One pot direct synthesis of oxazolines, benzoxazoles, and oxadiazoles from carboxylic acids using the Deoxo-Fluor reagent

Tetrahedron Letters

Volumn 47, Issue 37, 2006, Pages 6497-6499

  Kangani, Cyrous O ^a   Kelley, David E ^a   Day, Billy W ^b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOXAZOLE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; OXADIAZOLE DERIVATIVE; OXAZOLINE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; OXIDATION; QUANTITATIVE ANALYSIS; SYNTHESIS; THERMAL ANALYSIS;

EID: 33746802369     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.07.032     Document Type: Article

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45. 4), filtered, and concentrated in vacuo. Flash column chromatography (silica gel, 1.5 × 20 cm, 10 → 50 EtOAc/hexanes) provided 9 (60.3 mg, 97%) as a light yellow solid.
46. -1; at a stable ambient temperature (21 °C) were used.
47. GC-MS analysis of the crude cyclized products 1,3,4-oxadiazoles as well oxazolines and benzoxazoles showed that the products generally were ≥90% pure.