mineralization and osteoblast differentiation. J Bone Miner Res 18: 493-501.
5. Davies BR, Davies MP, Gibbs FE, Barraclough R, Rudland PS (1993) Induction of the metastatic phenotype by transfection of a benign rat mammary epithelial cell line with the gene for p9Ka, a rat calcium-binding protein, but not with the oncogene EJ-ras-1. Oncogene 8: 999-1008.
6. Ford HL, Zain SB (1995) Interaction of metastasis associated Mts1 protein with nonmuscle myosin. Oncogene 10: 1597-1605.
7. Freije JM, Díez-Itza I, Balbín M, Sánchez LM, Blasco R, Tolivia J, López-Otín C (1994) Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas. J Biol Chem 269: 16766-1673.
8. Grigorian M, Ambartsumian N, Lykkesfeldt AE, Bastholm L, Elling F, Georgiev G, Lukanidin E (1996) Effect of mts1 (S100A4) expression on the progression of human breast cancer cells. Int J Cancer 67: 831-841.
9. Garrett SC, Varney KM, Weber DJ, Bresnick AR (2006) S100A4, a mediator of metastasis. J Biol Chem 281: 677-680.
10. Ismail NI, Kaur G, Hashim H, Hassan MS (2010) S100A4 overexpression proves to be independent marker for breast cancer progression. Cancer Cell Int 8: 12.
11. Jenkinson SR, Barraclough R, West CR, Rudland PS (2004) S100A4 regulates cell motility and invasion in an in vitro model for breast cancer metastasis. Br J Cancer 90: 253-262.
12. Klingelhöfer J, Ambartsumian NS, Lukanidin EM (1997) Expression of the metastasis-associated mts1 gene during mouse development. Dev Dyn 210: 87-95.
13. Levett D, Flecknell PA, Rudland PS, Barraclough R, Neal DE, Mellon JK, Davies BR (2002) Transfection of S100A4 produces metastatic variants of an orthotopic model of bladder cancer. Am J Pathol 160: 693-700.
14. Liu X, Li F, Sun SQ, Thangavel M, Kaminsky J, Balazs L, Ostrom RS (2010) Fibroblast-specific expression of AC6 enhances beta-adrenergic and prostacyclin signaling and blunts bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 298: L819-L829.
15. Lloyd BH, Platt-Higgins A, Rudland PS, Barraclough R (1998) Human S100A4 (p9Ka) induces the metastatic phenotype upon benign tumour cells. Oncogene 17: 465-473.
16. Malashkevich VN, Varney KM, Garrett SC, Wilder PT, Knight D, Charpentier TH, Ramagopal UA, Almo SC, Weber DJ, Bresnick AR (2008) Structure of Ca2_-bound S100A4 and its interaction with peptides derived from nonmuscle myosin-IIA. Biochemistry 47: 5111-5126.
17. Maelandsmo GM, Hovig E, Skrede M, Engebraaten O, Flørenes VA, Myklebost O, Grigorian M, Lukanidin E, Scanlon KJ, Fodstad O (1996) Reversal of the in vivo metastatic phenotype of human tumor cells by an anti-CAPL (mts1) ribozyme. Cancer Res 56: 5490-5498.
18. Matsuura I, Lai CY, Chiang KN (2010) Functional interaction between Smad3 and S100A4 (metastatin-1) for TGF-ß-mediated cancer cell invasiveness. Biochem J 426: 327-335.
19. McKay JA, Douglas JJ, Ross VG (2002) Analysis of key cell cycle checkpoint proteins in colorectal tumours. J Pathol 196: 386-393.
20. Neutzner M, Lopez T, Feng X, Bergmann-Leitner ES, Leitner WW, Udey MC (2007) MFG-E8/lactadherin promotes tumor growth in an angiogenesis-dependent transgenic mouse model of multistage carcinogenesis. Cancer Res 67: 6777-6785.
21. Novitskaya V, Grigorian M, Kriajevska M, Tarabykina S, Bronstein I, Berezin V, Bock E, Lukanidin E (2000) Oligomeric forms of the metastasis-related Mts1 (S100A4) protein stimulate neuronal differentiation in cultures of rat hippocampal neurons. J Biol Chem 275: 41278-41286.
22. Rudland PS, Platt-Higgins A, Renshaw C, West CR, Winstanley JH, Robertson L, Barraclough R (2000) Prognostic significance of the metastasis-inducing protein S100A4 (p9Ka) in human breast cancer. Cancer Res 60: 1595-1603.
23. Schmidt-Hansen B, Ornås D, Grigorian M, Klingelhöfer J, Tulchinsky E, Lukanidin E, Ambartsumian N (2004) Extracellular S100A4(mts1) stimulates invasive growth of mouse endothelial cells and modulates MMP-13 matrix metalloproteinase activity. Oncogene 23: 5487-5495.
24. Simpson PT, Shoker BS, Barraclough R, Halliwell N, Rudland PS, Sibson DR, Davies MP (2003) Examination of tumour histopathology and gene expression in a neu/S100A4 transgenic model of metastatic breast cancer. Int J Exp Pathol 84: 173-184.
25. Schmidt-Hansen B, Dorte O, Grigorian M, Klingelho J, Tulchinsky E, Lukanidin E, Ambartsumian N (2004) Extracellular S100A4(mts1) stimulates invasive growth of mouse endothelial cells and modulates MMP-13 matrix metalloproteinase activity. Oncogene 23: 5487-5495.
26. Wang G, Platt-Higgins A, Carroll J, de Silva Rudland S, Winstanley J, Barraclough R, Rudland PS (2006) Induction of metastasis by S100P in a rat mammary model and its association with poor survival of breast cancer patients. Cancer Res 66: 1199-1207.
27. Zhang B, Cao X, Liu Y, Cao W, Zhang F, Zhang S, Li H, Ning L, Fu L, Niu Y, Niu R, Sun B, Hao X (2008) Tumor-derived matrix metalloproteinase-13 (MMP-13) correlates with poor prognoses of invasive breast cancer. BMC Cancer 8: 83-90.