Reactive retinal astrocytic tumors (So-called vasoproliferative tumors): Histopathologic, immunohistochemical, and genetic studies of four cases

American Journal of Ophthalmology

Volumn 155, Issue 3, 2013, Pages 593-608.e1

  Poole Perry, Lynn J ^a   Jakobiec, Frederick A ^a   Zakka, Fouad R ^a   Reichel, Elias ^b   Herwig, Martina C ^c,e   Perry, Arie ^d   Brat, Daniel J ^e   Grossniklaus, Hans E ^e  

^a HARVARD MEDICAL SCHOOL   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF BONN   (Germany)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; BEVACIZUMAB; CD163 ANTIGEN; CD31 ANTIGEN; CD34 ANTIGEN; CHOLESTEROL; GLIAL FIBRILLARY ACIDIC PROTEIN; ISOCITRATE DEHYDROGENASE 1; KI 67 ANTIGEN; NEUROFILAMENT PROTEIN; PROTEIN P53; SYNAPTOPHYSIN;

ADULT; AGED; ARTICLE; ASTROCYTE; CASE REPORT; CELL ORGANELLE; CELL ULTRASTRUCTURE; CHOROID; CHOROIDITIS; CHRONIC INFLAMMATION; CRYOTHERAPY; CYTOPLASM; ENUCLEATION; EOSINOPHILIC GRANULAR BODY; EPITHELIUM CELL; EYE INJURY; EYE PAIN; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FOAM CELL; GENE MUTATION; GENE REARRANGEMENT; GENETIC ANALYSIS; HEMANGIOBLASTOMA; HISTIOCYTE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYALINE DEGENERATION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTERMEDIATE FILAMENT; INTRAOCULAR PRESSURE; LYSOSOME; MALE; MEDICAL RECORD REVIEW; MEDICAL SPECIALIST; METAPLASIA; MICROPHOTOGRAPHY; MICROVASCULATURE; MIDDLE AGED; NEOVASCULAR GLAUCOMA; OSSIFICATION; PENETRATING KERATOPLASTY; PERIODIC ACID SCHIFF STAIN; PIGMENT EPITHELIUM; PLACOID FIBROUS METAPLASIA; PRIORITY JOURNAL; PYROSEQUENCING; REACTIVE RETINAL ASTROCYTIC TUMOR; RETINA DETACHMENT; RETINA EXUDATE; RETINA FLUORESCEIN ANGIOGRAPHY; RETINA NEOVASCULARIZATION; RETINA TUMOR; RETROSPECTIVE STUDY; ROSENTHAL FIBER; SCLERA BUCKLING PROCEDURE; SPINDLE CELL; SUBCAPSULAR CATARACT; TUMOR LOCALIZATION; UPREGULATION; UVEITIS; VISUAL ACUITY;

EID: 84873725816     PISSN: 00029394     EISSN: 18791891     Source Type: Journal    
DOI: 10.1016/j.ajo.2012.09.002     Document Type: Article

References (70)

1. J.A. Shields, W.L. Decker, and G.E. Sanborn Presumed acquired retinal hemangiomas Ophthalmology 90 11 1983 1292 1300
2. C.L. Shields, J.A. Shields, J. Barrett, and P. De Potter Vasoproliferative tumors of the ocular fundus. Classification and clinical manifestations in 103 patients Arch Ophthalmol 113 5 1995 615 623
3. J.D. Palmer, and E.S. Gragoudas Advances in treatment of retinal angiomas Int Ophthalmol Clin 37 4 1997 159 170
4. C.C. Barr, T.A. Rice, and R.G. Michels Angioma-like mass in a patient with retrolental fibroplasia Am J Ophthalmol 89 5 1980 647 650
5. F. Gottlieb, J.J. Fammartino, T.P. Stratford, and R.J. Brockhurst Retinal angiomatous mass. A complication of retinal detachment surgery Retina 4 3 1984 152 157
6. P. Schmitz-Valckenberg, and G. Meyer-Schwickerath [Retinal angiomatosis in the aged] Ber Zusammenkunft Dtsch Ophthalmol Ges 74 1977 205 208 [in German]
7. S.O. Galinos, T.R. Smith, and R.J. Brockhurst Angioma-like lesion in hemoglobin sickle cell disease Ann Ophthalmol 11 10 1979 1549 1552
8. P. Hiscott, and H. Mudhar Is vasoproliferative tumour (reactive retinal glioangiosis) part of the spectrum of proliferative vitreoretinopathy? Eye (Lond) 23 9 2009 1851 1858
9. P.A. Campochiaro, and B.P. Conway Hemangiomalike masses of the retina Arch Ophthalmol 106 10 1988 1409 1413
10. H. Laqua, and A. Wessing Peripheral retinal telangiectasis in adults simulating a vascular tumor or melanoma Ophthalmology 90 11 1983 1284 1291
11. F. Kaba, F. el Baba, and W.R. Green Uveal neovascularization at the ora serrata and pars plana Ann Ophthalmol 19 3 1987 85 90
12. K.S. Felder, and R.J. Brockhurst Neovascular fundus abnormalities in peripheral uveitis Arch Ophthalmol 100 5 1982 750 754
13. H. Heimann, N. Bornfeld, and O. Vij Vasoproliferative tumours of the retina Br J Ophthalmol 84 10 2000 1162 1169
14. F. Irvine, N. O'Donnell, E. Kemp, and W.R. Lee Retinal vasoproliferative tumors: surgical management and histological findings Arch Ophthalmol 118 4 2000 563 569
15. M.H. Smeets, C.M. Mooy, and G.S. Baarsma Histopathology of a vasoproliferative tumor of the ocular fundus Retina 18 5 1998 470 472
16. Kim YH, Nonoguchi N, Paulus W, et al. Frequent BRAF gain in low-grade diffuse gliomas with 1p/19q loss. Brain Pathol. doi: 10.1111/j.1750-3639.2012. 00601.x. 2012.05.9.
17. G. Shindler, D. Capper, J. Meyer, W. Janzarik, and H. Omran Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma Acta Neuropathol 121 2011 397 405
18. D. Capper, S. Weissert, and J. Balss Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors Brain Pathol 20 1 2010 245 254
19. D.N. Louis The p53 gene and protein in human brain tumors J Neuropathol Exp Neurol 53 1 1994 11 21
20. S. Pfister, W.G. Janzarik, and M. Remke BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas J Clin Invest 118 5 2008 1739 1749
21. J. Shields, and C.L. Shields Intraocular tumors: an atlas and textbook 2008 Lippincott Williams and Wilkins / Walters Kluwer Philadelphia 396-427
22. B. Damato Vasoproliferative retinal tumour Br J Ophthalmol 90 4 2006 399 400
23. J. Wachtlin, H. Heimann, and C. Jandek Bilateral vasoproliferative retinal tumors with identical localization in a pair of monozygotic twins Arch Ophthalmol 120 6 2002 860 861
24. B.W. Scheithauer, C. Hawkins, T. Titan, S.R. Van den Berg, and P.C. Burger Pilocytic astrocytoma WHO classification of tumors of the central nervous system 2007 IARC Press Lyon 14 21
25. D.N. Louis, G. Reifenberger, J. Brat, and D.W. Ellison Tumors: introduction and neuroepithelial tumors S. Love, D.W. Louis, D.W. Wilson, Greenfields neuropathology 2008 Hodder Arnold London 1855 1860
26. C. Daumas-Duport, B. Scheithauer, J. O'Fallon, and P. Kelly Grading of astrocytomas. A simple and reproducible method Cancer 62 10 1988 2152 2165
27. T.M. Nork, M.W. Ghobrial, G.A. Peyman, and M.O. Tso Massive retinal gliosis. A reactive proliferation of Muller cells Arch Ophthalmol 104 9 1986 1383 1389
28. Y. Inayama, M. Hanashi, and T. Yazawa Massive gliosis of the retina: report of a case investigated by immunohistochemistry and clonality assays Hum Pathol 36 6 2005 702 705
29. F.J. Wippold 2nd, A. Perry, and J. Lennerz Neuropathology for the neuroradiologist: Rosenthal fibers AJNR Am J Neuroradiol 27 5 2006 958 961
30. G. Singh, and M. Tatke Rosenthal fibers and eosinophilic granular bodies in an acoustic schwannoma Indian J Pathol Microbiol 54 3 2011 629 631
31. A.G. Palestine, R.B. Nussenblatt, and C.C. Chan Histopathology of the subretinal fibrosis and uveitis syndrome Ophthalmology 92 6 1985 838 844
32. M.K. Kim, C.C. Chan, and R. Belfort Jr. Histopathologic and immunohistopathologic features of subretinal fibrosis and uveitis syndrome Am J Ophthalmol 104 1 1987 15 23
33. R.C. Wang, E. Zamir, and P.U. Dugel Progressive subretinal fibrosis and blindness associated with multifocal granulomatous chorioretinitis: a variant of sympathetic ophthalmia Ophthalmology 109 8 2002 1527 1531
34. Jakobiec FA, Callahan AB, Zakka FR. Intraocular PAS-positive macrophages simulating Whipple's disease. Graefes Arch Clin Exp Ophthalmol. doi 10.1007/s00417-012-2070-0.
35. F.A. Jakobiec, S.E. Brodie, B. Haik, and T. Iwamoto Giant cell astrocytoma of the retina. A tumor of possible Mueller cell origin Ophthalmology 90 12 1983 1565 1576
36. A. Bringmann, and P. Wiedemann Muller glial cells in retinal disease Ophthalmologica 227 1 2012 1 19
37. V.S. Gullapalli, I.K. Sugino, and M.A. Sarbin Mueller cells and the retinal pigment epithelium D.M. Albert, J.W. Miller, Albert and Jakobiec's principles and practice of ophthalmology 2008 Saunders/Elsevier Philadelphia 1633 1639
38. M.V. Sofroniew, and H.V. Vinters Astrocytes: biology and pathology Acta Neuropathol 119 1 2010 7 35
39. H. Lincoff, I. Kreissig, F. Jakobiec, and T. Iwamoto Remodeling of the cryosurgical adhesion Arch Ophthalmol 99 10 1981 1845 1849
40. G.P. Lewis, and S.K. Fisher Up-regulation of glial fibrillary acidic protein in response to retinal injury: its potential role in glial remodeling and a comparison to vimentin expression Int Rev Cytol 230 2003 263 290
41. S. Duke-Elder, and K.C. Wybar The anatomy of the visual system 1961 Henry Kimpton London 256-258
42. M.J. Hogan, J.A. Alvarado, and J.E. Weddell Histology of the human eye: an atlas and textbook 1971 W.B. Saunders Philadelphia 22-23,462-468
43. B. Fine, and M. Yanoff Ocular histology: a text and atlas 1979 Harper and Row Hagerstown 99-101
44. N. Bornfels, E.P. Messmer, G. Theodossiadis, G. Meyer-Schwickerath, and A. Wessing Giant cell astrocytome of the retina: clinicopathologic report of a case not associated with Bourneville's disease Retina 7 3 1987 183 189
45. F.H. Reeser, T.M. Aaberg, and D.L. Van Horn Astrocytic hamartoma of the retina not associated with tuberous sclerosis Am J Ophthalmol 86 5 1978 688 698
46. M. Toteberg-Harms, V. Sturm, S. Sel, Am Sasse, and K. Landau Retinal astrocytomas: long-term follow-up Klin Monbl Augenheilkd 228 40 2011 337 339
47. E.A. Grant, K.M. Trzupek, J. Reiss, K. Crow, and L. Messiaen Combined retinal hamartomas leading to diagnosis of neurofibramotosis type 2 Ophthalmol Genet 29 3 2008 133 138
48. L.D. Kaye, A.D. Rothner, G.R. Beauchamp, S.M. Meyers, and M.L. Estes Ocular findings associated with neurofibromatosis type II Ophthalmology 99 9 1992 1423 1429
49. M.E. McLaughlin, D.M. Pepin, M. MacCollin, P. Choopong, and S. Lessell Ocular pathologic findings of neurofibramotosis type 2 Arch Ophthalmol 125 3 2007 389 394
50. C.L. Shields, J.A. Shields, R.C. Eagle Jr., and F. Cangemi Progressive enlargement of acquired retinal astrocytoma in 2 cases Ophthalmology 111 2 2004 363 368
51. C.T. Hood, L. Janku, C.Y. Lowder, and A.D. Singh Retinal vasoproliferative tumor in association with neurofibromatosis type 1 J Pediatr Ophthalmol Strabismus 2009 1 3
52. A.C. Arnold, R.S. Hepler, and R.W. Yee Solitary retinal astrocytoma Surv Ophthalmol 30 3 1985 173 181
53. Jung CS, Hubbard GB, Grossniklaus HE. Giant cell astrocytoma of the retina in a one month old infant. J Pediatr Ophthalmol Strabismus. doi: 10.3928/01913913-20091019-05. 2009.11.2.
54. J.A. Shields, R.C. Eagle, C.L. Shields, and B.P. Marr Aggressive retinal astrocytomas in four patients with tuberous sclerosis complex Trans Am Ophthalmol Soc 102 2004 139 148
55. J.A. Shields, C.G. Bianciotto, T. Kivela, and C.L. Shields Presumed solitary circumscribed retinal astrocytic proliferation: the 2010 Jonathan W. Wirtschafter Lecture Arch Ophthalmol 129 9 2011 1189 1194
56. J.P. Ganley, and B.W. Streeten Glial nodules of the inner retina Am J Ophthalmol 71 5 1971 1099 1103
57. T. Forshew, R.G. Tatevossian, and A.R. Lawson Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas J Pathol 218 2 2009 172 181
58. Dahiya S, Yu J, Kaul A, et al. Novel BRAF alteration in a sporadic pilocytic astrocytoma. Case Report Med. doi: 10.1155/2012/418672. 2012.02.07.
59. M.V. Sofroniew Molecular dissection of reactive astrogliosis and glial scar formation Trends Neurosci 32 12 2009 638 647
60. S.K. Houston, T.D. Bourne, M.B. Lopes, and N.G. Ghazi Bilateral massive retinal gliosis associated with retinopathy of prematurity Arch Pathol Lab Med 133 8 2009 1242 1245
61. P. Henkind, and G. Morgan Peripheral retinal angioma with exudative retinopathy in adults (Coats's lesion) Br J Ophthalmol 50 1 1966 2 11
62. D.W. Ellison, A. Perry, S.A. Rosenblum, R. Reid, and D.N. Louis Tumors: non-neuroepithelial tumors and secondary effects S. Love, D.N. Louis, D.W. Ellison, Greenfield's neuropathology 2008 Hodder Arnold London 2029 2031 2049-2053
63. N. Kenawy, C. Groenwald, and B. Damato Treatment of a vasoproliferative tumour with intravitreal bevacizumab (Avastin) Eye (Lond) 21 6 2007 893 894
64. R.P. Chan, and T.Y. Lai Photodynamic therapy with verteporfin for vasoproliferative tumour of the retina Acta Ophthalmol 88 6 2010 711 712
65. M.A. Blasi, A. Scupola, and A.C. Tiberti Photodynamic therapy for vasoproliferative retinal tumors Retina 26 4 2006 404 409
66. V.M. Cohen, C.L. Shields, H. Demirci, and J.A. Shields Iodine I -25 plaque radiotherapy for vasoproliferative tumors of the retina in 30 eyes Arch Ophthalmol 126 9 2008 1245 1251
67. G. Anastassiou, N. Bornfeld, and A.O. Schueler Ruthenium-106 plaque brachytherapy for symptomatic vasoproliferative tumours of the retina Br J Ophthalmol 90 4 2006 447 450
68. J. Smith, and D. Steel The surgical management of vasoproliferative tumours Ophthalmologica 226 Suppl 1 2011 42 45
69. S. Yeh, and D.J. Wilson Pars plana vitrectomy and endoresection of a retinal vasoproliferative tumor Arch Ophthalmol 128 9 2010 1196 1199
70. S.K. Gibran Trans-vitreal endoresection for vasoproliferative retinal tumours Clin Experiment Ophthalmol 36 8 2008 712 716