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Volumn 21, Issue 5, 2013, Pages 1344-1348

Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: Synthesis, crystallography, modeling, kinetic and cellular based studies

(7) Šilhár, Peter a Silvaggi, Nicholas R b Pellett, Sabine c Čapková, Kateřina a Johnson, Eric A c Allen, Karen N b Janda, Kim D a

a SCRIPPS RESEARCH INSTITUTE (United States)

b USA (United States)

c UNIVERSITY OF WISCONSIN MADISON (United States)

Author keywords

Adamantane derivatives; Botulinum neurotoxin; Protease inhibitor; Small molecule inhibitor; Zinc dependent metalloprotease

Indexed keywords

1 ADAMANTYL N HYDROXYACETAMIDE; 1 ADAMANTYLACETIC ACID; 1 ADAMANTYLACETOHYDROXAMIC ACID; ADAMANTANE DERIVATIVE; BOTULINUM TOXIN; BOTULINUM TOXIN A; HYDROXAMIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL KINETICS; COMPETITIVE INHIBITION; COMPUTER MODEL; DRUG BINDING SITE; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ADAMANTANE; ANIMALS; BINDING SITES; BOTULINUM TOXINS, TYPE A; CATALYTIC DOMAIN; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; HYDROXAMIC ACIDS; KINETICS; MOLECULAR DOCKING SIMULATION; PROTEASE INHIBITORS; RATS; STEM CELLS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84873722654 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.12.001 Document Type: Article

Times cited : (49)

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